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HEADER BIOSYNTHETIC PROTEIN 21-DEC-23 8VF7
TITLE MODIFYING PORTION OF HUMAN FASN WITH NADPH AND THE ACP AT THE ER
TITLE 2 DOMAIN
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: FATTY ACID SYNTHASE;
COMPND 3 CHAIN: A;
COMPND 4 SYNONYM: TYPE I FATTY ACID SYNTHASE;
COMPND 5 EC: 2.3.1.85,2.3.1.38,2.3.1.39,2.3.1.41,1.1.1.100,4.2.1.59,1.3.1.39,
COMPND 6 3.1.2.14;
COMPND 7 ENGINEERED: YES;
COMPND 8 MOL_ID: 2;
COMPND 9 MOLECULE: FATTY ACID SYNTHASE;
COMPND 10 CHAIN: B;
COMPND 11 SYNONYM: TYPE I FATTY ACID SYNTHASE;
COMPND 12 EC: 2.3.1.85,2.3.1.38,2.3.1.39,2.3.1.41,1.1.1.100,4.2.1.59,1.3.1.39,
COMPND 13 3.1.2.14;
COMPND 14 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 GENE: FASN, FAS;
SOURCE 6 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 7108;
SOURCE 8 EXPRESSION_SYSTEM_CELL_LINE: SF9;
SOURCE 9 MOL_ID: 2;
SOURCE 10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 11 ORGANISM_COMMON: HUMAN;
SOURCE 12 ORGANISM_TAXID: 9606;
SOURCE 13 GENE: FASN, FAS;
SOURCE 14 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;
SOURCE 15 EXPRESSION_SYSTEM_TAXID: 7108;
SOURCE 16 EXPRESSION_SYSTEM_CELL_LINE: SF9
KEYWDS MEGASYNTHASE, LIPOGENESIS, BIOSYNTHETIC PROTEIN
EXPDTA ELECTRON MICROSCOPY
AUTHOR K.SCHULTZ,R.MARMORSTEIN
REVDAT 1 26-FEB-25 8VF7 0
JRNL AUTH K.SCHULTZ,P.COSTA-PINHEIRO,L.GARDNER,L.V.PINHEIRO,
JRNL AUTH 2 J.RAMIREZ-SOLIS,S.M.GARDNER,K.E.WELLEN,R.MARMORSTEIN
JRNL TITL SNAPSHOTS OF ACYL CARRIER PROTEIN SHUTTLING IN HUMAN FATTY
JRNL TITL 2 ACID SYNTHASE
JRNL REF TO BE PUBLISHED
JRNL REFN
REMARK 2
REMARK 2 RESOLUTION. 3.20 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : TOPAZ, LEGINON, CRYOSPARC, UCSF
REMARK 3 CHIMERAX, CRYOSPARC, CRYOSPARC,
REMARK 3 CRYOSPARC, CRYOSPARC, PHENIX
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : 2CG5
REMARK 3 REFINEMENT SPACE : REAL
REMARK 3 REFINEMENT PROTOCOL : RIGID BODY FIT
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.200
REMARK 3 NUMBER OF PARTICLES : 103038
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 8VF7 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 31-DEC-23.
REMARK 100 THE DEPOSITION ID IS D_1000279247.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : HUMAN FATTY ACID SYNTHASE
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 3.50
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.00
REMARK 245 SAMPLE DETAILS : MODIFYING REGION FROM A FOCUSED
REMARK 245 REFINEMENT WITH THE ACP AT THE ER DOMAIN
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 19126
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : TFS KRIOS
REMARK 245 DETECTOR TYPE : GATAN K3 (6K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : 800.00
REMARK 245 MAXIMUM DEFOCUS (NM) : 3000.00
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 5240.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : 81000
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A -31
REMARK 465 SER A -30
REMARK 465 TYR A -29
REMARK 465 TYR A -28
REMARK 465 ASP A -27
REMARK 465 TYR A -26
REMARK 465 LYS A -25
REMARK 465 ASP A -24
REMARK 465 ASP A -23
REMARK 465 ASP A -22
REMARK 465 ASP A -21
REMARK 465 LYS A -20
REMARK 465 ASP A -19
REMARK 465 TYR A -18
REMARK 465 ASP A -17
REMARK 465 ILE A -16
REMARK 465 PRO A -15
REMARK 465 THR A -14
REMARK 465 THR A -13
REMARK 465 GLU A -12
REMARK 465 ASN A -11
REMARK 465 LEU A -10
REMARK 465 TYR A -9
REMARK 465 PHE A -8
REMARK 465 GLN A -7
REMARK 465 GLY A -6
REMARK 465 ALA A -5
REMARK 465 MET A -4
REMARK 465 GLY A -3
REMARK 465 SER A -2
REMARK 465 GLY A -1
REMARK 465 ILE A 0
REMARK 465 PRO A 1
REMARK 465 GLU A 2
REMARK 465 GLU A 3
REMARK 465 VAL A 4
REMARK 465 VAL A 5
REMARK 465 ILE A 6
REMARK 465 ALA A 7
REMARK 465 GLY A 8
REMARK 465 MET A 9
REMARK 465 SER A 10
REMARK 465 GLY A 11
REMARK 465 LYS A 12
REMARK 465 LEU A 13
REMARK 465 PRO A 14
REMARK 465 GLU A 15
REMARK 465 SER A 16
REMARK 465 GLU A 17
REMARK 465 ASN A 18
REMARK 465 LEU A 19
REMARK 465 GLN A 20
REMARK 465 GLU A 21
REMARK 465 PHE A 22
REMARK 465 TRP A 23
REMARK 465 ASP A 24
REMARK 465 ASN A 25
REMARK 465 LEU A 26
REMARK 465 ILE A 27
REMARK 465 GLY A 28
REMARK 465 GLY A 29
REMARK 465 VAL A 30
REMARK 465 ASP A 31
REMARK 465 MET A 32
REMARK 465 VAL A 33
REMARK 465 THR A 34
REMARK 465 ASP A 35
REMARK 465 ASP A 36
REMARK 465 ASP A 37
REMARK 465 ARG A 38
REMARK 465 ARG A 39
REMARK 465 TRP A 40
REMARK 465 LYS A 41
REMARK 465 ALA A 42
REMARK 465 GLY A 43
REMARK 465 LEU A 44
REMARK 465 TYR A 45
REMARK 465 GLY A 46
REMARK 465 LEU A 47
REMARK 465 PRO A 48
REMARK 465 ARG A 49
REMARK 465 ARG A 50
REMARK 465 SER A 51
REMARK 465 GLY A 52
REMARK 465 LYS A 53
REMARK 465 LEU A 54
REMARK 465 LYS A 55
REMARK 465 ASP A 56
REMARK 465 LEU A 57
REMARK 465 SER A 58
REMARK 465 ARG A 59
REMARK 465 PHE A 60
REMARK 465 ASP A 61
REMARK 465 ALA A 62
REMARK 465 SER A 63
REMARK 465 PHE A 64
REMARK 465 PHE A 65
REMARK 465 GLY A 66
REMARK 465 VAL A 67
REMARK 465 HIS A 68
REMARK 465 PRO A 69
REMARK 465 LYS A 70
REMARK 465 GLN A 71
REMARK 465 ALA A 72
REMARK 465 HIS A 73
REMARK 465 THR A 74
REMARK 465 MET A 75
REMARK 465 ASP A 76
REMARK 465 PRO A 77
REMARK 465 GLN A 78
REMARK 465 LEU A 79
REMARK 465 ARG A 80
REMARK 465 LEU A 81
REMARK 465 LEU A 82
REMARK 465 LEU A 83
REMARK 465 GLU A 84
REMARK 465 VAL A 85
REMARK 465 THR A 86
REMARK 465 TYR A 87
REMARK 465 GLU A 88
REMARK 465 ALA A 89
REMARK 465 ILE A 90
REMARK 465 VAL A 91
REMARK 465 ASP A 92
REMARK 465 GLY A 93
REMARK 465 GLY A 94
REMARK 465 ILE A 95
REMARK 465 ASN A 96
REMARK 465 PRO A 97
REMARK 465 ASP A 98
REMARK 465 SER A 99
REMARK 465 LEU A 100
REMARK 465 ARG A 101
REMARK 465 GLY A 102
REMARK 465 THR A 103
REMARK 465 HIS A 104
REMARK 465 THR A 105
REMARK 465 GLY A 106
REMARK 465 VAL A 107
REMARK 465 TRP A 108
REMARK 465 VAL A 109
REMARK 465 GLY A 110
REMARK 465 VAL A 111
REMARK 465 SER A 112
REMARK 465 GLY A 113
REMARK 465 SER A 114
REMARK 465 GLU A 115
REMARK 465 THR A 116
REMARK 465 SER A 117
REMARK 465 GLU A 118
REMARK 465 ALA A 119
REMARK 465 LEU A 120
REMARK 465 SER A 121
REMARK 465 ARG A 122
REMARK 465 ASP A 123
REMARK 465 PRO A 124
REMARK 465 GLU A 125
REMARK 465 THR A 126
REMARK 465 LEU A 127
REMARK 465 VAL A 128
REMARK 465 GLY A 129
REMARK 465 TYR A 130
REMARK 465 SER A 131
REMARK 465 MET A 132
REMARK 465 VAL A 133
REMARK 465 GLY A 134
REMARK 465 CYS A 135
REMARK 465 GLN A 136
REMARK 465 ARG A 137
REMARK 465 ALA A 138
REMARK 465 MET A 139
REMARK 465 MET A 140
REMARK 465 ALA A 141
REMARK 465 ASN A 142
REMARK 465 ARG A 143
REMARK 465 LEU A 144
REMARK 465 SER A 145
REMARK 465 PHE A 146
REMARK 465 PHE A 147
REMARK 465 PHE A 148
REMARK 465 ASP A 149
REMARK 465 PHE A 150
REMARK 465 ARG A 151
REMARK 465 GLY A 152
REMARK 465 PRO A 153
REMARK 465 SER A 154
REMARK 465 ILE A 155
REMARK 465 ALA A 156
REMARK 465 LEU A 157
REMARK 465 ASP A 158
REMARK 465 THR A 159
REMARK 465 ALA A 160
REMARK 465 CYS A 161
REMARK 465 SER A 162
REMARK 465 SER A 163
REMARK 465 SER A 164
REMARK 465 LEU A 165
REMARK 465 MET A 166
REMARK 465 ALA A 167
REMARK 465 LEU A 168
REMARK 465 GLN A 169
REMARK 465 ASN A 170
REMARK 465 ALA A 171
REMARK 465 TYR A 172
REMARK 465 GLN A 173
REMARK 465 ALA A 174
REMARK 465 ILE A 175
REMARK 465 HIS A 176
REMARK 465 SER A 177
REMARK 465 GLY A 178
REMARK 465 GLN A 179
REMARK 465 CYS A 180
REMARK 465 PRO A 181
REMARK 465 ALA A 182
REMARK 465 ALA A 183
REMARK 465 ILE A 184
REMARK 465 VAL A 185
REMARK 465 GLY A 186
REMARK 465 GLY A 187
REMARK 465 ILE A 188
REMARK 465 ASN A 189
REMARK 465 VAL A 190
REMARK 465 LEU A 191
REMARK 465 LEU A 192
REMARK 465 LYS A 193
REMARK 465 PRO A 194
REMARK 465 ASN A 195
REMARK 465 THR A 196
REMARK 465 SER A 197
REMARK 465 VAL A 198
REMARK 465 GLN A 199
REMARK 465 PHE A 200
REMARK 465 LEU A 201
REMARK 465 ARG A 202
REMARK 465 LEU A 203
REMARK 465 GLY A 204
REMARK 465 MET A 205
REMARK 465 LEU A 206
REMARK 465 SER A 207
REMARK 465 PRO A 208
REMARK 465 GLU A 209
REMARK 465 GLY A 210
REMARK 465 THR A 211
REMARK 465 CYS A 212
REMARK 465 LYS A 213
REMARK 465 ALA A 214
REMARK 465 PHE A 215
REMARK 465 ASP A 216
REMARK 465 THR A 217
REMARK 465 ALA A 218
REMARK 465 GLY A 219
REMARK 465 ASN A 220
REMARK 465 GLY A 221
REMARK 465 TYR A 222
REMARK 465 CYS A 223
REMARK 465 ARG A 224
REMARK 465 SER A 225
REMARK 465 GLU A 226
REMARK 465 GLY A 227
REMARK 465 VAL A 228
REMARK 465 VAL A 229
REMARK 465 ALA A 230
REMARK 465 VAL A 231
REMARK 465 LEU A 232
REMARK 465 LEU A 233
REMARK 465 THR A 234
REMARK 465 LYS A 235
REMARK 465 LYS A 236
REMARK 465 SER A 237
REMARK 465 LEU A 238
REMARK 465 ALA A 239
REMARK 465 ARG A 240
REMARK 465 ARG A 241
REMARK 465 VAL A 242
REMARK 465 TYR A 243
REMARK 465 ALA A 244
REMARK 465 THR A 245
REMARK 465 ILE A 246
REMARK 465 LEU A 247
REMARK 465 ASN A 248
REMARK 465 ALA A 249
REMARK 465 GLY A 250
REMARK 465 THR A 251
REMARK 465 ASN A 252
REMARK 465 THR A 253
REMARK 465 ASP A 254
REMARK 465 GLY A 255
REMARK 465 PHE A 256
REMARK 465 LYS A 257
REMARK 465 GLU A 258
REMARK 465 GLN A 259
REMARK 465 GLY A 260
REMARK 465 VAL A 261
REMARK 465 THR A 262
REMARK 465 PHE A 263
REMARK 465 PRO A 264
REMARK 465 SER A 265
REMARK 465 GLY A 266
REMARK 465 ASP A 267
REMARK 465 ILE A 268
REMARK 465 GLN A 269
REMARK 465 GLU A 270
REMARK 465 GLN A 271
REMARK 465 LEU A 272
REMARK 465 ILE A 273
REMARK 465 ARG A 274
REMARK 465 SER A 275
REMARK 465 LEU A 276
REMARK 465 TYR A 277
REMARK 465 GLN A 278
REMARK 465 SER A 279
REMARK 465 ALA A 280
REMARK 465 GLY A 281
REMARK 465 VAL A 282
REMARK 465 ALA A 283
REMARK 465 PRO A 284
REMARK 465 GLU A 285
REMARK 465 SER A 286
REMARK 465 PHE A 287
REMARK 465 GLU A 288
REMARK 465 TYR A 289
REMARK 465 ILE A 290
REMARK 465 GLU A 291
REMARK 465 ALA A 292
REMARK 465 HIS A 293
REMARK 465 GLY A 294
REMARK 465 THR A 295
REMARK 465 GLY A 296
REMARK 465 THR A 297
REMARK 465 LYS A 298
REMARK 465 VAL A 299
REMARK 465 GLY A 300
REMARK 465 ASP A 301
REMARK 465 PRO A 302
REMARK 465 GLN A 303
REMARK 465 GLU A 304
REMARK 465 LEU A 305
REMARK 465 ASN A 306
REMARK 465 GLY A 307
REMARK 465 ILE A 308
REMARK 465 THR A 309
REMARK 465 ARG A 310
REMARK 465 ALA A 311
REMARK 465 LEU A 312
REMARK 465 CYS A 313
REMARK 465 ALA A 314
REMARK 465 THR A 315
REMARK 465 ARG A 316
REMARK 465 GLN A 317
REMARK 465 GLU A 318
REMARK 465 PRO A 319
REMARK 465 LEU A 320
REMARK 465 LEU A 321
REMARK 465 ILE A 322
REMARK 465 GLY A 323
REMARK 465 SER A 324
REMARK 465 THR A 325
REMARK 465 LYS A 326
REMARK 465 SER A 327
REMARK 465 ASN A 328
REMARK 465 MET A 329
REMARK 465 GLY A 330
REMARK 465 HIS A 331
REMARK 465 PRO A 332
REMARK 465 GLU A 333
REMARK 465 PRO A 334
REMARK 465 ALA A 335
REMARK 465 SER A 336
REMARK 465 GLY A 337
REMARK 465 LEU A 338
REMARK 465 ALA A 339
REMARK 465 ALA A 340
REMARK 465 LEU A 341
REMARK 465 ALA A 342
REMARK 465 LYS A 343
REMARK 465 VAL A 344
REMARK 465 LEU A 345
REMARK 465 LEU A 346
REMARK 465 SER A 347
REMARK 465 LEU A 348
REMARK 465 GLU A 349
REMARK 465 HIS A 350
REMARK 465 GLY A 351
REMARK 465 LEU A 352
REMARK 465 TRP A 353
REMARK 465 ALA A 354
REMARK 465 PRO A 355
REMARK 465 ASN A 356
REMARK 465 LEU A 357
REMARK 465 HIS A 358
REMARK 465 PHE A 359
REMARK 465 HIS A 360
REMARK 465 SER A 361
REMARK 465 PRO A 362
REMARK 465 ASN A 363
REMARK 465 PRO A 364
REMARK 465 GLU A 365
REMARK 465 ILE A 366
REMARK 465 PRO A 367
REMARK 465 ALA A 368
REMARK 465 LEU A 369
REMARK 465 LEU A 370
REMARK 465 ASP A 371
REMARK 465 GLY A 372
REMARK 465 ARG A 373
REMARK 465 LEU A 374
REMARK 465 GLN A 375
REMARK 465 VAL A 376
REMARK 465 VAL A 377
REMARK 465 ASP A 378
REMARK 465 GLN A 379
REMARK 465 PRO A 380
REMARK 465 LEU A 381
REMARK 465 PRO A 382
REMARK 465 VAL A 383
REMARK 465 ARG A 384
REMARK 465 GLY A 385
REMARK 465 GLY A 386
REMARK 465 ASN A 387
REMARK 465 VAL A 388
REMARK 465 GLY A 389
REMARK 465 ILE A 390
REMARK 465 ASN A 391
REMARK 465 SER A 392
REMARK 465 PHE A 393
REMARK 465 GLY A 394
REMARK 465 PHE A 395
REMARK 465 GLY A 396
REMARK 465 GLY A 397
REMARK 465 SER A 398
REMARK 465 ASN A 399
REMARK 465 VAL A 400
REMARK 465 HIS A 401
REMARK 465 ILE A 402
REMARK 465 ILE A 403
REMARK 465 LEU A 404
REMARK 465 ARG A 405
REMARK 465 PRO A 406
REMARK 465 ASN A 407
REMARK 465 THR A 408
REMARK 465 GLN A 409
REMARK 465 PRO A 410
REMARK 465 PRO A 411
REMARK 465 PRO A 412
REMARK 465 ALA A 413
REMARK 465 PRO A 414
REMARK 465 ALA A 415
REMARK 465 PRO A 416
REMARK 465 HIS A 417
REMARK 465 ALA A 418
REMARK 465 THR A 419
REMARK 465 LEU A 420
REMARK 465 PRO A 421
REMARK 465 ARG A 422
REMARK 465 LEU A 423
REMARK 465 LEU A 424
REMARK 465 ARG A 425
REMARK 465 ALA A 426
REMARK 465 SER A 427
REMARK 465 GLY A 428
REMARK 465 ARG A 429
REMARK 465 THR A 430
REMARK 465 PRO A 431
REMARK 465 GLU A 432
REMARK 465 ALA A 433
REMARK 465 VAL A 434
REMARK 465 GLN A 435
REMARK 465 LYS A 436
REMARK 465 LEU A 437
REMARK 465 LEU A 438
REMARK 465 GLU A 439
REMARK 465 GLN A 440
REMARK 465 GLY A 441
REMARK 465 LEU A 442
REMARK 465 ARG A 443
REMARK 465 HIS A 444
REMARK 465 SER A 445
REMARK 465 GLN A 446
REMARK 465 ASP A 447
REMARK 465 LEU A 448
REMARK 465 ALA A 449
REMARK 465 PHE A 450
REMARK 465 LEU A 451
REMARK 465 SER A 452
REMARK 465 MET A 453
REMARK 465 LEU A 454
REMARK 465 ASN A 455
REMARK 465 ASP A 456
REMARK 465 ILE A 457
REMARK 465 ALA A 458
REMARK 465 ALA A 459
REMARK 465 VAL A 460
REMARK 465 PRO A 461
REMARK 465 ALA A 462
REMARK 465 THR A 463
REMARK 465 ALA A 464
REMARK 465 MET A 465
REMARK 465 PRO A 466
REMARK 465 PHE A 467
REMARK 465 ARG A 468
REMARK 465 GLY A 469
REMARK 465 TYR A 470
REMARK 465 ALA A 471
REMARK 465 VAL A 472
REMARK 465 LEU A 473
REMARK 465 GLY A 474
REMARK 465 GLY A 475
REMARK 465 GLU A 476
REMARK 465 ARG A 477
REMARK 465 GLY A 478
REMARK 465 GLY A 479
REMARK 465 PRO A 480
REMARK 465 GLU A 481
REMARK 465 VAL A 482
REMARK 465 GLN A 483
REMARK 465 GLN A 484
REMARK 465 VAL A 485
REMARK 465 PRO A 486
REMARK 465 ALA A 487
REMARK 465 GLY A 488
REMARK 465 GLU A 489
REMARK 465 ARG A 490
REMARK 465 PRO A 491
REMARK 465 LEU A 492
REMARK 465 TRP A 493
REMARK 465 PHE A 494
REMARK 465 ILE A 495
REMARK 465 CYS A 496
REMARK 465 SER A 497
REMARK 465 GLY A 498
REMARK 465 MET A 499
REMARK 465 GLY A 500
REMARK 465 THR A 501
REMARK 465 GLN A 502
REMARK 465 TRP A 503
REMARK 465 ARG A 504
REMARK 465 GLY A 505
REMARK 465 MET A 506
REMARK 465 GLY A 507
REMARK 465 LEU A 508
REMARK 465 SER A 509
REMARK 465 LEU A 510
REMARK 465 MET A 511
REMARK 465 ARG A 512
REMARK 465 LEU A 513
REMARK 465 ASP A 514
REMARK 465 ARG A 515
REMARK 465 PHE A 516
REMARK 465 ARG A 517
REMARK 465 ASP A 518
REMARK 465 SER A 519
REMARK 465 ILE A 520
REMARK 465 LEU A 521
REMARK 465 ARG A 522
REMARK 465 SER A 523
REMARK 465 ASP A 524
REMARK 465 GLU A 525
REMARK 465 ALA A 526
REMARK 465 VAL A 527
REMARK 465 LYS A 528
REMARK 465 PRO A 529
REMARK 465 PHE A 530
REMARK 465 GLY A 531
REMARK 465 LEU A 532
REMARK 465 LYS A 533
REMARK 465 VAL A 534
REMARK 465 SER A 535
REMARK 465 GLN A 536
REMARK 465 LEU A 537
REMARK 465 LEU A 538
REMARK 465 LEU A 539
REMARK 465 SER A 540
REMARK 465 THR A 541
REMARK 465 ASP A 542
REMARK 465 GLU A 543
REMARK 465 SER A 544
REMARK 465 THR A 545
REMARK 465 PHE A 546
REMARK 465 ASP A 547
REMARK 465 ASP A 548
REMARK 465 ILE A 549
REMARK 465 VAL A 550
REMARK 465 HIS A 551
REMARK 465 SER A 552
REMARK 465 PHE A 553
REMARK 465 VAL A 554
REMARK 465 SER A 555
REMARK 465 LEU A 556
REMARK 465 THR A 557
REMARK 465 ALA A 558
REMARK 465 ILE A 559
REMARK 465 GLN A 560
REMARK 465 ILE A 561
REMARK 465 GLY A 562
REMARK 465 LEU A 563
REMARK 465 ILE A 564
REMARK 465 ASP A 565
REMARK 465 LEU A 566
REMARK 465 LEU A 567
REMARK 465 SER A 568
REMARK 465 CYS A 569
REMARK 465 MET A 570
REMARK 465 GLY A 571
REMARK 465 LEU A 572
REMARK 465 ARG A 573
REMARK 465 PRO A 574
REMARK 465 ASP A 575
REMARK 465 GLY A 576
REMARK 465 ILE A 577
REMARK 465 VAL A 578
REMARK 465 GLY A 579
REMARK 465 HIS A 580
REMARK 465 SER A 581
REMARK 465 LEU A 582
REMARK 465 GLY A 583
REMARK 465 GLU A 584
REMARK 465 VAL A 585
REMARK 465 ALA A 586
REMARK 465 CYS A 587
REMARK 465 GLY A 588
REMARK 465 TYR A 589
REMARK 465 ALA A 590
REMARK 465 ASP A 591
REMARK 465 GLY A 592
REMARK 465 CYS A 593
REMARK 465 LEU A 594
REMARK 465 SER A 595
REMARK 465 GLN A 596
REMARK 465 GLU A 597
REMARK 465 GLU A 598
REMARK 465 ALA A 599
REMARK 465 VAL A 600
REMARK 465 LEU A 601
REMARK 465 ALA A 602
REMARK 465 ALA A 603
REMARK 465 TYR A 604
REMARK 465 TRP A 605
REMARK 465 ARG A 606
REMARK 465 GLY A 607
REMARK 465 GLN A 608
REMARK 465 CYS A 609
REMARK 465 ILE A 610
REMARK 465 LYS A 611
REMARK 465 GLU A 612
REMARK 465 ALA A 613
REMARK 465 HIS A 614
REMARK 465 LEU A 615
REMARK 465 PRO A 616
REMARK 465 PRO A 617
REMARK 465 GLY A 618
REMARK 465 ALA A 619
REMARK 465 MET A 620
REMARK 465 ALA A 621
REMARK 465 ALA A 622
REMARK 465 VAL A 623
REMARK 465 GLY A 624
REMARK 465 LEU A 625
REMARK 465 SER A 626
REMARK 465 TRP A 627
REMARK 465 GLU A 628
REMARK 465 GLU A 629
REMARK 465 CYS A 630
REMARK 465 LYS A 631
REMARK 465 GLN A 632
REMARK 465 ARG A 633
REMARK 465 CYS A 634
REMARK 465 PRO A 635
REMARK 465 PRO A 636
REMARK 465 GLY A 637
REMARK 465 VAL A 638
REMARK 465 VAL A 639
REMARK 465 PRO A 640
REMARK 465 ALA A 641
REMARK 465 CYS A 642
REMARK 465 HIS A 643
REMARK 465 ASN A 644
REMARK 465 SER A 645
REMARK 465 LYS A 646
REMARK 465 ASP A 647
REMARK 465 THR A 648
REMARK 465 VAL A 649
REMARK 465 THR A 650
REMARK 465 ILE A 651
REMARK 465 SER A 652
REMARK 465 GLY A 653
REMARK 465 PRO A 654
REMARK 465 GLN A 655
REMARK 465 ALA A 656
REMARK 465 PRO A 657
REMARK 465 VAL A 658
REMARK 465 PHE A 659
REMARK 465 GLU A 660
REMARK 465 PHE A 661
REMARK 465 VAL A 662
REMARK 465 GLU A 663
REMARK 465 GLN A 664
REMARK 465 LEU A 665
REMARK 465 ARG A 666
REMARK 465 LYS A 667
REMARK 465 GLU A 668
REMARK 465 GLY A 669
REMARK 465 VAL A 670
REMARK 465 PHE A 671
REMARK 465 ALA A 672
REMARK 465 LYS A 673
REMARK 465 GLU A 674
REMARK 465 VAL A 675
REMARK 465 ARG A 676
REMARK 465 THR A 677
REMARK 465 GLY A 678
REMARK 465 GLY A 679
REMARK 465 MET A 680
REMARK 465 ALA A 681
REMARK 465 PHE A 682
REMARK 465 HIS A 683
REMARK 465 SER A 684
REMARK 465 TYR A 685
REMARK 465 PHE A 686
REMARK 465 MET A 687
REMARK 465 GLU A 688
REMARK 465 ALA A 689
REMARK 465 ILE A 690
REMARK 465 ALA A 691
REMARK 465 PRO A 692
REMARK 465 PRO A 693
REMARK 465 LEU A 694
REMARK 465 LEU A 695
REMARK 465 GLN A 696
REMARK 465 GLU A 697
REMARK 465 LEU A 698
REMARK 465 LYS A 699
REMARK 465 LYS A 700
REMARK 465 VAL A 701
REMARK 465 ILE A 702
REMARK 465 ARG A 703
REMARK 465 GLU A 704
REMARK 465 PRO A 705
REMARK 465 LYS A 706
REMARK 465 PRO A 707
REMARK 465 ARG A 708
REMARK 465 SER A 709
REMARK 465 ALA A 710
REMARK 465 ARG A 711
REMARK 465 TRP A 712
REMARK 465 LEU A 713
REMARK 465 SER A 714
REMARK 465 THR A 715
REMARK 465 SER A 716
REMARK 465 ILE A 717
REMARK 465 PRO A 718
REMARK 465 GLU A 719
REMARK 465 ALA A 720
REMARK 465 GLN A 721
REMARK 465 TRP A 722
REMARK 465 HIS A 723
REMARK 465 SER A 724
REMARK 465 SER A 725
REMARK 465 LEU A 726
REMARK 465 ALA A 727
REMARK 465 ARG A 728
REMARK 465 THR A 729
REMARK 465 SER A 730
REMARK 465 SER A 731
REMARK 465 ALA A 732
REMARK 465 GLU A 733
REMARK 465 TYR A 734
REMARK 465 ASN A 735
REMARK 465 VAL A 736
REMARK 465 ASN A 737
REMARK 465 ASN A 738
REMARK 465 LEU A 739
REMARK 465 VAL A 740
REMARK 465 SER A 741
REMARK 465 PRO A 742
REMARK 465 VAL A 743
REMARK 465 LEU A 744
REMARK 465 PHE A 745
REMARK 465 GLN A 746
REMARK 465 GLU A 747
REMARK 465 ALA A 748
REMARK 465 LEU A 749
REMARK 465 TRP A 750
REMARK 465 HIS A 751
REMARK 465 VAL A 752
REMARK 465 PRO A 753
REMARK 465 GLU A 754
REMARK 465 HIS A 755
REMARK 465 ALA A 756
REMARK 465 VAL A 757
REMARK 465 VAL A 758
REMARK 465 LEU A 759
REMARK 465 GLU A 760
REMARK 465 ILE A 761
REMARK 465 ALA A 762
REMARK 465 PRO A 763
REMARK 465 HIS A 764
REMARK 465 ALA A 765
REMARK 465 LEU A 766
REMARK 465 LEU A 767
REMARK 465 GLN A 768
REMARK 465 ALA A 769
REMARK 465 VAL A 770
REMARK 465 LEU A 771
REMARK 465 LYS A 772
REMARK 465 ARG A 773
REMARK 465 GLY A 774
REMARK 465 LEU A 775
REMARK 465 LYS A 776
REMARK 465 PRO A 777
REMARK 465 SER A 778
REMARK 465 CYS A 779
REMARK 465 THR A 780
REMARK 465 ILE A 781
REMARK 465 ILE A 782
REMARK 465 PRO A 783
REMARK 465 LEU A 784
REMARK 465 MET A 785
REMARK 465 LYS A 786
REMARK 465 LYS A 787
REMARK 465 ASP A 788
REMARK 465 HIS A 789
REMARK 465 ARG A 790
REMARK 465 ASP A 791
REMARK 465 ASN A 792
REMARK 465 LEU A 793
REMARK 465 GLU A 794
REMARK 465 PHE A 795
REMARK 465 PHE A 796
REMARK 465 LEU A 797
REMARK 465 ALA A 798
REMARK 465 GLY A 799
REMARK 465 ILE A 800
REMARK 465 GLY A 801
REMARK 465 ARG A 802
REMARK 465 LEU A 803
REMARK 465 HIS A 804
REMARK 465 LEU A 805
REMARK 465 SER A 806
REMARK 465 GLY A 807
REMARK 465 ILE A 808
REMARK 465 ASP A 809
REMARK 465 ALA A 810
REMARK 465 ASN A 811
REMARK 465 PRO A 812
REMARK 465 ASN A 813
REMARK 465 ALA A 814
REMARK 465 LEU A 815
REMARK 465 PHE A 816
REMARK 465 PRO A 817
REMARK 465 PRO A 818
REMARK 465 VAL A 819
REMARK 465 GLU A 820
REMARK 465 PHE A 821
REMARK 465 PRO A 822
REMARK 465 ALA A 823
REMARK 465 PRO A 824
REMARK 465 ARG A 825
REMARK 465 GLY A 826
REMARK 465 THR A 827
REMARK 465 PRO A 828
REMARK 465 LEU A 829
REMARK 465 ILE A 830
REMARK 465 SER A 831
REMARK 465 PRO A 832
REMARK 465 LEU A 833
REMARK 465 ILE A 834
REMARK 465 LYS A 835
REMARK 465 TRP A 836
REMARK 465 ASP A 837
REMARK 465 HIS A 838
REMARK 465 SER A 839
REMARK 465 LEU A 840
REMARK 465 ALA A 841
REMARK 465 TRP A 842
REMARK 465 ASP A 843
REMARK 465 VAL A 844
REMARK 465 PRO A 845
REMARK 465 ALA A 846
REMARK 465 ALA A 847
REMARK 465 GLU A 848
REMARK 465 ASP A 849
REMARK 465 PHE A 850
REMARK 465 PRO A 851
REMARK 465 ASN A 852
REMARK 465 GLY A 853
REMARK 465 SER A 854
REMARK 465 GLY A 855
REMARK 465 SER A 856
REMARK 465 PRO A 857
REMARK 465 SER A 858
REMARK 465 GLN A 1149
REMARK 465 THR A 1150
REMARK 465 THR A 1151
REMARK 465 VAL A 1152
REMARK 465 THR A 1153
REMARK 465 GLN A 1154
REMARK 465 GLN A 1155
REMARK 465 GLY A 1156
REMARK 465 LEU A 1157
REMARK 465 LYS A 1158
REMARK 465 MET A 1159
REMARK 465 VAL A 1160
REMARK 465 VAL A 1161
REMARK 465 PRO A 1162
REMARK 465 GLY A 1163
REMARK 465 LEU A 1164
REMARK 465 ASP A 1165
REMARK 465 GLY A 1166
REMARK 465 ALA A 1167
REMARK 465 GLN A 1168
REMARK 465 ILE A 1169
REMARK 465 PRO A 1170
REMARK 465 ARG A 1171
REMARK 465 ASP A 1172
REMARK 465 GLY A 2067
REMARK 465 ILE A 2068
REMARK 465 LEU A 2069
REMARK 465 VAL A 2070
REMARK 465 GLU A 2071
REMARK 465 THR A 2072
REMARK 465 MET A 2073
REMARK 465 SER A 2074
REMARK 465 THR A 2075
REMARK 465 ASN A 2076
REMARK 465 ASP A 2077
REMARK 465 THR A 2078
REMARK 465 ILE A 2079
REMARK 465 VAL A 2080
REMARK 465 GLU A 2113
REMARK 465 LYS A 2114
REMARK 465 ALA A 2115
REMARK 465 ALA A 2116
REMARK 465 ALA A 2117
REMARK 465 TYR A 2118
REMARK 465 ARG A 2119
REMARK 465 ASP A 2120
REMARK 465 ARG A 2121
REMARK 465 ASP A 2122
REMARK 465 SER A 2123
REMARK 465 GLN A 2124
REMARK 465 ARG A 2125
REMARK 465 ASP A 2126
REMARK 465 LEU A 2127
REMARK 465 VAL A 2128
REMARK 465 GLU A 2129
REMARK 465 ALA A 2130
REMARK 465 VAL A 2131
REMARK 465 ALA A 2132
REMARK 465 HIS A 2133
REMARK 465 ILE A 2134
REMARK 465 LEU A 2135
REMARK 465 GLY A 2136
REMARK 465 ILE A 2137
REMARK 465 ARG A 2138
REMARK 465 ASP A 2139
REMARK 465 LEU A 2140
REMARK 465 ALA A 2141
REMARK 465 ALA A 2142
REMARK 465 VAL A 2143
REMARK 465 ASN A 2144
REMARK 465 LEU A 2145
REMARK 465 ASP A 2146
REMARK 465 SER A 2147
REMARK 465 SER A 2148
REMARK 465 LEU A 2149
REMARK 465 ALA A 2150
REMARK 465 ASP A 2151
REMARK 465 LEU A 2152
REMARK 465 GLY A 2153
REMARK 465 LEU A 2154
REMARK 465 ASP A 2155
REMARK 465 SER A 2156
REMARK 465 LEU A 2157
REMARK 465 MET A 2158
REMARK 465 SER A 2159
REMARK 465 VAL A 2160
REMARK 465 GLU A 2161
REMARK 465 VAL A 2162
REMARK 465 ARG A 2163
REMARK 465 GLN A 2164
REMARK 465 THR A 2165
REMARK 465 LEU A 2166
REMARK 465 GLU A 2167
REMARK 465 ARG A 2168
REMARK 465 GLU A 2169
REMARK 465 LEU A 2170
REMARK 465 ASN A 2171
REMARK 465 LEU A 2172
REMARK 465 VAL A 2173
REMARK 465 LEU A 2174
REMARK 465 SER A 2175
REMARK 465 VAL A 2176
REMARK 465 ARG A 2177
REMARK 465 GLU A 2178
REMARK 465 VAL A 2179
REMARK 465 ARG A 2180
REMARK 465 GLN A 2181
REMARK 465 LEU A 2182
REMARK 465 THR A 2183
REMARK 465 LEU A 2184
REMARK 465 ARG A 2185
REMARK 465 LYS A 2186
REMARK 465 LEU A 2187
REMARK 465 GLN A 2188
REMARK 465 GLU A 2189
REMARK 465 LEU A 2190
REMARK 465 SER A 2191
REMARK 465 SER A 2192
REMARK 465 LYS A 2193
REMARK 465 ALA A 2194
REMARK 465 ASP A 2195
REMARK 465 GLU A 2196
REMARK 465 ALA A 2197
REMARK 465 SER A 2198
REMARK 465 GLU A 2199
REMARK 465 LEU A 2200
REMARK 465 ALA A 2201
REMARK 465 CYS A 2202
REMARK 465 PRO A 2203
REMARK 465 THR A 2204
REMARK 465 PRO A 2205
REMARK 465 LYS A 2206
REMARK 465 GLU A 2207
REMARK 465 ASP A 2208
REMARK 465 GLY A 2209
REMARK 465 LEU A 2210
REMARK 465 ALA A 2211
REMARK 465 GLN A 2212
REMARK 465 GLN A 2213
REMARK 465 GLN A 2214
REMARK 465 THR A 2215
REMARK 465 GLN A 2216
REMARK 465 LEU A 2217
REMARK 465 ASN A 2218
REMARK 465 LEU A 2219
REMARK 465 ARG A 2220
REMARK 465 SER A 2221
REMARK 465 LEU A 2222
REMARK 465 LEU A 2223
REMARK 465 VAL A 2224
REMARK 465 ASN A 2225
REMARK 465 PRO A 2226
REMARK 465 GLU A 2227
REMARK 465 GLY A 2228
REMARK 465 PRO A 2229
REMARK 465 THR A 2230
REMARK 465 LEU A 2231
REMARK 465 MET A 2232
REMARK 465 ARG A 2233
REMARK 465 LEU A 2234
REMARK 465 ASN A 2235
REMARK 465 SER A 2236
REMARK 465 VAL A 2237
REMARK 465 GLN A 2238
REMARK 465 SER A 2239
REMARK 465 SER A 2240
REMARK 465 GLU A 2241
REMARK 465 ARG A 2242
REMARK 465 PRO A 2243
REMARK 465 LEU A 2244
REMARK 465 PHE A 2245
REMARK 465 LEU A 2246
REMARK 465 VAL A 2247
REMARK 465 HIS A 2248
REMARK 465 PRO A 2249
REMARK 465 ILE A 2250
REMARK 465 GLU A 2251
REMARK 465 GLY A 2252
REMARK 465 SER A 2253
REMARK 465 THR A 2254
REMARK 465 THR A 2255
REMARK 465 VAL A 2256
REMARK 465 PHE A 2257
REMARK 465 HIS A 2258
REMARK 465 SER A 2259
REMARK 465 LEU A 2260
REMARK 465 ALA A 2261
REMARK 465 SER A 2262
REMARK 465 ARG A 2263
REMARK 465 LEU A 2264
REMARK 465 SER A 2265
REMARK 465 ILE A 2266
REMARK 465 PRO A 2267
REMARK 465 THR A 2268
REMARK 465 TYR A 2269
REMARK 465 GLY A 2270
REMARK 465 LEU A 2271
REMARK 465 GLN A 2272
REMARK 465 CYS A 2273
REMARK 465 THR A 2274
REMARK 465 ARG A 2275
REMARK 465 ALA A 2276
REMARK 465 ALA A 2277
REMARK 465 PRO A 2278
REMARK 465 LEU A 2279
REMARK 465 ASP A 2280
REMARK 465 SER A 2281
REMARK 465 ILE A 2282
REMARK 465 HIS A 2283
REMARK 465 SER A 2284
REMARK 465 LEU A 2285
REMARK 465 ALA A 2286
REMARK 465 ALA A 2287
REMARK 465 TYR A 2288
REMARK 465 TYR A 2289
REMARK 465 ILE A 2290
REMARK 465 ASP A 2291
REMARK 465 CYS A 2292
REMARK 465 ILE A 2293
REMARK 465 ARG A 2294
REMARK 465 GLN A 2295
REMARK 465 VAL A 2296
REMARK 465 GLN A 2297
REMARK 465 PRO A 2298
REMARK 465 GLU A 2299
REMARK 465 GLY A 2300
REMARK 465 PRO A 2301
REMARK 465 TYR A 2302
REMARK 465 ARG A 2303
REMARK 465 VAL A 2304
REMARK 465 ALA A 2305
REMARK 465 GLY A 2306
REMARK 465 TYR A 2307
REMARK 465 SER A 2308
REMARK 465 TYR A 2309
REMARK 465 GLY A 2310
REMARK 465 ALA A 2311
REMARK 465 CYS A 2312
REMARK 465 VAL A 2313
REMARK 465 ALA A 2314
REMARK 465 PHE A 2315
REMARK 465 GLU A 2316
REMARK 465 MET A 2317
REMARK 465 CYS A 2318
REMARK 465 SER A 2319
REMARK 465 GLN A 2320
REMARK 465 LEU A 2321
REMARK 465 GLN A 2322
REMARK 465 ALA A 2323
REMARK 465 GLN A 2324
REMARK 465 GLN A 2325
REMARK 465 SER A 2326
REMARK 465 PRO A 2327
REMARK 465 ALA A 2328
REMARK 465 PRO A 2329
REMARK 465 THR A 2330
REMARK 465 HIS A 2331
REMARK 465 ASN A 2332
REMARK 465 SER A 2333
REMARK 465 LEU A 2334
REMARK 465 PHE A 2335
REMARK 465 LEU A 2336
REMARK 465 PHE A 2337
REMARK 465 ASP A 2338
REMARK 465 GLY A 2339
REMARK 465 SER A 2340
REMARK 465 PRO A 2341
REMARK 465 THR A 2342
REMARK 465 TYR A 2343
REMARK 465 VAL A 2344
REMARK 465 LEU A 2345
REMARK 465 ALA A 2346
REMARK 465 TYR A 2347
REMARK 465 THR A 2348
REMARK 465 GLN A 2349
REMARK 465 SER A 2350
REMARK 465 TYR A 2351
REMARK 465 ARG A 2352
REMARK 465 ALA A 2353
REMARK 465 LYS A 2354
REMARK 465 LEU A 2355
REMARK 465 THR A 2356
REMARK 465 PRO A 2357
REMARK 465 GLY A 2358
REMARK 465 CYS A 2359
REMARK 465 GLU A 2360
REMARK 465 ALA A 2361
REMARK 465 GLU A 2362
REMARK 465 ALA A 2363
REMARK 465 GLU A 2364
REMARK 465 THR A 2365
REMARK 465 GLU A 2366
REMARK 465 ALA A 2367
REMARK 465 ILE A 2368
REMARK 465 CYS A 2369
REMARK 465 PHE A 2370
REMARK 465 PHE A 2371
REMARK 465 VAL A 2372
REMARK 465 GLN A 2373
REMARK 465 GLN A 2374
REMARK 465 PHE A 2375
REMARK 465 THR A 2376
REMARK 465 ASP A 2377
REMARK 465 MET A 2378
REMARK 465 GLU A 2379
REMARK 465 HIS A 2380
REMARK 465 ASN A 2381
REMARK 465 ARG A 2382
REMARK 465 VAL A 2383
REMARK 465 LEU A 2384
REMARK 465 GLU A 2385
REMARK 465 ALA A 2386
REMARK 465 LEU A 2387
REMARK 465 LEU A 2388
REMARK 465 PRO A 2389
REMARK 465 LEU A 2390
REMARK 465 LYS A 2391
REMARK 465 GLY A 2392
REMARK 465 LEU A 2393
REMARK 465 GLU A 2394
REMARK 465 GLU A 2395
REMARK 465 ARG A 2396
REMARK 465 VAL A 2397
REMARK 465 ALA A 2398
REMARK 465 ALA A 2399
REMARK 465 ALA A 2400
REMARK 465 VAL A 2401
REMARK 465 ASP A 2402
REMARK 465 LEU A 2403
REMARK 465 ILE A 2404
REMARK 465 ILE A 2405
REMARK 465 LYS A 2406
REMARK 465 SER A 2407
REMARK 465 HIS A 2408
REMARK 465 GLN A 2409
REMARK 465 GLY A 2410
REMARK 465 LEU A 2411
REMARK 465 ASP A 2412
REMARK 465 ARG A 2413
REMARK 465 GLN A 2414
REMARK 465 GLU A 2415
REMARK 465 LEU A 2416
REMARK 465 SER A 2417
REMARK 465 PHE A 2418
REMARK 465 ALA A 2419
REMARK 465 ALA A 2420
REMARK 465 ARG A 2421
REMARK 465 SER A 2422
REMARK 465 PHE A 2423
REMARK 465 TYR A 2424
REMARK 465 TYR A 2425
REMARK 465 LYS A 2426
REMARK 465 LEU A 2427
REMARK 465 ARG A 2428
REMARK 465 ALA A 2429
REMARK 465 ALA A 2430
REMARK 465 GLU A 2431
REMARK 465 GLN A 2432
REMARK 465 TYR A 2433
REMARK 465 THR A 2434
REMARK 465 PRO A 2435
REMARK 465 LYS A 2436
REMARK 465 ALA A 2437
REMARK 465 LYS A 2438
REMARK 465 TYR A 2439
REMARK 465 HIS A 2440
REMARK 465 GLY A 2441
REMARK 465 ASN A 2442
REMARK 465 VAL A 2443
REMARK 465 MET A 2444
REMARK 465 LEU A 2445
REMARK 465 LEU A 2446
REMARK 465 ARG A 2447
REMARK 465 ALA A 2448
REMARK 465 LYS A 2449
REMARK 465 THR A 2450
REMARK 465 GLY A 2451
REMARK 465 GLY A 2452
REMARK 465 ALA A 2453
REMARK 465 TYR A 2454
REMARK 465 GLY A 2455
REMARK 465 GLU A 2456
REMARK 465 ASP A 2457
REMARK 465 LEU A 2458
REMARK 465 GLY A 2459
REMARK 465 ALA A 2460
REMARK 465 ASP A 2461
REMARK 465 TYR A 2462
REMARK 465 ASN A 2463
REMARK 465 LEU A 2464
REMARK 465 SER A 2465
REMARK 465 GLN A 2466
REMARK 465 VAL A 2467
REMARK 465 CYS A 2468
REMARK 465 ASP A 2469
REMARK 465 GLY A 2470
REMARK 465 LYS A 2471
REMARK 465 VAL A 2472
REMARK 465 SER A 2473
REMARK 465 VAL A 2474
REMARK 465 HIS A 2475
REMARK 465 VAL A 2476
REMARK 465 ILE A 2477
REMARK 465 GLU A 2478
REMARK 465 GLY A 2479
REMARK 465 ASP A 2480
REMARK 465 HIS A 2481
REMARK 465 ARG A 2482
REMARK 465 THR A 2483
REMARK 465 LEU A 2484
REMARK 465 LEU A 2485
REMARK 465 GLU A 2486
REMARK 465 GLY A 2487
REMARK 465 SER A 2488
REMARK 465 GLY A 2489
REMARK 465 LEU A 2490
REMARK 465 GLU A 2491
REMARK 465 SER A 2492
REMARK 465 ILE A 2493
REMARK 465 ILE A 2494
REMARK 465 SER A 2495
REMARK 465 ILE A 2496
REMARK 465 ILE A 2497
REMARK 465 HIS A 2498
REMARK 465 SER A 2499
REMARK 465 SER A 2500
REMARK 465 LEU A 2501
REMARK 465 ALA A 2502
REMARK 465 GLU A 2503
REMARK 465 PRO A 2504
REMARK 465 ARG A 2505
REMARK 465 VAL A 2506
REMARK 465 SER A 2507
REMARK 465 VAL A 2508
REMARK 465 ARG A 2509
REMARK 465 GLU A 2510
REMARK 465 GLY A 2511
REMARK 465 LEU A 2512
REMARK 465 GLU A 2513
REMARK 465 HIS A 2514
REMARK 465 HIS A 2515
REMARK 465 HIS A 2516
REMARK 465 HIS A 2517
REMARK 465 HIS A 2518
REMARK 465 HIS A 2519
REMARK 465 HIS A 2520
REMARK 465 HIS A 2521
REMARK 465 MET B -31
REMARK 465 SER B -30
REMARK 465 TYR B -29
REMARK 465 TYR B -28
REMARK 465 ASP B -27
REMARK 465 TYR B -26
REMARK 465 LYS B -25
REMARK 465 ASP B -24
REMARK 465 ASP B -23
REMARK 465 ASP B -22
REMARK 465 ASP B -21
REMARK 465 LYS B -20
REMARK 465 ASP B -19
REMARK 465 TYR B -18
REMARK 465 ASP B -17
REMARK 465 ILE B -16
REMARK 465 PRO B -15
REMARK 465 THR B -14
REMARK 465 THR B -13
REMARK 465 GLU B -12
REMARK 465 ASN B -11
REMARK 465 LEU B -10
REMARK 465 TYR B -9
REMARK 465 PHE B -8
REMARK 465 GLN B -7
REMARK 465 GLY B -6
REMARK 465 ALA B -5
REMARK 465 MET B -4
REMARK 465 GLY B -3
REMARK 465 SER B -2
REMARK 465 GLY B -1
REMARK 465 ILE B 0
REMARK 465 PRO B 1
REMARK 465 GLU B 2
REMARK 465 GLU B 3
REMARK 465 VAL B 4
REMARK 465 VAL B 5
REMARK 465 ILE B 6
REMARK 465 ALA B 7
REMARK 465 GLY B 8
REMARK 465 MET B 9
REMARK 465 SER B 10
REMARK 465 GLY B 11
REMARK 465 LYS B 12
REMARK 465 LEU B 13
REMARK 465 PRO B 14
REMARK 465 GLU B 15
REMARK 465 SER B 16
REMARK 465 GLU B 17
REMARK 465 ASN B 18
REMARK 465 LEU B 19
REMARK 465 GLN B 20
REMARK 465 GLU B 21
REMARK 465 PHE B 22
REMARK 465 TRP B 23
REMARK 465 ASP B 24
REMARK 465 ASN B 25
REMARK 465 LEU B 26
REMARK 465 ILE B 27
REMARK 465 GLY B 28
REMARK 465 GLY B 29
REMARK 465 VAL B 30
REMARK 465 ASP B 31
REMARK 465 MET B 32
REMARK 465 VAL B 33
REMARK 465 THR B 34
REMARK 465 ASP B 35
REMARK 465 ASP B 36
REMARK 465 ASP B 37
REMARK 465 ARG B 38
REMARK 465 ARG B 39
REMARK 465 TRP B 40
REMARK 465 LYS B 41
REMARK 465 ALA B 42
REMARK 465 GLY B 43
REMARK 465 LEU B 44
REMARK 465 TYR B 45
REMARK 465 GLY B 46
REMARK 465 LEU B 47
REMARK 465 PRO B 48
REMARK 465 ARG B 49
REMARK 465 ARG B 50
REMARK 465 SER B 51
REMARK 465 GLY B 52
REMARK 465 LYS B 53
REMARK 465 LEU B 54
REMARK 465 LYS B 55
REMARK 465 ASP B 56
REMARK 465 LEU B 57
REMARK 465 SER B 58
REMARK 465 ARG B 59
REMARK 465 PHE B 60
REMARK 465 ASP B 61
REMARK 465 ALA B 62
REMARK 465 SER B 63
REMARK 465 PHE B 64
REMARK 465 PHE B 65
REMARK 465 GLY B 66
REMARK 465 VAL B 67
REMARK 465 HIS B 68
REMARK 465 PRO B 69
REMARK 465 LYS B 70
REMARK 465 GLN B 71
REMARK 465 ALA B 72
REMARK 465 HIS B 73
REMARK 465 THR B 74
REMARK 465 MET B 75
REMARK 465 ASP B 76
REMARK 465 PRO B 77
REMARK 465 GLN B 78
REMARK 465 LEU B 79
REMARK 465 ARG B 80
REMARK 465 LEU B 81
REMARK 465 LEU B 82
REMARK 465 LEU B 83
REMARK 465 GLU B 84
REMARK 465 VAL B 85
REMARK 465 THR B 86
REMARK 465 TYR B 87
REMARK 465 GLU B 88
REMARK 465 ALA B 89
REMARK 465 ILE B 90
REMARK 465 VAL B 91
REMARK 465 ASP B 92
REMARK 465 GLY B 93
REMARK 465 GLY B 94
REMARK 465 ILE B 95
REMARK 465 ASN B 96
REMARK 465 PRO B 97
REMARK 465 ASP B 98
REMARK 465 SER B 99
REMARK 465 LEU B 100
REMARK 465 ARG B 101
REMARK 465 GLY B 102
REMARK 465 THR B 103
REMARK 465 HIS B 104
REMARK 465 THR B 105
REMARK 465 GLY B 106
REMARK 465 VAL B 107
REMARK 465 TRP B 108
REMARK 465 VAL B 109
REMARK 465 GLY B 110
REMARK 465 VAL B 111
REMARK 465 SER B 112
REMARK 465 GLY B 113
REMARK 465 SER B 114
REMARK 465 GLU B 115
REMARK 465 THR B 116
REMARK 465 SER B 117
REMARK 465 GLU B 118
REMARK 465 ALA B 119
REMARK 465 LEU B 120
REMARK 465 SER B 121
REMARK 465 ARG B 122
REMARK 465 ASP B 123
REMARK 465 PRO B 124
REMARK 465 GLU B 125
REMARK 465 THR B 126
REMARK 465 LEU B 127
REMARK 465 VAL B 128
REMARK 465 GLY B 129
REMARK 465 TYR B 130
REMARK 465 SER B 131
REMARK 465 MET B 132
REMARK 465 VAL B 133
REMARK 465 GLY B 134
REMARK 465 CYS B 135
REMARK 465 GLN B 136
REMARK 465 ARG B 137
REMARK 465 ALA B 138
REMARK 465 MET B 139
REMARK 465 MET B 140
REMARK 465 ALA B 141
REMARK 465 ASN B 142
REMARK 465 ARG B 143
REMARK 465 LEU B 144
REMARK 465 SER B 145
REMARK 465 PHE B 146
REMARK 465 PHE B 147
REMARK 465 PHE B 148
REMARK 465 ASP B 149
REMARK 465 PHE B 150
REMARK 465 ARG B 151
REMARK 465 GLY B 152
REMARK 465 PRO B 153
REMARK 465 SER B 154
REMARK 465 ILE B 155
REMARK 465 ALA B 156
REMARK 465 LEU B 157
REMARK 465 ASP B 158
REMARK 465 THR B 159
REMARK 465 ALA B 160
REMARK 465 CYS B 161
REMARK 465 SER B 162
REMARK 465 SER B 163
REMARK 465 SER B 164
REMARK 465 LEU B 165
REMARK 465 MET B 166
REMARK 465 ALA B 167
REMARK 465 LEU B 168
REMARK 465 GLN B 169
REMARK 465 ASN B 170
REMARK 465 ALA B 171
REMARK 465 TYR B 172
REMARK 465 GLN B 173
REMARK 465 ALA B 174
REMARK 465 ILE B 175
REMARK 465 HIS B 176
REMARK 465 SER B 177
REMARK 465 GLY B 178
REMARK 465 GLN B 179
REMARK 465 CYS B 180
REMARK 465 PRO B 181
REMARK 465 ALA B 182
REMARK 465 ALA B 183
REMARK 465 ILE B 184
REMARK 465 VAL B 185
REMARK 465 GLY B 186
REMARK 465 GLY B 187
REMARK 465 ILE B 188
REMARK 465 ASN B 189
REMARK 465 VAL B 190
REMARK 465 LEU B 191
REMARK 465 LEU B 192
REMARK 465 LYS B 193
REMARK 465 PRO B 194
REMARK 465 ASN B 195
REMARK 465 THR B 196
REMARK 465 SER B 197
REMARK 465 VAL B 198
REMARK 465 GLN B 199
REMARK 465 PHE B 200
REMARK 465 LEU B 201
REMARK 465 ARG B 202
REMARK 465 LEU B 203
REMARK 465 GLY B 204
REMARK 465 MET B 205
REMARK 465 LEU B 206
REMARK 465 SER B 207
REMARK 465 PRO B 208
REMARK 465 GLU B 209
REMARK 465 GLY B 210
REMARK 465 THR B 211
REMARK 465 CYS B 212
REMARK 465 LYS B 213
REMARK 465 ALA B 214
REMARK 465 PHE B 215
REMARK 465 ASP B 216
REMARK 465 THR B 217
REMARK 465 ALA B 218
REMARK 465 GLY B 219
REMARK 465 ASN B 220
REMARK 465 GLY B 221
REMARK 465 TYR B 222
REMARK 465 CYS B 223
REMARK 465 ARG B 224
REMARK 465 SER B 225
REMARK 465 GLU B 226
REMARK 465 GLY B 227
REMARK 465 VAL B 228
REMARK 465 VAL B 229
REMARK 465 ALA B 230
REMARK 465 VAL B 231
REMARK 465 LEU B 232
REMARK 465 LEU B 233
REMARK 465 THR B 234
REMARK 465 LYS B 235
REMARK 465 LYS B 236
REMARK 465 SER B 237
REMARK 465 LEU B 238
REMARK 465 ALA B 239
REMARK 465 ARG B 240
REMARK 465 ARG B 241
REMARK 465 VAL B 242
REMARK 465 TYR B 243
REMARK 465 ALA B 244
REMARK 465 THR B 245
REMARK 465 ILE B 246
REMARK 465 LEU B 247
REMARK 465 ASN B 248
REMARK 465 ALA B 249
REMARK 465 GLY B 250
REMARK 465 THR B 251
REMARK 465 ASN B 252
REMARK 465 THR B 253
REMARK 465 ASP B 254
REMARK 465 GLY B 255
REMARK 465 PHE B 256
REMARK 465 LYS B 257
REMARK 465 GLU B 258
REMARK 465 GLN B 259
REMARK 465 GLY B 260
REMARK 465 VAL B 261
REMARK 465 THR B 262
REMARK 465 PHE B 263
REMARK 465 PRO B 264
REMARK 465 SER B 265
REMARK 465 GLY B 266
REMARK 465 ASP B 267
REMARK 465 ILE B 268
REMARK 465 GLN B 269
REMARK 465 GLU B 270
REMARK 465 GLN B 271
REMARK 465 LEU B 272
REMARK 465 ILE B 273
REMARK 465 ARG B 274
REMARK 465 SER B 275
REMARK 465 LEU B 276
REMARK 465 TYR B 277
REMARK 465 GLN B 278
REMARK 465 SER B 279
REMARK 465 ALA B 280
REMARK 465 GLY B 281
REMARK 465 VAL B 282
REMARK 465 ALA B 283
REMARK 465 PRO B 284
REMARK 465 GLU B 285
REMARK 465 SER B 286
REMARK 465 PHE B 287
REMARK 465 GLU B 288
REMARK 465 TYR B 289
REMARK 465 ILE B 290
REMARK 465 GLU B 291
REMARK 465 ALA B 292
REMARK 465 HIS B 293
REMARK 465 GLY B 294
REMARK 465 THR B 295
REMARK 465 GLY B 296
REMARK 465 THR B 297
REMARK 465 LYS B 298
REMARK 465 VAL B 299
REMARK 465 GLY B 300
REMARK 465 ASP B 301
REMARK 465 PRO B 302
REMARK 465 GLN B 303
REMARK 465 GLU B 304
REMARK 465 LEU B 305
REMARK 465 ASN B 306
REMARK 465 GLY B 307
REMARK 465 ILE B 308
REMARK 465 THR B 309
REMARK 465 ARG B 310
REMARK 465 ALA B 311
REMARK 465 LEU B 312
REMARK 465 CYS B 313
REMARK 465 ALA B 314
REMARK 465 THR B 315
REMARK 465 ARG B 316
REMARK 465 GLN B 317
REMARK 465 GLU B 318
REMARK 465 PRO B 319
REMARK 465 LEU B 320
REMARK 465 LEU B 321
REMARK 465 ILE B 322
REMARK 465 GLY B 323
REMARK 465 SER B 324
REMARK 465 THR B 325
REMARK 465 LYS B 326
REMARK 465 SER B 327
REMARK 465 ASN B 328
REMARK 465 MET B 329
REMARK 465 GLY B 330
REMARK 465 HIS B 331
REMARK 465 PRO B 332
REMARK 465 GLU B 333
REMARK 465 PRO B 334
REMARK 465 ALA B 335
REMARK 465 SER B 336
REMARK 465 GLY B 337
REMARK 465 LEU B 338
REMARK 465 ALA B 339
REMARK 465 ALA B 340
REMARK 465 LEU B 341
REMARK 465 ALA B 342
REMARK 465 LYS B 343
REMARK 465 VAL B 344
REMARK 465 LEU B 345
REMARK 465 LEU B 346
REMARK 465 SER B 347
REMARK 465 LEU B 348
REMARK 465 GLU B 349
REMARK 465 HIS B 350
REMARK 465 GLY B 351
REMARK 465 LEU B 352
REMARK 465 TRP B 353
REMARK 465 ALA B 354
REMARK 465 PRO B 355
REMARK 465 ASN B 356
REMARK 465 LEU B 357
REMARK 465 HIS B 358
REMARK 465 PHE B 359
REMARK 465 HIS B 360
REMARK 465 SER B 361
REMARK 465 PRO B 362
REMARK 465 ASN B 363
REMARK 465 PRO B 364
REMARK 465 GLU B 365
REMARK 465 ILE B 366
REMARK 465 PRO B 367
REMARK 465 ALA B 368
REMARK 465 LEU B 369
REMARK 465 LEU B 370
REMARK 465 ASP B 371
REMARK 465 GLY B 372
REMARK 465 ARG B 373
REMARK 465 LEU B 374
REMARK 465 GLN B 375
REMARK 465 VAL B 376
REMARK 465 VAL B 377
REMARK 465 ASP B 378
REMARK 465 GLN B 379
REMARK 465 PRO B 380
REMARK 465 LEU B 381
REMARK 465 PRO B 382
REMARK 465 VAL B 383
REMARK 465 ARG B 384
REMARK 465 GLY B 385
REMARK 465 GLY B 386
REMARK 465 ASN B 387
REMARK 465 VAL B 388
REMARK 465 GLY B 389
REMARK 465 ILE B 390
REMARK 465 ASN B 391
REMARK 465 SER B 392
REMARK 465 PHE B 393
REMARK 465 GLY B 394
REMARK 465 PHE B 395
REMARK 465 GLY B 396
REMARK 465 GLY B 397
REMARK 465 SER B 398
REMARK 465 ASN B 399
REMARK 465 VAL B 400
REMARK 465 HIS B 401
REMARK 465 ILE B 402
REMARK 465 ILE B 403
REMARK 465 LEU B 404
REMARK 465 ARG B 405
REMARK 465 PRO B 406
REMARK 465 ASN B 407
REMARK 465 THR B 408
REMARK 465 GLN B 409
REMARK 465 PRO B 410
REMARK 465 PRO B 411
REMARK 465 PRO B 412
REMARK 465 ALA B 413
REMARK 465 PRO B 414
REMARK 465 ALA B 415
REMARK 465 PRO B 416
REMARK 465 HIS B 417
REMARK 465 ALA B 418
REMARK 465 THR B 419
REMARK 465 LEU B 420
REMARK 465 PRO B 421
REMARK 465 ARG B 422
REMARK 465 LEU B 423
REMARK 465 LEU B 424
REMARK 465 ARG B 425
REMARK 465 ALA B 426
REMARK 465 SER B 427
REMARK 465 GLY B 428
REMARK 465 ARG B 429
REMARK 465 THR B 430
REMARK 465 PRO B 431
REMARK 465 GLU B 432
REMARK 465 ALA B 433
REMARK 465 VAL B 434
REMARK 465 GLN B 435
REMARK 465 LYS B 436
REMARK 465 LEU B 437
REMARK 465 LEU B 438
REMARK 465 GLU B 439
REMARK 465 GLN B 440
REMARK 465 GLY B 441
REMARK 465 LEU B 442
REMARK 465 ARG B 443
REMARK 465 HIS B 444
REMARK 465 SER B 445
REMARK 465 GLN B 446
REMARK 465 ASP B 447
REMARK 465 LEU B 448
REMARK 465 ALA B 449
REMARK 465 PHE B 450
REMARK 465 LEU B 451
REMARK 465 SER B 452
REMARK 465 MET B 453
REMARK 465 LEU B 454
REMARK 465 ASN B 455
REMARK 465 ASP B 456
REMARK 465 ILE B 457
REMARK 465 ALA B 458
REMARK 465 ALA B 459
REMARK 465 VAL B 460
REMARK 465 PRO B 461
REMARK 465 ALA B 462
REMARK 465 THR B 463
REMARK 465 ALA B 464
REMARK 465 MET B 465
REMARK 465 PRO B 466
REMARK 465 PHE B 467
REMARK 465 ARG B 468
REMARK 465 GLY B 469
REMARK 465 TYR B 470
REMARK 465 ALA B 471
REMARK 465 VAL B 472
REMARK 465 LEU B 473
REMARK 465 GLY B 474
REMARK 465 GLY B 475
REMARK 465 GLU B 476
REMARK 465 ARG B 477
REMARK 465 GLY B 478
REMARK 465 GLY B 479
REMARK 465 PRO B 480
REMARK 465 GLU B 481
REMARK 465 VAL B 482
REMARK 465 GLN B 483
REMARK 465 GLN B 484
REMARK 465 VAL B 485
REMARK 465 PRO B 486
REMARK 465 ALA B 487
REMARK 465 GLY B 488
REMARK 465 GLU B 489
REMARK 465 ARG B 490
REMARK 465 PRO B 491
REMARK 465 LEU B 492
REMARK 465 TRP B 493
REMARK 465 PHE B 494
REMARK 465 ILE B 495
REMARK 465 CYS B 496
REMARK 465 SER B 497
REMARK 465 GLY B 498
REMARK 465 MET B 499
REMARK 465 GLY B 500
REMARK 465 THR B 501
REMARK 465 GLN B 502
REMARK 465 TRP B 503
REMARK 465 ARG B 504
REMARK 465 GLY B 505
REMARK 465 MET B 506
REMARK 465 GLY B 507
REMARK 465 LEU B 508
REMARK 465 SER B 509
REMARK 465 LEU B 510
REMARK 465 MET B 511
REMARK 465 ARG B 512
REMARK 465 LEU B 513
REMARK 465 ASP B 514
REMARK 465 ARG B 515
REMARK 465 PHE B 516
REMARK 465 ARG B 517
REMARK 465 ASP B 518
REMARK 465 SER B 519
REMARK 465 ILE B 520
REMARK 465 LEU B 521
REMARK 465 ARG B 522
REMARK 465 SER B 523
REMARK 465 ASP B 524
REMARK 465 GLU B 525
REMARK 465 ALA B 526
REMARK 465 VAL B 527
REMARK 465 LYS B 528
REMARK 465 PRO B 529
REMARK 465 PHE B 530
REMARK 465 GLY B 531
REMARK 465 LEU B 532
REMARK 465 LYS B 533
REMARK 465 VAL B 534
REMARK 465 SER B 535
REMARK 465 GLN B 536
REMARK 465 LEU B 537
REMARK 465 LEU B 538
REMARK 465 LEU B 539
REMARK 465 SER B 540
REMARK 465 THR B 541
REMARK 465 ASP B 542
REMARK 465 GLU B 543
REMARK 465 SER B 544
REMARK 465 THR B 545
REMARK 465 PHE B 546
REMARK 465 ASP B 547
REMARK 465 ASP B 548
REMARK 465 ILE B 549
REMARK 465 VAL B 550
REMARK 465 HIS B 551
REMARK 465 SER B 552
REMARK 465 PHE B 553
REMARK 465 VAL B 554
REMARK 465 SER B 555
REMARK 465 LEU B 556
REMARK 465 THR B 557
REMARK 465 ALA B 558
REMARK 465 ILE B 559
REMARK 465 GLN B 560
REMARK 465 ILE B 561
REMARK 465 GLY B 562
REMARK 465 LEU B 563
REMARK 465 ILE B 564
REMARK 465 ASP B 565
REMARK 465 LEU B 566
REMARK 465 LEU B 567
REMARK 465 SER B 568
REMARK 465 CYS B 569
REMARK 465 MET B 570
REMARK 465 GLY B 571
REMARK 465 LEU B 572
REMARK 465 ARG B 573
REMARK 465 PRO B 574
REMARK 465 ASP B 575
REMARK 465 GLY B 576
REMARK 465 ILE B 577
REMARK 465 VAL B 578
REMARK 465 GLY B 579
REMARK 465 HIS B 580
REMARK 465 SER B 581
REMARK 465 LEU B 582
REMARK 465 GLY B 583
REMARK 465 GLU B 584
REMARK 465 VAL B 585
REMARK 465 ALA B 586
REMARK 465 CYS B 587
REMARK 465 GLY B 588
REMARK 465 TYR B 589
REMARK 465 ALA B 590
REMARK 465 ASP B 591
REMARK 465 GLY B 592
REMARK 465 CYS B 593
REMARK 465 LEU B 594
REMARK 465 SER B 595
REMARK 465 GLN B 596
REMARK 465 GLU B 597
REMARK 465 GLU B 598
REMARK 465 ALA B 599
REMARK 465 VAL B 600
REMARK 465 LEU B 601
REMARK 465 ALA B 602
REMARK 465 ALA B 603
REMARK 465 TYR B 604
REMARK 465 TRP B 605
REMARK 465 ARG B 606
REMARK 465 GLY B 607
REMARK 465 GLN B 608
REMARK 465 CYS B 609
REMARK 465 ILE B 610
REMARK 465 LYS B 611
REMARK 465 GLU B 612
REMARK 465 ALA B 613
REMARK 465 HIS B 614
REMARK 465 LEU B 615
REMARK 465 PRO B 616
REMARK 465 PRO B 617
REMARK 465 GLY B 618
REMARK 465 ALA B 619
REMARK 465 MET B 620
REMARK 465 ALA B 621
REMARK 465 ALA B 622
REMARK 465 VAL B 623
REMARK 465 GLY B 624
REMARK 465 LEU B 625
REMARK 465 SER B 626
REMARK 465 TRP B 627
REMARK 465 GLU B 628
REMARK 465 GLU B 629
REMARK 465 CYS B 630
REMARK 465 LYS B 631
REMARK 465 GLN B 632
REMARK 465 ARG B 633
REMARK 465 CYS B 634
REMARK 465 PRO B 635
REMARK 465 PRO B 636
REMARK 465 GLY B 637
REMARK 465 VAL B 638
REMARK 465 VAL B 639
REMARK 465 PRO B 640
REMARK 465 ALA B 641
REMARK 465 CYS B 642
REMARK 465 HIS B 643
REMARK 465 ASN B 644
REMARK 465 SER B 645
REMARK 465 LYS B 646
REMARK 465 ASP B 647
REMARK 465 THR B 648
REMARK 465 VAL B 649
REMARK 465 THR B 650
REMARK 465 ILE B 651
REMARK 465 SER B 652
REMARK 465 GLY B 653
REMARK 465 PRO B 654
REMARK 465 GLN B 655
REMARK 465 ALA B 656
REMARK 465 PRO B 657
REMARK 465 VAL B 658
REMARK 465 PHE B 659
REMARK 465 GLU B 660
REMARK 465 PHE B 661
REMARK 465 VAL B 662
REMARK 465 GLU B 663
REMARK 465 GLN B 664
REMARK 465 LEU B 665
REMARK 465 ARG B 666
REMARK 465 LYS B 667
REMARK 465 GLU B 668
REMARK 465 GLY B 669
REMARK 465 VAL B 670
REMARK 465 PHE B 671
REMARK 465 ALA B 672
REMARK 465 LYS B 673
REMARK 465 GLU B 674
REMARK 465 VAL B 675
REMARK 465 ARG B 676
REMARK 465 THR B 677
REMARK 465 GLY B 678
REMARK 465 GLY B 679
REMARK 465 MET B 680
REMARK 465 ALA B 681
REMARK 465 PHE B 682
REMARK 465 HIS B 683
REMARK 465 SER B 684
REMARK 465 TYR B 685
REMARK 465 PHE B 686
REMARK 465 MET B 687
REMARK 465 GLU B 688
REMARK 465 ALA B 689
REMARK 465 ILE B 690
REMARK 465 ALA B 691
REMARK 465 PRO B 692
REMARK 465 PRO B 693
REMARK 465 LEU B 694
REMARK 465 LEU B 695
REMARK 465 GLN B 696
REMARK 465 GLU B 697
REMARK 465 LEU B 698
REMARK 465 LYS B 699
REMARK 465 LYS B 700
REMARK 465 VAL B 701
REMARK 465 ILE B 702
REMARK 465 ARG B 703
REMARK 465 GLU B 704
REMARK 465 PRO B 705
REMARK 465 LYS B 706
REMARK 465 PRO B 707
REMARK 465 ARG B 708
REMARK 465 SER B 709
REMARK 465 ALA B 710
REMARK 465 ARG B 711
REMARK 465 TRP B 712
REMARK 465 LEU B 713
REMARK 465 SER B 714
REMARK 465 THR B 715
REMARK 465 SER B 716
REMARK 465 ILE B 717
REMARK 465 PRO B 718
REMARK 465 GLU B 719
REMARK 465 ALA B 720
REMARK 465 GLN B 721
REMARK 465 TRP B 722
REMARK 465 HIS B 723
REMARK 465 SER B 724
REMARK 465 SER B 725
REMARK 465 LEU B 726
REMARK 465 ALA B 727
REMARK 465 ARG B 728
REMARK 465 THR B 729
REMARK 465 SER B 730
REMARK 465 SER B 731
REMARK 465 ALA B 732
REMARK 465 GLU B 733
REMARK 465 TYR B 734
REMARK 465 ASN B 735
REMARK 465 VAL B 736
REMARK 465 ASN B 737
REMARK 465 ASN B 738
REMARK 465 LEU B 739
REMARK 465 VAL B 740
REMARK 465 SER B 741
REMARK 465 PRO B 742
REMARK 465 VAL B 743
REMARK 465 LEU B 744
REMARK 465 PHE B 745
REMARK 465 GLN B 746
REMARK 465 GLU B 747
REMARK 465 ALA B 748
REMARK 465 LEU B 749
REMARK 465 TRP B 750
REMARK 465 HIS B 751
REMARK 465 VAL B 752
REMARK 465 PRO B 753
REMARK 465 GLU B 754
REMARK 465 HIS B 755
REMARK 465 ALA B 756
REMARK 465 VAL B 757
REMARK 465 VAL B 758
REMARK 465 LEU B 759
REMARK 465 GLU B 760
REMARK 465 ILE B 761
REMARK 465 ALA B 762
REMARK 465 PRO B 763
REMARK 465 HIS B 764
REMARK 465 ALA B 765
REMARK 465 LEU B 766
REMARK 465 LEU B 767
REMARK 465 GLN B 768
REMARK 465 ALA B 769
REMARK 465 VAL B 770
REMARK 465 LEU B 771
REMARK 465 LYS B 772
REMARK 465 ARG B 773
REMARK 465 GLY B 774
REMARK 465 LEU B 775
REMARK 465 LYS B 776
REMARK 465 PRO B 777
REMARK 465 SER B 778
REMARK 465 CYS B 779
REMARK 465 THR B 780
REMARK 465 ILE B 781
REMARK 465 ILE B 782
REMARK 465 PRO B 783
REMARK 465 LEU B 784
REMARK 465 MET B 785
REMARK 465 LYS B 786
REMARK 465 LYS B 787
REMARK 465 ASP B 788
REMARK 465 HIS B 789
REMARK 465 ARG B 790
REMARK 465 ASP B 791
REMARK 465 ASN B 792
REMARK 465 LEU B 793
REMARK 465 GLU B 794
REMARK 465 PHE B 795
REMARK 465 PHE B 796
REMARK 465 LEU B 797
REMARK 465 ALA B 798
REMARK 465 GLY B 799
REMARK 465 ILE B 800
REMARK 465 GLY B 801
REMARK 465 ARG B 802
REMARK 465 LEU B 803
REMARK 465 HIS B 804
REMARK 465 LEU B 805
REMARK 465 SER B 806
REMARK 465 GLY B 807
REMARK 465 ILE B 808
REMARK 465 ASP B 809
REMARK 465 ALA B 810
REMARK 465 ASN B 811
REMARK 465 PRO B 812
REMARK 465 ASN B 813
REMARK 465 ALA B 814
REMARK 465 LEU B 815
REMARK 465 PHE B 816
REMARK 465 PRO B 817
REMARK 465 PRO B 818
REMARK 465 VAL B 819
REMARK 465 GLU B 820
REMARK 465 PHE B 821
REMARK 465 PRO B 822
REMARK 465 ALA B 823
REMARK 465 PRO B 824
REMARK 465 ARG B 825
REMARK 465 GLY B 826
REMARK 465 THR B 827
REMARK 465 PRO B 828
REMARK 465 LEU B 829
REMARK 465 ILE B 830
REMARK 465 SER B 831
REMARK 465 PRO B 832
REMARK 465 LEU B 833
REMARK 465 ILE B 834
REMARK 465 LYS B 835
REMARK 465 TRP B 836
REMARK 465 ASP B 837
REMARK 465 HIS B 838
REMARK 465 SER B 839
REMARK 465 LEU B 840
REMARK 465 ALA B 841
REMARK 465 TRP B 842
REMARK 465 ASP B 843
REMARK 465 VAL B 844
REMARK 465 PRO B 845
REMARK 465 ALA B 846
REMARK 465 ALA B 847
REMARK 465 GLU B 848
REMARK 465 ASP B 849
REMARK 465 PHE B 850
REMARK 465 PRO B 851
REMARK 465 ASN B 852
REMARK 465 GLY B 853
REMARK 465 SER B 854
REMARK 465 GLY B 855
REMARK 465 SER B 856
REMARK 465 PRO B 857
REMARK 465 SER B 858
REMARK 465 THR B 1151
REMARK 465 VAL B 1152
REMARK 465 THR B 1153
REMARK 465 GLN B 1154
REMARK 465 GLN B 1155
REMARK 465 GLY B 1156
REMARK 465 LEU B 1157
REMARK 465 LYS B 1158
REMARK 465 MET B 1159
REMARK 465 VAL B 1160
REMARK 465 VAL B 1161
REMARK 465 PRO B 1162
REMARK 465 GLY B 1163
REMARK 465 LEU B 1164
REMARK 465 ASP B 1165
REMARK 465 GLY B 1166
REMARK 465 ALA B 1167
REMARK 465 GLN B 1168
REMARK 465 ILE B 1169
REMARK 465 PRO B 1170
REMARK 465 ARG B 1171
REMARK 465 ASP B 1172
REMARK 465 GLY B 2067
REMARK 465 ILE B 2068
REMARK 465 LEU B 2069
REMARK 465 VAL B 2070
REMARK 465 GLU B 2071
REMARK 465 THR B 2072
REMARK 465 MET B 2073
REMARK 465 SER B 2074
REMARK 465 THR B 2075
REMARK 465 ASN B 2076
REMARK 465 ASP B 2077
REMARK 465 THR B 2078
REMARK 465 ILE B 2079
REMARK 465 VAL B 2080
REMARK 465 LYS B 2114
REMARK 465 ALA B 2115
REMARK 465 ALA B 2116
REMARK 465 ALA B 2117
REMARK 465 TYR B 2118
REMARK 465 ARG B 2119
REMARK 465 ASP B 2120
REMARK 465 ARG B 2121
REMARK 465 ASP B 2122
REMARK 465 SER B 2123
REMARK 465 GLN B 2124
REMARK 465 ASP B 2195
REMARK 465 GLU B 2196
REMARK 465 ALA B 2197
REMARK 465 SER B 2198
REMARK 465 GLU B 2199
REMARK 465 LEU B 2200
REMARK 465 ALA B 2201
REMARK 465 CYS B 2202
REMARK 465 PRO B 2203
REMARK 465 THR B 2204
REMARK 465 PRO B 2205
REMARK 465 LYS B 2206
REMARK 465 GLU B 2207
REMARK 465 ASP B 2208
REMARK 465 GLY B 2209
REMARK 465 LEU B 2210
REMARK 465 ALA B 2211
REMARK 465 GLN B 2212
REMARK 465 GLN B 2213
REMARK 465 GLN B 2214
REMARK 465 THR B 2215
REMARK 465 GLN B 2216
REMARK 465 LEU B 2217
REMARK 465 ASN B 2218
REMARK 465 LEU B 2219
REMARK 465 ARG B 2220
REMARK 465 SER B 2221
REMARK 465 LEU B 2222
REMARK 465 LEU B 2223
REMARK 465 VAL B 2224
REMARK 465 ASN B 2225
REMARK 465 PRO B 2226
REMARK 465 GLU B 2227
REMARK 465 GLY B 2228
REMARK 465 PRO B 2229
REMARK 465 THR B 2230
REMARK 465 LEU B 2231
REMARK 465 MET B 2232
REMARK 465 ARG B 2233
REMARK 465 LEU B 2234
REMARK 465 ASN B 2235
REMARK 465 SER B 2236
REMARK 465 VAL B 2237
REMARK 465 GLN B 2238
REMARK 465 SER B 2239
REMARK 465 SER B 2240
REMARK 465 GLU B 2241
REMARK 465 ARG B 2242
REMARK 465 PRO B 2243
REMARK 465 LEU B 2244
REMARK 465 PHE B 2245
REMARK 465 LEU B 2246
REMARK 465 VAL B 2247
REMARK 465 HIS B 2248
REMARK 465 PRO B 2249
REMARK 465 ILE B 2250
REMARK 465 GLU B 2251
REMARK 465 GLY B 2252
REMARK 465 SER B 2253
REMARK 465 THR B 2254
REMARK 465 THR B 2255
REMARK 465 VAL B 2256
REMARK 465 PHE B 2257
REMARK 465 HIS B 2258
REMARK 465 SER B 2259
REMARK 465 LEU B 2260
REMARK 465 ALA B 2261
REMARK 465 SER B 2262
REMARK 465 ARG B 2263
REMARK 465 LEU B 2264
REMARK 465 SER B 2265
REMARK 465 ILE B 2266
REMARK 465 PRO B 2267
REMARK 465 THR B 2268
REMARK 465 TYR B 2269
REMARK 465 GLY B 2270
REMARK 465 LEU B 2271
REMARK 465 GLN B 2272
REMARK 465 CYS B 2273
REMARK 465 THR B 2274
REMARK 465 ARG B 2275
REMARK 465 ALA B 2276
REMARK 465 ALA B 2277
REMARK 465 PRO B 2278
REMARK 465 LEU B 2279
REMARK 465 ASP B 2280
REMARK 465 SER B 2281
REMARK 465 ILE B 2282
REMARK 465 HIS B 2283
REMARK 465 SER B 2284
REMARK 465 LEU B 2285
REMARK 465 ALA B 2286
REMARK 465 ALA B 2287
REMARK 465 TYR B 2288
REMARK 465 TYR B 2289
REMARK 465 ILE B 2290
REMARK 465 ASP B 2291
REMARK 465 CYS B 2292
REMARK 465 ILE B 2293
REMARK 465 ARG B 2294
REMARK 465 GLN B 2295
REMARK 465 VAL B 2296
REMARK 465 GLN B 2297
REMARK 465 PRO B 2298
REMARK 465 GLU B 2299
REMARK 465 GLY B 2300
REMARK 465 PRO B 2301
REMARK 465 TYR B 2302
REMARK 465 ARG B 2303
REMARK 465 VAL B 2304
REMARK 465 ALA B 2305
REMARK 465 GLY B 2306
REMARK 465 TYR B 2307
REMARK 465 SER B 2308
REMARK 465 TYR B 2309
REMARK 465 GLY B 2310
REMARK 465 ALA B 2311
REMARK 465 CYS B 2312
REMARK 465 VAL B 2313
REMARK 465 ALA B 2314
REMARK 465 PHE B 2315
REMARK 465 GLU B 2316
REMARK 465 MET B 2317
REMARK 465 CYS B 2318
REMARK 465 SER B 2319
REMARK 465 GLN B 2320
REMARK 465 LEU B 2321
REMARK 465 GLN B 2322
REMARK 465 ALA B 2323
REMARK 465 GLN B 2324
REMARK 465 GLN B 2325
REMARK 465 SER B 2326
REMARK 465 PRO B 2327
REMARK 465 ALA B 2328
REMARK 465 PRO B 2329
REMARK 465 THR B 2330
REMARK 465 HIS B 2331
REMARK 465 ASN B 2332
REMARK 465 SER B 2333
REMARK 465 LEU B 2334
REMARK 465 PHE B 2335
REMARK 465 LEU B 2336
REMARK 465 PHE B 2337
REMARK 465 ASP B 2338
REMARK 465 GLY B 2339
REMARK 465 SER B 2340
REMARK 465 PRO B 2341
REMARK 465 THR B 2342
REMARK 465 TYR B 2343
REMARK 465 VAL B 2344
REMARK 465 LEU B 2345
REMARK 465 ALA B 2346
REMARK 465 TYR B 2347
REMARK 465 THR B 2348
REMARK 465 GLN B 2349
REMARK 465 SER B 2350
REMARK 465 TYR B 2351
REMARK 465 ARG B 2352
REMARK 465 ALA B 2353
REMARK 465 LYS B 2354
REMARK 465 LEU B 2355
REMARK 465 THR B 2356
REMARK 465 PRO B 2357
REMARK 465 GLY B 2358
REMARK 465 CYS B 2359
REMARK 465 GLU B 2360
REMARK 465 ALA B 2361
REMARK 465 GLU B 2362
REMARK 465 ALA B 2363
REMARK 465 GLU B 2364
REMARK 465 THR B 2365
REMARK 465 GLU B 2366
REMARK 465 ALA B 2367
REMARK 465 ILE B 2368
REMARK 465 CYS B 2369
REMARK 465 PHE B 2370
REMARK 465 PHE B 2371
REMARK 465 VAL B 2372
REMARK 465 GLN B 2373
REMARK 465 GLN B 2374
REMARK 465 PHE B 2375
REMARK 465 THR B 2376
REMARK 465 ASP B 2377
REMARK 465 MET B 2378
REMARK 465 GLU B 2379
REMARK 465 HIS B 2380
REMARK 465 ASN B 2381
REMARK 465 ARG B 2382
REMARK 465 VAL B 2383
REMARK 465 LEU B 2384
REMARK 465 GLU B 2385
REMARK 465 ALA B 2386
REMARK 465 LEU B 2387
REMARK 465 LEU B 2388
REMARK 465 PRO B 2389
REMARK 465 LEU B 2390
REMARK 465 LYS B 2391
REMARK 465 GLY B 2392
REMARK 465 LEU B 2393
REMARK 465 GLU B 2394
REMARK 465 GLU B 2395
REMARK 465 ARG B 2396
REMARK 465 VAL B 2397
REMARK 465 ALA B 2398
REMARK 465 ALA B 2399
REMARK 465 ALA B 2400
REMARK 465 VAL B 2401
REMARK 465 ASP B 2402
REMARK 465 LEU B 2403
REMARK 465 ILE B 2404
REMARK 465 ILE B 2405
REMARK 465 LYS B 2406
REMARK 465 SER B 2407
REMARK 465 HIS B 2408
REMARK 465 GLN B 2409
REMARK 465 GLY B 2410
REMARK 465 LEU B 2411
REMARK 465 ASP B 2412
REMARK 465 ARG B 2413
REMARK 465 GLN B 2414
REMARK 465 GLU B 2415
REMARK 465 LEU B 2416
REMARK 465 SER B 2417
REMARK 465 PHE B 2418
REMARK 465 ALA B 2419
REMARK 465 ALA B 2420
REMARK 465 ARG B 2421
REMARK 465 SER B 2422
REMARK 465 PHE B 2423
REMARK 465 TYR B 2424
REMARK 465 TYR B 2425
REMARK 465 LYS B 2426
REMARK 465 LEU B 2427
REMARK 465 ARG B 2428
REMARK 465 ALA B 2429
REMARK 465 ALA B 2430
REMARK 465 GLU B 2431
REMARK 465 GLN B 2432
REMARK 465 TYR B 2433
REMARK 465 THR B 2434
REMARK 465 PRO B 2435
REMARK 465 LYS B 2436
REMARK 465 ALA B 2437
REMARK 465 LYS B 2438
REMARK 465 TYR B 2439
REMARK 465 HIS B 2440
REMARK 465 GLY B 2441
REMARK 465 ASN B 2442
REMARK 465 VAL B 2443
REMARK 465 MET B 2444
REMARK 465 LEU B 2445
REMARK 465 LEU B 2446
REMARK 465 ARG B 2447
REMARK 465 ALA B 2448
REMARK 465 LYS B 2449
REMARK 465 THR B 2450
REMARK 465 GLY B 2451
REMARK 465 GLY B 2452
REMARK 465 ALA B 2453
REMARK 465 TYR B 2454
REMARK 465 GLY B 2455
REMARK 465 GLU B 2456
REMARK 465 ASP B 2457
REMARK 465 LEU B 2458
REMARK 465 GLY B 2459
REMARK 465 ALA B 2460
REMARK 465 ASP B 2461
REMARK 465 TYR B 2462
REMARK 465 ASN B 2463
REMARK 465 LEU B 2464
REMARK 465 SER B 2465
REMARK 465 GLN B 2466
REMARK 465 VAL B 2467
REMARK 465 CYS B 2468
REMARK 465 ASP B 2469
REMARK 465 GLY B 2470
REMARK 465 LYS B 2471
REMARK 465 VAL B 2472
REMARK 465 SER B 2473
REMARK 465 VAL B 2474
REMARK 465 HIS B 2475
REMARK 465 VAL B 2476
REMARK 465 ILE B 2477
REMARK 465 GLU B 2478
REMARK 465 GLY B 2479
REMARK 465 ASP B 2480
REMARK 465 HIS B 2481
REMARK 465 ARG B 2482
REMARK 465 THR B 2483
REMARK 465 LEU B 2484
REMARK 465 LEU B 2485
REMARK 465 GLU B 2486
REMARK 465 GLY B 2487
REMARK 465 SER B 2488
REMARK 465 GLY B 2489
REMARK 465 LEU B 2490
REMARK 465 GLU B 2491
REMARK 465 SER B 2492
REMARK 465 ILE B 2493
REMARK 465 ILE B 2494
REMARK 465 SER B 2495
REMARK 465 ILE B 2496
REMARK 465 ILE B 2497
REMARK 465 HIS B 2498
REMARK 465 SER B 2499
REMARK 465 SER B 2500
REMARK 465 LEU B 2501
REMARK 465 ALA B 2502
REMARK 465 GLU B 2503
REMARK 465 PRO B 2504
REMARK 465 ARG B 2505
REMARK 465 VAL B 2506
REMARK 465 SER B 2507
REMARK 465 VAL B 2508
REMARK 465 ARG B 2509
REMARK 465 GLU B 2510
REMARK 465 GLY B 2511
REMARK 465 LEU B 2512
REMARK 465 GLU B 2513
REMARK 465 HIS B 2514
REMARK 465 HIS B 2515
REMARK 465 HIS B 2516
REMARK 465 HIS B 2517
REMARK 465 HIS B 2518
REMARK 465 HIS B 2519
REMARK 465 HIS B 2520
REMARK 465 HIS B 2521
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 HG SER A 1723 O3X NDP A 2601 1.56
REMARK 500 H LEU A 1342 O CYS A 1403 1.57
REMARK 500 OE1 GLN A 1595 HE ARG A 1907 1.58
REMARK 500 O THR B 1230 HD22 ASN B 1234 1.59
REMARK 500 HE1 TRP A 1297 O ASP A 1301 1.59
REMARK 500 OE1 GLU A 1244 OH TYR A 1270 2.07
REMARK 500 OG1 THR B 1363 OE1 GLN B 1366 2.10
REMARK 500 O SER B 1478 OG SER B 1481 2.10
REMARK 500 O ARG B 1552 NE2 GLN B 1555 2.14
REMARK 500 O GLU A 1244 OG1 THR A 1273 2.16
REMARK 500 OE1 GLU A 945 OG SER B 941 2.18
REMARK 500 NZ LYS B 1241 O LEU B 1307 2.19
REMARK 500 OG SER A 1570 O ALA A 1646 2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 VAL A 953 -59.28 -121.58
REMARK 500 ASN A 978 63.61 61.73
REMARK 500 ALA A1203 -0.94 73.40
REMARK 500 ASN A1234 -2.45 77.19
REMARK 500 SER A1421 -3.87 76.87
REMARK 500 ASP A1508 60.33 60.16
REMARK 500 ALA A1510 117.35 -160.90
REMARK 500 PHE A1632 35.64 -97.60
REMARK 500 LEU A1748 -167.89 -79.56
REMARK 500 GLU A1750 -129.03 40.57
REMARK 500 ARG A1921 14.57 -141.52
REMARK 500 CYS A2010 74.42 -152.33
REMARK 500 HIS B 878 54.31 -90.93
REMARK 500 LEU B1194 48.93 38.92
REMARK 500 LEU B1238 -6.21 75.28
REMARK 500 TRP B1297 146.62 -172.49
REMARK 500 SER B1385 -1.59 72.71
REMARK 500 PRO B1408 48.70 -80.62
REMARK 500 ARG B1662 -60.37 -94.13
REMARK 500 GLU B1750 -124.58 41.84
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-43187 RELATED DB: EMDB
REMARK 900 MODIFYING PORTION OF HUMAN FASN WITH NADPH AND THE ACP AT THE ER
REMARK 900 DOMAIN
DBREF 8VF7 A 2 2511 UNP P49327 FAS_HUMAN 2 2511
DBREF 8VF7 B 2 2511 UNP P49327 FAS_HUMAN 2 2511
SEQADV 8VF7 MET A -31 UNP P49327 INITIATING METHIONINE
SEQADV 8VF7 SER A -30 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 TYR A -29 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 TYR A -28 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP A -27 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 TYR A -26 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 LYS A -25 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP A -24 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP A -23 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP A -22 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP A -21 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 LYS A -20 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP A -19 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 TYR A -18 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP A -17 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ILE A -16 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 PRO A -15 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 THR A -14 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 THR A -13 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLU A -12 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASN A -11 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 LEU A -10 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 TYR A -9 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 PHE A -8 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLN A -7 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLY A -6 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ALA A -5 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 MET A -4 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLY A -3 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 SER A -2 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLY A -1 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ILE A 0 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 PRO A 1 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 THR A 1151 UNP P49327 LYS 1151 CONFLICT
SEQADV 8VF7 LEU A 2512 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLU A 2513 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS A 2514 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS A 2515 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS A 2516 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS A 2517 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS A 2518 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS A 2519 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS A 2520 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS A 2521 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 MET B -31 UNP P49327 INITIATING METHIONINE
SEQADV 8VF7 SER B -30 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 TYR B -29 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 TYR B -28 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP B -27 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 TYR B -26 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 LYS B -25 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP B -24 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP B -23 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP B -22 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP B -21 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 LYS B -20 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP B -19 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 TYR B -18 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASP B -17 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ILE B -16 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 PRO B -15 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 THR B -14 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 THR B -13 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLU B -12 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ASN B -11 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 LEU B -10 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 TYR B -9 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 PHE B -8 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLN B -7 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLY B -6 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ALA B -5 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 MET B -4 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLY B -3 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 SER B -2 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLY B -1 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 ILE B 0 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 PRO B 1 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 THR B 1151 UNP P49327 LYS 1151 CONFLICT
SEQADV 8VF7 LEU B 2512 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 GLU B 2513 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS B 2514 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS B 2515 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS B 2516 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS B 2517 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS B 2518 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS B 2519 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS B 2520 UNP P49327 EXPRESSION TAG
SEQADV 8VF7 HIS B 2521 UNP P49327 EXPRESSION TAG
SEQRES 1 A 2553 MET SER TYR TYR ASP TYR LYS ASP ASP ASP ASP LYS ASP
SEQRES 2 A 2553 TYR ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY
SEQRES 3 A 2553 ALA MET GLY SER GLY ILE PRO GLU GLU VAL VAL ILE ALA
SEQRES 4 A 2553 GLY MET SER GLY LYS LEU PRO GLU SER GLU ASN LEU GLN
SEQRES 5 A 2553 GLU PHE TRP ASP ASN LEU ILE GLY GLY VAL ASP MET VAL
SEQRES 6 A 2553 THR ASP ASP ASP ARG ARG TRP LYS ALA GLY LEU TYR GLY
SEQRES 7 A 2553 LEU PRO ARG ARG SER GLY LYS LEU LYS ASP LEU SER ARG
SEQRES 8 A 2553 PHE ASP ALA SER PHE PHE GLY VAL HIS PRO LYS GLN ALA
SEQRES 9 A 2553 HIS THR MET ASP PRO GLN LEU ARG LEU LEU LEU GLU VAL
SEQRES 10 A 2553 THR TYR GLU ALA ILE VAL ASP GLY GLY ILE ASN PRO ASP
SEQRES 11 A 2553 SER LEU ARG GLY THR HIS THR GLY VAL TRP VAL GLY VAL
SEQRES 12 A 2553 SER GLY SER GLU THR SER GLU ALA LEU SER ARG ASP PRO
SEQRES 13 A 2553 GLU THR LEU VAL GLY TYR SER MET VAL GLY CYS GLN ARG
SEQRES 14 A 2553 ALA MET MET ALA ASN ARG LEU SER PHE PHE PHE ASP PHE
SEQRES 15 A 2553 ARG GLY PRO SER ILE ALA LEU ASP THR ALA CYS SER SER
SEQRES 16 A 2553 SER LEU MET ALA LEU GLN ASN ALA TYR GLN ALA ILE HIS
SEQRES 17 A 2553 SER GLY GLN CYS PRO ALA ALA ILE VAL GLY GLY ILE ASN
SEQRES 18 A 2553 VAL LEU LEU LYS PRO ASN THR SER VAL GLN PHE LEU ARG
SEQRES 19 A 2553 LEU GLY MET LEU SER PRO GLU GLY THR CYS LYS ALA PHE
SEQRES 20 A 2553 ASP THR ALA GLY ASN GLY TYR CYS ARG SER GLU GLY VAL
SEQRES 21 A 2553 VAL ALA VAL LEU LEU THR LYS LYS SER LEU ALA ARG ARG
SEQRES 22 A 2553 VAL TYR ALA THR ILE LEU ASN ALA GLY THR ASN THR ASP
SEQRES 23 A 2553 GLY PHE LYS GLU GLN GLY VAL THR PHE PRO SER GLY ASP
SEQRES 24 A 2553 ILE GLN GLU GLN LEU ILE ARG SER LEU TYR GLN SER ALA
SEQRES 25 A 2553 GLY VAL ALA PRO GLU SER PHE GLU TYR ILE GLU ALA HIS
SEQRES 26 A 2553 GLY THR GLY THR LYS VAL GLY ASP PRO GLN GLU LEU ASN
SEQRES 27 A 2553 GLY ILE THR ARG ALA LEU CYS ALA THR ARG GLN GLU PRO
SEQRES 28 A 2553 LEU LEU ILE GLY SER THR LYS SER ASN MET GLY HIS PRO
SEQRES 29 A 2553 GLU PRO ALA SER GLY LEU ALA ALA LEU ALA LYS VAL LEU
SEQRES 30 A 2553 LEU SER LEU GLU HIS GLY LEU TRP ALA PRO ASN LEU HIS
SEQRES 31 A 2553 PHE HIS SER PRO ASN PRO GLU ILE PRO ALA LEU LEU ASP
SEQRES 32 A 2553 GLY ARG LEU GLN VAL VAL ASP GLN PRO LEU PRO VAL ARG
SEQRES 33 A 2553 GLY GLY ASN VAL GLY ILE ASN SER PHE GLY PHE GLY GLY
SEQRES 34 A 2553 SER ASN VAL HIS ILE ILE LEU ARG PRO ASN THR GLN PRO
SEQRES 35 A 2553 PRO PRO ALA PRO ALA PRO HIS ALA THR LEU PRO ARG LEU
SEQRES 36 A 2553 LEU ARG ALA SER GLY ARG THR PRO GLU ALA VAL GLN LYS
SEQRES 37 A 2553 LEU LEU GLU GLN GLY LEU ARG HIS SER GLN ASP LEU ALA
SEQRES 38 A 2553 PHE LEU SER MET LEU ASN ASP ILE ALA ALA VAL PRO ALA
SEQRES 39 A 2553 THR ALA MET PRO PHE ARG GLY TYR ALA VAL LEU GLY GLY
SEQRES 40 A 2553 GLU ARG GLY GLY PRO GLU VAL GLN GLN VAL PRO ALA GLY
SEQRES 41 A 2553 GLU ARG PRO LEU TRP PHE ILE CYS SER GLY MET GLY THR
SEQRES 42 A 2553 GLN TRP ARG GLY MET GLY LEU SER LEU MET ARG LEU ASP
SEQRES 43 A 2553 ARG PHE ARG ASP SER ILE LEU ARG SER ASP GLU ALA VAL
SEQRES 44 A 2553 LYS PRO PHE GLY LEU LYS VAL SER GLN LEU LEU LEU SER
SEQRES 45 A 2553 THR ASP GLU SER THR PHE ASP ASP ILE VAL HIS SER PHE
SEQRES 46 A 2553 VAL SER LEU THR ALA ILE GLN ILE GLY LEU ILE ASP LEU
SEQRES 47 A 2553 LEU SER CYS MET GLY LEU ARG PRO ASP GLY ILE VAL GLY
SEQRES 48 A 2553 HIS SER LEU GLY GLU VAL ALA CYS GLY TYR ALA ASP GLY
SEQRES 49 A 2553 CYS LEU SER GLN GLU GLU ALA VAL LEU ALA ALA TYR TRP
SEQRES 50 A 2553 ARG GLY GLN CYS ILE LYS GLU ALA HIS LEU PRO PRO GLY
SEQRES 51 A 2553 ALA MET ALA ALA VAL GLY LEU SER TRP GLU GLU CYS LYS
SEQRES 52 A 2553 GLN ARG CYS PRO PRO GLY VAL VAL PRO ALA CYS HIS ASN
SEQRES 53 A 2553 SER LYS ASP THR VAL THR ILE SER GLY PRO GLN ALA PRO
SEQRES 54 A 2553 VAL PHE GLU PHE VAL GLU GLN LEU ARG LYS GLU GLY VAL
SEQRES 55 A 2553 PHE ALA LYS GLU VAL ARG THR GLY GLY MET ALA PHE HIS
SEQRES 56 A 2553 SER TYR PHE MET GLU ALA ILE ALA PRO PRO LEU LEU GLN
SEQRES 57 A 2553 GLU LEU LYS LYS VAL ILE ARG GLU PRO LYS PRO ARG SER
SEQRES 58 A 2553 ALA ARG TRP LEU SER THR SER ILE PRO GLU ALA GLN TRP
SEQRES 59 A 2553 HIS SER SER LEU ALA ARG THR SER SER ALA GLU TYR ASN
SEQRES 60 A 2553 VAL ASN ASN LEU VAL SER PRO VAL LEU PHE GLN GLU ALA
SEQRES 61 A 2553 LEU TRP HIS VAL PRO GLU HIS ALA VAL VAL LEU GLU ILE
SEQRES 62 A 2553 ALA PRO HIS ALA LEU LEU GLN ALA VAL LEU LYS ARG GLY
SEQRES 63 A 2553 LEU LYS PRO SER CYS THR ILE ILE PRO LEU MET LYS LYS
SEQRES 64 A 2553 ASP HIS ARG ASP ASN LEU GLU PHE PHE LEU ALA GLY ILE
SEQRES 65 A 2553 GLY ARG LEU HIS LEU SER GLY ILE ASP ALA ASN PRO ASN
SEQRES 66 A 2553 ALA LEU PHE PRO PRO VAL GLU PHE PRO ALA PRO ARG GLY
SEQRES 67 A 2553 THR PRO LEU ILE SER PRO LEU ILE LYS TRP ASP HIS SER
SEQRES 68 A 2553 LEU ALA TRP ASP VAL PRO ALA ALA GLU ASP PHE PRO ASN
SEQRES 69 A 2553 GLY SER GLY SER PRO SER ALA ALA ILE TYR ASN ILE ASP
SEQRES 70 A 2553 THR SER SER GLU SER PRO ASP HIS TYR LEU VAL ASP HIS
SEQRES 71 A 2553 THR LEU ASP GLY ARG VAL LEU PHE PRO ALA THR GLY TYR
SEQRES 72 A 2553 LEU SER ILE VAL TRP LYS THR LEU ALA ARG ALA LEU GLY
SEQRES 73 A 2553 LEU GLY VAL GLU GLN LEU PRO VAL VAL PHE GLU ASP VAL
SEQRES 74 A 2553 VAL LEU HIS GLN ALA THR ILE LEU PRO LYS THR GLY THR
SEQRES 75 A 2553 VAL SER LEU GLU VAL ARG LEU LEU GLU ALA SER ARG ALA
SEQRES 76 A 2553 PHE GLU VAL SER GLU ASN GLY ASN LEU VAL VAL SER GLY
SEQRES 77 A 2553 LYS VAL TYR GLN TRP ASP ASP PRO ASP PRO ARG LEU PHE
SEQRES 78 A 2553 ASP HIS PRO GLU SER PRO THR PRO ASN PRO THR GLU PRO
SEQRES 79 A 2553 LEU PHE LEU ALA GLN ALA GLU VAL TYR LYS GLU LEU ARG
SEQRES 80 A 2553 LEU ARG GLY TYR ASP TYR GLY PRO HIS PHE GLN GLY ILE
SEQRES 81 A 2553 LEU GLU ALA SER LEU GLU GLY ASP SER GLY ARG LEU LEU
SEQRES 82 A 2553 TRP LYS ASP ASN TRP VAL SER PHE MET ASP THR MET LEU
SEQRES 83 A 2553 GLN MET SER ILE LEU GLY SER ALA LYS HIS GLY LEU TYR
SEQRES 84 A 2553 LEU PRO THR ARG VAL THR ALA ILE HIS ILE ASP PRO ALA
SEQRES 85 A 2553 THR HIS ARG GLN LYS LEU TYR THR LEU GLN ASP LYS ALA
SEQRES 86 A 2553 GLN VAL ALA ASP VAL VAL VAL SER ARG TRP LEU ARG VAL
SEQRES 87 A 2553 THR VAL ALA GLY GLY VAL HIS ILE SER GLY LEU HIS THR
SEQRES 88 A 2553 GLU SER ALA PRO ARG ARG GLN GLN GLU GLN GLN VAL PRO
SEQRES 89 A 2553 ILE LEU GLU LYS PHE CYS PHE THR PRO HIS THR GLU GLU
SEQRES 90 A 2553 GLY CYS LEU SER GLU ARG ALA ALA LEU GLN GLU GLU LEU
SEQRES 91 A 2553 GLN LEU CYS LYS GLY LEU VAL GLN ALA LEU GLN THR THR
SEQRES 92 A 2553 VAL THR GLN GLN GLY LEU LYS MET VAL VAL PRO GLY LEU
SEQRES 93 A 2553 ASP GLY ALA GLN ILE PRO ARG ASP PRO SER GLN GLN GLU
SEQRES 94 A 2553 LEU PRO ARG LEU LEU SER ALA ALA CYS ARG LEU GLN LEU
SEQRES 95 A 2553 ASN GLY ASN LEU GLN LEU GLU LEU ALA GLN VAL LEU ALA
SEQRES 96 A 2553 GLN GLU ARG PRO LYS LEU PRO GLU ASP PRO LEU LEU SER
SEQRES 97 A 2553 GLY LEU LEU ASP SER PRO ALA LEU LYS ALA CYS LEU ASP
SEQRES 98 A 2553 THR ALA VAL GLU ASN MET PRO SER LEU LYS MET LYS VAL
SEQRES 99 A 2553 VAL GLU VAL LEU ALA GLY HIS GLY HIS LEU TYR SER ARG
SEQRES 100 A 2553 ILE PRO GLY LEU LEU SER PRO HIS PRO LEU LEU GLN LEU
SEQRES 101 A 2553 SER TYR THR ALA THR ASP ARG HIS PRO GLN ALA LEU GLU
SEQRES 102 A 2553 ALA ALA GLN ALA GLU LEU GLN GLN HIS ASP VAL ALA GLN
SEQRES 103 A 2553 GLY GLN TRP ASP PRO ALA ASP PRO ALA PRO SER ALA LEU
SEQRES 104 A 2553 GLY SER ALA ASP LEU LEU VAL CYS ASN CYS ALA VAL ALA
SEQRES 105 A 2553 ALA LEU GLY ASP PRO ALA SER ALA LEU SER ASN MET VAL
SEQRES 106 A 2553 ALA ALA LEU ARG GLU GLY GLY PHE LEU LEU LEU HIS THR
SEQRES 107 A 2553 LEU LEU ARG GLY HIS PRO LEU GLY ASP ILE VAL ALA PHE
SEQRES 108 A 2553 LEU THR SER THR GLU PRO GLN TYR GLY GLN GLY ILE LEU
SEQRES 109 A 2553 SER GLN ASP ALA TRP GLU SER LEU PHE SER ARG VAL SER
SEQRES 110 A 2553 LEU ARG LEU VAL GLY LEU LYS LYS SER PHE TYR GLY SER
SEQRES 111 A 2553 THR LEU PHE LEU CYS ARG ARG PRO THR PRO GLN ASP SER
SEQRES 112 A 2553 PRO ILE PHE LEU PRO VAL ASP ASP THR SER PHE ARG TRP
SEQRES 113 A 2553 VAL GLU SER LEU LYS GLY ILE LEU ALA ASP GLU ASP SER
SEQRES 114 A 2553 SER ARG PRO VAL TRP LEU LYS ALA ILE ASN CYS ALA THR
SEQRES 115 A 2553 SER GLY VAL VAL GLY LEU VAL ASN CYS LEU ARG ARG GLU
SEQRES 116 A 2553 PRO GLY GLY ASN ARG LEU ARG CYS VAL LEU LEU SER ASN
SEQRES 117 A 2553 LEU SER SER THR SER HIS VAL PRO GLU VAL ASP PRO GLY
SEQRES 118 A 2553 SER ALA GLU LEU GLN LYS VAL LEU GLN GLY ASP LEU VAL
SEQRES 119 A 2553 MET ASN VAL TYR ARG ASP GLY ALA TRP GLY ALA PHE ARG
SEQRES 120 A 2553 HIS PHE LEU LEU GLU GLU ASP LYS PRO GLU GLU PRO THR
SEQRES 121 A 2553 ALA HIS ALA PHE VAL SER THR LEU THR ARG GLY ASP LEU
SEQRES 122 A 2553 SER SER ILE ARG TRP VAL CYS SER SER LEU ARG HIS ALA
SEQRES 123 A 2553 GLN PRO THR CYS PRO GLY ALA GLN LEU CYS THR VAL TYR
SEQRES 124 A 2553 TYR ALA SER LEU ASN PHE ARG ASP ILE MET LEU ALA THR
SEQRES 125 A 2553 GLY LYS LEU SER PRO ASP ALA ILE PRO GLY LYS TRP THR
SEQRES 126 A 2553 SER GLN ASP SER LEU LEU GLY MET GLU PHE SER GLY ARG
SEQRES 127 A 2553 ASP ALA SER GLY LYS ARG VAL MET GLY LEU VAL PRO ALA
SEQRES 128 A 2553 LYS GLY LEU ALA THR SER VAL LEU LEU SER PRO ASP PHE
SEQRES 129 A 2553 LEU TRP ASP VAL PRO SER ASN TRP THR LEU GLU GLU ALA
SEQRES 130 A 2553 ALA SER VAL PRO VAL VAL TYR SER THR ALA TYR TYR ALA
SEQRES 131 A 2553 LEU VAL VAL ARG GLY ARG VAL ARG PRO GLY GLU THR LEU
SEQRES 132 A 2553 LEU ILE HIS SER GLY SER GLY GLY VAL GLY GLN ALA ALA
SEQRES 133 A 2553 ILE ALA ILE ALA LEU SER LEU GLY CYS ARG VAL PHE THR
SEQRES 134 A 2553 THR VAL GLY SER ALA GLU LYS ARG ALA TYR LEU GLN ALA
SEQRES 135 A 2553 ARG PHE PRO GLN LEU ASP SER THR SER PHE ALA ASN SER
SEQRES 136 A 2553 ARG ASP THR SER PHE GLU GLN HIS VAL LEU TRP HIS THR
SEQRES 137 A 2553 GLY GLY LYS GLY VAL ASP LEU VAL LEU ASN SER LEU ALA
SEQRES 138 A 2553 GLU GLU LYS LEU GLN ALA SER VAL ARG CYS LEU ALA THR
SEQRES 139 A 2553 HIS GLY ARG PHE LEU GLU ILE GLY LYS PHE ASP LEU SER
SEQRES 140 A 2553 GLN ASN HIS PRO LEU GLY MET ALA ILE PHE LEU LYS ASN
SEQRES 141 A 2553 VAL THR PHE HIS GLY VAL LEU LEU ASP ALA PHE PHE ASN
SEQRES 142 A 2553 GLU SER SER ALA ASP TRP ARG GLU VAL TRP ALA LEU VAL
SEQRES 143 A 2553 GLN ALA GLY ILE ARG ASP GLY VAL VAL ARG PRO LEU LYS
SEQRES 144 A 2553 CYS THR VAL PHE HIS GLY ALA GLN VAL GLU ASP ALA PHE
SEQRES 145 A 2553 ARG TYR MET ALA GLN GLY LYS HIS ILE GLY LYS VAL VAL
SEQRES 146 A 2553 VAL GLN VAL LEU ALA GLU GLU PRO GLU ALA VAL LEU LYS
SEQRES 147 A 2553 GLY ALA LYS PRO LYS LEU MET SER ALA ILE SER LYS THR
SEQRES 148 A 2553 PHE CYS PRO ALA HIS LYS SER TYR ILE ILE ALA GLY GLY
SEQRES 149 A 2553 LEU GLY GLY PHE GLY LEU GLU LEU ALA GLN TRP LEU ILE
SEQRES 150 A 2553 GLN ARG GLY VAL GLN LYS LEU VAL LEU THR SER ARG SER
SEQRES 151 A 2553 GLY ILE ARG THR GLY TYR GLN ALA LYS GLN VAL ARG ARG
SEQRES 152 A 2553 TRP ARG ARG GLN GLY VAL GLN VAL GLN VAL SER THR SER
SEQRES 153 A 2553 ASN ILE SER SER LEU GLU GLY ALA ARG GLY LEU ILE ALA
SEQRES 154 A 2553 GLU ALA ALA GLN LEU GLY PRO VAL GLY GLY VAL PHE ASN
SEQRES 155 A 2553 LEU ALA VAL VAL LEU ARG ASP GLY LEU LEU GLU ASN GLN
SEQRES 156 A 2553 THR PRO GLU PHE PHE GLN ASP VAL CYS LYS PRO LYS TYR
SEQRES 157 A 2553 SER GLY THR LEU ASN LEU ASP ARG VAL THR ARG GLU ALA
SEQRES 158 A 2553 CYS PRO GLU LEU ASP TYR PHE VAL VAL PHE SER SER VAL
SEQRES 159 A 2553 SER CYS GLY ARG GLY ASN ALA GLY GLN SER ASN TYR GLY
SEQRES 160 A 2553 PHE ALA ASN SER ALA MET GLU ARG ILE CYS GLU LYS ARG
SEQRES 161 A 2553 ARG HIS GLU GLY LEU PRO GLY LEU ALA VAL GLN TRP GLY
SEQRES 162 A 2553 ALA ILE GLY ASP VAL GLY ILE LEU VAL GLU THR MET SER
SEQRES 163 A 2553 THR ASN ASP THR ILE VAL SER GLY THR LEU PRO GLN ARG
SEQRES 164 A 2553 MET ALA SER CYS LEU GLU VAL LEU ASP LEU PHE LEU ASN
SEQRES 165 A 2553 GLN PRO HIS MET VAL LEU SER SER PHE VAL LEU ALA GLU
SEQRES 166 A 2553 LYS ALA ALA ALA TYR ARG ASP ARG ASP SER GLN ARG ASP
SEQRES 167 A 2553 LEU VAL GLU ALA VAL ALA HIS ILE LEU GLY ILE ARG ASP
SEQRES 168 A 2553 LEU ALA ALA VAL ASN LEU ASP SER SER LEU ALA ASP LEU
SEQRES 169 A 2553 GLY LEU ASP SER LEU MET SER VAL GLU VAL ARG GLN THR
SEQRES 170 A 2553 LEU GLU ARG GLU LEU ASN LEU VAL LEU SER VAL ARG GLU
SEQRES 171 A 2553 VAL ARG GLN LEU THR LEU ARG LYS LEU GLN GLU LEU SER
SEQRES 172 A 2553 SER LYS ALA ASP GLU ALA SER GLU LEU ALA CYS PRO THR
SEQRES 173 A 2553 PRO LYS GLU ASP GLY LEU ALA GLN GLN GLN THR GLN LEU
SEQRES 174 A 2553 ASN LEU ARG SER LEU LEU VAL ASN PRO GLU GLY PRO THR
SEQRES 175 A 2553 LEU MET ARG LEU ASN SER VAL GLN SER SER GLU ARG PRO
SEQRES 176 A 2553 LEU PHE LEU VAL HIS PRO ILE GLU GLY SER THR THR VAL
SEQRES 177 A 2553 PHE HIS SER LEU ALA SER ARG LEU SER ILE PRO THR TYR
SEQRES 178 A 2553 GLY LEU GLN CYS THR ARG ALA ALA PRO LEU ASP SER ILE
SEQRES 179 A 2553 HIS SER LEU ALA ALA TYR TYR ILE ASP CYS ILE ARG GLN
SEQRES 180 A 2553 VAL GLN PRO GLU GLY PRO TYR ARG VAL ALA GLY TYR SER
SEQRES 181 A 2553 TYR GLY ALA CYS VAL ALA PHE GLU MET CYS SER GLN LEU
SEQRES 182 A 2553 GLN ALA GLN GLN SER PRO ALA PRO THR HIS ASN SER LEU
SEQRES 183 A 2553 PHE LEU PHE ASP GLY SER PRO THR TYR VAL LEU ALA TYR
SEQRES 184 A 2553 THR GLN SER TYR ARG ALA LYS LEU THR PRO GLY CYS GLU
SEQRES 185 A 2553 ALA GLU ALA GLU THR GLU ALA ILE CYS PHE PHE VAL GLN
SEQRES 186 A 2553 GLN PHE THR ASP MET GLU HIS ASN ARG VAL LEU GLU ALA
SEQRES 187 A 2553 LEU LEU PRO LEU LYS GLY LEU GLU GLU ARG VAL ALA ALA
SEQRES 188 A 2553 ALA VAL ASP LEU ILE ILE LYS SER HIS GLN GLY LEU ASP
SEQRES 189 A 2553 ARG GLN GLU LEU SER PHE ALA ALA ARG SER PHE TYR TYR
SEQRES 190 A 2553 LYS LEU ARG ALA ALA GLU GLN TYR THR PRO LYS ALA LYS
SEQRES 191 A 2553 TYR HIS GLY ASN VAL MET LEU LEU ARG ALA LYS THR GLY
SEQRES 192 A 2553 GLY ALA TYR GLY GLU ASP LEU GLY ALA ASP TYR ASN LEU
SEQRES 193 A 2553 SER GLN VAL CYS ASP GLY LYS VAL SER VAL HIS VAL ILE
SEQRES 194 A 2553 GLU GLY ASP HIS ARG THR LEU LEU GLU GLY SER GLY LEU
SEQRES 195 A 2553 GLU SER ILE ILE SER ILE ILE HIS SER SER LEU ALA GLU
SEQRES 196 A 2553 PRO ARG VAL SER VAL ARG GLU GLY LEU GLU HIS HIS HIS
SEQRES 197 A 2553 HIS HIS HIS HIS HIS
SEQRES 1 B 2553 MET SER TYR TYR ASP TYR LYS ASP ASP ASP ASP LYS ASP
SEQRES 2 B 2553 TYR ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY
SEQRES 3 B 2553 ALA MET GLY SER GLY ILE PRO GLU GLU VAL VAL ILE ALA
SEQRES 4 B 2553 GLY MET SER GLY LYS LEU PRO GLU SER GLU ASN LEU GLN
SEQRES 5 B 2553 GLU PHE TRP ASP ASN LEU ILE GLY GLY VAL ASP MET VAL
SEQRES 6 B 2553 THR ASP ASP ASP ARG ARG TRP LYS ALA GLY LEU TYR GLY
SEQRES 7 B 2553 LEU PRO ARG ARG SER GLY LYS LEU LYS ASP LEU SER ARG
SEQRES 8 B 2553 PHE ASP ALA SER PHE PHE GLY VAL HIS PRO LYS GLN ALA
SEQRES 9 B 2553 HIS THR MET ASP PRO GLN LEU ARG LEU LEU LEU GLU VAL
SEQRES 10 B 2553 THR TYR GLU ALA ILE VAL ASP GLY GLY ILE ASN PRO ASP
SEQRES 11 B 2553 SER LEU ARG GLY THR HIS THR GLY VAL TRP VAL GLY VAL
SEQRES 12 B 2553 SER GLY SER GLU THR SER GLU ALA LEU SER ARG ASP PRO
SEQRES 13 B 2553 GLU THR LEU VAL GLY TYR SER MET VAL GLY CYS GLN ARG
SEQRES 14 B 2553 ALA MET MET ALA ASN ARG LEU SER PHE PHE PHE ASP PHE
SEQRES 15 B 2553 ARG GLY PRO SER ILE ALA LEU ASP THR ALA CYS SER SER
SEQRES 16 B 2553 SER LEU MET ALA LEU GLN ASN ALA TYR GLN ALA ILE HIS
SEQRES 17 B 2553 SER GLY GLN CYS PRO ALA ALA ILE VAL GLY GLY ILE ASN
SEQRES 18 B 2553 VAL LEU LEU LYS PRO ASN THR SER VAL GLN PHE LEU ARG
SEQRES 19 B 2553 LEU GLY MET LEU SER PRO GLU GLY THR CYS LYS ALA PHE
SEQRES 20 B 2553 ASP THR ALA GLY ASN GLY TYR CYS ARG SER GLU GLY VAL
SEQRES 21 B 2553 VAL ALA VAL LEU LEU THR LYS LYS SER LEU ALA ARG ARG
SEQRES 22 B 2553 VAL TYR ALA THR ILE LEU ASN ALA GLY THR ASN THR ASP
SEQRES 23 B 2553 GLY PHE LYS GLU GLN GLY VAL THR PHE PRO SER GLY ASP
SEQRES 24 B 2553 ILE GLN GLU GLN LEU ILE ARG SER LEU TYR GLN SER ALA
SEQRES 25 B 2553 GLY VAL ALA PRO GLU SER PHE GLU TYR ILE GLU ALA HIS
SEQRES 26 B 2553 GLY THR GLY THR LYS VAL GLY ASP PRO GLN GLU LEU ASN
SEQRES 27 B 2553 GLY ILE THR ARG ALA LEU CYS ALA THR ARG GLN GLU PRO
SEQRES 28 B 2553 LEU LEU ILE GLY SER THR LYS SER ASN MET GLY HIS PRO
SEQRES 29 B 2553 GLU PRO ALA SER GLY LEU ALA ALA LEU ALA LYS VAL LEU
SEQRES 30 B 2553 LEU SER LEU GLU HIS GLY LEU TRP ALA PRO ASN LEU HIS
SEQRES 31 B 2553 PHE HIS SER PRO ASN PRO GLU ILE PRO ALA LEU LEU ASP
SEQRES 32 B 2553 GLY ARG LEU GLN VAL VAL ASP GLN PRO LEU PRO VAL ARG
SEQRES 33 B 2553 GLY GLY ASN VAL GLY ILE ASN SER PHE GLY PHE GLY GLY
SEQRES 34 B 2553 SER ASN VAL HIS ILE ILE LEU ARG PRO ASN THR GLN PRO
SEQRES 35 B 2553 PRO PRO ALA PRO ALA PRO HIS ALA THR LEU PRO ARG LEU
SEQRES 36 B 2553 LEU ARG ALA SER GLY ARG THR PRO GLU ALA VAL GLN LYS
SEQRES 37 B 2553 LEU LEU GLU GLN GLY LEU ARG HIS SER GLN ASP LEU ALA
SEQRES 38 B 2553 PHE LEU SER MET LEU ASN ASP ILE ALA ALA VAL PRO ALA
SEQRES 39 B 2553 THR ALA MET PRO PHE ARG GLY TYR ALA VAL LEU GLY GLY
SEQRES 40 B 2553 GLU ARG GLY GLY PRO GLU VAL GLN GLN VAL PRO ALA GLY
SEQRES 41 B 2553 GLU ARG PRO LEU TRP PHE ILE CYS SER GLY MET GLY THR
SEQRES 42 B 2553 GLN TRP ARG GLY MET GLY LEU SER LEU MET ARG LEU ASP
SEQRES 43 B 2553 ARG PHE ARG ASP SER ILE LEU ARG SER ASP GLU ALA VAL
SEQRES 44 B 2553 LYS PRO PHE GLY LEU LYS VAL SER GLN LEU LEU LEU SER
SEQRES 45 B 2553 THR ASP GLU SER THR PHE ASP ASP ILE VAL HIS SER PHE
SEQRES 46 B 2553 VAL SER LEU THR ALA ILE GLN ILE GLY LEU ILE ASP LEU
SEQRES 47 B 2553 LEU SER CYS MET GLY LEU ARG PRO ASP GLY ILE VAL GLY
SEQRES 48 B 2553 HIS SER LEU GLY GLU VAL ALA CYS GLY TYR ALA ASP GLY
SEQRES 49 B 2553 CYS LEU SER GLN GLU GLU ALA VAL LEU ALA ALA TYR TRP
SEQRES 50 B 2553 ARG GLY GLN CYS ILE LYS GLU ALA HIS LEU PRO PRO GLY
SEQRES 51 B 2553 ALA MET ALA ALA VAL GLY LEU SER TRP GLU GLU CYS LYS
SEQRES 52 B 2553 GLN ARG CYS PRO PRO GLY VAL VAL PRO ALA CYS HIS ASN
SEQRES 53 B 2553 SER LYS ASP THR VAL THR ILE SER GLY PRO GLN ALA PRO
SEQRES 54 B 2553 VAL PHE GLU PHE VAL GLU GLN LEU ARG LYS GLU GLY VAL
SEQRES 55 B 2553 PHE ALA LYS GLU VAL ARG THR GLY GLY MET ALA PHE HIS
SEQRES 56 B 2553 SER TYR PHE MET GLU ALA ILE ALA PRO PRO LEU LEU GLN
SEQRES 57 B 2553 GLU LEU LYS LYS VAL ILE ARG GLU PRO LYS PRO ARG SER
SEQRES 58 B 2553 ALA ARG TRP LEU SER THR SER ILE PRO GLU ALA GLN TRP
SEQRES 59 B 2553 HIS SER SER LEU ALA ARG THR SER SER ALA GLU TYR ASN
SEQRES 60 B 2553 VAL ASN ASN LEU VAL SER PRO VAL LEU PHE GLN GLU ALA
SEQRES 61 B 2553 LEU TRP HIS VAL PRO GLU HIS ALA VAL VAL LEU GLU ILE
SEQRES 62 B 2553 ALA PRO HIS ALA LEU LEU GLN ALA VAL LEU LYS ARG GLY
SEQRES 63 B 2553 LEU LYS PRO SER CYS THR ILE ILE PRO LEU MET LYS LYS
SEQRES 64 B 2553 ASP HIS ARG ASP ASN LEU GLU PHE PHE LEU ALA GLY ILE
SEQRES 65 B 2553 GLY ARG LEU HIS LEU SER GLY ILE ASP ALA ASN PRO ASN
SEQRES 66 B 2553 ALA LEU PHE PRO PRO VAL GLU PHE PRO ALA PRO ARG GLY
SEQRES 67 B 2553 THR PRO LEU ILE SER PRO LEU ILE LYS TRP ASP HIS SER
SEQRES 68 B 2553 LEU ALA TRP ASP VAL PRO ALA ALA GLU ASP PHE PRO ASN
SEQRES 69 B 2553 GLY SER GLY SER PRO SER ALA ALA ILE TYR ASN ILE ASP
SEQRES 70 B 2553 THR SER SER GLU SER PRO ASP HIS TYR LEU VAL ASP HIS
SEQRES 71 B 2553 THR LEU ASP GLY ARG VAL LEU PHE PRO ALA THR GLY TYR
SEQRES 72 B 2553 LEU SER ILE VAL TRP LYS THR LEU ALA ARG ALA LEU GLY
SEQRES 73 B 2553 LEU GLY VAL GLU GLN LEU PRO VAL VAL PHE GLU ASP VAL
SEQRES 74 B 2553 VAL LEU HIS GLN ALA THR ILE LEU PRO LYS THR GLY THR
SEQRES 75 B 2553 VAL SER LEU GLU VAL ARG LEU LEU GLU ALA SER ARG ALA
SEQRES 76 B 2553 PHE GLU VAL SER GLU ASN GLY ASN LEU VAL VAL SER GLY
SEQRES 77 B 2553 LYS VAL TYR GLN TRP ASP ASP PRO ASP PRO ARG LEU PHE
SEQRES 78 B 2553 ASP HIS PRO GLU SER PRO THR PRO ASN PRO THR GLU PRO
SEQRES 79 B 2553 LEU PHE LEU ALA GLN ALA GLU VAL TYR LYS GLU LEU ARG
SEQRES 80 B 2553 LEU ARG GLY TYR ASP TYR GLY PRO HIS PHE GLN GLY ILE
SEQRES 81 B 2553 LEU GLU ALA SER LEU GLU GLY ASP SER GLY ARG LEU LEU
SEQRES 82 B 2553 TRP LYS ASP ASN TRP VAL SER PHE MET ASP THR MET LEU
SEQRES 83 B 2553 GLN MET SER ILE LEU GLY SER ALA LYS HIS GLY LEU TYR
SEQRES 84 B 2553 LEU PRO THR ARG VAL THR ALA ILE HIS ILE ASP PRO ALA
SEQRES 85 B 2553 THR HIS ARG GLN LYS LEU TYR THR LEU GLN ASP LYS ALA
SEQRES 86 B 2553 GLN VAL ALA ASP VAL VAL VAL SER ARG TRP LEU ARG VAL
SEQRES 87 B 2553 THR VAL ALA GLY GLY VAL HIS ILE SER GLY LEU HIS THR
SEQRES 88 B 2553 GLU SER ALA PRO ARG ARG GLN GLN GLU GLN GLN VAL PRO
SEQRES 89 B 2553 ILE LEU GLU LYS PHE CYS PHE THR PRO HIS THR GLU GLU
SEQRES 90 B 2553 GLY CYS LEU SER GLU ARG ALA ALA LEU GLN GLU GLU LEU
SEQRES 91 B 2553 GLN LEU CYS LYS GLY LEU VAL GLN ALA LEU GLN THR THR
SEQRES 92 B 2553 VAL THR GLN GLN GLY LEU LYS MET VAL VAL PRO GLY LEU
SEQRES 93 B 2553 ASP GLY ALA GLN ILE PRO ARG ASP PRO SER GLN GLN GLU
SEQRES 94 B 2553 LEU PRO ARG LEU LEU SER ALA ALA CYS ARG LEU GLN LEU
SEQRES 95 B 2553 ASN GLY ASN LEU GLN LEU GLU LEU ALA GLN VAL LEU ALA
SEQRES 96 B 2553 GLN GLU ARG PRO LYS LEU PRO GLU ASP PRO LEU LEU SER
SEQRES 97 B 2553 GLY LEU LEU ASP SER PRO ALA LEU LYS ALA CYS LEU ASP
SEQRES 98 B 2553 THR ALA VAL GLU ASN MET PRO SER LEU LYS MET LYS VAL
SEQRES 99 B 2553 VAL GLU VAL LEU ALA GLY HIS GLY HIS LEU TYR SER ARG
SEQRES 100 B 2553 ILE PRO GLY LEU LEU SER PRO HIS PRO LEU LEU GLN LEU
SEQRES 101 B 2553 SER TYR THR ALA THR ASP ARG HIS PRO GLN ALA LEU GLU
SEQRES 102 B 2553 ALA ALA GLN ALA GLU LEU GLN GLN HIS ASP VAL ALA GLN
SEQRES 103 B 2553 GLY GLN TRP ASP PRO ALA ASP PRO ALA PRO SER ALA LEU
SEQRES 104 B 2553 GLY SER ALA ASP LEU LEU VAL CYS ASN CYS ALA VAL ALA
SEQRES 105 B 2553 ALA LEU GLY ASP PRO ALA SER ALA LEU SER ASN MET VAL
SEQRES 106 B 2553 ALA ALA LEU ARG GLU GLY GLY PHE LEU LEU LEU HIS THR
SEQRES 107 B 2553 LEU LEU ARG GLY HIS PRO LEU GLY ASP ILE VAL ALA PHE
SEQRES 108 B 2553 LEU THR SER THR GLU PRO GLN TYR GLY GLN GLY ILE LEU
SEQRES 109 B 2553 SER GLN ASP ALA TRP GLU SER LEU PHE SER ARG VAL SER
SEQRES 110 B 2553 LEU ARG LEU VAL GLY LEU LYS LYS SER PHE TYR GLY SER
SEQRES 111 B 2553 THR LEU PHE LEU CYS ARG ARG PRO THR PRO GLN ASP SER
SEQRES 112 B 2553 PRO ILE PHE LEU PRO VAL ASP ASP THR SER PHE ARG TRP
SEQRES 113 B 2553 VAL GLU SER LEU LYS GLY ILE LEU ALA ASP GLU ASP SER
SEQRES 114 B 2553 SER ARG PRO VAL TRP LEU LYS ALA ILE ASN CYS ALA THR
SEQRES 115 B 2553 SER GLY VAL VAL GLY LEU VAL ASN CYS LEU ARG ARG GLU
SEQRES 116 B 2553 PRO GLY GLY ASN ARG LEU ARG CYS VAL LEU LEU SER ASN
SEQRES 117 B 2553 LEU SER SER THR SER HIS VAL PRO GLU VAL ASP PRO GLY
SEQRES 118 B 2553 SER ALA GLU LEU GLN LYS VAL LEU GLN GLY ASP LEU VAL
SEQRES 119 B 2553 MET ASN VAL TYR ARG ASP GLY ALA TRP GLY ALA PHE ARG
SEQRES 120 B 2553 HIS PHE LEU LEU GLU GLU ASP LYS PRO GLU GLU PRO THR
SEQRES 121 B 2553 ALA HIS ALA PHE VAL SER THR LEU THR ARG GLY ASP LEU
SEQRES 122 B 2553 SER SER ILE ARG TRP VAL CYS SER SER LEU ARG HIS ALA
SEQRES 123 B 2553 GLN PRO THR CYS PRO GLY ALA GLN LEU CYS THR VAL TYR
SEQRES 124 B 2553 TYR ALA SER LEU ASN PHE ARG ASP ILE MET LEU ALA THR
SEQRES 125 B 2553 GLY LYS LEU SER PRO ASP ALA ILE PRO GLY LYS TRP THR
SEQRES 126 B 2553 SER GLN ASP SER LEU LEU GLY MET GLU PHE SER GLY ARG
SEQRES 127 B 2553 ASP ALA SER GLY LYS ARG VAL MET GLY LEU VAL PRO ALA
SEQRES 128 B 2553 LYS GLY LEU ALA THR SER VAL LEU LEU SER PRO ASP PHE
SEQRES 129 B 2553 LEU TRP ASP VAL PRO SER ASN TRP THR LEU GLU GLU ALA
SEQRES 130 B 2553 ALA SER VAL PRO VAL VAL TYR SER THR ALA TYR TYR ALA
SEQRES 131 B 2553 LEU VAL VAL ARG GLY ARG VAL ARG PRO GLY GLU THR LEU
SEQRES 132 B 2553 LEU ILE HIS SER GLY SER GLY GLY VAL GLY GLN ALA ALA
SEQRES 133 B 2553 ILE ALA ILE ALA LEU SER LEU GLY CYS ARG VAL PHE THR
SEQRES 134 B 2553 THR VAL GLY SER ALA GLU LYS ARG ALA TYR LEU GLN ALA
SEQRES 135 B 2553 ARG PHE PRO GLN LEU ASP SER THR SER PHE ALA ASN SER
SEQRES 136 B 2553 ARG ASP THR SER PHE GLU GLN HIS VAL LEU TRP HIS THR
SEQRES 137 B 2553 GLY GLY LYS GLY VAL ASP LEU VAL LEU ASN SER LEU ALA
SEQRES 138 B 2553 GLU GLU LYS LEU GLN ALA SER VAL ARG CYS LEU ALA THR
SEQRES 139 B 2553 HIS GLY ARG PHE LEU GLU ILE GLY LYS PHE ASP LEU SER
SEQRES 140 B 2553 GLN ASN HIS PRO LEU GLY MET ALA ILE PHE LEU LYS ASN
SEQRES 141 B 2553 VAL THR PHE HIS GLY VAL LEU LEU ASP ALA PHE PHE ASN
SEQRES 142 B 2553 GLU SER SER ALA ASP TRP ARG GLU VAL TRP ALA LEU VAL
SEQRES 143 B 2553 GLN ALA GLY ILE ARG ASP GLY VAL VAL ARG PRO LEU LYS
SEQRES 144 B 2553 CYS THR VAL PHE HIS GLY ALA GLN VAL GLU ASP ALA PHE
SEQRES 145 B 2553 ARG TYR MET ALA GLN GLY LYS HIS ILE GLY LYS VAL VAL
SEQRES 146 B 2553 VAL GLN VAL LEU ALA GLU GLU PRO GLU ALA VAL LEU LYS
SEQRES 147 B 2553 GLY ALA LYS PRO LYS LEU MET SER ALA ILE SER LYS THR
SEQRES 148 B 2553 PHE CYS PRO ALA HIS LYS SER TYR ILE ILE ALA GLY GLY
SEQRES 149 B 2553 LEU GLY GLY PHE GLY LEU GLU LEU ALA GLN TRP LEU ILE
SEQRES 150 B 2553 GLN ARG GLY VAL GLN LYS LEU VAL LEU THR SER ARG SER
SEQRES 151 B 2553 GLY ILE ARG THR GLY TYR GLN ALA LYS GLN VAL ARG ARG
SEQRES 152 B 2553 TRP ARG ARG GLN GLY VAL GLN VAL GLN VAL SER THR SER
SEQRES 153 B 2553 ASN ILE SER SER LEU GLU GLY ALA ARG GLY LEU ILE ALA
SEQRES 154 B 2553 GLU ALA ALA GLN LEU GLY PRO VAL GLY GLY VAL PHE ASN
SEQRES 155 B 2553 LEU ALA VAL VAL LEU ARG ASP GLY LEU LEU GLU ASN GLN
SEQRES 156 B 2553 THR PRO GLU PHE PHE GLN ASP VAL CYS LYS PRO LYS TYR
SEQRES 157 B 2553 SER GLY THR LEU ASN LEU ASP ARG VAL THR ARG GLU ALA
SEQRES 158 B 2553 CYS PRO GLU LEU ASP TYR PHE VAL VAL PHE SER SER VAL
SEQRES 159 B 2553 SER CYS GLY ARG GLY ASN ALA GLY GLN SER ASN TYR GLY
SEQRES 160 B 2553 PHE ALA ASN SER ALA MET GLU ARG ILE CYS GLU LYS ARG
SEQRES 161 B 2553 ARG HIS GLU GLY LEU PRO GLY LEU ALA VAL GLN TRP GLY
SEQRES 162 B 2553 ALA ILE GLY ASP VAL GLY ILE LEU VAL GLU THR MET SER
SEQRES 163 B 2553 THR ASN ASP THR ILE VAL SER GLY THR LEU PRO GLN ARG
SEQRES 164 B 2553 MET ALA SER CYS LEU GLU VAL LEU ASP LEU PHE LEU ASN
SEQRES 165 B 2553 GLN PRO HIS MET VAL LEU SER SER PHE VAL LEU ALA GLU
SEQRES 166 B 2553 LYS ALA ALA ALA TYR ARG ASP ARG ASP SER GLN ARG ASP
SEQRES 167 B 2553 LEU VAL GLU ALA VAL ALA HIS ILE LEU GLY ILE ARG ASP
SEQRES 168 B 2553 LEU ALA ALA VAL ASN LEU ASP SER SER LEU ALA ASP LEU
SEQRES 169 B 2553 GLY LEU ASP 4HH LEU MET SER VAL GLU VAL ARG GLN THR
SEQRES 170 B 2553 LEU GLU ARG GLU LEU ASN LEU VAL LEU SER VAL ARG GLU
SEQRES 171 B 2553 VAL ARG GLN LEU THR LEU ARG LYS LEU GLN GLU LEU SER
SEQRES 172 B 2553 SER LYS ALA ASP GLU ALA SER GLU LEU ALA CYS PRO THR
SEQRES 173 B 2553 PRO LYS GLU ASP GLY LEU ALA GLN GLN GLN THR GLN LEU
SEQRES 174 B 2553 ASN LEU ARG SER LEU LEU VAL ASN PRO GLU GLY PRO THR
SEQRES 175 B 2553 LEU MET ARG LEU ASN SER VAL GLN SER SER GLU ARG PRO
SEQRES 176 B 2553 LEU PHE LEU VAL HIS PRO ILE GLU GLY SER THR THR VAL
SEQRES 177 B 2553 PHE HIS SER LEU ALA SER ARG LEU SER ILE PRO THR TYR
SEQRES 178 B 2553 GLY LEU GLN CYS THR ARG ALA ALA PRO LEU ASP SER ILE
SEQRES 179 B 2553 HIS SER LEU ALA ALA TYR TYR ILE ASP CYS ILE ARG GLN
SEQRES 180 B 2553 VAL GLN PRO GLU GLY PRO TYR ARG VAL ALA GLY TYR SER
SEQRES 181 B 2553 TYR GLY ALA CYS VAL ALA PHE GLU MET CYS SER GLN LEU
SEQRES 182 B 2553 GLN ALA GLN GLN SER PRO ALA PRO THR HIS ASN SER LEU
SEQRES 183 B 2553 PHE LEU PHE ASP GLY SER PRO THR TYR VAL LEU ALA TYR
SEQRES 184 B 2553 THR GLN SER TYR ARG ALA LYS LEU THR PRO GLY CYS GLU
SEQRES 185 B 2553 ALA GLU ALA GLU THR GLU ALA ILE CYS PHE PHE VAL GLN
SEQRES 186 B 2553 GLN PHE THR ASP MET GLU HIS ASN ARG VAL LEU GLU ALA
SEQRES 187 B 2553 LEU LEU PRO LEU LYS GLY LEU GLU GLU ARG VAL ALA ALA
SEQRES 188 B 2553 ALA VAL ASP LEU ILE ILE LYS SER HIS GLN GLY LEU ASP
SEQRES 189 B 2553 ARG GLN GLU LEU SER PHE ALA ALA ARG SER PHE TYR TYR
SEQRES 190 B 2553 LYS LEU ARG ALA ALA GLU GLN TYR THR PRO LYS ALA LYS
SEQRES 191 B 2553 TYR HIS GLY ASN VAL MET LEU LEU ARG ALA LYS THR GLY
SEQRES 192 B 2553 GLY ALA TYR GLY GLU ASP LEU GLY ALA ASP TYR ASN LEU
SEQRES 193 B 2553 SER GLN VAL CYS ASP GLY LYS VAL SER VAL HIS VAL ILE
SEQRES 194 B 2553 GLU GLY ASP HIS ARG THR LEU LEU GLU GLY SER GLY LEU
SEQRES 195 B 2553 GLU SER ILE ILE SER ILE ILE HIS SER SER LEU ALA GLU
SEQRES 196 B 2553 PRO ARG VAL SER VAL ARG GLU GLY LEU GLU HIS HIS HIS
SEQRES 197 B 2553 HIS HIS HIS HIS HIS
MODRES 8VF7 4HH B 2156 SER MODIFIED RESIDUE
HET 4HH B2156 27
HET NDP A2601 74
HET NDP A2602 74
HET NDP B2601 74
HET NDP B2602 74
HETNAM 4HH 4'-PHOSPHOPANTHETHEINE-SERINE
HETNAM NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE
HETNAM 2 NDP PHOSPHATE
HETSYN 4HH O-[(S)-HYDROXY{[(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-
HETSYN 2 4HH ({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)
HETSYN 3 4HH BUTYL]OXY}PHOSPHORYL]-L-SERINE
FORMUL 2 4HH C14 H28 N3 O9 P S
FORMUL 3 NDP 4(C21 H30 N7 O17 P3)
HELIX 1 AA1 SER A 870 ASP A 877 5 8
HELIX 2 AA2 PRO A 887 GLY A 904 1 18
HELIX 3 AA3 GLY A 906 LEU A 910 5 5
HELIX 4 AA4 ASP A 965 ASP A 970 5 6
HELIX 5 AA5 GLN A 987 GLY A 998 1 12
HELIX 6 AA6 ASN A 1025 GLY A 1040 1 16
HELIX 7 AA7 ASP A 1058 LEU A 1066 1 9
HELIX 8 AA8 GLY A 1126 GLU A 1130 5 5
HELIX 9 AA9 ARG A 1131 VAL A 1145 1 15
HELIX 10 AB1 GLN A 1176 GLN A 1189 1 14
HELIX 11 AB2 LEU A 1194 GLN A 1200 1 7
HELIX 12 AB3 LYS A 1208 ASP A 1212 5 5
HELIX 13 AB4 SER A 1216 SER A 1221 1 6
HELIX 14 AB5 SER A 1221 GLU A 1233 1 13
HELIX 15 AB6 LEU A 1246 HIS A 1251 1 6
HELIX 16 AB7 LEU A 1252 SER A 1254 5 3
HELIX 17 AB8 ARG A 1255 LEU A 1260 1 6
HELIX 18 AB9 ALA A 1283 HIS A 1290 1 8
HELIX 19 AC1 ASP A 1324 ALA A 1335 1 12
HELIX 20 AC2 HIS A 1351 LEU A 1360 1 10
HELIX 21 AC3 GLU A 1364 GLN A 1369 1 6
HELIX 22 AC4 SER A 1373 VAL A 1384 1 12
HELIX 23 AC5 ASP A 1419 PHE A 1422 5 4
HELIX 24 AC6 ARG A 1423 LEU A 1432 1 10
HELIX 25 AC7 GLY A 1452 ARG A 1461 1 10
HELIX 26 AC8 GLY A 1465 ASN A 1467 5 3
HELIX 27 AC9 SER A 1490 ASP A 1500 1 11
HELIX 28 AD1 ASP A 1540 SER A 1542 5 3
HELIX 29 AD2 SER A 1550 HIS A 1553 5 4
HELIX 30 AD3 ASN A 1572 THR A 1580 1 9
HELIX 31 AD4 SER A 1584 ILE A 1588 5 5
HELIX 32 AD5 SER A 1629 ASP A 1631 5 3
HELIX 33 AD6 THR A 1641 ALA A 1646 1 6
HELIX 34 AD7 VAL A 1648 VAL A 1661 1 14
HELIX 35 AD8 GLY A 1678 LEU A 1691 1 14
HELIX 36 AD9 SER A 1701 PHE A 1712 1 12
HELIX 37 AE1 ASP A 1716 THR A 1718 5 3
HELIX 38 AE2 THR A 1726 THR A 1736 1 11
HELIX 39 AE3 ALA A 1749 ARG A 1758 1 10
HELIX 40 AE4 LYS A 1771 ASN A 1777 1 7
HELIX 41 AE5 ALA A 1783 ASN A 1788 5 6
HELIX 42 AE6 ASP A 1797 GLU A 1802 1 6
HELIX 43 AE7 SER A 1803 ASP A 1820 1 18
HELIX 44 AE8 HIS A 1832 ALA A 1834 5 3
HELIX 45 AE9 GLN A 1835 GLN A 1845 1 11
HELIX 46 AF1 GLY A 1894 ARG A 1907 1 14
HELIX 47 AF2 THR A 1922 GLN A 1935 1 14
HELIX 48 AF3 SER A 1948 GLY A 1963 1 16
HELIX 49 AF4 THR A 1984 CYS A 2010 1 27
HELIX 50 AF5 VAL A 2022 GLY A 2027 1 6
HELIX 51 AF6 GLN A 2031 GLU A 2051 1 21
HELIX 52 AF7 ARG A 2087 LEU A 2099 1 13
HELIX 53 AF8 ASP B 872 VAL B 876 5 5
HELIX 54 AF9 PRO B 887 GLY B 904 1 18
HELIX 55 AG1 GLY B 906 LEU B 910 5 5
HELIX 56 AG2 ASP B 965 ASP B 970 5 6
HELIX 57 AG3 ALA B 986 GLY B 998 1 13
HELIX 58 AG4 ASN B 1025 GLY B 1040 1 16
HELIX 59 AG5 ASP B 1058 LEU B 1066 1 9
HELIX 60 AG6 ARG B 1131 THR B 1150 1 20
HELIX 61 AG7 GLN B 1176 LEU B 1188 1 13
HELIX 62 AG8 ASN B 1191 LEU B 1194 5 4
HELIX 63 AG9 GLN B 1195 ALA B 1203 1 9
HELIX 64 AH1 LYS B 1208 GLU B 1211 5 4
HELIX 65 AH2 ASP B 1212 SER B 1221 1 10
HELIX 66 AH3 SER B 1221 ASN B 1234 1 14
HELIX 67 AH4 LEU B 1246 HIS B 1251 1 6
HELIX 68 AH5 LEU B 1252 SER B 1254 5 3
HELIX 69 AH6 ARG B 1255 LEU B 1260 1 6
HELIX 70 AH7 HIS B 1276 ALA B 1283 1 8
HELIX 71 AH8 ALA B 1283 GLN B 1288 1 6
HELIX 72 AH9 ASP B 1324 ALA B 1335 1 12
HELIX 73 AI1 HIS B 1351 THR B 1361 1 11
HELIX 74 AI2 GLN B 1366 ILE B 1371 1 6
HELIX 75 AI3 SER B 1373 VAL B 1384 1 12
HELIX 76 AI4 ARG B 1423 GLU B 1435 1 13
HELIX 77 AI5 GLY B 1452 ARG B 1461 1 10
HELIX 78 AI6 GLY B 1465 ASN B 1467 5 3
HELIX 79 AI7 SER B 1490 ASP B 1500 1 11
HELIX 80 AI8 SER B 1550 HIS B 1553 5 4
HELIX 81 AI9 ASN B 1572 GLY B 1581 1 10
HELIX 82 AJ1 SER B 1629 ASP B 1631 5 3
HELIX 83 AJ2 THR B 1641 ALA B 1646 1 6
HELIX 84 AJ3 VAL B 1648 VAL B 1660 1 13
HELIX 85 AJ4 GLY B 1678 LEU B 1691 1 14
HELIX 86 AJ5 SER B 1701 PHE B 1712 1 12
HELIX 87 AJ6 ASP B 1716 THR B 1718 5 3
HELIX 88 AJ7 SER B 1727 THR B 1736 1 10
HELIX 89 AJ8 ALA B 1749 CYS B 1759 1 11
HELIX 90 AJ9 LYS B 1771 ASN B 1777 1 7
HELIX 91 AK1 ALA B 1783 LYS B 1787 5 5
HELIX 92 AK2 LEU B 1795 PHE B 1799 5 5
HELIX 93 AK3 SER B 1804 GLY B 1821 1 18
HELIX 94 AK4 GLN B 1835 GLY B 1846 1 12
HELIX 95 AK5 GLY B 1894 GLN B 1906 1 13
HELIX 96 AK6 THR B 1922 GLN B 1935 1 14
HELIX 97 AK7 SER B 1948 GLY B 1963 1 16
HELIX 98 AK8 LEU B 1979 GLN B 1983 5 5
HELIX 99 AK9 THR B 1984 CYS B 2010 1 27
HELIX 100 AL1 VAL B 2022 GLY B 2027 1 6
HELIX 101 AL2 GLN B 2031 GLU B 2051 1 21
HELIX 102 AL3 ARG B 2087 ASN B 2100 1 14
HELIX 103 AL4 ASP B 2126 GLY B 2136 1 11
HELIX 104 AL5 SER B 2148 GLY B 2153 1 6
HELIX 105 AL6 ASP B 2155 ASN B 2171 1 17
HELIX 106 AL7 SER B 2175 LEU B 2182 1 8
HELIX 107 AL8 THR B 2183 LYS B 2193 1 11
SHEET 1 AA112 ALA A 860 ILE A 864 0
SHEET 2 AA112 VAL A 931 LEU A 938 -1 O VAL A 935 N ALA A 860
SHEET 3 AA112 ALA A 943 GLU A 948 -1 O ALA A 943 N LEU A 938
SHEET 4 AA112 ASN A 951 GLN A 960 -1 O VAL A 954 N VAL A 946
SHEET 5 AA112 VAL A 912 LEU A 919 -1 N GLU A 915 O LYS A 957
SHEET 6 AA112 TYR A1047 ILE A1057 -1 O ILE A1055 N PHE A 914
SHEET 7 AA112 VAL A1092 SER A1101 -1 O HIS A1098 N THR A1050
SHEET 8 AA112 VAL A1086 ALA A1089 -1 N THR A1087 O ILE A1094
SHEET 9 AA112 GLN A1074 SER A1081 -1 N VAL A1079 O VAL A1088
SHEET 10 AA112 SER A1017 TRP A1022 -1 N GLY A1018 O VAL A1078
SHEET 11 AA112 ILE A1008 ALA A1011 -1 N LEU A1009 O ARG A1019
SHEET 12 AA112 LEU A 985 ALA A 986 -1 N LEU A 985 O ALA A1011
SHEET 1 AA210 ALA A 860 ILE A 864 0
SHEET 2 AA210 VAL A 931 LEU A 938 -1 O VAL A 935 N ALA A 860
SHEET 3 AA210 ALA A 943 GLU A 948 -1 O ALA A 943 N LEU A 938
SHEET 4 AA210 ASN A 951 GLN A 960 -1 O VAL A 954 N VAL A 946
SHEET 5 AA210 VAL A 912 LEU A 919 -1 N GLU A 915 O LYS A 957
SHEET 6 AA210 TYR A1047 ILE A1057 -1 O ILE A1055 N PHE A 914
SHEET 7 AA210 VAL A1092 SER A1101 -1 O HIS A1098 N THR A1050
SHEET 8 AA210 VAL A1086 ALA A1089 -1 N THR A1087 O ILE A1094
SHEET 9 AA210 GLN A1074 SER A1081 -1 N VAL A1079 O VAL A1088
SHEET 10 AA210 TYR A1067 THR A1068 -1 N TYR A1067 O VAL A1075
SHEET 1 AA3 2 THR A 879 LEU A 880 0
SHEET 2 AA3 2 ARG A 883 VAL A 884 -1 O ARG A 883 N LEU A 880
SHEET 1 AA413 ILE A1413 PRO A1416 0
SHEET 2 AA413 VAL A1441 ALA A1445 1 O TRP A1442 N ILE A1413
SHEET 3 AA413 LEU A1469 LEU A1474 1 O ARG A1470 N LEU A1443
SHEET 4 AA413 VAL A1505 TYR A1506 1 O TYR A1506 N LEU A1473
SHEET 5 AA413 TRP A1511 LEU A1518 -1 O GLY A1512 N VAL A1505
SHEET 6 AA413 ILE A1113 PRO A1121 -1 N LYS A1116 O PHE A1517
SHEET 7 AA413 VAL A2105 LEU A2111 -1 O PHE A2109 N ILE A1113
SHEET 8 AA413 LEU A2056 TRP A2060 1 N GLN A2059 O LEU A2106
SHEET 9 AA413 TYR A2015 SER A2021 1 N SER A2020 O VAL A2058
SHEET 10 AA413 VAL A1965 ASN A1970 1 N VAL A1968 O TYR A2015
SHEET 11 AA413 SER A1886 ALA A1890 1 N SER A1886 O GLY A1966
SHEET 12 AA413 LYS A1911 THR A1915 1 O VAL A1913 N TYR A1887
SHEET 13 AA413 GLN A1938 VAL A1941 1 O GLN A1938 N LEU A1912
SHEET 1 AA5 8 ILE A1413 PRO A1416 0
SHEET 2 AA5 8 VAL A1441 ALA A1445 1 O TRP A1442 N ILE A1413
SHEET 3 AA5 8 LEU A1469 LEU A1474 1 O ARG A1470 N LEU A1443
SHEET 4 AA5 8 VAL A1505 TYR A1506 1 O TYR A1506 N LEU A1473
SHEET 5 AA5 8 TRP A1511 LEU A1518 -1 O GLY A1512 N VAL A1505
SHEET 6 AA5 8 ILE A1113 PRO A1121 -1 N LYS A1116 O PHE A1517
SHEET 7 AA5 8 VAL A2105 LEU A2111 -1 O PHE A2109 N ILE A1113
SHEET 8 AA5 8 THR A2083 LEU A2084 -1 N LEU A2084 O VAL A2110
SHEET 1 AA6 7 THR A1123 GLU A1124 0
SHEET 2 AA6 7 ARG A1387 LYS A1393 1 O LYS A1393 N GLU A1124
SHEET 3 AA6 7 THR A1399 ARG A1404 -1 O LEU A1402 N VAL A1389
SHEET 4 AA6 7 PHE A1341 THR A1346 -1 N LEU A1342 O CYS A1403
SHEET 5 AA6 7 LEU A1312 VAL A1314 1 N LEU A1313 O LEU A1343
SHEET 6 AA6 7 MET A1240 GLU A1244 1 N LYS A1241 O LEU A1312
SHEET 7 AA6 7 LEU A1268 ALA A1272 1 O SER A1269 N VAL A1242
SHEET 1 AA7 2 GLU A1525 THR A1528 0
SHEET 2 AA7 2 MET A1873 ILE A1876 -1 O MET A1873 N THR A1528
SHEET 1 AA8 2 ALA A1531 THR A1535 0
SHEET 2 AA8 2 ILE A1544 CYS A1548 -1 O VAL A1547 N PHE A1532
SHEET 1 AA9 5 SER A1625 LEU A1628 0
SHEET 2 AA9 5 GLN A1562 SER A1570 -1 N GLN A1562 O LEU A1628
SHEET 3 AA9 5 GLU A1602 ARG A1606 -1 O SER A1604 N TYR A1567
SHEET 4 AA9 5 ARG A1612 LEU A1616 -1 O VAL A1613 N GLY A1605
SHEET 5 AA9 5 LEU A1633 TRP A1634 -1 O TRP A1634 N MET A1614
SHEET 1 AB1 4 SER A1625 LEU A1628 0
SHEET 2 AB1 4 GLN A1562 SER A1570 -1 N GLN A1562 O LEU A1628
SHEET 3 AB1 4 LYS A1851 GLN A1855 -1 O VAL A1854 N ALA A1569
SHEET 4 AB1 4 CYS A1828 PHE A1831 1 N PHE A1831 O GLN A1855
SHEET 1 AB212 PHE A1720 ASN A1722 0
SHEET 2 AB212 ARG A1694 VAL A1699 1 N VAL A1699 O ALA A1721
SHEET 3 AB212 THR A1670 ILE A1673 1 N ILE A1673 O PHE A1696
SHEET 4 AB212 VAL A1741 ASN A1746 1 O LEU A1745 N LEU A1672
SHEET 5 AB212 LEU A1760 GLU A1768 1 O LEU A1767 N VAL A1744
SHEET 6 AB212 THR A1790 GLY A1793 1 O HIS A1792 N PHE A1766
SHEET 7 AB212 VAL B1789 GLY B1793 -1 O PHE B1791 N PHE A1791
SHEET 8 AB212 LEU B1760 GLU B1768 1 N PHE B1766 O HIS B1792
SHEET 9 AB212 VAL B1741 ASN B1746 1 N ASP B1742 O ARG B1765
SHEET 10 AB212 THR B1670 HIS B1674 1 N LEU B1672 O LEU B1743
SHEET 11 AB212 ARG B1694 VAL B1699 1 O PHE B1696 N ILE B1673
SHEET 12 AB212 PHE B1720 ASN B1722 1 O ALA B1721 N VAL B1699
SHEET 1 AB3 2 PRO A1779 GLY A1781 0
SHEET 2 AB3 2 PRO B1779 GLY B1781 -1 O LEU B1780 N LEU A1780
SHEET 1 AB411 ALA B 860 ASP B 865 0
SHEET 2 AB411 THR B 930 LEU B 938 -1 O LEU B 933 N TYR B 862
SHEET 3 AB411 ALA B 943 GLU B 948 -1 O SER B 947 N GLU B 934
SHEET 4 AB411 ASN B 951 GLN B 960 -1 O VAL B 953 N VAL B 946
SHEET 5 AB411 VAL B 912 LEU B 919 -1 N GLU B 915 O LYS B 957
SHEET 6 AB411 TYR B1047 ILE B1057 -1 O VAL B1052 N VAL B 917
SHEET 7 AB411 VAL B1092 SER B1101 -1 O HIS B1093 N HIS B1056
SHEET 8 AB411 VAL B1086 ALA B1089 -1 N THR B1087 O ILE B1094
SHEET 9 AB411 GLN B1074 SER B1081 -1 N SER B1081 O VAL B1086
SHEET 10 AB411 GLY B1018 LEU B1021 -1 N LEU B1020 O ALA B1076
SHEET 11 AB411 ILE B1008 ALA B1011 -1 N LEU B1009 O ARG B1019
SHEET 1 AB510 ALA B 860 ASP B 865 0
SHEET 2 AB510 THR B 930 LEU B 938 -1 O LEU B 933 N TYR B 862
SHEET 3 AB510 ALA B 943 GLU B 948 -1 O SER B 947 N GLU B 934
SHEET 4 AB510 ASN B 951 GLN B 960 -1 O VAL B 953 N VAL B 946
SHEET 5 AB510 VAL B 912 LEU B 919 -1 N GLU B 915 O LYS B 957
SHEET 6 AB510 TYR B1047 ILE B1057 -1 O VAL B1052 N VAL B 917
SHEET 7 AB510 VAL B1092 SER B1101 -1 O HIS B1093 N HIS B1056
SHEET 8 AB510 VAL B1086 ALA B1089 -1 N THR B1087 O ILE B1094
SHEET 9 AB510 GLN B1074 SER B1081 -1 N SER B1081 O VAL B1086
SHEET 10 AB510 TYR B1067 THR B1068 -1 N TYR B1067 O VAL B1075
SHEET 1 AB6 3 ARG B 883 VAL B 884 0
SHEET 2 AB6 3 HIS B 878 LEU B 880 -1 N LEU B 880 O ARG B 883
SHEET 3 AB6 3 TYR B 999 TYR B1001 -1 O ASP B1000 N THR B 879
SHEET 1 AB713 ILE B1413 PRO B1416 0
SHEET 2 AB713 VAL B1441 ALA B1445 1 O TRP B1442 N ILE B1413
SHEET 3 AB713 LEU B1469 LEU B1474 1 O ARG B1470 N LEU B1443
SHEET 4 AB713 VAL B1505 TYR B1506 1 O TYR B1506 N LEU B1473
SHEET 5 AB713 TRP B1511 LEU B1518 -1 O GLY B1512 N VAL B1505
SHEET 6 AB713 ILE B1113 PRO B1121 -1 N LYS B1116 O PHE B1517
SHEET 7 AB713 VAL B2105 PHE B2109 -1 O SER B2107 N GLU B1115
SHEET 8 AB713 LEU B2056 TRP B2060 1 N GLN B2059 O LEU B2106
SHEET 9 AB713 TYR B2015 SER B2021 1 N SER B2020 O VAL B2058
SHEET 10 AB713 VAL B1965 ASN B1970 1 N VAL B1968 O TYR B2015
SHEET 11 AB713 SER B1886 ALA B1890 1 N SER B1886 O GLY B1966
SHEET 12 AB713 LYS B1911 THR B1915 1 O VAL B1913 N ILE B1889
SHEET 13 AB713 GLN B1938 SER B1942 1 O SER B1942 N LEU B1914
SHEET 1 AB8 7 THR B1123 GLU B1125 0
SHEET 2 AB8 7 ARG B1387 LYS B1393 1 O LEU B1391 N GLU B1124
SHEET 3 AB8 7 THR B1399 ARG B1404 -1 O ARG B1404 N ARG B1387
SHEET 4 AB8 7 LEU B1336 THR B1346 -1 N LEU B1342 O CYS B1403
SHEET 5 AB8 7 ALA B1310 VAL B1314 1 N LEU B1313 O LEU B1343
SHEET 6 AB8 7 LYS B1241 GLU B1244 1 N VAL B1243 O LEU B1312
SHEET 7 AB8 7 SER B1269 ALA B1272 1 O THR B1271 N GLU B1244
SHEET 1 AB9 2 GLU B1525 THR B1528 0
SHEET 2 AB9 2 MET B1873 ILE B1876 -1 O MET B1873 N THR B1528
SHEET 1 AC1 2 ALA B1531 THR B1535 0
SHEET 2 AC1 2 ILE B1544 CYS B1548 -1 O VAL B1547 N PHE B1532
SHEET 1 AC2 5 SER B1625 LEU B1628 0
SHEET 2 AC2 5 GLN B1562 SER B1570 -1 N CYS B1564 O VAL B1626
SHEET 3 AC2 5 GLU B1602 ARG B1606 -1 O ARG B1606 N THR B1565
SHEET 4 AC2 5 ARG B1612 LEU B1616 -1 O VAL B1613 N GLY B1605
SHEET 5 AC2 5 LEU B1633 ASP B1635 -1 O TRP B1634 N MET B1614
SHEET 1 AC3 4 SER B1625 LEU B1628 0
SHEET 2 AC3 4 GLN B1562 SER B1570 -1 N CYS B1564 O VAL B1626
SHEET 3 AC3 4 LYS B1851 GLN B1855 -1 O VAL B1854 N ALA B1569
SHEET 4 AC3 4 CYS B1828 HIS B1832 1 N THR B1829 O VAL B1853
SHEET 1 AC4 2 ALA B2062 ILE B2063 0
SHEET 2 AC4 2 PRO B2085 GLN B2086 1 O GLN B2086 N ALA B2062
LINK C ASP B2155 N 4HH B2156 1555 1555 1.34
LINK C 4HH B2156 N LEU B2157 1555 1555 1.33
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
TER 18704 ALA A2112
TER 38596 ALA B2194
MASTER 2768 0 5 107 138 0 0 619474 2 325 394
END |