longtext: 8ze6-pdb

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HEADER    VIRAL PROTEIN                           04-MAY-24   8ZE6
TITLE     CRYSTAL STRUCTURE OF MJHKU4R-COV-1 RBD BOUND TO MJDPP4
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: DIPEPTIDYL PEPTIDASE 4;
COMPND   3 CHAIN: B, D;
COMPND   4 ENGINEERED: YES;
COMPND   5 MOL_ID: 2;
COMPND   6 MOLECULE: SPIKE GLYCOPROTEIN;
COMPND   7 CHAIN: C, A;
COMPND   8 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN;
COMPND   9 ENGINEERED: YES;
COMPND  10 OTHER_DETAILS: SEQUENCE REFERENCE FOR SOURCE ORGANISM PANGOLIN
COMPND  11 CORONAVIRUS HKU4 IS NOT AVAILABLE IN UNIPROT AT THE TIME OF
COMPND  12 BIOCURATION. CURRENT SEQUENCE REFERENCE IS FROM UNIPROT ID
COMPND  13 A0AAE8ZFM2.
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: MANIS JAVANICA;
SOURCE   3 ORGANISM_TAXID: 9974;
SOURCE   4 EXPRESSION_SYSTEM: BACULOVIRUS EXPRESSION VECTOR PFASTBAC1-HM;
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 274590;
SOURCE   6 MOL_ID: 2;
SOURCE   7 ORGANISM_SCIENTIFIC: PANGOLIN CORONAVIRUS HKU4;
SOURCE   8 ORGANISM_TAXID: 3027597;
SOURCE   9 EXPRESSION_SYSTEM: BACULOVIRUS EXPRESSION VECTOR PFASTBAC1-HM;
SOURCE  10 EXPRESSION_SYSTEM_TAXID: 274590
KEYWDS    VIRUS PROTEIN AND RECEPTOR COMPLEX, VIRAL PROTEIN
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.YANG,Z.LI,Y.XU,S.ZHANG
REVDAT   1   30-OCT-24 8ZE6    0
JRNL        AUTH   M.YANG,Z.LI,Y.XU,S.ZHANG
JRNL        TITL   CRYSTAL STRUCTURE OF MJHKU4R-COV-1 RBD BOUND TO MJDPP4
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.70 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (1.20.1_4487: ???)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.70
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.49
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.350
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.8
REMARK   3   NUMBER OF REFLECTIONS             : 66672
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.244
REMARK   3   R VALUE            (WORKING SET) : 0.242
REMARK   3   FREE R VALUE                     : 0.274
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.010
REMARK   3   FREE R VALUE TEST SET COUNT      : 3342
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 47.4900 -  7.7900    0.97     2664   136  0.2016 0.2187
REMARK   3     2  7.7800 -  6.1800    0.99     2660   149  0.2331 0.2823
REMARK   3     3  6.1800 -  5.4000    0.99     2674   139  0.2176 0.2309
REMARK   3     4  5.4000 -  4.9100    0.99     2642   162  0.1976 0.2031
REMARK   3     5  4.9100 -  4.5600    0.99     2646   144  0.1897 0.2226
REMARK   3     6  4.5600 -  4.2900    0.99     2658   129  0.1915 0.1994
REMARK   3     7  4.2900 -  4.0700    0.99     2626   127  0.2158 0.2603
REMARK   3     8  4.0700 -  3.9000    0.99     2663   146  0.2179 0.2765
REMARK   3     9  3.9000 -  3.7500    0.99     2630   164  0.2392 0.2755
REMARK   3    10  3.7500 -  3.6200    0.99     2631   146  0.2357 0.2733
REMARK   3    11  3.6200 -  3.5000    0.99     2638   125  0.2550 0.2755
REMARK   3    12  3.5000 -  3.4000    0.99     2689   128  0.2687 0.3111
REMARK   3    13  3.4000 -  3.3200    0.99     2634   133  0.2844 0.3452
REMARK   3    14  3.3200 -  3.2300    0.99     2605   154  0.2974 0.3560
REMARK   3    15  3.2300 -  3.1600    0.99     2659   125  0.2941 0.3325
REMARK   3    16  3.1600 -  3.0900    0.99     2659   139  0.2946 0.3405
REMARK   3    17  3.0900 -  3.0300    0.99     2646   125  0.3097 0.3527
REMARK   3    18  3.0300 -  2.9700    0.99     2637   129  0.3138 0.3791
REMARK   3    19  2.9700 -  2.9200    0.99     2607   144  0.3302 0.3744
REMARK   3    20  2.9200 -  2.8700    0.99     2620   157  0.3223 0.3685
REMARK   3    21  2.8700 -  2.8300    0.98     2641   124  0.3290 0.3569
REMARK   3    22  2.8300 -  2.7800    0.99     2624   125  0.3420 0.3597
REMARK   3    23  2.7800 -  2.7400    0.98     2615   139  0.3485 0.3655
REMARK   3    24  2.7400 -  2.7000    0.96     2562   153  0.3603 0.4002
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.10
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.490
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 31.620
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.002          15699
REMARK   3   ANGLE     :  0.482          21342
REMARK   3   CHIRALITY :  0.049           2310
REMARK   3   PLANARITY :  0.004           2708
REMARK   3   DIHEDRAL  : 14.985           5648
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : 27
REMARK   3   TLS GROUP : 1
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 41 THROUGH 130 )
REMARK   3    ORIGIN FOR THE GROUP (A):  51.6120 105.6043  92.0975
REMARK   3    T TENSOR
REMARK   3      T11:   0.3503 T22:   0.3806
REMARK   3      T33:   0.4508 T12:  -0.0040
REMARK   3      T13:   0.0520 T23:  -0.0128
REMARK   3    L TENSOR
REMARK   3      L11:   0.9501 L22:   0.9022
REMARK   3      L33:   2.5763 L12:   0.9327
REMARK   3      L13:  -0.1242 L23:  -0.3342
REMARK   3    S TENSOR
REMARK   3      S11:   0.0740 S12:  -0.1847 S13:   0.0467
REMARK   3      S21:  -0.0746 S22:  -0.0519 S23:   0.0412
REMARK   3      S31:   0.2271 S32:  -0.1641 S33:   0.0117
REMARK   3   TLS GROUP : 2
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 131 THROUGH 317 )
REMARK   3    ORIGIN FOR THE GROUP (A):  66.0947 112.5981 110.7656
REMARK   3    T TENSOR
REMARK   3      T11:   0.3086 T22:   0.2927
REMARK   3      T33:   0.4060 T12:  -0.0063
REMARK   3      T13:   0.0612 T23:  -0.0172
REMARK   3    L TENSOR
REMARK   3      L11:   1.0156 L22:   1.2712
REMARK   3      L33:   1.4087 L12:   0.4355
REMARK   3      L13:   0.0752 L23:  -0.1970
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0203 S12:   0.1404 S13:  -0.0561
REMARK   3      S21:  -0.0354 S22:   0.0705 S23:  -0.1310
REMARK   3      S31:  -0.0416 S32:   0.1438 S33:  -0.0613
REMARK   3   TLS GROUP : 3
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 318 THROUGH 766 )
REMARK   3    ORIGIN FOR THE GROUP (A):  38.5349 123.2402 108.9750
REMARK   3    T TENSOR
REMARK   3      T11:   0.4140 T22:   0.4203
REMARK   3      T33:   0.5033 T12:   0.0639
REMARK   3      T13:   0.0510 T23:   0.0520
REMARK   3    L TENSOR
REMARK   3      L11:   0.6684 L22:   0.3882
REMARK   3      L33:   1.5341 L12:   0.0604
REMARK   3      L13:   0.0020 L23:  -0.0134
REMARK   3    S TENSOR
REMARK   3      S11:   0.0000 S12:   0.0153 S13:   0.0997
REMARK   3      S21:  -0.0065 S22:   0.0204 S23:   0.0908
REMARK   3      S31:  -0.2375 S32:  -0.3689 S33:  -0.0307
REMARK   3   TLS GROUP : 4
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 388 THROUGH 407 )
REMARK   3    ORIGIN FOR THE GROUP (A): -55.9058 123.8682  59.4062
REMARK   3    T TENSOR
REMARK   3      T11:   0.7576 T22:   1.8959
REMARK   3      T33:   1.2096 T12:  -0.1842
REMARK   3      T13:   0.1214 T23:  -0.2862
REMARK   3    L TENSOR
REMARK   3      L11:   1.0104 L22:   0.1417
REMARK   3      L33:   0.1469 L12:   0.1912
REMARK   3      L13:  -0.2696 L23:  -0.1397
REMARK   3    S TENSOR
REMARK   3      S11:  -0.4539 S12:   0.1684 S13:  -0.6732
REMARK   3      S21:  -0.0528 S22:  -0.3358 S23:   0.6662
REMARK   3      S31:   0.6669 S32:  -1.2680 S33:   0.6718
REMARK   3   TLS GROUP : 5
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 408 THROUGH 418 )
REMARK   3    ORIGIN FOR THE GROUP (A): -60.4043 115.0904  58.1451
REMARK   3    T TENSOR
REMARK   3      T11:   0.5436 T22:   1.9358
REMARK   3      T33:   1.5681 T12:  -0.2494
REMARK   3      T13:   0.0634 T23:  -0.1716
REMARK   3    L TENSOR
REMARK   3      L11:   4.0486 L22:   0.3056
REMARK   3      L33:   0.8271 L12:   0.0941
REMARK   3      L13:   1.7679 L23:   0.1699
REMARK   3    S TENSOR
REMARK   3      S11:   0.2106 S12:   0.4773 S13:  -1.0158
REMARK   3      S21:  -0.3398 S22:   0.0461 S23:   0.6106
REMARK   3      S31:   0.4946 S32:  -1.3060 S33:  -0.1174
REMARK   3   TLS GROUP : 6
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 419 THROUGH 434 )
REMARK   3    ORIGIN FOR THE GROUP (A): -55.4911 122.1453  45.2099
REMARK   3    T TENSOR
REMARK   3      T11:   0.9342 T22:   2.0962
REMARK   3      T33:   1.0980 T12:   0.3450
REMARK   3      T13:  -0.3093 T23:  -0.1673
REMARK   3    L TENSOR
REMARK   3      L11:   4.4009 L22:   0.1087
REMARK   3      L33:   0.0084 L12:  -0.6823
REMARK   3      L13:   0.1484 L23:  -0.0268
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0587 S12:   0.8504 S13:   0.5041
REMARK   3      S21:  -0.1540 S22:  -0.3722 S23:   0.1709
REMARK   3      S31:  -0.1422 S32:  -0.6080 S33:   0.3758
REMARK   3   TLS GROUP : 7
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 435 THROUGH 447 )
REMARK   3    ORIGIN FOR THE GROUP (A): -59.0288 109.7410  46.5595
REMARK   3    T TENSOR
REMARK   3      T11:   1.1306 T22:   1.4180
REMARK   3      T33:   1.7809 T12:  -0.2062
REMARK   3      T13:  -0.4338 T23:  -0.4906
REMARK   3    L TENSOR
REMARK   3      L11:   1.7561 L22:   0.4135
REMARK   3      L33:   0.0237 L12:  -0.8503
REMARK   3      L13:  -0.1733 L23:   0.0810
REMARK   3    S TENSOR
REMARK   3      S11:   0.2316 S12:   0.3431 S13:  -0.7059
REMARK   3      S21:  -0.4120 S22:  -0.3186 S23:   0.9243
REMARK   3      S31:   0.2521 S32:  -1.1482 S33:   0.0886
REMARK   3   TLS GROUP : 8
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 448 THROUGH 463 )
REMARK   3    ORIGIN FOR THE GROUP (A): -45.6899 122.7565  51.6277
REMARK   3    T TENSOR
REMARK   3      T11:   0.4393 T22:   1.1246
REMARK   3      T33:   0.7137 T12:   0.0812
REMARK   3      T13:  -0.0441 T23:  -0.0040
REMARK   3    L TENSOR
REMARK   3      L11:   4.8249 L22:   5.9269
REMARK   3      L33:   4.2524 L12:  -0.3506
REMARK   3      L13:   2.2242 L23:   2.0908
REMARK   3    S TENSOR
REMARK   3      S11:   0.1505 S12:  -0.0356 S13:  -0.3862
REMARK   3      S21:  -0.5027 S22:  -0.2572 S23:   1.1238
REMARK   3      S31:  -0.1906 S32:  -0.8278 S33:   0.2812
REMARK   3   TLS GROUP : 9
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 464 THROUGH 503 )
REMARK   3    ORIGIN FOR THE GROUP (A): -45.2257 122.3969  51.9739
REMARK   3    T TENSOR
REMARK   3      T11:   0.4904 T22:   1.0166
REMARK   3      T33:   0.6621 T12:  -0.0865
REMARK   3      T13:   0.0632 T23:  -0.0821
REMARK   3    L TENSOR
REMARK   3      L11:   5.3168 L22:   7.6166
REMARK   3      L33:   3.9489 L12:  -3.7585
REMARK   3      L13:   0.1583 L23:  -0.3354
REMARK   3    S TENSOR
REMARK   3      S11:   0.3429 S12:   0.2416 S13:  -0.5834
REMARK   3      S21:  -0.6794 S22:  -0.3850 S23:   1.0851
REMARK   3      S31:   0.3673 S32:  -1.2471 S33:  -0.0400
REMARK   3   TLS GROUP : 10
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 504 THROUGH 537 )
REMARK   3    ORIGIN FOR THE GROUP (A): -30.6483 120.0172  64.7593
REMARK   3    T TENSOR
REMARK   3      T11:   0.5945 T22:   0.5502
REMARK   3      T33:   0.5585 T12:   0.0193
REMARK   3      T13:   0.1230 T23:  -0.1399
REMARK   3    L TENSOR
REMARK   3      L11:   6.7934 L22:   2.4816
REMARK   3      L33:   3.9773 L12:   1.1774
REMARK   3      L13:   2.9035 L23:   0.2418
REMARK   3    S TENSOR
REMARK   3      S11:   0.2903 S12:  -0.0751 S13:  -0.6126
REMARK   3      S21:   0.3913 S22:   0.0236 S23:   0.0323
REMARK   3      S31:   0.7287 S32:  -0.4317 S33:  -0.1486
REMARK   3   TLS GROUP : 11
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 538 THROUGH 560 )
REMARK   3    ORIGIN FOR THE GROUP (A): -32.6608 126.0207  70.7866
REMARK   3    T TENSOR
REMARK   3      T11:   0.6579 T22:   0.5032
REMARK   3      T33:   0.6221 T12:  -0.0004
REMARK   3      T13:   0.0850 T23:  -0.1582
REMARK   3    L TENSOR
REMARK   3      L11:   3.8120 L22:   2.6630
REMARK   3      L33:   7.6820 L12:   2.9623
REMARK   3      L13:  -1.5017 L23:  -2.7610
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0067 S12:  -0.2745 S13:   0.2590
REMARK   3      S21:  -0.5391 S22:  -0.3510 S23:  -0.0518
REMARK   3      S31:   0.2128 S32:   0.0067 S33:   0.4741
REMARK   3   TLS GROUP : 12
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 561 THROUGH 588 )
REMARK   3    ORIGIN FOR THE GROUP (A): -46.1664 123.0204  55.3887
REMARK   3    T TENSOR
REMARK   3      T11:   0.5064 T22:   0.6593
REMARK   3      T33:   0.5786 T12:   0.0805
REMARK   3      T13:  -0.0163 T23:  -0.0466
REMARK   3    L TENSOR
REMARK   3      L11:   5.4163 L22:   1.8769
REMARK   3      L33:   4.5364 L12:   0.3199
REMARK   3      L13:   1.1123 L23:  -0.3895
REMARK   3    S TENSOR
REMARK   3      S11:  -0.3535 S12:   0.8746 S13:   0.4295
REMARK   3      S21:  -0.1275 S22:   0.3143 S23:   0.6153
REMARK   3      S31:  -0.3055 S32:  -0.8335 S33:   0.1163
REMARK   3   TLS GROUP : 13
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 40 THROUGH 130 )
REMARK   3    ORIGIN FOR THE GROUP (A):   7.2093 155.2139  49.0062
REMARK   3    T TENSOR
REMARK   3      T11:   0.5634 T22:   0.5230
REMARK   3      T33:   0.5387 T12:  -0.0634
REMARK   3      T13:   0.0752 T23:  -0.0106
REMARK   3    L TENSOR
REMARK   3      L11:   0.9028 L22:   0.3266
REMARK   3      L33:   2.2952 L12:   0.2250
REMARK   3      L13:   1.1095 L23:   0.7773
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1047 S12:   0.1141 S13:   0.0018
REMARK   3      S21:  -0.0897 S22:   0.0117 S23:  -0.1166
REMARK   3      S31:  -0.1998 S32:   0.2655 S33:   0.0653
REMARK   3   TLS GROUP : 14
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 131 THROUGH 221 )
REMARK   3    ORIGIN FOR THE GROUP (A): -13.9858 152.3802  51.4089
REMARK   3    T TENSOR
REMARK   3      T11:   0.3876 T22:   0.4479
REMARK   3      T33:   0.5077 T12:   0.0576
REMARK   3      T13:   0.0529 T23:   0.0135
REMARK   3    L TENSOR
REMARK   3      L11:   1.8237 L22:   2.0714
REMARK   3      L33:   1.8642 L12:   0.5151
REMARK   3      L13:  -0.4286 L23:  -0.4431
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1247 S12:   0.4270 S13:   0.1279
REMARK   3      S21:  -0.2302 S22:  -0.0046 S23:  -0.0616
REMARK   3      S31:   0.2484 S32:  -0.0521 S33:   0.0937
REMARK   3   TLS GROUP : 15
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 222 THROUGH 264 )
REMARK   3    ORIGIN FOR THE GROUP (A): -13.1118 154.1961  73.2089
REMARK   3    T TENSOR
REMARK   3      T11:   0.3677 T22:   0.2892
REMARK   3      T33:   0.3913 T12:   0.0373
REMARK   3      T13:   0.0612 T23:  -0.0012
REMARK   3    L TENSOR
REMARK   3      L11:   0.3306 L22:   0.6013
REMARK   3      L33:   1.0701 L12:   0.3153
REMARK   3      L13:  -0.0748 L23:   0.4829
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0297 S12:  -0.1135 S13:   0.1491
REMARK   3      S21:   0.1518 S22:  -0.1367 S23:   0.1454
REMARK   3      S31:   0.0448 S32:   0.0139 S33:   0.1392
REMARK   3   TLS GROUP : 16
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 265 THROUGH 388 )
REMARK   3    ORIGIN FOR THE GROUP (A): -13.1695 129.5775  57.7057
REMARK   3    T TENSOR
REMARK   3      T11:   0.5783 T22:   0.3825
REMARK   3      T33:   0.5025 T12:  -0.0419
REMARK   3      T13:   0.1241 T23:  -0.0724
REMARK   3    L TENSOR
REMARK   3      L11:   1.4975 L22:   0.6489
REMARK   3      L33:   0.8625 L12:  -0.0621
REMARK   3      L13:   0.1635 L23:   0.0870
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1953 S12:   0.1948 S13:  -0.1796
REMARK   3      S21:  -0.1096 S22:   0.0604 S23:   0.0062
REMARK   3      S31:   0.1285 S32:  -0.0921 S33:   0.1040
REMARK   3   TLS GROUP : 17
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 389 THROUGH 456 )
REMARK   3    ORIGIN FOR THE GROUP (A):  10.7888 125.4045  53.6116
REMARK   3    T TENSOR
REMARK   3      T11:   0.6325 T22:   0.4003
REMARK   3      T33:   0.6205 T12:   0.0952
REMARK   3      T13:   0.1606 T23:  -0.1124
REMARK   3    L TENSOR
REMARK   3      L11:   2.8307 L22:   0.4265
REMARK   3      L33:   2.1597 L12:   0.3360
REMARK   3      L13:  -0.5018 L23:  -0.0053
REMARK   3    S TENSOR
REMARK   3      S11:  -0.4387 S12:  -0.0254 S13:  -0.4596
REMARK   3      S21:   0.1254 S22:   0.1805 S23:  -0.3470
REMARK   3      S31:   0.4202 S32:   0.1422 S33:   0.1441
REMARK   3   TLS GROUP : 18
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 457 THROUGH 503 )
REMARK   3    ORIGIN FOR THE GROUP (A):  16.9758 140.7495  47.0080
REMARK   3    T TENSOR
REMARK   3      T11:   0.4216 T22:   0.5297
REMARK   3      T33:   0.4495 T12:   0.0164
REMARK   3      T13:   0.0759 T23:   0.0085
REMARK   3    L TENSOR
REMARK   3      L11:   3.0748 L22:   1.0398
REMARK   3      L33:   2.9754 L12:   0.9529
REMARK   3      L13:   0.1721 L23:   0.4317
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1397 S12:   0.4644 S13:  -0.3191
REMARK   3      S21:  -0.1070 S22:   0.2046 S23:  -0.0100
REMARK   3      S31:  -0.0833 S32:   0.5573 S33:  -0.0058
REMARK   3   TLS GROUP : 19
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 504 THROUGH 697 )
REMARK   3    ORIGIN FOR THE GROUP (A):  14.1014 139.0198  79.9423
REMARK   3    T TENSOR
REMARK   3      T11:   0.3749 T22:   0.4444
REMARK   3      T33:   0.4387 T12:   0.0989
REMARK   3      T13:   0.0475 T23:   0.0209
REMARK   3    L TENSOR
REMARK   3      L11:   1.7796 L22:   0.9709
REMARK   3      L33:   1.0516 L12:   0.3765
REMARK   3      L13:   0.0098 L23:  -0.2207
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0150 S12:  -0.0720 S13:  -0.2517
REMARK   3      S21:   0.0801 S22:  -0.0890 S23:  -0.1323
REMARK   3      S31:   0.1306 S32:   0.3305 S33:   0.1068
REMARK   3   TLS GROUP : 20
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 698 THROUGH 767 )
REMARK   3    ORIGIN FOR THE GROUP (A):   9.2462 155.7598  83.3871
REMARK   3    T TENSOR
REMARK   3      T11:   0.4301 T22:   0.3977
REMARK   3      T33:   0.4425 T12:   0.0332
REMARK   3      T13:   0.0377 T23:  -0.0528
REMARK   3    L TENSOR
REMARK   3      L11:   1.8034 L22:   1.5788
REMARK   3      L33:   1.9946 L12:  -0.2116
REMARK   3      L13:  -0.7275 L23:  -0.5594
REMARK   3    S TENSOR
REMARK   3      S11:   0.0181 S12:  -0.0994 S13:   0.0242
REMARK   3      S21:   0.0245 S22:   0.1036 S23:  -0.1495
REMARK   3      S31:   0.0034 S32:   0.3738 S33:  -0.0874
REMARK   3   TLS GROUP : 21
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 390 THROUGH 422 )
REMARK   3    ORIGIN FOR THE GROUP (A): 102.1544 140.7744 131.7949
REMARK   3    T TENSOR
REMARK   3      T11:   0.6913 T22:   1.9649
REMARK   3      T33:   1.1318 T12:  -0.2390
REMARK   3      T13:  -0.0597 T23:  -0.0204
REMARK   3    L TENSOR
REMARK   3      L11:   2.5714 L22:   2.3066
REMARK   3      L33:   0.3855 L12:  -2.1963
REMARK   3      L13:  -0.7659 L23:   0.3894
REMARK   3    S TENSOR
REMARK   3      S11:  -0.0036 S12:   0.2544 S13:  -0.3123
REMARK   3      S21:   0.3032 S22:  -0.0459 S23:  -1.3103
REMARK   3      S31:  -0.5304 S32:   1.3423 S33:   0.0309
REMARK   3   TLS GROUP : 22
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 423 THROUGH 438 )
REMARK   3    ORIGIN FOR THE GROUP (A): 105.1873 142.1002 118.0066
REMARK   3    T TENSOR
REMARK   3      T11:   0.7966 T22:   2.2051
REMARK   3      T33:   1.0933 T12:  -0.0846
REMARK   3      T13:   0.2345 T23:  -0.0044
REMARK   3    L TENSOR
REMARK   3      L11:   9.3331 L22:   1.6434
REMARK   3      L33:   2.5671 L12:  -3.9087
REMARK   3      L13:   3.4093 L23:  -1.3244
REMARK   3    S TENSOR
REMARK   3      S11:   0.3429 S12:  -0.6493 S13:  -0.6531
REMARK   3      S21:   0.0068 S22:   0.1988 S23:   0.1943
REMARK   3      S31:  -0.0084 S32:   1.1530 S33:  -0.5642
REMARK   3   TLS GROUP : 23
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 439 THROUGH 448 )
REMARK   3    ORIGIN FOR THE GROUP (A): 109.5405 152.9733 126.1572
REMARK   3    T TENSOR
REMARK   3      T11:   1.0070 T22:   1.9119
REMARK   3      T33:   1.5124 T12:  -0.5315
REMARK   3      T13:  -0.2084 T23:  -0.2986
REMARK   3    L TENSOR
REMARK   3      L11:   0.0584 L22:   1.3870
REMARK   3      L33:   0.1782 L12:   0.1955
REMARK   3      L13:  -0.1019 L23:  -0.3149
REMARK   3    S TENSOR
REMARK   3      S11:   0.5176 S12:  -0.2919 S13:   0.5714
REMARK   3      S21:   0.7226 S22:  -0.6035 S23:  -1.1203
REMARK   3      S31:  -0.3091 S32:   0.6003 S33:  -0.0300
REMARK   3   TLS GROUP : 24
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 449 THROUGH 492 )
REMARK   3    ORIGIN FOR THE GROUP (A):  93.1696 141.6539 119.2341
REMARK   3    T TENSOR
REMARK   3      T11:   0.6721 T22:   1.1467
REMARK   3      T33:   0.6629 T12:  -0.1966
REMARK   3      T13:   0.1012 T23:  -0.0953
REMARK   3    L TENSOR
REMARK   3      L11:   5.1249 L22:   4.0087
REMARK   3      L33:   4.5651 L12:  -1.0317
REMARK   3      L13:   0.1433 L23:  -0.7613
REMARK   3    S TENSOR
REMARK   3      S11:  -0.3037 S12:  -0.0117 S13:   0.0560
REMARK   3      S21:  -0.2324 S22:   0.0448 S23:  -0.9201
REMARK   3      S31:  -0.4190 S32:   1.8366 S33:   0.1575
REMARK   3   TLS GROUP : 25
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 493 THROUGH 503 )
REMARK   3    ORIGIN FOR THE GROUP (A): 100.4574 125.3704 128.0288
REMARK   3    T TENSOR
REMARK   3      T11:   1.0478 T22:   1.5787
REMARK   3      T33:   1.1762 T12:   0.0984
REMARK   3      T13:  -0.0849 T23:   0.0088
REMARK   3    L TENSOR
REMARK   3      L11:   0.4193 L22:   1.7596
REMARK   3      L33:   0.9805 L12:   0.5054
REMARK   3      L13:  -0.2144 L23:   0.5754
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1847 S12:  -0.4862 S13:  -1.0311
REMARK   3      S21:   0.3841 S22:   0.2042 S23:  -1.3380
REMARK   3      S31:   0.4981 S32:   1.9770 S33:  -0.0608
REMARK   3   TLS GROUP : 26
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 504 THROUGH 569 )
REMARK   3    ORIGIN FOR THE GROUP (A):  75.1980 137.8489 126.7693
REMARK   3    T TENSOR
REMARK   3      T11:   0.4265 T22:   0.5103
REMARK   3      T33:   0.4393 T12:  -0.0889
REMARK   3      T13:   0.0007 T23:   0.0656
REMARK   3    L TENSOR
REMARK   3      L11:   5.6285 L22:   4.3595
REMARK   3      L33:   3.8416 L12:  -0.2444
REMARK   3      L13:  -0.1443 L23:   1.8183
REMARK   3    S TENSOR
REMARK   3      S11:  -0.1673 S12:  -0.4441 S13:  -0.0947
REMARK   3      S21:   0.1318 S22:   0.2046 S23:  -0.0161
REMARK   3      S31:  -0.2518 S32:   0.5948 S33:  -0.0572
REMARK   3   TLS GROUP : 27
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 570 THROUGH 590 )
REMARK   3    ORIGIN FOR THE GROUP (A): 100.3357 142.9410 125.1741
REMARK   3    T TENSOR
REMARK   3      T11:   0.7871 T22:   1.7402
REMARK   3      T33:   1.0325 T12:   0.0815
REMARK   3      T13:   0.1025 T23:   0.0039
REMARK   3    L TENSOR
REMARK   3      L11:   3.2353 L22:   1.9812
REMARK   3      L33:   3.0611 L12:   2.2139
REMARK   3      L13:  -0.0090 L23:  -0.1046
REMARK   3    S TENSOR
REMARK   3      S11:   0.0140 S12:   0.5486 S13:  -0.2029
REMARK   3      S21:  -0.0088 S22:   0.9514 S23:  -0.5991
REMARK   3      S31:  -0.5685 S32:   0.6347 S33:  -1.0823
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 8ZE6 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC ON 08-MAY-24.
REMARK 100 THE DEPOSITION ID IS D_1300047545.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 12-OCT-23
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SSRF
REMARK 200  BEAMLINE                       : BL02U1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.979183
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER2 S 9M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS JUN 30, 2023
REMARK 200  DATA SCALING SOFTWARE          : XDS JUN 30, 2023
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 66775
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.700
REMARK 200  RESOLUTION RANGE LOW       (A) : 47.490
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.8
REMARK 200  DATA REDUNDANCY                : 3.880
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 4.9800
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.70
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.87
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER 2.8.3
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 58.13
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.94
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M AMMONIUM TARTRATE DIBASIC (PH
REMARK 280  7.0) AND 12% (WT/VOL) PEG 3350., VAPOR DIFFUSION, SITTING DROP,
REMARK 280  TEMPERATURE 291K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       60.72000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 12680 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 77600 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 36.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, A, E, F, G
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D, H, I, J
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000       38.78406
REMARK 350   BIOMT2   2  0.000000  1.000000  0.000000      -60.72000
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000      213.57868
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     ARG B    40
REMARK 465     GLU B   767
REMARK 465     THR C   589
REMARK 465     ASN C   590
REMARK 465     ASP A   388
REMARK 465     LYS A   389
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLU D  97    CG   CD   OE1  OE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   ND2  ASN B    92     O5   NAG B   802              2.06
REMARK 500   O    LYS D   123     OG   SER D   127              2.09
REMARK 500   O    LYS B   123     OG   SER B   127              2.13
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    SER B  64     -168.33   -162.35
REMARK 500    HIS B  66       17.57   -142.40
REMARK 500    ASP B  96       16.45     57.26
REMARK 500    TRP B 124     -161.87     57.43
REMARK 500    GLU B 146       71.39     58.24
REMARK 500    HIS B 162       35.58   -144.60
REMARK 500    VAL B 193      -65.81   -131.83
REMARK 500    ASP B 200     -152.89    -88.85
REMARK 500    VAL B 207      -61.22   -100.22
REMARK 500    ALA B 213       43.29   -142.82
REMARK 500    ASP B 230       49.13   -107.39
REMARK 500    SER B 242     -152.64     59.76
REMARK 500    PHE B 357      -50.71   -131.19
REMARK 500    VAL B 401       43.85    -87.26
REMARK 500    THR B 411     -164.97   -110.47
REMARK 500    LYS B 423       14.38     56.71
REMARK 500    ASN B 450       76.82   -151.77
REMARK 500    SER B 486      -71.70    -66.39
REMARK 500    TYR B 547      -60.86   -126.81
REMARK 500    THR B 557       55.06   -118.92
REMARK 500    ASN B 562     -157.30   -123.43
REMARK 500    ARG B 596       17.66     56.42
REMARK 500    ARG B 597       53.32   -143.39
REMARK 500    LEU B 601      -57.32     64.45
REMARK 500    ASN B 615        0.86    -68.54
REMARK 500    SER B 630     -112.63     57.65
REMARK 500    ASP B 678     -102.16   -127.59
REMARK 500    SER B 686       50.28    -95.36
REMARK 500    ASN B 710      -76.71    -98.92
REMARK 500    ASP B 739     -161.95    -77.81
REMARK 500    LYS C 389     -158.52    -88.85
REMARK 500    PHE C 431       69.11   -156.07
REMARK 500    ALA C 440        3.86    -69.15
REMARK 500    ASN C 476      -76.05   -141.65
REMARK 500    THR C 497       35.32    -91.52
REMARK 500    CYS C 510       79.41   -152.52
REMARK 500    GLU C 557       35.72    -87.79
REMARK 500    SER D  64     -157.41   -157.33
REMARK 500    PRO D 109       12.28    -68.74
REMARK 500    TRP D 124     -164.25     61.76
REMARK 500    GLU D 146       83.41     56.50
REMARK 500    HIS D 162       32.46   -141.02
REMARK 500    VAL D 193      -63.17   -128.32
REMARK 500    ASP D 230       46.14   -108.06
REMARK 500    SER D 242     -156.51     59.24
REMARK 500    PRO D 255       99.55    -59.37
REMARK 500    LYS D 423       17.62     59.27
REMARK 500    ASN D 450       85.64   -151.28
REMARK 500    TYR D 547      -50.36   -120.36
REMARK 500    THR D 557       52.61    -98.52
REMARK 500
REMARK 500 THIS ENTRY HAS      76 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
DBREF  8ZE6 B   40   767  PDB    8ZE6     8ZE6            40    767
DBREF1 8ZE6 C  388   590  UNP                  A0AAE8ZFM2_9BETC
DBREF2 8ZE6 C     A0AAE8ZFM2                        388         590
DBREF  8ZE6 D   40   767  PDB    8ZE6     8ZE6            40    767
DBREF1 8ZE6 A  388   590  UNP                  A0AAE8ZFM2_9BETC
DBREF2 8ZE6 A     A0AAE8ZFM2                        388         590
SEQADV 8ZE6 ASP C  388  UNP  A0AAE8ZFM SER   388 CONFLICT
SEQADV 8ZE6 ALA C  482  UNP  A0AAE8ZFM SER   482 CONFLICT
SEQADV 8ZE6 GLU C  544  UNP  A0AAE8ZFM VAL   544 CONFLICT
SEQADV 8ZE6 ASP A  388  UNP  A0AAE8ZFM SER   388 CONFLICT
SEQADV 8ZE6 ALA A  482  UNP  A0AAE8ZFM SER   482 CONFLICT
SEQADV 8ZE6 GLU A  544  UNP  A0AAE8ZFM VAL   544 CONFLICT
SEQRES   1 B  728  ARG ARG THR TYR THR LEU THR ASP TYR LEU LYS ASN THR
SEQRES   2 B  728  PHE ARG VAL LYS PHE TYR SER LEU ARG TRP VAL SER ASP
SEQRES   3 B  728  HIS GLU TYR LEU TYR LYS GLN GLU ASN ASN ILE LEU LEU
SEQRES   4 B  728  PHE ASN ALA GLU TYR GLY ASN SER SER ILE PHE LEU GLU
SEQRES   5 B  728  ASN SER THR PHE ASP GLU PHE GLY HIS SER ILE ASN ASP
SEQRES   6 B  728  TYR SER VAL SER PRO ASP GLY GLN PHE ILE LEU PHE GLU
SEQRES   7 B  728  TYR ASN TYR VAL LYS LYS TRP ARG HIS SER TYR THR ALA
SEQRES   8 B  728  SER TYR ASP ILE TYR ASP LEU HIS LYS ARG GLN LEU ILE
SEQRES   9 B  728  THR GLU GLU ARG ILE PRO ASN ASN THR GLN TRP ILE THR
SEQRES  10 B  728  TRP SER PRO VAL GLY HIS LYS LEU ALA TYR VAL TRP HIS
SEQRES  11 B  728  ASN ASP ILE TYR ILE LYS LYS GLU PRO ASN LEU GLN SER
SEQRES  12 B  728  GLN ARG ILE THR TRP THR GLY LYS GLU ASP VAL ILE TYR
SEQRES  13 B  728  ASN GLY ILE THR ASP TRP VAL TYR GLU GLU GLU VAL PHE
SEQRES  14 B  728  SER ALA TYR SER ALA LEU TRP TRP SER PRO ASN GLY THR
SEQRES  15 B  728  PHE LEU ALA TYR ALA GLN PHE ASN ASP THR GLU VAL PRO
SEQRES  16 B  728  LEU ILE GLU TYR SER PHE TYR SER ASP GLU SER LEU GLN
SEQRES  17 B  728  TYR PRO LYS THR MET GLN VAL PRO TYR PRO LYS ALA GLY
SEQRES  18 B  728  ALA ALA ASN PRO THR VAL LYS LEU PHE VAL VAL ASN THR
SEQRES  19 B  728  ASP SER LEU ASN SER THR ALA ASN ALA THR SER VAL GLN
SEQRES  20 B  728  VAL VAL PRO PRO ALA SER VAL LEU ILE GLY ASP HIS TYR
SEQRES  21 B  728  LEU CYS ASP VAL THR TRP VAL ASN GLU GLU ARG ILE SER
SEQRES  22 B  728  LEU GLN TRP LEU ARG ARG ILE GLN ASN TYR SER VAL LEU
SEQRES  23 B  728  ALA ILE CYS ASP TYR ASP LYS PRO THR GLY ARG TRP ALA
SEQRES  24 B  728  SER HIS VAL ARG GLN GLN HIS ILE GLU SER SER THR THR
SEQRES  25 B  728  GLY TRP VAL GLY ARG PHE LYS PRO SER GLU PRO HIS PHE
SEQRES  26 B  728  THR SER ASP GLY ASN SER PHE TYR LYS ILE ILE SER ASN
SEQRES  27 B  728  LYS GLU GLY TYR LYS HIS ILE CYS HIS PHE GLN VAL ASP
SEQRES  28 B  728  ARG GLU ASN CYS THR PHE ILE THR LYS GLY VAL TRP GLU
SEQRES  29 B  728  VAL ILE GLY ILE GLU ALA LEU THR SER ASP ASP LEU TYR
SEQRES  30 B  728  TYR ILE SER ASN GLU TYR LYS GLY MET PRO GLY GLY ARG
SEQRES  31 B  728  ASN LEU TYR LYS ILE GLN LEU ASN ASP HIS THR LYS VAL
SEQRES  32 B  728  THR CYS LEU SER CYS GLU LEU ASN THR GLU ARG CYS GLN
SEQRES  33 B  728  TYR TYR SER VAL SER PHE SER LYS GLU ALA LYS TYR TYR
SEQRES  34 B  728  GLN LEU ARG CYS SER GLY PRO GLY LEU PRO LEU TYR THR
SEQRES  35 B  728  LEU HIS SER SER SER ASN ASP LYS GLU LEU ARG VAL LEU
SEQRES  36 B  728  GLU ASP ASN SER ALA LEU ASP LYS MET LEU GLN ASP VAL
SEQRES  37 B  728  GLN MET PRO SER LYS LYS LEU ASP PHE ILE ILE TRP ASN
SEQRES  38 B  728  GLY ILE LYS LEU TRP TYR GLN MET ILE LEU PRO PRO HIS
SEQRES  39 B  728  PHE ASP LYS LEU LYS LYS TYR PRO LEU LEU ILE ASP VAL
SEQRES  40 B  728  TYR ALA GLY PRO CYS SER GLN LYS ALA ASP THR VAL PHE
SEQRES  41 B  728  ARG LEU ASN TRP ALA THR TYR LEU ALA SER THR GLU LYS
SEQRES  42 B  728  ILE ILE VAL ALA SER PHE ASP GLY ARG GLY SER GLY TYR
SEQRES  43 B  728  GLN GLY ASP LYS ILE LEU HIS ALA ILE ASN ARG ARG LEU
SEQRES  44 B  728  GLY THR LEU GLU VAL GLU ASP GLN ILE GLU ALA ALA ARG
SEQRES  45 B  728  GLN PHE THR ASN MET GLY PHE VAL ASP GLU LYS ARG ILE
SEQRES  46 B  728  ALA ILE TRP GLY TRP SER TYR GLY GLY TYR VAL THR SER
SEQRES  47 B  728  MET VAL LEU GLY ALA GLY SER GLY VAL PHE LYS CYS GLY
SEQRES  48 B  728  ILE ALA VAL ALA PRO VAL SER ARG TRP GLU TYR TYR ASP
SEQRES  49 B  728  SER VAL TYR THR GLU ARG TYR MET GLY LEU PRO THR PRO
SEQRES  50 B  728  GLU ASP ASN LEU GLU HIS TYR ARG ASN SER THR VAL MET
SEQRES  51 B  728  SER ARG ALA GLU ASN PHE LYS GLN VAL GLU TYR LEU LEU
SEQRES  52 B  728  ILE HIS GLY THR ALA ASP ASP ASN VAL HIS PHE GLN GLN
SEQRES  53 B  728  SER ALA GLN ILE SER LYS ALA LEU VAL ASP ALA GLY VAL
SEQRES  54 B  728  ASP PHE GLN ALA MET TRP TYR THR ASP GLU ASP HIS GLY
SEQRES  55 B  728  ILE ALA SER SER THR ALA HIS GLN HIS ILE TYR THR HIS
SEQRES  56 B  728  MET SER HIS PHE ILE LYS GLN CYS PHE SER LEU PRO GLU
SEQRES   1 C  203  ASP LYS GLU CYS ASP PHE THR PRO MET LEU VAL GLY VAL
SEQRES   2 C  203  PRO PRO GLN VAL TYR ASN PHE LYS ARG LEU VAL PHE THR
SEQRES   3 C  203  ASN CYS ASN TYR ASN LEU THR LYS LEU LEU SER LEU PHE
SEQRES   4 C  203  MET VAL ASN GLU PHE SER CYS ASN GLY ILE SER PRO ASP
SEQRES   5 C  203  ALA ILE ALA ARG GLY CYS TYR SER SER LEU THR VAL ASP
SEQRES   6 C  203  TYR PHE ALA TYR PRO LEU SER MET ARG SER TYR ILE GLN
SEQRES   7 C  203  PRO GLY SER ALA GLY ASP ILE SER LEU TYR ASN TYR LYS
SEQRES   8 C  203  GLN SER PHE ALA ASN PRO THR CYS ARG VAL LEU ALA THR
SEQRES   9 C  203  ALA PRO ALA ASN LEU THR LEU THR LYS PRO SER ALA TYR
SEQRES  10 C  203  GLY TYR PHE GLN LYS CYS SER ARG VAL SER GLY GLU HIS
SEQRES  11 C  203  ASN SER VAL GLU THR PRO LEU TYR ILE ASN PRO GLY GLU
SEQRES  12 C  203  TYR SER ILE CYS ARG SER PHE SER PRO TYR GLY PHE SER
SEQRES  13 C  203  GLU ASP GLY GLU VAL PHE ARG ARG GLN LEU THR GLN TYR
SEQRES  14 C  203  GLU GLY GLY GLY ILE LEU VAL GLY VAL GLY ALA LYS LEU
SEQRES  15 C  203  ALA MET THR ASP LYS LEU GLU MET GLY PHE ILE ILE SER
SEQRES  16 C  203  VAL GLN TYR GLY THR ASP THR ASN
SEQRES   1 D  728  ARG ARG THR TYR THR LEU THR ASP TYR LEU LYS ASN THR
SEQRES   2 D  728  PHE ARG VAL LYS PHE TYR SER LEU ARG TRP VAL SER ASP
SEQRES   3 D  728  HIS GLU TYR LEU TYR LYS GLN GLU ASN ASN ILE LEU LEU
SEQRES   4 D  728  PHE ASN ALA GLU TYR GLY ASN SER SER ILE PHE LEU GLU
SEQRES   5 D  728  ASN SER THR PHE ASP GLU PHE GLY HIS SER ILE ASN ASP
SEQRES   6 D  728  TYR SER VAL SER PRO ASP GLY GLN PHE ILE LEU PHE GLU
SEQRES   7 D  728  TYR ASN TYR VAL LYS LYS TRP ARG HIS SER TYR THR ALA
SEQRES   8 D  728  SER TYR ASP ILE TYR ASP LEU HIS LYS ARG GLN LEU ILE
SEQRES   9 D  728  THR GLU GLU ARG ILE PRO ASN ASN THR GLN TRP ILE THR
SEQRES  10 D  728  TRP SER PRO VAL GLY HIS LYS LEU ALA TYR VAL TRP HIS
SEQRES  11 D  728  ASN ASP ILE TYR ILE LYS LYS GLU PRO ASN LEU GLN SER
SEQRES  12 D  728  GLN ARG ILE THR TRP THR GLY LYS GLU ASP VAL ILE TYR
SEQRES  13 D  728  ASN GLY ILE THR ASP TRP VAL TYR GLU GLU GLU VAL PHE
SEQRES  14 D  728  SER ALA TYR SER ALA LEU TRP TRP SER PRO ASN GLY THR
SEQRES  15 D  728  PHE LEU ALA TYR ALA GLN PHE ASN ASP THR GLU VAL PRO
SEQRES  16 D  728  LEU ILE GLU TYR SER PHE TYR SER ASP GLU SER LEU GLN
SEQRES  17 D  728  TYR PRO LYS THR MET GLN VAL PRO TYR PRO LYS ALA GLY
SEQRES  18 D  728  ALA ALA ASN PRO THR VAL LYS LEU PHE VAL VAL ASN THR
SEQRES  19 D  728  ASP SER LEU ASN SER THR ALA ASN ALA THR SER VAL GLN
SEQRES  20 D  728  VAL VAL PRO PRO ALA SER VAL LEU ILE GLY ASP HIS TYR
SEQRES  21 D  728  LEU CYS ASP VAL THR TRP VAL ASN GLU GLU ARG ILE SER
SEQRES  22 D  728  LEU GLN TRP LEU ARG ARG ILE GLN ASN TYR SER VAL LEU
SEQRES  23 D  728  ALA ILE CYS ASP TYR ASP LYS PRO THR GLY ARG TRP ALA
SEQRES  24 D  728  SER HIS VAL ARG GLN GLN HIS ILE GLU SER SER THR THR
SEQRES  25 D  728  GLY TRP VAL GLY ARG PHE LYS PRO SER GLU PRO HIS PHE
SEQRES  26 D  728  THR SER ASP GLY ASN SER PHE TYR LYS ILE ILE SER ASN
SEQRES  27 D  728  LYS GLU GLY TYR LYS HIS ILE CYS HIS PHE GLN VAL ASP
SEQRES  28 D  728  ARG GLU ASN CYS THR PHE ILE THR LYS GLY VAL TRP GLU
SEQRES  29 D  728  VAL ILE GLY ILE GLU ALA LEU THR SER ASP ASP LEU TYR
SEQRES  30 D  728  TYR ILE SER ASN GLU TYR LYS GLY MET PRO GLY GLY ARG
SEQRES  31 D  728  ASN LEU TYR LYS ILE GLN LEU ASN ASP HIS THR LYS VAL
SEQRES  32 D  728  THR CYS LEU SER CYS GLU LEU ASN THR GLU ARG CYS GLN
SEQRES  33 D  728  TYR TYR SER VAL SER PHE SER LYS GLU ALA LYS TYR TYR
SEQRES  34 D  728  GLN LEU ARG CYS SER GLY PRO GLY LEU PRO LEU TYR THR
SEQRES  35 D  728  LEU HIS SER SER SER ASN ASP LYS GLU LEU ARG VAL LEU
SEQRES  36 D  728  GLU ASP ASN SER ALA LEU ASP LYS MET LEU GLN ASP VAL
SEQRES  37 D  728  GLN MET PRO SER LYS LYS LEU ASP PHE ILE ILE TRP ASN
SEQRES  38 D  728  GLY ILE LYS LEU TRP TYR GLN MET ILE LEU PRO PRO HIS
SEQRES  39 D  728  PHE ASP LYS LEU LYS LYS TYR PRO LEU LEU ILE ASP VAL
SEQRES  40 D  728  TYR ALA GLY PRO CYS SER GLN LYS ALA ASP THR VAL PHE
SEQRES  41 D  728  ARG LEU ASN TRP ALA THR TYR LEU ALA SER THR GLU LYS
SEQRES  42 D  728  ILE ILE VAL ALA SER PHE ASP GLY ARG GLY SER GLY TYR
SEQRES  43 D  728  GLN GLY ASP LYS ILE LEU HIS ALA ILE ASN ARG ARG LEU
SEQRES  44 D  728  GLY THR LEU GLU VAL GLU ASP GLN ILE GLU ALA ALA ARG
SEQRES  45 D  728  GLN PHE THR ASN MET GLY PHE VAL ASP GLU LYS ARG ILE
SEQRES  46 D  728  ALA ILE TRP GLY TRP SER TYR GLY GLY TYR VAL THR SER
SEQRES  47 D  728  MET VAL LEU GLY ALA GLY SER GLY VAL PHE LYS CYS GLY
SEQRES  48 D  728  ILE ALA VAL ALA PRO VAL SER ARG TRP GLU TYR TYR ASP
SEQRES  49 D  728  SER VAL TYR THR GLU ARG TYR MET GLY LEU PRO THR PRO
SEQRES  50 D  728  GLU ASP ASN LEU GLU HIS TYR ARG ASN SER THR VAL MET
SEQRES  51 D  728  SER ARG ALA GLU ASN PHE LYS GLN VAL GLU TYR LEU LEU
SEQRES  52 D  728  ILE HIS GLY THR ALA ASP ASP ASN VAL HIS PHE GLN GLN
SEQRES  53 D  728  SER ALA GLN ILE SER LYS ALA LEU VAL ASP ALA GLY VAL
SEQRES  54 D  728  ASP PHE GLN ALA MET TRP TYR THR ASP GLU ASP HIS GLY
SEQRES  55 D  728  ILE ALA SER SER THR ALA HIS GLN HIS ILE TYR THR HIS
SEQRES  56 D  728  MET SER HIS PHE ILE LYS GLN CYS PHE SER LEU PRO GLU
SEQRES   1 A  203  ASP LYS GLU CYS ASP PHE THR PRO MET LEU VAL GLY VAL
SEQRES   2 A  203  PRO PRO GLN VAL TYR ASN PHE LYS ARG LEU VAL PHE THR
SEQRES   3 A  203  ASN CYS ASN TYR ASN LEU THR LYS LEU LEU SER LEU PHE
SEQRES   4 A  203  MET VAL ASN GLU PHE SER CYS ASN GLY ILE SER PRO ASP
SEQRES   5 A  203  ALA ILE ALA ARG GLY CYS TYR SER SER LEU THR VAL ASP
SEQRES   6 A  203  TYR PHE ALA TYR PRO LEU SER MET ARG SER TYR ILE GLN
SEQRES   7 A  203  PRO GLY SER ALA GLY ASP ILE SER LEU TYR ASN TYR LYS
SEQRES   8 A  203  GLN SER PHE ALA ASN PRO THR CYS ARG VAL LEU ALA THR
SEQRES   9 A  203  ALA PRO ALA ASN LEU THR LEU THR LYS PRO SER ALA TYR
SEQRES  10 A  203  GLY TYR PHE GLN LYS CYS SER ARG VAL SER GLY GLU HIS
SEQRES  11 A  203  ASN SER VAL GLU THR PRO LEU TYR ILE ASN PRO GLY GLU
SEQRES  12 A  203  TYR SER ILE CYS ARG SER PHE SER PRO TYR GLY PHE SER
SEQRES  13 A  203  GLU ASP GLY GLU VAL PHE ARG ARG GLN LEU THR GLN TYR
SEQRES  14 A  203  GLU GLY GLY GLY ILE LEU VAL GLY VAL GLY ALA LYS LEU
SEQRES  15 A  203  ALA MET THR ASP LYS LEU GLU MET GLY PHE ILE ILE SER
SEQRES  16 A  203  VAL GLN TYR GLY THR ASP THR ASN
HET    NAG  E   1      14
HET    NAG  E   2      14
HET    NAG  F   1      14
HET    NAG  F   2      14
HET    NAG  G   1      14
HET    NAG  G   2      14
HET    NAG  H   1      14
HET    NAG  H   2      14
HET    NAG  I   1      14
HET    NAG  I   2      14
HET    NAG  J   1      14
HET    NAG  J   2      14
HET    NAG  B 801      14
HET    NAG  B 802      14
HET    GOL  B 803       6
HET    NAG  D 801      14
HET    NAG  D 802      14
HET    NAG  D 803      14
HETNAM     NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE
HETNAM     GOL GLYCEROL
HETSYN     NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA-
HETSYN   2 NAG  D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO-
HETSYN   3 NAG  2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   5  NAG    17(C8 H15 N O6)
FORMUL  13  GOL    C3 H8 O3
FORMUL  17  HOH   *157(H2 O)
HELIX    1 AA1 THR B   44  LYS B   50  1                                   7
HELIX    2 AA2 ASP B  200  GLU B  206  1                                   7
HELIX    3 AA3 GLU B  421  MET B  425  5                                   5
HELIX    4 AA4 LYS B  463  LYS B  466  5                                   4
HELIX    5 AA5 ASN B  497  LEU B  504  1                                   8
HELIX    6 AA6 ASN B  562  THR B  570  1                                   9
HELIX    7 AA7 GLY B  587  HIS B  592  1                                   6
HELIX    8 AA8 ALA B  593  ASN B  595  5                                   3
HELIX    9 AA9 LEU B  601  ASN B  615  1                                  15
HELIX   10 AB1 SER B  630  GLY B  641  1                                  12
HELIX   11 AB2 ARG B  658  TYR B  662  5                                   5
HELIX   12 AB3 ASP B  663  GLY B  672  1                                  10
HELIX   13 AB4 ASN B  679  SER B  686  1                                   8
HELIX   14 AB5 VAL B  688  VAL B  698  5                                  11
HELIX   15 AB6 HIS B  712  ALA B  726  1                                  15
HELIX   16 AB7 SER B  744  SER B  764  1                                  21
HELIX   17 AB8 PHE C  393  LEU C  397  5                                   5
HELIX   18 AB9 ASN C  418  PHE C  426  1                                   9
HELIX   19 AC1 PRO C  457  ILE C  464  5                                   8
HELIX   20 AC2 GLY C  470  ASN C  476  1                                   7
HELIX   21 AC3 GLY C  515  SER C  519  5                                   5
HELIX   22 AC4 SER C  532  PHE C  537  5                                   6
HELIX   23 AC5 THR D   44  LYS D   50  1                                   7
HELIX   24 AC6 GLU D   91  ASP D   96  1                                   6
HELIX   25 AC7 ASP D  200  GLU D  206  1                                   7
HELIX   26 AC8 ASP D  274  LEU D  276  5                                   3
HELIX   27 AC9 PRO D  290  LEU D  294  5                                   5
HELIX   28 AD1 GLU D  421  MET D  425  5                                   5
HELIX   29 AD2 LYS D  463  ALA D  465  5                                   3
HELIX   30 AD3 ASN D  497  LEU D  504  1                                   8
HELIX   31 AD4 ASN D  562  THR D  570  1                                   9
HELIX   32 AD5 GLY D  587  HIS D  592  1                                   6
HELIX   33 AD6 ALA D  593  ASN D  595  5                                   3
HELIX   34 AD7 THR D  600  ASN D  615  1                                  16
HELIX   35 AD8 SER D  630  GLY D  641  1                                  12
HELIX   36 AD9 ASP D  663  GLY D  672  1                                  10
HELIX   37 AE1 ASN D  679  SER D  686  1                                   8
HELIX   38 AE2 VAL D  688  VAL D  698  5                                  11
HELIX   39 AE3 HIS D  712  ALA D  726  1                                  15
HELIX   40 AE4 SER D  744  PHE D  763  1                                  20
HELIX   41 AE5 PHE A  393  VAL A  398  5                                   6
HELIX   42 AE6 GLN A  403  PHE A  407  5                                   5
HELIX   43 AE7 LEU A  422  PHE A  426  5                                   5
HELIX   44 AE8 PRO A  438  ARG A  443  5                                   6
HELIX   45 AE9 PRO A  457  ILE A  464  5                                   8
HELIX   46 AF1 GLY A  470  ASN A  476  1                                   7
HELIX   47 AF2 GLY A  515  SER A  519  5                                   5
HELIX   48 AF3 SER A  532  SER A  536  5                                   5
HELIX   49 AF4 THR A  554  GLY A  558  5                                   5
SHEET    1 AA1 4 LEU B  60  TRP B  62  0
SHEET    2 AA1 4 GLU B  67  LYS B  71 -1  O  LEU B  69   N  ARG B  61
SHEET    3 AA1 4 ILE B  76  ASN B  80 -1  O  PHE B  79   N  TYR B  68
SHEET    4 AA1 4 SER B  86  LEU B  90 -1  O  SER B  87   N  LEU B  78
SHEET    1 AA2 3 ASP B 104  VAL B 107  0
SHEET    2 AA2 3 PHE B 113  LYS B 123 -1  O  GLU B 117   N  ASP B 104
SHEET    3 AA2 3 SER B 127  ASP B 136 -1  O  SER B 131   N  TYR B 118
SHEET    1 AA3 4 TRP B 154  TRP B 157  0
SHEET    2 AA3 4 LEU B 164  TRP B 168 -1  O  VAL B 167   N  TRP B 154
SHEET    3 AA3 4 ASP B 171  LYS B 175 -1  O  LYS B 175   N  LEU B 164
SHEET    4 AA3 4 GLN B 183  ARG B 184 -1  O  GLN B 183   N  ILE B 174
SHEET    1 AA4 3 ILE B 194  ASN B 196  0
SHEET    2 AA4 3 PHE B 222  ASN B 229 -1  O  PHE B 228   N  TYR B 195
SHEET    3 AA4 3 LEU B 214  TRP B 216 -1  N  TRP B 215   O  ALA B 224
SHEET    1 AA5 4 ILE B 194  ASN B 196  0
SHEET    2 AA5 4 PHE B 222  ASN B 229 -1  O  PHE B 228   N  TYR B 195
SHEET    3 AA5 4 THR B 265  ASN B 272 -1  O  PHE B 269   N  TYR B 225
SHEET    4 AA5 4 SER B 284  GLN B 286 -1  O  VAL B 285   N  VAL B 270
SHEET    1 AA6 2 LEU B 235  PHE B 240  0
SHEET    2 AA6 2 LYS B 250  PRO B 255 -1  O  LYS B 250   N  PHE B 240
SHEET    1 AA7 4 HIS B 298  ASN B 307  0
SHEET    2 AA7 4 ARG B 310  ARG B 317 -1  O  LEU B 316   N  TYR B 299
SHEET    3 AA7 4 TYR B 322  TYR B 330 -1  O  ALA B 326   N  LEU B 313
SHEET    4 AA7 4 TRP B 337  SER B 348 -1  O  HIS B 345   N  LEU B 325
SHEET    1 AA8 4 HIS B 363  PHE B 364  0
SHEET    2 AA8 4 SER B 370  SER B 376 -1  O  TYR B 372   N  HIS B 363
SHEET    3 AA8 4 LYS B 382  GLN B 388 -1  O  CYS B 385   N  LYS B 373
SHEET    4 AA8 4 CYS B 394  PHE B 396 -1  O  THR B 395   N  HIS B 386
SHEET    1 AA9 4 VAL B 404  LEU B 410  0
SHEET    2 AA9 4 ASP B 414  SER B 419 -1  O  TYR B 416   N  GLU B 408
SHEET    3 AA9 4 ASN B 430  GLN B 435 -1  O  TYR B 432   N  TYR B 417
SHEET    4 AA9 4 VAL B 442  CYS B 444 -1  O  THR B 443   N  LYS B 433
SHEET    1 AB1 4 TYR B 457  PHE B 461  0
SHEET    2 AB1 4 TYR B 468  CYS B 472 -1  O  ARG B 471   N  SER B 458
SHEET    3 AB1 4 TYR B 480  SER B 484 -1  O  THR B 481   N  LEU B 470
SHEET    4 AB1 4 LYS B 489  GLU B 495 -1  O  GLU B 495   N  TYR B 480
SHEET    1 AB2 8 LYS B 513  TRP B 519  0
SHEET    2 AB2 8 ILE B 522  ILE B 529 -1  O  LEU B 524   N  ILE B 517
SHEET    3 AB2 8 ILE B 574  ASP B 579 -1  O  VAL B 575   N  ILE B 529
SHEET    4 AB2 8 TYR B 540  VAL B 546  1  N  LEU B 543   O  ILE B 574
SHEET    5 AB2 8 VAL B 619  TRP B 629  1  O  ASP B 620   N  TYR B 540
SHEET    6 AB2 8 CYS B 649  VAL B 653  1  O  VAL B 653   N  GLY B 628
SHEET    7 AB2 8 GLU B 699  GLY B 705  1  O  ILE B 703   N  ALA B 652
SHEET    8 AB2 8 GLN B 731  TYR B 735  1  O  GLN B 731   N  TYR B 700
SHEET    1 AB3 2 LYS C 389  GLU C 390  0
SHEET    2 AB3 2 CYS C 415  ASN C 416  1  O  ASN C 416   N  LYS C 389
SHEET    1 AB4 3 LYS C 408  PHE C 412  0
SHEET    2 AB4 3 LEU C 449  ALA C 455 -1  O  VAL C 451   N  LEU C 410
SHEET    3 AB4 3 LEU C 575  VAL C 583 -1  O  ILE C 580   N  ASP C 452
SHEET    1 AB5 2 MET C 427  ASN C 434  0
SHEET    2 AB5 2 THR C 485  ALA C 492 -1  O  LEU C 489   N  ASN C 429
SHEET    1 AB6 4 VAL C 520  PRO C 523  0
SHEET    2 AB6 4 TYR C 504  SER C 514 -1  N  SER C 514   O  VAL C 520
SHEET    3 AB6 4 ILE C 561  LEU C 569 -1  O  ALA C 567   N  TYR C 506
SHEET    4 AB6 4 VAL C 548  GLN C 552 -1  N  ARG C 551   O  LEU C 562
SHEET    1 AB7 4 ARG D  61  TRP D  62  0
SHEET    2 AB7 4 GLU D  67  GLN D  72 -1  O  LEU D  69   N  ARG D  61
SHEET    3 AB7 4 ASN D  75  ASN D  80 -1  O  LEU D  77   N  TYR D  70
SHEET    4 AB7 4 SER D  86  LEU D  90 -1  O  SER D  87   N  LEU D  78
SHEET    1 AB8 4 ASP D 104  VAL D 107  0
SHEET    2 AB8 4 PHE D 113  LYS D 122 -1  O  LEU D 115   N  SER D 106
SHEET    3 AB8 4 TYR D 128  ASP D 136 -1  O  TYR D 135   N  ILE D 114
SHEET    4 AB8 4 GLN D 141  LEU D 142 -1  O  GLN D 141   N  ASP D 136
SHEET    1 AB9 4 ASP D 104  VAL D 107  0
SHEET    2 AB9 4 PHE D 113  LYS D 122 -1  O  LEU D 115   N  SER D 106
SHEET    3 AB9 4 TYR D 128  ASP D 136 -1  O  TYR D 135   N  ILE D 114
SHEET    4 AB9 4 ILE D 148  THR D 152 -1  O  THR D 152   N  ALA D 130
SHEET    1 AC1 4 TRP D 154  TRP D 157  0
SHEET    2 AC1 4 LEU D 164  VAL D 167 -1  O  VAL D 167   N  TRP D 154
SHEET    3 AC1 4 ILE D 172  LYS D 175 -1  O  LYS D 175   N  LEU D 164
SHEET    4 AC1 4 GLN D 183  ARG D 184 -1  O  GLN D 183   N  ILE D 174
SHEET    1 AC2 3 ILE D 194  ASN D 196  0
SHEET    2 AC2 3 PHE D 222  ASN D 229 -1  O  PHE D 228   N  TYR D 195
SHEET    3 AC2 3 LEU D 214  TRP D 216 -1  N  TRP D 215   O  ALA D 224
SHEET    1 AC3 4 ILE D 194  ASN D 196  0
SHEET    2 AC3 4 PHE D 222  ASN D 229 -1  O  PHE D 228   N  TYR D 195
SHEET    3 AC3 4 THR D 265  ASN D 272 -1  O  LYS D 267   N  GLN D 227
SHEET    4 AC3 4 SER D 284  GLN D 286 -1  O  VAL D 285   N  VAL D 270
SHEET    1 AC4 2 LEU D 235  PHE D 240  0
SHEET    2 AC4 2 LYS D 250  PRO D 255 -1  O  LYS D 250   N  PHE D 240
SHEET    1 AC5 4 HIS D 298  ASN D 307  0
SHEET    2 AC5 4 ARG D 310  ARG D 317 -1  O  SER D 312   N  THR D 304
SHEET    3 AC5 4 TYR D 322  TYR D 330 -1  O  ALA D 326   N  LEU D 313
SHEET    4 AC5 4 TRP D 337  SER D 348 -1  O  ALA D 338   N  ASP D 329
SHEET    1 AC6 4 HIS D 363  PHE D 364  0
SHEET    2 AC6 4 SER D 370  SER D 376 -1  O  TYR D 372   N  HIS D 363
SHEET    3 AC6 4 LYS D 382  GLN D 388 -1  O  HIS D 383   N  ILE D 375
SHEET    4 AC6 4 CYS D 394  PHE D 396 -1  O  THR D 395   N  HIS D 386
SHEET    1 AC7 4 VAL D 404  LEU D 410  0
SHEET    2 AC7 4 ASP D 414  SER D 419 -1  O  TYR D 416   N  ALA D 409
SHEET    3 AC7 4 ASN D 430  GLN D 435 -1  O  TYR D 432   N  TYR D 417
SHEET    4 AC7 4 VAL D 442  CYS D 444 -1  O  THR D 443   N  LYS D 433
SHEET    1 AC8 4 CYS D 454  PHE D 461  0
SHEET    2 AC8 4 TYR D 467  PRO D 475 -1  O  GLY D 474   N  GLN D 455
SHEET    3 AC8 4 LEU D 479  SER D 484 -1  O  LEU D 479   N  CYS D 472
SHEET    4 AC8 4 LYS D 489  GLU D 495 -1  O  GLU D 495   N  TYR D 480
SHEET    1 AC9 8 SER D 511  ILE D 518  0
SHEET    2 AC9 8 LYS D 523  LEU D 530 -1  O  MET D 528   N  LYS D 513
SHEET    3 AC9 8 ILE D 574  PHE D 578 -1  O  VAL D 575   N  ILE D 529
SHEET    4 AC9 8 TYR D 540  VAL D 546  1  N  ASP D 545   O  ALA D 576
SHEET    5 AC9 8 VAL D 619  TRP D 629  1  O  ASP D 620   N  TYR D 540
SHEET    6 AC9 8 CYS D 649  VAL D 653  1  O  VAL D 653   N  GLY D 628
SHEET    7 AC9 8 GLU D 699  GLY D 705  1  O  LEU D 701   N  ALA D 652
SHEET    8 AC9 8 GLN D 731  TYR D 735  1  O  GLN D 731   N  TYR D 700
SHEET    1 AD1 5 LYS A 408  PHE A 412  0
SHEET    2 AD1 5 LEU A 449  ALA A 455 -1  O  VAL A 451   N  LEU A 410
SHEET    3 AD1 5 GLU A 576  VAL A 583 -1  O  SER A 582   N  THR A 450
SHEET    4 AD1 5 THR A 485  THR A 491 -1  N  VAL A 488   O  PHE A 579
SHEET    5 AD1 5 MET A 427  GLU A 430 -1  N  GLU A 430   O  LEU A 489
SHEET    1 AD2 5 LYS A 408  PHE A 412  0
SHEET    2 AD2 5 LEU A 449  ALA A 455 -1  O  VAL A 451   N  LEU A 410
SHEET    3 AD2 5 GLU A 576  VAL A 583 -1  O  SER A 582   N  THR A 450
SHEET    4 AD2 5 THR A 485  THR A 491 -1  N  VAL A 488   O  PHE A 579
SHEET    5 AD2 5 CYS A 433  ASN A 434 -1  N  ASN A 434   O  THR A 485
SHEET    1 AD3 4 VAL A 520  PRO A 523  0
SHEET    2 AD3 4 TYR A 504  SER A 514 -1  N  ARG A 512   O  THR A 522
SHEET    3 AD3 4 ILE A 561  LEU A 569 -1  O  VAL A 563   N  SER A 511
SHEET    4 AD3 4 VAL A 548  GLN A 552 -1  N  ARG A 551   O  LEU A 562
SSBOND   1 CYS B  385    CYS B  394                          1555   1555  2.03
SSBOND   2 CYS B  444    CYS B  447                          1555   1555  2.03
SSBOND   3 CYS B  649    CYS B  762                          1555   1555  2.03
SSBOND   4 CYS C  391    CYS C  415                          1555   1555  2.03
SSBOND   5 CYS C  433    CYS C  486                          1555   1555  2.03
SSBOND   6 CYS C  510    CYS C  534                          1555   1555  2.03
SSBOND   7 CYS D  385    CYS D  394                          1555   1555  2.03
SSBOND   8 CYS D  444    CYS D  447                          1555   1555  2.03
SSBOND   9 CYS D  454    CYS D  472                          1555   1555  2.03
SSBOND  10 CYS D  649    CYS D  762                          1555   1555  2.03
SSBOND  11 CYS A  391    CYS A  415                          1555   1555  2.03
SSBOND  12 CYS A  433    CYS A  486                          1555   1555  2.03
SSBOND  13 CYS A  510    CYS A  534                          1555   1555  2.03
LINK         ND2 ASN B  85                 C1  NAG E   1     1555   1555  1.44
LINK         ND2 ASN B  92                 C1  NAG B 802     1555   1555  1.42
LINK         ND2 ASN B 229                 C1  NAG F   1     1555   1555  1.44
LINK         ND2 ASN B 281                 C1  NAG B 801     1555   1555  1.44
LINK         ND2 ASN B 321                 C1  NAG G   1     1555   1555  1.46
LINK         ND2 ASN D  85                 C1  NAG H   1     1555   1555  1.44
LINK         ND2 ASN D  92                 C1  NAG D 801     1555   1555  1.44
LINK         ND2 ASN D 150                 C1  NAG D 802     1555   1555  1.44
LINK         ND2 ASN D 229                 C1  NAG I   1     1555   1555  1.44
LINK         ND2 ASN D 281                 C1  NAG D 803     1555   1555  1.44
LINK         ND2 ASN D 321                 C1  NAG J   1     1555   1555  1.44
LINK         O4  NAG E   1                 C1  NAG E   2     1555   1555  1.45
LINK         O4  NAG F   1                 C1  NAG F   2     1555   1555  1.44
LINK         O4  NAG G   1                 C1  NAG G   2     1555   1555  1.43
LINK         O4  NAG H   1                 C1  NAG H   2     1555   1555  1.42
LINK         O4  NAG I   1                 C1  NAG I   2     1555   1555  1.43
LINK         O4  NAG J   1                 C1  NAG J   2     1555   1555  1.44
CISPEP   1 GLY B  474    PRO B  475          0         2.40
CISPEP   2 GLY D  474    PRO D  475          0         2.70
CRYST1   96.532  121.440  110.624  90.00 105.13  90.00 P 1 21 1      4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.010359  0.000000  0.002801        0.00000
SCALE2      0.000000  0.008235  0.000000        0.00000
SCALE3      0.000000  0.000000  0.009364        0.00000
TER    5945      PRO B 766
TER    7510      ASP C 588
TER   13471      GLU D 767
TER   15034      ASN A 590
MASTER      718    0   18   49  118    0    0    615431    4  281  144
END