longtext: 8spk-pdb

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HEADER    HYDROLASE                               03-MAY-23   8SPK
TITLE     CRYSTAL STRUCTURE OF ANTARCTIC PET-DEGRADING ENZYME
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: LIPASE 1;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: TRIACYLGLYCEROL LIPASE;
COMPND   5 EC: 3.1.1.3;
COMPND   6 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: MORAXELLA;
SOURCE   3 ORGANISM_TAXID: 475;
SOURCE   4 GENE: LIP1, L1;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   7 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;
SOURCE   8 EXPRESSION_SYSTEM_PLASMID: PET28A-TEV
KEYWDS    PET-DEGRADING ENZYME, ANTARCTIC, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    A.A.FURTADO,P.BLAZQUEZ-SANCHEZ,A.GRINEN,J.A.VARGAS,D.A.LEONARDO,
AUTHOR   2 S.A.SCULACCIO,H.M.PEREIRA,B.DIEZ,R.C.GARRATT,C.A.RAMIREZ-SARMIENTO
REVDAT   1   23-AUG-23 8SPK    0
JRNL        AUTH   P.BLAZQUEZ-SANCHEZ,J.A.VARGAS,A.A.FURTADO,A.GRINEN,
JRNL        AUTH 2 D.A.LEONARDO,S.A.SCULACCIO,H.D.PEREIRA,C.SONNENDECKER,
JRNL        AUTH 3 W.ZIMMERMANN,B.DIEZ,R.C.GARRATT,C.A.RAMIREZ-SARMIENTO
JRNL        TITL   ENGINEERING THE CATALYTIC ACTIVITY OF AN ANTARCTIC
JRNL        TITL 2 PET-DEGRADING ENZYME BY LOOP EXCHANGE.
JRNL        REF    PROTEIN SCI.                         E4757 2023
JRNL        REFN                   ESSN 1469-896X
JRNL        PMID   37574805
JRNL        DOI    10.1002/PRO.4757
REMARK   2
REMARK   2 RESOLUTION.    1.60 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (1.20.1_4487: ???)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.60
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 92.76
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.350
REMARK   3   COMPLETENESS FOR RANGE        (%) : 100.0
REMARK   3   NUMBER OF REFLECTIONS             : 99232
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.154
REMARK   3   R VALUE            (WORKING SET) : 0.153
REMARK   3   FREE R VALUE                     : 0.180
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.950
REMARK   3   FREE R VALUE TEST SET COUNT      : 4908
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 92.7600 -  4.9700    1.00     3315   186  0.1660 0.1735
REMARK   3     2  4.9600 -  3.9400    1.00     3228   149  0.1129 0.1268
REMARK   3     3  3.9400 -  3.4400    1.00     3202   151  0.1223 0.1396
REMARK   3     4  3.4400 -  3.1300    1.00     3188   146  0.1347 0.1912
REMARK   3     5  3.1300 -  2.9000    1.00     3156   168  0.1513 0.1693
REMARK   3     6  2.9000 -  2.7300    1.00     3164   149  0.1530 0.1647
REMARK   3     7  2.7300 -  2.6000    1.00     3174   178  0.1484 0.1548
REMARK   3     8  2.6000 -  2.4800    1.00     3131   179  0.1504 0.1797
REMARK   3     9  2.4800 -  2.3900    1.00     3125   166  0.1419 0.1695
REMARK   3    10  2.3900 -  2.3000    1.00     3157   153  0.1383 0.1631
REMARK   3    11  2.3000 -  2.2300    1.00     3152   152  0.1450 0.1776
REMARK   3    12  2.2300 -  2.1700    1.00     3170   171  0.1567 0.1775
REMARK   3    13  2.1700 -  2.1100    1.00     3102   145  0.1608 0.1809
REMARK   3    14  2.1100 -  2.0600    1.00     3145   163  0.1572 0.1787
REMARK   3    15  2.0600 -  2.0100    1.00     3135   159  0.1546 0.1828
REMARK   3    16  2.0100 -  1.9700    1.00     3107   176  0.1562 0.1856
REMARK   3    17  1.9700 -  1.9300    1.00     3134   136  0.1539 0.1985
REMARK   3    18  1.9300 -  1.8900    1.00     3186   142  0.1592 0.1918
REMARK   3    19  1.8900 -  1.8600    1.00     3103   199  0.1578 0.1897
REMARK   3    20  1.8600 -  1.8300    1.00     3093   173  0.1694 0.2172
REMARK   3    21  1.8300 -  1.8000    1.00     3135   143  0.1825 0.2194
REMARK   3    22  1.8000 -  1.7700    1.00     3126   180  0.2079 0.2126
REMARK   3    23  1.7700 -  1.7500    1.00     3117   151  0.2131 0.3075
REMARK   3    24  1.7500 -  1.7200    1.00     3102   165  0.2268 0.2606
REMARK   3    25  1.7200 -  1.7000    1.00     3118   162  0.2310 0.2878
REMARK   3    26  1.7000 -  1.6800    1.00     3155   167  0.1935 0.2253
REMARK   3    27  1.6800 -  1.6600    1.00     3077   196  0.1957 0.2422
REMARK   3    28  1.6500 -  1.6400    1.00     3134   166  0.1921 0.2019
REMARK   3    29  1.6300 -  1.6200    1.00     3079   174  0.2015 0.2292
REMARK   3    30  1.6200 -  1.6000    1.00     3114   163  0.2037 0.2366
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.150
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 17.080
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.017           4216
REMARK   3   ANGLE     :  1.501           5724
REMARK   3   CHIRALITY :  0.104            614
REMARK   3   PLANARITY :  0.015            747
REMARK   3   DIHEDRAL  : 12.079           1552
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 12
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: ( CHAIN A AND RESID 55:71 )
REMARK   3    ORIGIN FOR THE GROUP (A):   39.901  -21.914    5.548
REMARK   3    T TENSOR
REMARK   3      T11:   0.3174 T22:   0.2154
REMARK   3      T33:   0.1680 T12:   0.0377
REMARK   3      T13:   0.0495 T23:  -0.0241
REMARK   3    L TENSOR
REMARK   3      L11:   0.7207 L22:   5.9475
REMARK   3      L33:   0.5824 L12:   0.7417
REMARK   3      L13:  -0.2808 L23:   0.6641
REMARK   3    S TENSOR
REMARK   3      S11:  -0.2508 S12:  -0.0095 S13:  -0.3795
REMARK   3      S21:   0.0953 S22:   0.0119 S23:  -0.1584
REMARK   3      S31:   0.7746 S32:   0.0702 S33:  -0.1044
REMARK   3   TLS GROUP : 2
REMARK   3    SELECTION: ( CHAIN A AND RESID 72:97 )
REMARK   3    ORIGIN FOR THE GROUP (A):   52.159  -23.012  -11.796
REMARK   3    T TENSOR
REMARK   3      T11:   0.1914 T22:   0.2160
REMARK   3      T33:   0.1384 T12:   0.0183
REMARK   3      T13:  -0.0091 T23:  -0.0234
REMARK   3    L TENSOR
REMARK   3      L11:   1.1412 L22:   0.5489
REMARK   3      L33:   4.2982 L12:  -0.4609
REMARK   3      L13:  -1.4324 L23:   1.2232
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0131 S12:  -0.3665 S13:   0.1380
REMARK   3      S21:   0.0761 S22:   0.1458 S23:  -0.0949
REMARK   3      S31:  -0.2576 S32:   0.5641 S33:  -0.3514
REMARK   3   TLS GROUP : 3
REMARK   3    SELECTION: ( CHAIN A AND RESID 98:225 )
REMARK   3    ORIGIN FOR THE GROUP (A):   41.555  -24.660  -16.335
REMARK   3    T TENSOR
REMARK   3      T11:   0.1257 T22:   0.0837
REMARK   3      T33:   0.0772 T12:   0.0060
REMARK   3      T13:   0.0104 T23:  -0.0041
REMARK   3    L TENSOR
REMARK   3      L11:   1.2972 L22:   0.8765
REMARK   3      L33:   1.4608 L12:  -0.1904
REMARK   3      L13:  -0.5135 L23:   0.1967
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0690 S12:  -0.0871 S13:  -0.0520
REMARK   3      S21:   0.0972 S22:   0.0318 S23:   0.0079
REMARK   3      S31:   0.1236 S32:   0.0641 S33:   0.0286
REMARK   3   TLS GROUP : 4
REMARK   3    SELECTION: ( CHAIN A AND RESID 226:259 )
REMARK   3    ORIGIN FOR THE GROUP (A):   27.443  -12.477  -18.657
REMARK   3    T TENSOR
REMARK   3      T11:   0.1070 T22:   0.0985
REMARK   3      T33:   0.0909 T12:   0.0217
REMARK   3      T13:   0.0044 T23:  -0.0199
REMARK   3    L TENSOR
REMARK   3      L11:   2.0328 L22:   2.7932
REMARK   3      L33:   3.3629 L12:   0.8828
REMARK   3      L13:  -0.7727 L23:  -0.4953
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0105 S12:   0.0496 S13:   0.0766
REMARK   3      S21:  -0.0633 S22:  -0.0016 S23:   0.0238
REMARK   3      S31:  -0.1327 S32:  -0.2064 S33:  -0.0163
REMARK   3   TLS GROUP : 5
REMARK   3    SELECTION: ( CHAIN A AND RESID 260:319 )
REMARK   3    ORIGIN FOR THE GROUP (A):   32.846  -13.500   -6.606
REMARK   3    T TENSOR
REMARK   3      T11:   0.1483 T22:   0.1250
REMARK   3      T33:   0.1058 T12:   0.0040
REMARK   3      T13:   0.0032 T23:  -0.0169
REMARK   3    L TENSOR
REMARK   3      L11:   0.6043 L22:   1.4379
REMARK   3      L33:   2.2949 L12:  -0.1066
REMARK   3      L13:  -0.5273 L23:  -0.5934
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0220 S12:  -0.0598 S13:   0.0271
REMARK   3      S21:   0.0841 S22:   0.0245 S23:   0.0309
REMARK   3      S31:  -0.0573 S32:   0.0269 S33:   0.0008
REMARK   3   TLS GROUP : 6
REMARK   3    SELECTION: ( CHAIN B AND RESID 56:71 )
REMARK   3    ORIGIN FOR THE GROUP (A):   41.929   24.198  -44.238
REMARK   3    T TENSOR
REMARK   3      T11:   0.3351 T22:   0.1395
REMARK   3      T33:   0.2613 T12:   0.0048
REMARK   3      T13:   0.0035 T23:   0.0112
REMARK   3    L TENSOR
REMARK   3      L11:   1.2875 L22:   0.4815
REMARK   3      L33:   4.7021 L12:  -0.3249
REMARK   3      L13:  -0.4949 L23:   1.4263
REMARK   3    S TENSOR
REMARK   3      S11:  -0.3658 S12:   0.1534 S13:   0.3891
REMARK   3      S21:  -0.4490 S22:  -0.0534 S23:  -0.2422
REMARK   3      S31:  -0.3037 S32:  -0.4367 S33:  -0.0006
REMARK   3   TLS GROUP : 7
REMARK   3    SELECTION: ( CHAIN B AND RESID 72:97 )
REMARK   3    ORIGIN FOR THE GROUP (A):   30.497    5.898  -45.024
REMARK   3    T TENSOR
REMARK   3      T11:   0.1380 T22:   0.1397
REMARK   3      T33:   0.0989 T12:   0.0189
REMARK   3      T13:   0.0006 T23:  -0.0042
REMARK   3    L TENSOR
REMARK   3      L11:   1.4570 L22:   4.8352
REMARK   3      L33:   0.4874 L12:   0.5803
REMARK   3      L13:   0.3295 L23:   1.0787
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0132 S12:  -0.1047 S13:   0.1798
REMARK   3      S21:   0.1933 S22:  -0.0643 S23:   0.4437
REMARK   3      S31:  -0.0874 S32:  -0.1092 S33:   0.1848
REMARK   3   TLS GROUP : 8
REMARK   3    SELECTION: ( CHAIN B AND RESID 98:169 )
REMARK   3    ORIGIN FOR THE GROUP (A):   37.177    2.754  -44.312
REMARK   3    T TENSOR
REMARK   3      T11:   0.0673 T22:   0.0829
REMARK   3      T33:   0.0512 T12:  -0.0009
REMARK   3      T13:  -0.0034 T23:  -0.0059
REMARK   3    L TENSOR
REMARK   3      L11:   1.1176 L22:   1.9082
REMARK   3      L33:   1.1133 L12:  -0.1757
REMARK   3      L13:   0.0124 L23:   0.2960
REMARK   3    S TENSOR
REMARK   3      S11:   0.0074 S12:  -0.0280 S13:   0.0629
REMARK   3      S21:   0.0101 S22:  -0.0136 S23:   0.0483
REMARK   3      S31:  -0.1289 S32:  -0.0702 S33:  -0.0116
REMARK   3   TLS GROUP : 9
REMARK   3    SELECTION: ( CHAIN B AND RESID 170:182 )
REMARK   3    ORIGIN FOR THE GROUP (A):   36.583    8.481  -57.246
REMARK   3    T TENSOR
REMARK   3      T11:   0.1649 T22:   0.1322
REMARK   3      T33:   0.0536 T12:   0.0186
REMARK   3      T13:  -0.0015 T23:   0.0049
REMARK   3    L TENSOR
REMARK   3      L11:   3.1725 L22:   7.3355
REMARK   3      L33:   5.4069 L12:   1.0832
REMARK   3      L13:   1.8624 L23:   0.0096
REMARK   3    S TENSOR
REMARK   3      S11:   0.1219 S12:   0.2042 S13:   0.2764
REMARK   3      S21:  -0.0626 S22:  -0.1415 S23:   0.2653
REMARK   3      S31:  -0.1867 S32:  -0.2207 S33:   0.0636
REMARK   3   TLS GROUP : 10
REMARK   3    SELECTION: ( CHAIN B AND RESID 183:225 )
REMARK   3    ORIGIN FOR THE GROUP (A):   50.231   -0.788  -43.224
REMARK   3    T TENSOR
REMARK   3      T11:   0.0960 T22:   0.0814
REMARK   3      T33:   0.0910 T12:  -0.0129
REMARK   3      T13:   0.0018 T23:  -0.0108
REMARK   3    L TENSOR
REMARK   3      L11:   1.3567 L22:   2.5571
REMARK   3      L33:   2.9255 L12:  -0.5141
REMARK   3      L13:   0.3097 L23:  -1.2014
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0082 S12:   0.0596 S13:  -0.0288
REMARK   3      S21:  -0.1170 S22:  -0.0118 S23:  -0.1438
REMARK   3      S31:   0.1150 S32:   0.0799 S33:   0.0236
REMARK   3   TLS GROUP : 11
REMARK   3    SELECTION: ( CHAIN B AND RESID 226:272 )
REMARK   3    ORIGIN FOR THE GROUP (A):   50.779    2.098  -30.530
REMARK   3    T TENSOR
REMARK   3      T11:   0.1045 T22:   0.0819
REMARK   3      T33:   0.0735 T12:  -0.0132
REMARK   3      T13:  -0.0185 T23:  -0.0187
REMARK   3    L TENSOR
REMARK   3      L11:   2.0551 L22:   1.8476
REMARK   3      L33:   2.4260 L12:   0.6775
REMARK   3      L13:  -1.2118 L23:  -0.2965
REMARK   3    S TENSOR
REMARK   3      S11:   0.0376 S12:  -0.0699 S13:   0.0054
REMARK   3      S21:   0.2118 S22:  -0.0004 S23:  -0.0394
REMARK   3      S31:   0.0642 S32:  -0.0823 S33:  -0.0181
REMARK   3   TLS GROUP : 12
REMARK   3    SELECTION: ( CHAIN B AND RESID 273:319 )
REMARK   3    ORIGIN FOR THE GROUP (A):   50.619   15.992  -36.539
REMARK   3    T TENSOR
REMARK   3      T11:   0.1324 T22:   0.0947
REMARK   3      T33:   0.1474 T12:   0.0007
REMARK   3      T13:   0.0042 T23:  -0.0168
REMARK   3    L TENSOR
REMARK   3      L11:   1.1790 L22:   1.0445
REMARK   3      L33:   1.9161 L12:   0.2759
REMARK   3      L13:   0.3154 L23:  -0.1836
REMARK   3    S TENSOR
REMARK   3      S11:   0.0021 S12:  -0.0243 S13:   0.1755
REMARK   3      S21:  -0.0118 S22:  -0.0335 S23:   0.0153
REMARK   3      S31:  -0.1576 S32:  -0.0075 S33:   0.0395
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 8SPK COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 04-MAY-23.
REMARK 100 THE DEPOSITION ID IS D_1000274230.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 09-JUN-22
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : LNLS SIRIUS
REMARK 200  BEAMLINE                       : MANACA
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9772
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 2M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 99279
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.600
REMARK 200  RESOLUTION RANGE LOW       (A) : 92.760
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0
REMARK 200  DATA REDUNDANCY                : 38.40
REMARK 200  R MERGE                    (I) : 0.27200
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 13.3000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.60
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.68
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : 39.30
REMARK 200  R MERGE FOR SHELL          (I) : 2.19500
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 59.54
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.04
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 1.4 M SODIUM MALONATE DIBASIC
REMARK 280  MONOHYDRATE AT PH 7.0, VAPOR DIFFUSION, SITTING DROP,
REMARK 280  TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 3
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X+1/2,-Y,Z+1/2
REMARK 290       3555   -X,Y+1/2,-Z+1/2
REMARK 290       4555   X+1/2,-Y+1/2,-Z
REMARK 290       5555   Z,X,Y
REMARK 290       6555   Z+1/2,-X+1/2,-Y
REMARK 290       7555   -Z+1/2,-X,Y+1/2
REMARK 290       8555   -Z,X+1/2,-Y+1/2
REMARK 290       9555   Y,Z,X
REMARK 290      10555   -Y,Z+1/2,-X+1/2
REMARK 290      11555   Y+1/2,-Z+1/2,-X
REMARK 290      12555   -Y+1/2,-Z,X+1/2
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       65.59000
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       65.59000
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       65.59000
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       65.59000
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       65.59000
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       65.59000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY2   5  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   5  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY1   6  0.000000  0.000000  1.000000       65.59000
REMARK 290   SMTRY2   6 -1.000000  0.000000  0.000000       65.59000
REMARK 290   SMTRY3   6  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY1   7  0.000000  0.000000 -1.000000       65.59000
REMARK 290   SMTRY2   7 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY3   7  0.000000  1.000000  0.000000       65.59000
REMARK 290   SMTRY1   8  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY2   8  1.000000  0.000000  0.000000       65.59000
REMARK 290   SMTRY3   8  0.000000 -1.000000  0.000000       65.59000
REMARK 290   SMTRY1   9  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY2   9  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY3   9  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  10  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY2  10  0.000000  0.000000  1.000000       65.59000
REMARK 290   SMTRY3  10 -1.000000  0.000000  0.000000       65.59000
REMARK 290   SMTRY1  11  0.000000  1.000000  0.000000       65.59000
REMARK 290   SMTRY2  11  0.000000  0.000000 -1.000000       65.59000
REMARK 290   SMTRY3  11 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY1  12  0.000000 -1.000000  0.000000       65.59000
REMARK 290   SMTRY2  12  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY3  12  1.000000  0.000000  0.000000       65.59000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A    38
REMARK 465     GLY A    39
REMARK 465     SER A    40
REMARK 465     SER A    41
REMARK 465     HIS A    42
REMARK 465     HIS A    43
REMARK 465     HIS A    44
REMARK 465     HIS A    45
REMARK 465     HIS A    46
REMARK 465     HIS A    47
REMARK 465     SER A    48
REMARK 465     SER A    49
REMARK 465     GLY A    50
REMARK 465     LEU A    51
REMARK 465     VAL A    52
REMARK 465     PRO A    53
REMARK 465     ARG A    54
REMARK 465     MET B    38
REMARK 465     GLY B    39
REMARK 465     SER B    40
REMARK 465     SER B    41
REMARK 465     HIS B    42
REMARK 465     HIS B    43
REMARK 465     HIS B    44
REMARK 465     HIS B    45
REMARK 465     HIS B    46
REMARK 465     HIS B    47
REMARK 465     SER B    48
REMARK 465     SER B    49
REMARK 465     GLY B    50
REMARK 465     LEU B    51
REMARK 465     VAL B    52
REMARK 465     PRO B    53
REMARK 465     ARG B    54
REMARK 465     GLY B    55
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     SER A  56    OG
REMARK 470     SER B  56    OG
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH B   424     O    HOH B   691              1.95
REMARK 500   O    HOH B   525     O    HOH B   665              1.99
REMARK 500   ND2  ASN B   249     O    HOH B   401              2.01
REMARK 500   O    HOH B   525     O    HOH B   563              2.02
REMARK 500   OE1  GLN B    90     O    HOH B   402              2.02
REMARK 500   O    HOH A   611     O    HOH A   750              2.03
REMARK 500   OD1  ASP A    63     O    HOH A   501              2.04
REMARK 500   O    HOH B   698     O    HOH B   701              2.09
REMARK 500   O    HOH A   602     O    HOH A   740              2.09
REMARK 500   O    HOH A   664     O    HOH A   695              2.10
REMARK 500   O    HOH A   635     O    HOH A   768              2.11
REMARK 500   O    HOH A   556     O    HOH A   763              2.12
REMARK 500   OE1  GLU B   221     O    HOH B   403              2.14
REMARK 500   O    HOH B   503     O    HOH B   604              2.15
REMARK 500   OG   SER B   218     O    HOH B   404              2.16
REMARK 500   OD2  ASP A   233     O    HOH A   502              2.17
REMARK 500   O    HOH A   550     O    HOH A   658              2.17
REMARK 500   O    HOH A   700     O    HOH A   746              2.17
REMARK 500   O    HOH B   609     O    HOH B   629              2.18
REMARK 500   OD2  ASP A   233     O    HOH A   503              2.18
REMARK 500   N    ASN B   272     O    HOH B   405              2.18
REMARK 500   O    HOH A   565     O    HOH A   705              2.18
REMARK 500   O    HOH A   505     O    HOH A   673              2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE
REMARK 500   O    HOH A   676     O    HOH A   726     8544     1.88
REMARK 500   O    HOH A   635     O    HOH A   646    11545     2.01
REMARK 500   O    HOH A   711     O    HOH B   478     2555     2.09
REMARK 500   O    HOH A   646     O    HOH A   768     8544     2.14
REMARK 500   O    HOH A   522     O    HOH B   584     2555     2.14
REMARK 500   O    HOH A   548     O    HOH B   625     6555     2.18
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    ARG A 134   CG  -  CD  -  NE  ANGL. DEV. = -18.3 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER A  56     -113.21     47.41
REMARK 500    ARG A  75     -133.02     57.68
REMARK 500    SER A 189     -124.44     64.29
REMARK 500    ALA A 237       68.45   -112.56
REMARK 500    TYR A 242      -91.38   -113.72
REMARK 500    CYS A 299     -131.84     57.19
REMARK 500    ARG B  75     -130.41     53.31
REMARK 500    SER B 189     -124.69     63.04
REMARK 500    ALA B 237       71.23   -111.15
REMARK 500    TYR B 242      -90.08   -112.56
REMARK 500    CYS B 299     -134.40     55.16
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    ARG A 157         0.09    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
DBREF  8SPK A   59   319  UNP    P19833   LIP1_MORS1      59    319
DBREF  8SPK B   59   319  UNP    P19833   LIP1_MORS1      59    319
SEQADV 8SPK MET A   38  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK GLY A   39  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK SER A   40  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK SER A   41  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS A   42  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS A   43  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS A   44  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS A   45  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS A   46  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS A   47  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK SER A   48  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK SER A   49  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK GLY A   50  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK LEU A   51  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK VAL A   52  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK PRO A   53  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK ARG A   54  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK GLY A   55  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK SER A   56  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS A   57  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK MET A   58  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK MET B   38  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK GLY B   39  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK SER B   40  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK SER B   41  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS B   42  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS B   43  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS B   44  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS B   45  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS B   46  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS B   47  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK SER B   48  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK SER B   49  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK GLY B   50  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK LEU B   51  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK VAL B   52  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK PRO B   53  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK ARG B   54  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK GLY B   55  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK SER B   56  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK HIS B   57  UNP  P19833              EXPRESSION TAG
SEQADV 8SPK MET B   58  UNP  P19833              EXPRESSION TAG
SEQRES   1 A  282  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 A  282  LEU VAL PRO ARG GLY SER HIS MET ASP CYS ILE ALA ASP
SEQRES   3 A  282  SER LYS ILE THR ALA VAL ALA LEU SER ASP THR ARG ASP
SEQRES   4 A  282  ASN GLY PRO PHE SER ILE ARG THR LYS ARG ILE SER ARG
SEQRES   5 A  282  GLN SER ALA LYS GLY PHE GLY GLY GLY THR ILE HIS TYR
SEQRES   6 A  282  PRO THR ASN ALA SER GLY CYS GLY LEU LEU GLY ALA ILE
SEQRES   7 A  282  ALA VAL VAL PRO GLY TYR VAL SER TYR GLU ASN SER ILE
SEQRES   8 A  282  LYS TRP TRP GLY PRO ARG LEU ALA SER TRP GLY PHE VAL
SEQRES   9 A  282  VAL ILE THR ILE ASN THR ASN SER ILE TYR ASP ASP PRO
SEQRES  10 A  282  ASP SER ARG ALA ALA GLN LEU ASN ALA ALA LEU ASP ASN
SEQRES  11 A  282  MET ILE ALA ASP ASP THR VAL GLY SER MET ILE ASP PRO
SEQRES  12 A  282  LYS ARG LEU GLY ALA ILE GLY TRP SER MET GLY GLY GLY
SEQRES  13 A  282  GLY ALA LEU LYS LEU ALA THR GLU ARG SER THR VAL ARG
SEQRES  14 A  282  ALA ILE MET PRO LEU ALA PRO TYR HIS ASP LYS SER TYR
SEQRES  15 A  282  GLY GLU VAL LYS THR PRO THR LEU VAL ILE ALA CYS GLU
SEQRES  16 A  282  ASP ASP ARG ILE ALA GLU THR LYS LYS TYR ALA ASN ALA
SEQRES  17 A  282  PHE TYR LYS ASN ALA ILE GLY PRO LYS MET LYS VAL GLU
SEQRES  18 A  282  VAL ASN ASN GLY SER HIS PHE CYS PRO SER TYR ARG PHE
SEQRES  19 A  282  ASN GLU ILE LEU LEU SER LYS PRO GLY ILE ALA TRP MET
SEQRES  20 A  282  GLN ARG TYR ILE ASN ASN ASP THR ARG PHE ASP LYS PHE
SEQRES  21 A  282  LEU CYS ALA ASN GLU ASN TYR SER LYS SER PRO ARG ILE
SEQRES  22 A  282  SER ALA TYR ASP TYR LYS ASP CYS PRO
SEQRES   1 B  282  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY
SEQRES   2 B  282  LEU VAL PRO ARG GLY SER HIS MET ASP CYS ILE ALA ASP
SEQRES   3 B  282  SER LYS ILE THR ALA VAL ALA LEU SER ASP THR ARG ASP
SEQRES   4 B  282  ASN GLY PRO PHE SER ILE ARG THR LYS ARG ILE SER ARG
SEQRES   5 B  282  GLN SER ALA LYS GLY PHE GLY GLY GLY THR ILE HIS TYR
SEQRES   6 B  282  PRO THR ASN ALA SER GLY CYS GLY LEU LEU GLY ALA ILE
SEQRES   7 B  282  ALA VAL VAL PRO GLY TYR VAL SER TYR GLU ASN SER ILE
SEQRES   8 B  282  LYS TRP TRP GLY PRO ARG LEU ALA SER TRP GLY PHE VAL
SEQRES   9 B  282  VAL ILE THR ILE ASN THR ASN SER ILE TYR ASP ASP PRO
SEQRES  10 B  282  ASP SER ARG ALA ALA GLN LEU ASN ALA ALA LEU ASP ASN
SEQRES  11 B  282  MET ILE ALA ASP ASP THR VAL GLY SER MET ILE ASP PRO
SEQRES  12 B  282  LYS ARG LEU GLY ALA ILE GLY TRP SER MET GLY GLY GLY
SEQRES  13 B  282  GLY ALA LEU LYS LEU ALA THR GLU ARG SER THR VAL ARG
SEQRES  14 B  282  ALA ILE MET PRO LEU ALA PRO TYR HIS ASP LYS SER TYR
SEQRES  15 B  282  GLY GLU VAL LYS THR PRO THR LEU VAL ILE ALA CYS GLU
SEQRES  16 B  282  ASP ASP ARG ILE ALA GLU THR LYS LYS TYR ALA ASN ALA
SEQRES  17 B  282  PHE TYR LYS ASN ALA ILE GLY PRO LYS MET LYS VAL GLU
SEQRES  18 B  282  VAL ASN ASN GLY SER HIS PHE CYS PRO SER TYR ARG PHE
SEQRES  19 B  282  ASN GLU ILE LEU LEU SER LYS PRO GLY ILE ALA TRP MET
SEQRES  20 B  282  GLN ARG TYR ILE ASN ASN ASP THR ARG PHE ASP LYS PHE
SEQRES  21 B  282  LEU CYS ALA ASN GLU ASN TYR SER LYS SER PRO ARG ILE
SEQRES  22 B  282  SER ALA TYR ASP TYR LYS ASP CYS PRO
HET    MLI  A 401       7
HET    MLI  A 402       7
HETNAM     MLI MALONATE ION
FORMUL   3  MLI    2(C3 H2 O4 2-)
FORMUL   5  HOH   *672(H2 O)
HELIX    1 AA1 ALA A   62  ILE A   66  5                                   5
HELIX    2 AA2 THR A   67  SER A   72  1                                   6
HELIX    3 AA3 ALA A  106  GLY A  110  5                                   5
HELIX    4 AA4 TYR A  124  LYS A  129  5                                   6
HELIX    5 AA5 TRP A  130  SER A  137  1                                   8
HELIX    6 AA6 ASP A  153  ASP A  171  1                                  19
HELIX    7 AA7 VAL A  174  SER A  176  5                                   3
HELIX    8 AA8 SER A  189  ARG A  202  1                                  14
HELIX    9 AA9 TYR A  242  ALA A  250  1                                   9
HELIX   10 AB1 ASN A  272  ASN A  290  1                                  19
HELIX   11 AB2 ASP A  291  GLU A  302  5                                  12
HELIX   12 AB3 ASN A  303  SER A  307  5                                   5
HELIX   13 AB4 ALA B   62  ILE B   66  5                                   5
HELIX   14 AB5 THR B   67  SER B   72  1                                   6
HELIX   15 AB6 ALA B  106  GLY B  110  5                                   5
HELIX   16 AB7 TYR B  124  LYS B  129  5                                   6
HELIX   17 AB8 TRP B  130  SER B  137  1                                   8
HELIX   18 AB9 ASP B  153  ASP B  171  1                                  19
HELIX   19 AC1 VAL B  174  SER B  176  5                                   3
HELIX   20 AC2 SER B  189  ARG B  202  1                                  14
HELIX   21 AC3 TYR B  242  ALA B  250  1                                   9
HELIX   22 AC4 ASN B  272  ASN B  289  1                                  18
HELIX   23 AC5 ASP B  291  GLU B  302  5                                  12
HELIX   24 AC6 ASN B  303  SER B  307  5                                   5
SHEET    1 AA1 6 ILE A  82  ILE A  87  0
SHEET    2 AA1 6 GLY A  98  PRO A 103 -1  O  GLY A  98   N  ILE A  87
SHEET    3 AA1 6 VAL A 141  ILE A 145 -1  O  VAL A 142   N  HIS A 101
SHEET    4 AA1 6 LEU A 112  VAL A 118  1  N  ILE A 115   O  VAL A 141
SHEET    5 AA1 6 ILE A 178  TRP A 188  1  O  ASP A 179   N  LEU A 112
SHEET    6 AA1 6 VAL A 205  LEU A 211  1  O  LEU A 211   N  GLY A 187
SHEET    1 AA2 3 THR A 226  CYS A 231  0
SHEET    2 AA2 3 LYS A 254  VAL A 259  1  O  VAL A 259   N  ALA A 230
SHEET    3 AA2 3 ILE A 310  LYS A 316 -1  O  ASP A 314   N  LYS A 256
SHEET    1 AA3 6 ILE B  82  ILE B  87  0
SHEET    2 AA3 6 GLY B  98  PRO B 103 -1  O  ILE B 100   N  LYS B  85
SHEET    3 AA3 6 VAL B 141  ILE B 145 -1  O  VAL B 142   N  HIS B 101
SHEET    4 AA3 6 LEU B 112  VAL B 118  1  N  VAL B 117   O  ILE B 143
SHEET    5 AA3 6 ILE B 178  TRP B 188  1  O  ASP B 179   N  LEU B 112
SHEET    6 AA3 6 VAL B 205  LEU B 211  1  O  LEU B 211   N  GLY B 187
SHEET    1 AA4 3 THR B 226  CYS B 231  0
SHEET    2 AA4 3 LYS B 254  VAL B 259  1  O  MET B 255   N  VAL B 228
SHEET    3 AA4 3 ILE B 310  LYS B 316 -1  O  ASP B 314   N  LYS B 256
SSBOND   1 CYS A   60    CYS A  109                          1555   1555  2.02
SSBOND   2 CYS A  231    CYS A  266                          1555   1555  2.07
SSBOND   3 CYS A  299    CYS A  318                          1555   1555  2.12
SSBOND   4 CYS B   60    CYS B  109                          1555   1555  2.01
SSBOND   5 CYS B  231    CYS B  266                          1555   1555  2.09
SSBOND   6 CYS B  299    CYS B  318                          1555   1555  2.07
CISPEP   1 CYS A  318    PRO A  319          0        -6.08
CISPEP   2 PRO B  119    GLY B  120          0        -4.81
CISPEP   3 CYS B  318    PRO B  319          0        -6.75
CRYST1  131.180  131.180  131.180  90.00  90.00  90.00 P 21 3       24
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.007623  0.000000  0.000000        0.00000
SCALE2      0.000000  0.007623  0.000000        0.00000
SCALE3      0.000000  0.000000  0.007623        0.00000
TER    2044      PRO A 319
TER    4099      PRO B 319
MASTER      605    0    2   24   18    0    0    6 4756    2   26   44
END