longtext: 9K9N-pdb

content
HEADER    VIRAL PROTEIN/HYDROLASE                 27-OCT-24   9K9N
TITLE     CRYO-EM STRUCTURE OF MJHKU4R-COV-1 RECEPTOR-BINDING DOMAIN COMPLEXED
TITLE    2 WITH HUMAN CD26
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: DIPEPTIDYL PEPTIDASE 4 SOLUBLE FORM;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: DIPEPTIDYL PEPTIDASE IV SOLUBLE FORM;
COMPND   5 ENGINEERED: YES;
COMPND   6 MOL_ID: 2;
COMPND   7 MOLECULE: SPIKE PROTEIN S1;
COMPND   8 CHAIN: C;
COMPND   9 SYNONYM: S GLYCOPROTEIN,E2,PEPLOMER PROTEIN;
COMPND  10 ENGINEERED: YES;
COMPND  11 OTHER_DETAILS: SEQUENCE REFERENCE FOR STRAIN 'TYLONYCTERIS BAT
COMPND  12 CORONAVIRUS HKU4' IS NOT AVAILABLE IN UNIPROT AT THE TIME OF
COMPND  13 BIOCURATION. CURRENT SEQUENCE REFERENCE IS FROM UNIPROT ID
COMPND  14 A0AAE8ZFM2.
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE   3 ORGANISM_COMMON: HUMAN;
SOURCE   4 ORGANISM_TAXID: 9606;
SOURCE   5 GENE: DPP4, ADCP2, CD26;
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE   8 MOL_ID: 2;
SOURCE   9 ORGANISM_SCIENTIFIC: TYLONYCTERIS BAT CORONAVIRUS HKU4;
SOURCE  10 ORGANISM_TAXID: 694007;
SOURCE  11 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE  12 EXPRESSION_SYSTEM_TAXID: 9606
KEYWDS    COMPLEX, VIRAL PROTEIN/HYDROLASE, VIRAL PROTEIN-HYDROLASE COMPLEX
EXPDTA    ELECTRON MICROSCOPY
AUTHOR    J.Q.SUN
REVDAT   1   03-SEP-25 9K9N    0
JRNL        AUTH   Y.ZHANG,M.TIAN,Y.HAN,J.SUN,W.LI,C.BAI,C.SU,P.HAN
JRNL        TITL   RATIONAL DESIGN OF HUMAN CD26 RECEPTOR FOR A STRONG
JRNL        TITL 2 NEUTRALIZING ABILITY AGAINST MJHKU4R-COV-1 AND MERS-COV
JRNL        REF    HLIFE                                      2025
JRNL        REFN                   ESSN 2949-9283
JRNL        DOI    10.1016/J.HLIFE.2025.05.005
REMARK   2
REMARK   2 RESOLUTION.    2.61 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   SOFTWARE PACKAGES      : PHENIX
REMARK   3   RECONSTRUCTION SCHEMA  : NULL
REMARK   3
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK   3   PDB ENTRY                    : NULL
REMARK   3   REFINEMENT SPACE             : NULL
REMARK   3   REFINEMENT PROTOCOL          : NULL
REMARK   3   REFINEMENT TARGET            : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL
REMARK   3
REMARK   3 FITTING PROCEDURE : NULL
REMARK   3
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 2.610
REMARK   3   NUMBER OF PARTICLES               : 237919
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE
REMARK   3                                       CORRECTION
REMARK   3
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK   3
REMARK   3 OTHER DETAILS: NULL
REMARK   4
REMARK   4 9K9N COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBC ON 29-OCT-24.
REMARK 100 THE DEPOSITION ID IS D_1300053103.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE
REMARK 245   SPECIMEN TYPE                  : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245   SAMPLE TYPE                    : PARTICLE
REMARK 245   PARTICLE TYPE                  : POINT
REMARK 245   NAME OF SAMPLE                 : CRYO-EM STRUCTURE OF MJHKU4R
REMARK 245                                    -COV-1 RECEPTOR-BINDING DOMAIN
REMARK 245                                    COMPLEXED WITH HUMAN CD26
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL
REMARK 245   SAMPLE BUFFER                  : NULL
REMARK 245   PH                             : 8.00
REMARK 245   SAMPLE DETAILS                 : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245   DATE OF EXPERIMENT                : NULL
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL
REMARK 245   TEMPERATURE (KELVIN)              : NULL
REMARK 245   MICROSCOPE MODEL                  : TFS KRIOS
REMARK 245   DETECTOR TYPE                     : GATAN K3 (6K X 4K)
REMARK 245   MINIMUM DEFOCUS (NM)              : 1000.00
REMARK 245   MAXIMUM DEFOCUS (NM)              : 2000.00
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL
REMARK 245   NOMINAL CS                        : NULL
REMARK 245   IMAGING MODE                      : BRIGHT FIELD
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 6000.00
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM
REMARK 245   NOMINAL MAGNIFICATION             : NULL
REMARK 245   CALIBRATED MAGNIFICATION          : NULL
REMARK 245   SOURCE                            : FIELD EMISSION GUN
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300
REMARK 245   IMAGING DETAILS                   : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247  OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     MET A     7
REMARK 465     GLY A     8
REMARK 465     ILE A     9
REMARK 465     LEU A    10
REMARK 465     PRO A    11
REMARK 465     SER A    12
REMARK 465     PRO A    13
REMARK 465     GLY A    14
REMARK 465     MET A    15
REMARK 465     PRO A    16
REMARK 465     ALA A    17
REMARK 465     LEU A    18
REMARK 465     LEU A    19
REMARK 465     SER A    20
REMARK 465     LEU A    21
REMARK 465     VAL A    22
REMARK 465     SER A    23
REMARK 465     LEU A    24
REMARK 465     LEU A    25
REMARK 465     SER A    26
REMARK 465     VAL A    27
REMARK 465     LEU A    28
REMARK 465     LEU A    29
REMARK 465     MET A    30
REMARK 465     GLY A    31
REMARK 465     CYS A    32
REMARK 465     VAL A    33
REMARK 465     ALA A    34
REMARK 465     GLU A    35
REMARK 465     THR A    36
REMARK 465     GLY A    37
REMARK 465     THR A    38
REMARK 465     SER A   764
REMARK 465     LEU A   765
REMARK 465     PRO A   766
REMARK 465     HIS A   767
REMARK 465     HIS A   768
REMARK 465     HIS A   769
REMARK 465     HIS A   770
REMARK 465     HIS A   771
REMARK 465     HIS A   772
REMARK 465     MET B     7
REMARK 465     GLY B     8
REMARK 465     ILE B     9
REMARK 465     LEU B    10
REMARK 465     PRO B    11
REMARK 465     SER B    12
REMARK 465     PRO B    13
REMARK 465     GLY B    14
REMARK 465     MET B    15
REMARK 465     PRO B    16
REMARK 465     ALA B    17
REMARK 465     LEU B    18
REMARK 465     LEU B    19
REMARK 465     SER B    20
REMARK 465     LEU B    21
REMARK 465     VAL B    22
REMARK 465     SER B    23
REMARK 465     LEU B    24
REMARK 465     LEU B    25
REMARK 465     SER B    26
REMARK 465     VAL B    27
REMARK 465     LEU B    28
REMARK 465     LEU B    29
REMARK 465     MET B    30
REMARK 465     GLY B    31
REMARK 465     CYS B    32
REMARK 465     VAL B    33
REMARK 465     ALA B    34
REMARK 465     GLU B    35
REMARK 465     THR B    36
REMARK 465     GLY B    37
REMARK 465     THR B    38
REMARK 465     SER B   764
REMARK 465     LEU B   765
REMARK 465     PRO B   766
REMARK 465     HIS B   767
REMARK 465     HIS B   768
REMARK 465     HIS B   769
REMARK 465     HIS B   770
REMARK 465     HIS B   771
REMARK 465     HIS B   772
REMARK 465     MET C   371
REMARK 465     HIS C   372
REMARK 465     SER C   373
REMARK 465     SER C   374
REMARK 465     ALA C   375
REMARK 465     LEU C   376
REMARK 465     LEU C   377
REMARK 465     CYS C   378
REMARK 465     CYS C   379
REMARK 465     LEU C   380
REMARK 465     VAL C   381
REMARK 465     LEU C   382
REMARK 465     LEU C   383
REMARK 465     THR C   384
REMARK 465     GLY C   385
REMARK 465     VAL C   386
REMARK 465     ARG C   387
REMARK 465     ALA C   388
REMARK 465     HIS C   596
REMARK 465     HIS C   597
REMARK 465     HIS C   598
REMARK 465     HIS C   599
REMARK 465     HIS C   600
REMARK 465     HIS C   601
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   ND2  ASN B   229     O5   NAG G     1              2.12
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3
REMARK 500    CYS B 385   CA  -  CB  -  SG  ANGL. DEV. =   7.3 DEGREES
REMARK 500    CYS B 394   CA  -  CB  -  SG  ANGL. DEV. =   8.4 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    TRP A 124     -144.41     57.68
REMARK 500    ILE A 193      -58.74   -124.47
REMARK 500    VAL A 207      -62.85   -109.10
REMARK 500    SER A 242     -148.14     64.33
REMARK 500    THR A 401       55.94    -93.63
REMARK 500    LYS A 423       10.77     59.23
REMARK 500    ASN A 450       83.09   -159.38
REMARK 500    SER A 630     -112.60     57.26
REMARK 500    HIS B  66       16.98   -142.09
REMARK 500    TRP B 124     -164.78   -128.65
REMARK 500    ILE B 193      -62.74   -123.89
REMARK 500    VAL B 207      -61.10   -109.41
REMARK 500    ALA B 213       32.18   -140.25
REMARK 500    ASP B 243      165.56     73.25
REMARK 500    THR B 401       53.74    -92.77
REMARK 500    ARG B 453      -10.17     69.33
REMARK 500    SER B 630     -107.02     55.36
REMARK 500    ALA B 707       32.17    -95.81
REMARK 500    MET C 460       49.94    -84.86
REMARK 500    GLU C 521       69.11     60.32
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-62194   RELATED DB: EMDB
REMARK 900 CRYO-EM STRUCTURE OF MJHKU4R-COV-1 RECEPTOR-BINDING DOMAIN
REMARK 900 COMPLEXED WITH HUMAN CD26
DBREF  9K9N A   39   766  UNP    P27487   DPP4_HUMAN      39    766
DBREF  9K9N B   39   766  UNP    P27487   DPP4_HUMAN      39    766
DBREF1 9K9N C  389   595  UNP                  A0AAE8ZFM2_9BETC
DBREF2 9K9N C     A0AAE8ZFM2                        389         595
SEQADV 9K9N MET A    7  UNP  P27487              INITIATING METHIONINE
SEQADV 9K9N GLY A    8  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N ILE A    9  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU A   10  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N PRO A   11  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N SER A   12  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N PRO A   13  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N GLY A   14  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N MET A   15  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N PRO A   16  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N ALA A   17  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU A   18  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU A   19  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N SER A   20  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU A   21  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N VAL A   22  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N SER A   23  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU A   24  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU A   25  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N SER A   26  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N VAL A   27  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU A   28  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU A   29  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N MET A   30  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N GLY A   31  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N CYS A   32  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N VAL A   33  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N ALA A   34  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N GLU A   35  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N THR A   36  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N GLY A   37  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N THR A   38  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS A  767  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS A  768  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS A  769  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS A  770  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS A  771  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS A  772  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N MET B    7  UNP  P27487              INITIATING METHIONINE
SEQADV 9K9N GLY B    8  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N ILE B    9  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU B   10  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N PRO B   11  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N SER B   12  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N PRO B   13  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N GLY B   14  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N MET B   15  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N PRO B   16  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N ALA B   17  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU B   18  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU B   19  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N SER B   20  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU B   21  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N VAL B   22  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N SER B   23  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU B   24  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU B   25  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N SER B   26  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N VAL B   27  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU B   28  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N LEU B   29  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N MET B   30  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N GLY B   31  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N CYS B   32  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N VAL B   33  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N ALA B   34  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N GLU B   35  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N THR B   36  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N GLY B   37  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N THR B   38  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS B  767  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS B  768  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS B  769  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS B  770  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS B  771  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N HIS B  772  UNP  P27487              EXPRESSION TAG
SEQADV 9K9N MET C  371  UNP  A0AAE8ZFM           INITIATING METHIONINE
SEQADV 9K9N HIS C  372  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N SER C  373  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N SER C  374  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N ALA C  375  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N LEU C  376  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N LEU C  377  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N CYS C  378  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N CYS C  379  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N LEU C  380  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N VAL C  381  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N LEU C  382  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N LEU C  383  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N THR C  384  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N GLY C  385  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N VAL C  386  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N ARG C  387  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N ALA C  388  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N ALA C  482  UNP  A0AAE8ZFM SER   482 CONFLICT
SEQADV 9K9N GLU C  544  UNP  A0AAE8ZFM VAL   544 CONFLICT
SEQADV 9K9N HIS C  596  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N HIS C  597  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N HIS C  598  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N HIS C  599  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N HIS C  600  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQADV 9K9N HIS C  601  UNP  A0AAE8ZFM           EXPRESSION TAG
SEQRES   1 A  766  MET GLY ILE LEU PRO SER PRO GLY MET PRO ALA LEU LEU
SEQRES   2 A  766  SER LEU VAL SER LEU LEU SER VAL LEU LEU MET GLY CYS
SEQRES   3 A  766  VAL ALA GLU THR GLY THR SER ARG LYS THR TYR THR LEU
SEQRES   4 A  766  THR ASP TYR LEU LYS ASN THR TYR ARG LEU LYS LEU TYR
SEQRES   5 A  766  SER LEU ARG TRP ILE SER ASP HIS GLU TYR LEU TYR LYS
SEQRES   6 A  766  GLN GLU ASN ASN ILE LEU VAL PHE ASN ALA GLU TYR GLY
SEQRES   7 A  766  ASN SER SER VAL PHE LEU GLU ASN SER THR PHE ASP GLU
SEQRES   8 A  766  PHE GLY HIS SER ILE ASN ASP TYR SER ILE SER PRO ASP
SEQRES   9 A  766  GLY GLN PHE ILE LEU LEU GLU TYR ASN TYR VAL LYS GLN
SEQRES  10 A  766  TRP ARG HIS SER TYR THR ALA SER TYR ASP ILE TYR ASP
SEQRES  11 A  766  LEU ASN LYS ARG GLN LEU ILE THR GLU GLU ARG ILE PRO
SEQRES  12 A  766  ASN ASN THR GLN TRP VAL THR TRP SER PRO VAL GLY HIS
SEQRES  13 A  766  LYS LEU ALA TYR VAL TRP ASN ASN ASP ILE TYR VAL LYS
SEQRES  14 A  766  ILE GLU PRO ASN LEU PRO SER TYR ARG ILE THR TRP THR
SEQRES  15 A  766  GLY LYS GLU ASP ILE ILE TYR ASN GLY ILE THR ASP TRP
SEQRES  16 A  766  VAL TYR GLU GLU GLU VAL PHE SER ALA TYR SER ALA LEU
SEQRES  17 A  766  TRP TRP SER PRO ASN GLY THR PHE LEU ALA TYR ALA GLN
SEQRES  18 A  766  PHE ASN ASP THR GLU VAL PRO LEU ILE GLU TYR SER PHE
SEQRES  19 A  766  TYR SER ASP GLU SER LEU GLN TYR PRO LYS THR VAL ARG
SEQRES  20 A  766  VAL PRO TYR PRO LYS ALA GLY ALA VAL ASN PRO THR VAL
SEQRES  21 A  766  LYS PHE PHE VAL VAL ASN THR ASP SER LEU SER SER VAL
SEQRES  22 A  766  THR ASN ALA THR SER ILE GLN ILE THR ALA PRO ALA SER
SEQRES  23 A  766  MET LEU ILE GLY ASP HIS TYR LEU CYS ASP VAL THR TRP
SEQRES  24 A  766  ALA THR GLN GLU ARG ILE SER LEU GLN TRP LEU ARG ARG
SEQRES  25 A  766  ILE GLN ASN TYR SER VAL MET ASP ILE CYS ASP TYR ASP
SEQRES  26 A  766  GLU SER SER GLY ARG TRP ASN CYS LEU VAL ALA ARG GLN
SEQRES  27 A  766  HIS ILE GLU MET SER THR THR GLY TRP VAL GLY ARG PHE
SEQRES  28 A  766  ARG PRO SER GLU PRO HIS PHE THR LEU ASP GLY ASN SER
SEQRES  29 A  766  PHE TYR LYS ILE ILE SER ASN GLU GLU GLY TYR ARG HIS
SEQRES  30 A  766  ILE CYS TYR PHE GLN ILE ASP LYS LYS ASP CYS THR PHE
SEQRES  31 A  766  ILE THR LYS GLY THR TRP GLU VAL ILE GLY ILE GLU ALA
SEQRES  32 A  766  LEU THR SER ASP TYR LEU TYR TYR ILE SER ASN GLU TYR
SEQRES  33 A  766  LYS GLY MET PRO GLY GLY ARG ASN LEU TYR LYS ILE GLN
SEQRES  34 A  766  LEU SER ASP TYR THR LYS VAL THR CYS LEU SER CYS GLU
SEQRES  35 A  766  LEU ASN PRO GLU ARG CYS GLN TYR TYR SER VAL SER PHE
SEQRES  36 A  766  SER LYS GLU ALA LYS TYR TYR GLN LEU ARG CYS SER GLY
SEQRES  37 A  766  PRO GLY LEU PRO LEU TYR THR LEU HIS SER SER VAL ASN
SEQRES  38 A  766  ASP LYS GLY LEU ARG VAL LEU GLU ASP ASN SER ALA LEU
SEQRES  39 A  766  ASP LYS MET LEU GLN ASN VAL GLN MET PRO SER LYS LYS
SEQRES  40 A  766  LEU ASP PHE ILE ILE LEU ASN GLU THR LYS PHE TRP TYR
SEQRES  41 A  766  GLN MET ILE LEU PRO PRO HIS PHE ASP LYS SER LYS LYS
SEQRES  42 A  766  TYR PRO LEU LEU LEU ASP VAL TYR ALA GLY PRO CYS SER
SEQRES  43 A  766  GLN LYS ALA ASP THR VAL PHE ARG LEU ASN TRP ALA THR
SEQRES  44 A  766  TYR LEU ALA SER THR GLU ASN ILE ILE VAL ALA SER PHE
SEQRES  45 A  766  ASP GLY ARG GLY SER GLY TYR GLN GLY ASP LYS ILE MET
SEQRES  46 A  766  HIS ALA ILE ASN ARG ARG LEU GLY THR PHE GLU VAL GLU
SEQRES  47 A  766  ASP GLN ILE GLU ALA ALA ARG GLN PHE SER LYS MET GLY
SEQRES  48 A  766  PHE VAL ASP ASN LYS ARG ILE ALA ILE TRP GLY TRP SER
SEQRES  49 A  766  TYR GLY GLY TYR VAL THR SER MET VAL LEU GLY SER GLY
SEQRES  50 A  766  SER GLY VAL PHE LYS CYS GLY ILE ALA VAL ALA PRO VAL
SEQRES  51 A  766  SER ARG TRP GLU TYR TYR ASP SER VAL TYR THR GLU ARG
SEQRES  52 A  766  TYR MET GLY LEU PRO THR PRO GLU ASP ASN LEU ASP HIS
SEQRES  53 A  766  TYR ARG ASN SER THR VAL MET SER ARG ALA GLU ASN PHE
SEQRES  54 A  766  LYS GLN VAL GLU TYR LEU LEU ILE HIS GLY THR ALA ASP
SEQRES  55 A  766  ASP ASN VAL HIS PHE GLN GLN SER ALA GLN ILE SER LYS
SEQRES  56 A  766  ALA LEU VAL ASP VAL GLY VAL ASP PHE GLN ALA MET TRP
SEQRES  57 A  766  TYR THR ASP GLU ASP HIS GLY ILE ALA SER SER THR ALA
SEQRES  58 A  766  HIS GLN HIS ILE TYR THR HIS MET SER HIS PHE ILE LYS
SEQRES  59 A  766  GLN CYS PHE SER LEU PRO HIS HIS HIS HIS HIS HIS
SEQRES   1 B  766  MET GLY ILE LEU PRO SER PRO GLY MET PRO ALA LEU LEU
SEQRES   2 B  766  SER LEU VAL SER LEU LEU SER VAL LEU LEU MET GLY CYS
SEQRES   3 B  766  VAL ALA GLU THR GLY THR SER ARG LYS THR TYR THR LEU
SEQRES   4 B  766  THR ASP TYR LEU LYS ASN THR TYR ARG LEU LYS LEU TYR
SEQRES   5 B  766  SER LEU ARG TRP ILE SER ASP HIS GLU TYR LEU TYR LYS
SEQRES   6 B  766  GLN GLU ASN ASN ILE LEU VAL PHE ASN ALA GLU TYR GLY
SEQRES   7 B  766  ASN SER SER VAL PHE LEU GLU ASN SER THR PHE ASP GLU
SEQRES   8 B  766  PHE GLY HIS SER ILE ASN ASP TYR SER ILE SER PRO ASP
SEQRES   9 B  766  GLY GLN PHE ILE LEU LEU GLU TYR ASN TYR VAL LYS GLN
SEQRES  10 B  766  TRP ARG HIS SER TYR THR ALA SER TYR ASP ILE TYR ASP
SEQRES  11 B  766  LEU ASN LYS ARG GLN LEU ILE THR GLU GLU ARG ILE PRO
SEQRES  12 B  766  ASN ASN THR GLN TRP VAL THR TRP SER PRO VAL GLY HIS
SEQRES  13 B  766  LYS LEU ALA TYR VAL TRP ASN ASN ASP ILE TYR VAL LYS
SEQRES  14 B  766  ILE GLU PRO ASN LEU PRO SER TYR ARG ILE THR TRP THR
SEQRES  15 B  766  GLY LYS GLU ASP ILE ILE TYR ASN GLY ILE THR ASP TRP
SEQRES  16 B  766  VAL TYR GLU GLU GLU VAL PHE SER ALA TYR SER ALA LEU
SEQRES  17 B  766  TRP TRP SER PRO ASN GLY THR PHE LEU ALA TYR ALA GLN
SEQRES  18 B  766  PHE ASN ASP THR GLU VAL PRO LEU ILE GLU TYR SER PHE
SEQRES  19 B  766  TYR SER ASP GLU SER LEU GLN TYR PRO LYS THR VAL ARG
SEQRES  20 B  766  VAL PRO TYR PRO LYS ALA GLY ALA VAL ASN PRO THR VAL
SEQRES  21 B  766  LYS PHE PHE VAL VAL ASN THR ASP SER LEU SER SER VAL
SEQRES  22 B  766  THR ASN ALA THR SER ILE GLN ILE THR ALA PRO ALA SER
SEQRES  23 B  766  MET LEU ILE GLY ASP HIS TYR LEU CYS ASP VAL THR TRP
SEQRES  24 B  766  ALA THR GLN GLU ARG ILE SER LEU GLN TRP LEU ARG ARG
SEQRES  25 B  766  ILE GLN ASN TYR SER VAL MET ASP ILE CYS ASP TYR ASP
SEQRES  26 B  766  GLU SER SER GLY ARG TRP ASN CYS LEU VAL ALA ARG GLN
SEQRES  27 B  766  HIS ILE GLU MET SER THR THR GLY TRP VAL GLY ARG PHE
SEQRES  28 B  766  ARG PRO SER GLU PRO HIS PHE THR LEU ASP GLY ASN SER
SEQRES  29 B  766  PHE TYR LYS ILE ILE SER ASN GLU GLU GLY TYR ARG HIS
SEQRES  30 B  766  ILE CYS TYR PHE GLN ILE ASP LYS LYS ASP CYS THR PHE
SEQRES  31 B  766  ILE THR LYS GLY THR TRP GLU VAL ILE GLY ILE GLU ALA
SEQRES  32 B  766  LEU THR SER ASP TYR LEU TYR TYR ILE SER ASN GLU TYR
SEQRES  33 B  766  LYS GLY MET PRO GLY GLY ARG ASN LEU TYR LYS ILE GLN
SEQRES  34 B  766  LEU SER ASP TYR THR LYS VAL THR CYS LEU SER CYS GLU
SEQRES  35 B  766  LEU ASN PRO GLU ARG CYS GLN TYR TYR SER VAL SER PHE
SEQRES  36 B  766  SER LYS GLU ALA LYS TYR TYR GLN LEU ARG CYS SER GLY
SEQRES  37 B  766  PRO GLY LEU PRO LEU TYR THR LEU HIS SER SER VAL ASN
SEQRES  38 B  766  ASP LYS GLY LEU ARG VAL LEU GLU ASP ASN SER ALA LEU
SEQRES  39 B  766  ASP LYS MET LEU GLN ASN VAL GLN MET PRO SER LYS LYS
SEQRES  40 B  766  LEU ASP PHE ILE ILE LEU ASN GLU THR LYS PHE TRP TYR
SEQRES  41 B  766  GLN MET ILE LEU PRO PRO HIS PHE ASP LYS SER LYS LYS
SEQRES  42 B  766  TYR PRO LEU LEU LEU ASP VAL TYR ALA GLY PRO CYS SER
SEQRES  43 B  766  GLN LYS ALA ASP THR VAL PHE ARG LEU ASN TRP ALA THR
SEQRES  44 B  766  TYR LEU ALA SER THR GLU ASN ILE ILE VAL ALA SER PHE
SEQRES  45 B  766  ASP GLY ARG GLY SER GLY TYR GLN GLY ASP LYS ILE MET
SEQRES  46 B  766  HIS ALA ILE ASN ARG ARG LEU GLY THR PHE GLU VAL GLU
SEQRES  47 B  766  ASP GLN ILE GLU ALA ALA ARG GLN PHE SER LYS MET GLY
SEQRES  48 B  766  PHE VAL ASP ASN LYS ARG ILE ALA ILE TRP GLY TRP SER
SEQRES  49 B  766  TYR GLY GLY TYR VAL THR SER MET VAL LEU GLY SER GLY
SEQRES  50 B  766  SER GLY VAL PHE LYS CYS GLY ILE ALA VAL ALA PRO VAL
SEQRES  51 B  766  SER ARG TRP GLU TYR TYR ASP SER VAL TYR THR GLU ARG
SEQRES  52 B  766  TYR MET GLY LEU PRO THR PRO GLU ASP ASN LEU ASP HIS
SEQRES  53 B  766  TYR ARG ASN SER THR VAL MET SER ARG ALA GLU ASN PHE
SEQRES  54 B  766  LYS GLN VAL GLU TYR LEU LEU ILE HIS GLY THR ALA ASP
SEQRES  55 B  766  ASP ASN VAL HIS PHE GLN GLN SER ALA GLN ILE SER LYS
SEQRES  56 B  766  ALA LEU VAL ASP VAL GLY VAL ASP PHE GLN ALA MET TRP
SEQRES  57 B  766  TYR THR ASP GLU ASP HIS GLY ILE ALA SER SER THR ALA
SEQRES  58 B  766  HIS GLN HIS ILE TYR THR HIS MET SER HIS PHE ILE LYS
SEQRES  59 B  766  GLN CYS PHE SER LEU PRO HIS HIS HIS HIS HIS HIS
SEQRES   1 C  231  MET HIS SER SER ALA LEU LEU CYS CYS LEU VAL LEU LEU
SEQRES   2 C  231  THR GLY VAL ARG ALA LYS GLU CYS ASP PHE THR PRO MET
SEQRES   3 C  231  LEU VAL GLY VAL PRO PRO GLN VAL TYR ASN PHE LYS ARG
SEQRES   4 C  231  LEU VAL PHE THR ASN CYS ASN TYR ASN LEU THR LYS LEU
SEQRES   5 C  231  LEU SER LEU PHE MET VAL ASN GLU PHE SER CYS ASN GLY
SEQRES   6 C  231  ILE SER PRO ASP ALA ILE ALA ARG GLY CYS TYR SER SER
SEQRES   7 C  231  LEU THR VAL ASP TYR PHE ALA TYR PRO LEU SER MET ARG
SEQRES   8 C  231  SER TYR ILE GLN PRO GLY SER ALA GLY ASP ILE SER LEU
SEQRES   9 C  231  TYR ASN TYR LYS GLN SER PHE ALA ASN PRO THR CYS ARG
SEQRES  10 C  231  VAL LEU ALA THR ALA PRO ALA ASN LEU THR LEU THR LYS
SEQRES  11 C  231  PRO SER ALA TYR GLY TYR PHE GLN LYS CYS SER ARG VAL
SEQRES  12 C  231  SER GLY GLU HIS ASN SER VAL GLU THR PRO LEU TYR ILE
SEQRES  13 C  231  ASN PRO GLY GLU TYR SER ILE CYS ARG SER PHE SER PRO
SEQRES  14 C  231  TYR GLY PHE SER GLU ASP GLY GLU VAL PHE ARG ARG GLN
SEQRES  15 C  231  LEU THR GLN TYR GLU GLY GLY GLY ILE LEU VAL GLY VAL
SEQRES  16 C  231  GLY ALA LYS LEU ALA MET THR ASP LYS LEU GLU MET GLY
SEQRES  17 C  231  PHE ILE ILE SER VAL GLN TYR GLY THR ASP THR ASN SER
SEQRES  18 C  231  VAL CYS PRO MET HIS HIS HIS HIS HIS HIS
HET    NAG  D   1      14
HET    NAG  D   2      14
HET    NAG  E   1      14
HET    NAG  E   2      14
HET    NAG  F   1      14
HET    NAG  F   2      14
HET    NAG  G   1      14
HET    NAG  G   2      14
HET    BMA  G   3      11
HET    MAN  G   4      11
HET    MAN  G   5      11
HET    NAG  H   1      14
HET    NAG  H   2      14
HET    FUC  H   3      10
HET    NAG  I   1      14
HET    NAG  I   2      14
HET    NAG  A 801      14
HET    NAG  A 802      14
HET    NAG  A 803      14
HET    NAG  A 804      14
HET    NAG  A 805      14
HET    NAG  A 806      14
HET    NAG  B 801      14
HET    NAG  B 802      14
HET    NAG  B 803      14
HET    NAG  B 804      14
HETNAM     NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE
HETNAM     BMA BETA-D-MANNOPYRANOSE
HETNAM     MAN ALPHA-D-MANNOPYRANOSE
HETNAM     FUC ALPHA-L-FUCOPYRANOSE
HETSYN     NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA-
HETSYN   2 NAG  D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO-
HETSYN   3 NAG  2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE
HETSYN     BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE
HETSYN     MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE
HETSYN     FUC ALPHA-L-FUCOSE; 6-DEOXY-ALPHA-L-GALACTOPYRANOSE; L-
HETSYN   2 FUC  FUCOSE; FUCOSE
FORMUL   4  NAG    22(C8 H15 N O6)
FORMUL   7  BMA    C6 H12 O6
FORMUL   7  MAN    2(C6 H12 O6)
FORMUL   8  FUC    C6 H12 O5
HELIX    1 AA1 THR A   44  ASN A   51  1                                   8
HELIX    2 AA2 GLU A   91  GLU A   97  1                                   7
HELIX    3 AA3 ASP A  200  GLU A  206  1                                   7
HELIX    4 AA4 LEU A  340  GLN A  344  5                                   5
HELIX    5 AA5 GLU A  421  MET A  425  5                                   5
HELIX    6 AA6 ASN A  497  GLN A  505  1                                   9
HELIX    7 AA7 ASN A  562  THR A  570  1                                   9
HELIX    8 AA8 GLY A  587  HIS A  592  1                                   6
HELIX    9 AA9 ALA A  593  ASN A  595  5                                   3
HELIX   10 AB1 THR A  600  MET A  616  1                                  17
HELIX   11 AB2 SER A  630  GLY A  641  1                                  12
HELIX   12 AB3 ARG A  658  TYR A  662  5                                   5
HELIX   13 AB4 ASP A  663  GLY A  672  1                                  10
HELIX   14 AB5 LEU A  680  SER A  686  1                                   7
HELIX   15 AB6 THR A  687  VAL A  698  5                                  12
HELIX   16 AB7 HIS A  712  GLY A  727  1                                  16
HELIX   17 AB8 SER A  744  PHE A  763  1                                  20
HELIX   18 AB9 THR B   44  ASN B   51  1                                   8
HELIX   19 AC1 GLU B   91  PHE B   98  1                                   8
HELIX   20 AC2 ASP B  200  VAL B  207  1                                   8
HELIX   21 AC3 PRO B  290  ILE B  295  1                                   6
HELIX   22 AC4 VAL B  341  GLN B  344  5                                   4
HELIX   23 AC5 GLU B  421  MET B  425  5                                   5
HELIX   24 AC6 ASN B  497  GLN B  505  1                                   9
HELIX   25 AC7 ASN B  562  THR B  570  1                                   9
HELIX   26 AC8 GLY B  587  HIS B  592  1                                   6
HELIX   27 AC9 ALA B  593  ASN B  595  5                                   3
HELIX   28 AD1 THR B  600  LYS B  615  1                                  16
HELIX   29 AD2 SER B  630  GLY B  641  1                                  12
HELIX   30 AD3 ARG B  658  TYR B  662  5                                   5
HELIX   31 AD4 ASP B  663  MET B  671  1                                   9
HELIX   32 AD5 LEU B  680  SER B  686  1                                   7
HELIX   33 AD6 THR B  687  VAL B  698  5                                  12
HELIX   34 AD7 HIS B  712  GLY B  727  1                                  16
HELIX   35 AD8 SER B  744  PHE B  763  1                                  20
HELIX   36 AD9 PHE C  393  VAL C  398  5                                   6
HELIX   37 AE1 ASN C  418  PHE C  426  1                                   9
HELIX   38 AE2 SER C  437  ARG C  443  1                                   7
HELIX   39 AE3 GLY C  470  TYR C  475  1                                   6
HELIX   40 AE4 SER C  532  PHE C  537  5                                   6
HELIX   41 AE5 GLY C  586  ASN C  590  5                                   5
SHEET    1 AA1 2 LYS A  41  THR A  42  0
SHEET    2 AA1 2 VAL A 507  GLN A 508  1  O  GLN A 508   N  LYS A  41
SHEET    1 AA2 4 ARG A  61  TRP A  62  0
SHEET    2 AA2 4 GLU A  67  GLN A  72 -1  O  LEU A  69   N  ARG A  61
SHEET    3 AA2 4 ASN A  75  ASN A  80 -1  O  LEU A  77   N  TYR A  70
SHEET    4 AA2 4 SER A  86  LEU A  90 -1  O  PHE A  89   N  ILE A  76
SHEET    1 AA3 4 ASP A 104  ILE A 107  0
SHEET    2 AA3 4 PHE A 113  GLN A 123 -1  O  LEU A 115   N  SER A 106
SHEET    3 AA3 4 SER A 127  ASP A 136 -1  O  SER A 131   N  TYR A 118
SHEET    4 AA3 4 GLN A 141  LEU A 142 -1  O  GLN A 141   N  ASP A 136
SHEET    1 AA4 4 TRP A 154  TRP A 157  0
SHEET    2 AA4 4 LEU A 164  VAL A 167 -1  O  VAL A 167   N  TRP A 154
SHEET    3 AA4 4 ILE A 172  LYS A 175 -1  O  TYR A 173   N  TYR A 166
SHEET    4 AA4 4 TYR A 183  ARG A 184 -1  O  TYR A 183   N  VAL A 174
SHEET    1 AA5 3 ILE A 194  ASN A 196  0
SHEET    2 AA5 3 PHE A 222  ASN A 229 -1  O  PHE A 228   N  TYR A 195
SHEET    3 AA5 3 LEU A 214  TRP A 216 -1  N  TRP A 215   O  ALA A 224
SHEET    1 AA6 4 ILE A 194  ASN A 196  0
SHEET    2 AA6 4 PHE A 222  ASN A 229 -1  O  PHE A 228   N  TYR A 195
SHEET    3 AA6 4 THR A 265  ASN A 272 -1  O  VAL A 271   N  LEU A 223
SHEET    4 AA6 4 ILE A 285  GLN A 286 -1  O  ILE A 285   N  VAL A 270
SHEET    1 AA7 2 LEU A 235  PHE A 240  0
SHEET    2 AA7 2 LYS A 250  PRO A 255 -1  O  LYS A 250   N  PHE A 240
SHEET    1 AA8 4 HIS A 298  THR A 307  0
SHEET    2 AA8 4 ARG A 310  ARG A 317 -1  O  LEU A 316   N  TYR A 299
SHEET    3 AA8 4 TYR A 322  ASP A 331 -1  O  ASP A 326   N  LEU A 313
SHEET    4 AA8 4 ARG A 336  ASN A 338 -1  O  ARG A 336   N  ASP A 331
SHEET    1 AA9 4 HIS A 298  THR A 307  0
SHEET    2 AA9 4 ARG A 310  ARG A 317 -1  O  LEU A 316   N  TYR A 299
SHEET    3 AA9 4 TYR A 322  ASP A 331 -1  O  ASP A 326   N  LEU A 313
SHEET    4 AA9 4 HIS A 345  MET A 348 -1  O  HIS A 345   N  MET A 325
SHEET    1 AB1 4 HIS A 363  PHE A 364  0
SHEET    2 AB1 4 SER A 370  SER A 376 -1  O  TYR A 372   N  HIS A 363
SHEET    3 AB1 4 ARG A 382  GLN A 388 -1  O  HIS A 383   N  ILE A 375
SHEET    4 AB1 4 THR A 395  PHE A 396 -1  O  THR A 395   N  TYR A 386
SHEET    1 AB2 4 VAL A 404  LEU A 410  0
SHEET    2 AB2 4 TYR A 414  SER A 419 -1  O  ILE A 418   N  ILE A 405
SHEET    3 AB2 4 ASN A 430  GLN A 435 -1  O  TYR A 432   N  TYR A 417
SHEET    4 AB2 4 VAL A 442  CYS A 444 -1  O  THR A 443   N  LYS A 433
SHEET    1 AB3 4 TYR A 457  PHE A 461  0
SHEET    2 AB3 4 TYR A 467  CYS A 472 -1  O  ARG A 471   N  SER A 458
SHEET    3 AB3 4 LEU A 479  SER A 484 -1  O  HIS A 483   N  TYR A 468
SHEET    4 AB3 4 LYS A 489  GLU A 495 -1  O  GLU A 495   N  TYR A 480
SHEET    1 AB4 8 SER A 511  ILE A 518  0
SHEET    2 AB4 8 LYS A 523  LEU A 530 -1  O  PHE A 524   N  ILE A 517
SHEET    3 AB4 8 ILE A 574  PHE A 578 -1  O  VAL A 575   N  ILE A 529
SHEET    4 AB4 8 TYR A 540  ASP A 545  1  N  LEU A 543   O  ILE A 574
SHEET    5 AB4 8 VAL A 619  TRP A 629  1  O  ASP A 620   N  TYR A 540
SHEET    6 AB4 8 CYS A 649  VAL A 653  1  O  VAL A 653   N  GLY A 628
SHEET    7 AB4 8 GLU A 699  GLY A 705  1  O  LEU A 701   N  ALA A 652
SHEET    8 AB4 8 GLN A 731  TYR A 735  1  O  GLN A 731   N  TYR A 700
SHEET    1 AB5 2 LYS B  41  THR B  42  0
SHEET    2 AB5 2 VAL B 507  GLN B 508  1  O  GLN B 508   N  LYS B  41
SHEET    1 AB6 4 ARG B  61  TRP B  62  0
SHEET    2 AB6 4 GLU B  67  GLN B  72 -1  O  LEU B  69   N  ARG B  61
SHEET    3 AB6 4 ASN B  75  ASN B  80 -1  O  LEU B  77   N  TYR B  70
SHEET    4 AB6 4 SER B  86  LEU B  90 -1  O  PHE B  89   N  ILE B  76
SHEET    1 AB7 4 ASP B 104  ILE B 107  0
SHEET    2 AB7 4 PHE B 113  LYS B 122 -1  O  LEU B 115   N  SER B 106
SHEET    3 AB7 4 TYR B 128  ASP B 136 -1  O  SER B 131   N  TYR B 118
SHEET    4 AB7 4 GLN B 141  LEU B 142 -1  O  GLN B 141   N  ASP B 136
SHEET    1 AB8 4 TRP B 154  TRP B 157  0
SHEET    2 AB8 4 LEU B 164  TRP B 168 -1  O  VAL B 167   N  TRP B 154
SHEET    3 AB8 4 ASP B 171  LYS B 175 -1  O  TYR B 173   N  TYR B 166
SHEET    4 AB8 4 TYR B 183  ARG B 184 -1  O  TYR B 183   N  VAL B 174
SHEET    1 AB9 3 ILE B 194  ASN B 196  0
SHEET    2 AB9 3 PHE B 222  ASN B 229 -1  O  PHE B 228   N  TYR B 195
SHEET    3 AB9 3 LEU B 214  TRP B 216 -1  N  TRP B 215   O  ALA B 224
SHEET    1 AC1 4 ILE B 194  ASN B 196  0
SHEET    2 AC1 4 PHE B 222  ASN B 229 -1  O  PHE B 228   N  TYR B 195
SHEET    3 AC1 4 THR B 265  ASN B 272 -1  O  VAL B 271   N  LEU B 223
SHEET    4 AC1 4 SER B 284  GLN B 286 -1  O  ILE B 285   N  VAL B 270
SHEET    1 AC2 2 LEU B 235  PHE B 240  0
SHEET    2 AC2 2 LYS B 250  PRO B 255 -1  O  LYS B 250   N  PHE B 240
SHEET    1 AC3 4 HIS B 298  THR B 307  0
SHEET    2 AC3 4 ARG B 310  ARG B 317 -1  O  SER B 312   N  THR B 304
SHEET    3 AC3 4 TYR B 322  TYR B 330 -1  O  ASP B 326   N  LEU B 313
SHEET    4 AC3 4 TRP B 337  CYS B 339 -1  O  ASN B 338   N  ASP B 329
SHEET    1 AC4 4 HIS B 298  THR B 307  0
SHEET    2 AC4 4 ARG B 310  ARG B 317 -1  O  SER B 312   N  THR B 304
SHEET    3 AC4 4 TYR B 322  TYR B 330 -1  O  ASP B 326   N  LEU B 313
SHEET    4 AC4 4 HIS B 345  MET B 348 -1  O  HIS B 345   N  MET B 325
SHEET    1 AC5 3 HIS B 363  PHE B 364  0
SHEET    2 AC5 3 SER B 370  SER B 376 -1  O  TYR B 372   N  HIS B 363
SHEET    3 AC5 3 ARG B 382  GLN B 388 -1  O  HIS B 383   N  ILE B 375
SHEET    1 AC6 4 VAL B 404  LEU B 410  0
SHEET    2 AC6 4 TYR B 414  SER B 419 -1  O  ILE B 418   N  ILE B 405
SHEET    3 AC6 4 ASN B 430  GLN B 435 -1  O  TYR B 432   N  TYR B 417
SHEET    4 AC6 4 VAL B 442  CYS B 444 -1  O  THR B 443   N  LYS B 433
SHEET    1 AC7 4 TYR B 457  PHE B 461  0
SHEET    2 AC7 4 TYR B 467  CYS B 472 -1  O  ARG B 471   N  SER B 458
SHEET    3 AC7 4 LEU B 479  SER B 484 -1  O  HIS B 483   N  TYR B 468
SHEET    4 AC7 4 GLY B 490  GLU B 495 -1  O  GLU B 495   N  TYR B 480
SHEET    1 AC8 8 SER B 511  LEU B 519  0
SHEET    2 AC8 8 THR B 522  LEU B 530 -1  O  THR B 522   N  LEU B 519
SHEET    3 AC8 8 ILE B 574  PHE B 578 -1  O  VAL B 575   N  ILE B 529
SHEET    4 AC8 8 TYR B 540  VAL B 546  1  N  LEU B 543   O  ILE B 574
SHEET    5 AC8 8 VAL B 619  TRP B 629  1  O  ASP B 620   N  TYR B 540
SHEET    6 AC8 8 CYS B 649  VAL B 653  1  O  ILE B 651   N  ILE B 626
SHEET    7 AC8 8 GLU B 699  GLY B 705  1  O  LEU B 701   N  ALA B 652
SHEET    8 AC8 8 GLN B 731  TYR B 735  1  O  GLN B 731   N  TYR B 700
SHEET    1 AC9 5 LYS C 408  THR C 413  0
SHEET    2 AC9 5 SER C 448  ALA C 455 -1  O  VAL C 451   N  LEU C 410
SHEET    3 AC9 5 GLU C 576  GLN C 584 -1  O  SER C 582   N  THR C 450
SHEET    4 AC9 5 THR C 485  THR C 491 -1  N  VAL C 488   O  PHE C 579
SHEET    5 AC9 5 MET C 427  ASN C 434 -1  N  ASN C 434   O  THR C 485
SHEET    1 AD1 2 ASN C 416  TYR C 417  0
SHEET    2 AD1 2 CYS C 593  PRO C 594  1  O  CYS C 593   N  TYR C 417
SHEET    1 AD2 4 THR C 522  PRO C 523  0
SHEET    2 AD2 4 TYR C 504  VAL C 513 -1  N  ARG C 512   O  THR C 522
SHEET    3 AD2 4 ILE C 561  LEU C 569 -1  O  ALA C 567   N  TYR C 506
SHEET    4 AD2 4 VAL C 548  GLN C 552 -1  N  ARG C 551   O  LEU C 562
SSBOND   1 CYS A  328    CYS A  339                          1555   1555  2.03
SSBOND   2 CYS A  385    CYS A  394                          1555   1555  2.03
SSBOND   3 CYS A  444    CYS A  447                          1555   1555  2.03
SSBOND   4 CYS A  454    CYS A  472                          1555   1555  2.03
SSBOND   5 CYS A  649    CYS A  762                          1555   1555  2.04
SSBOND   6 CYS B  328    CYS B  339                          1555   1555  2.03
SSBOND   7 CYS B  385    CYS B  394                          1555   1555  2.05
SSBOND   8 CYS B  444    CYS B  447                          1555   1555  2.03
SSBOND   9 CYS B  454    CYS B  472                          1555   1555  2.04
SSBOND  10 CYS B  649    CYS B  762                          1555   1555  2.04
SSBOND  11 CYS C  391    CYS C  415                          1555   1555  2.03
SSBOND  12 CYS C  433    CYS C  486                          1555   1555  2.03
SSBOND  13 CYS C  445    CYS C  593                          1555   1555  2.03
SSBOND  14 CYS C  510    CYS C  534                          1555   1555  2.03
LINK         ND2 ASN A  85                 C1  NAG D   1     1555   1555  1.44
LINK         ND2 ASN A  92                 C1  NAG A 801     1555   1555  1.44
LINK         ND2 ASN A 150                 C1  NAG A 802     1555   1555  1.44
LINK         ND2 ASN A 219                 C1  NAG A 803     1555   1555  1.44
LINK         ND2 ASN A 229                 C1  NAG A 804     1555   1555  1.44
LINK         ND2 ASN A 281                 C1  NAG E   1     1555   1555  1.44
LINK         ND2 ASN A 321                 C1  NAG A 805     1555   1555  1.45
LINK         ND2 ASN A 520                 C1  NAG A 806     1555   1555  1.44
LINK         ND2 ASN B  85                 C1  NAG F   1     1555   1555  1.45
LINK         ND2 ASN B  92                 C1  NAG B 801     1555   1555  1.44
LINK         ND2 ASN B 150                 C1  NAG B 802     1555   1555  1.44
LINK         ND2 ASN B 219                 C1  NAG B 803     1555   1555  1.44
LINK         ND2 ASN B 229                 C1  NAG G   1     1555   1555  1.45
LINK         ND2 ASN B 281                 C1  NAG H   1     1555   1555  1.44
LINK         ND2 ASN B 321                 C1  NAG I   1     1555   1555  1.44
LINK         ND2 ASN B 520                 C1  NAG B 804     1555   1555  1.44
LINK         O4  NAG D   1                 C1  NAG D   2     1555   1555  1.44
LINK         O4  NAG E   1                 C1  NAG E   2     1555   1555  1.44
LINK         O4  NAG F   1                 C1  NAG F   2     1555   1555  1.44
LINK         O4  NAG G   1                 C1  NAG G   2     1555   1555  1.45
LINK         O4  NAG G   2                 C1  BMA G   3     1555   1555  1.45
LINK         O3  BMA G   3                 C1  MAN G   4     1555   1555  1.45
LINK         O2  MAN G   4                 C1  MAN G   5     1555   1555  1.44
LINK         O4  NAG H   1                 C1  NAG H   2     1555   1555  1.44
LINK         O6  NAG H   1                 C1  FUC H   3     1555   1555  1.44
LINK         O4  NAG I   1                 C1  NAG I   2     1555   1555  1.44
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      1.000000  0.000000  0.000000        0.00000
SCALE2      0.000000  1.000000  0.000000        0.00000
SCALE3      0.000000  0.000000  1.000000        0.00000
TER    5943      PHE A 763
TER   11886      PHE B 763
TER   13492      MET C 595
MASTER      282    0   26   41  112    0    0    613840    3  395  136
END