longtext: 9XHM-pdb

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HEADER    HYDROLASE                               01-NOV-25   9XHM
TITLE     CRYSTAL STRUCTURE OF ACVB FROM AGROBACTERIUM TUMEFACIENS
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ACVB;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES;
COMPND   5 OTHER_DETAILS: THE SEQUENCE ALSO FOUR ADDITIONAL RESIDUES (GLY-PRO-
COMPND   6 HIS-MET) DERIVED FROM THE EXPRESSION TAG AT THE N TERMINUS.
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: AGROBACTERIUM TUMEFACIENS;
SOURCE   3 ORGANISM_TAXID: 358;
SOURCE   4 STRAIN: NBRC15193;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE   7 EXPRESSION_SYSTEM_VARIANT: C43
KEYWDS    LYSYL-PHOSPHATIDYLGLYCEROL HYDROLASE, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.HOSHI,Y.WATANABE
REVDAT   1   15-APR-26 9XHM    0
JRNL        AUTH   M.HOSHI,Y.WATANABE
JRNL        TITL   STRUCTURAL BASIS OF SUBSTRATE RECOGNITION AND MEMBRANE
JRNL        TITL 2 ASSOCIATION BY THE BACTERIAL LYSYL-PHOSPHATIDYLGLYCEROL
JRNL        TITL 3 HYDROLASE ACVB
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    3.13 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX (1.20.1_4487: ???)
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : ML
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.13
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 40.60
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.980
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.6
REMARK   3   NUMBER OF REFLECTIONS             : 22037
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.227
REMARK   3   R VALUE            (WORKING SET) : 0.225
REMARK   3   FREE R VALUE                     : 0.280
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.920
REMARK   3   FREE R VALUE TEST SET COUNT      : 1084
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 40.6000 -  6.2600    0.99     2647   136  0.2052 0.2552
REMARK   3     2  6.2600 -  4.9700    0.99     2601   159  0.2187 0.2780
REMARK   3     3  4.9700 -  4.3400    0.99     2676   114  0.1812 0.2074
REMARK   3     4  4.3400 -  3.9400    0.99     2599   153  0.2128 0.2954
REMARK   3     5  3.9400 -  3.6600    0.99     2615   131  0.2458 0.3044
REMARK   3     6  3.6600 -  3.4500    0.98     2635   140  0.2484 0.3075
REMARK   3     7  3.4500 -  3.2700    0.98     2590   121  0.2876 0.2910
REMARK   3     8  3.2700 -  3.1300    0.97     2590   130  0.3415 0.4241
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.560
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 31.880
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.002           6294
REMARK   3   ANGLE     :  0.533           8571
REMARK   3   CHIRALITY :  0.044           1029
REMARK   3   PLANARITY :  0.007           1105
REMARK   3   DIHEDRAL  :  9.704            890
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 9XHM COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 06-NOV-25.
REMARK 100 THE DEPOSITION ID IS D_1300065407.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 08-FEB-22
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 7.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SPRING-8
REMARK 200  BEAMLINE                       : BL32XU
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 9M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XDS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 43700
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.130
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.2
REMARK 200  DATA REDUNDANCY                : 2.700
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : 0.12600
REMARK 200   FOR THE DATA SET  : 6.5000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.13
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.32
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.4
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.40
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : 0.99400
REMARK 200   FOR SHELL         : 1.000
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 64.89
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.50
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 2.4M SODIUM MALONATE (PH 7.0), VAPOR
REMARK 280  DIFFUSION, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1, 2
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 350
REMARK 350 BIOMOLECULE: 2
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLY A    21
REMARK 465     PRO A    22
REMARK 465     HIS A    23
REMARK 465     MET A    24
REMARK 465     GLN A    25
REMARK 465     ASP A    26
REMARK 465     LYS A    27
REMARK 465     PRO A    28
REMARK 465     ALA A   115
REMARK 465     GLY A   116
REMARK 465     THR A   117
REMARK 465     GLY A   118
REMARK 465     GLY B    21
REMARK 465     PRO B    22
REMARK 465     HIS B    23
REMARK 465     MET B    24
REMARK 465     GLN B    25
REMARK 465     ASP B    26
REMARK 465     LYS B    27
REMARK 465     PRO B    28
REMARK 465     THR B   114
REMARK 465     ALA B   115
REMARK 465     GLY B   116
REMARK 465     THR B   117
REMARK 465     GLY B   118
REMARK 465     ALA B   382
REMARK 465     GLY B   383
REMARK 465     GLU B   384
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     GLU A  62    CG   CD   OE1  OE2
REMARK 470     GLU A  65    CG   CD   OE1  OE2
REMARK 470     LYS A  69    CG   CD   CE   NZ
REMARK 470     GLU A  73    CG   CD   OE1  OE2
REMARK 470     GLU A  91    CG   CD   OE1  OE2
REMARK 470     ASP A  93    CG   OD1  OD2
REMARK 470     ASP A  94    CG   OD1  OD2
REMARK 470     GLN A 112    CG   CD   OE1  NE2
REMARK 470     GLU A 162    CG   CD   OE1  OE2
REMARK 470     LYS A 163    CG   CD   CE   NZ
REMARK 470     ASP A 175    CG   OD1  OD2
REMARK 470     ASP A 198    CG   OD1  OD2
REMARK 470     GLU A 228    CG   CD   OE1  OE2
REMARK 470     ASN A 246    CG   OD1  ND2
REMARK 470     GLU A 256    CG   CD   OE1  OE2
REMARK 470     ASP A 271    CG   OD1  OD2
REMARK 470     GLU A 279    CG   CD   OE1  OE2
REMARK 470     ASP A 306    CG   OD1  OD2
REMARK 470     LYS A 308    CG   CD   CE   NZ
REMARK 470     LYS A 328    CG   CD   CE   NZ
REMARK 470     ARG A 352    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU A 368    CG   CD   OE1  OE2
REMARK 470     LYS A 386    CG   CD   CE   NZ
REMARK 470     HIS A 433    CG   ND1  CD2  CE1  NE2
REMARK 470     LYS A 456    CG   CD   CE   NZ
REMARK 470     GLU B  62    CG   CD   OE1  OE2
REMARK 470     LYS B  69    CG   CD   CE   NZ
REMARK 470     GLU B  73    CG   CD   OE1  OE2
REMARK 470     GLU B  91    CG   CD   OE1  OE2
REMARK 470     ASP B  93    CG   OD1  OD2
REMARK 470     ASP B  94    CG   OD1  OD2
REMARK 470     ASP B 103    CG   OD1  OD2
REMARK 470     GLU B 149    CG   CD   OE1  OE2
REMARK 470     VAL B 174    CG1  CG2
REMARK 470     ASP B 175    CG   OD1  OD2
REMARK 470     ASP B 184    CG   OD1  OD2
REMARK 470     GLU B 218    CG   CD   OE1  OE2
REMARK 470     GLU B 228    CG   CD   OE1  OE2
REMARK 470     ASP B 236    CG   OD1  OD2
REMARK 470     GLU B 256    CG   CD   OE1  OE2
REMARK 470     LYS B 287    CG   CD   CE   NZ
REMARK 470     ASP B 306    CG   OD1  OD2
REMARK 470     LYS B 308    CG   CD   CE   NZ
REMARK 470     ASP B 351    CG   OD1  OD2
REMARK 470     GLU B 368    CG   CD   OE1  OE2
REMARK 470     LYS B 386    CG   CD   CE   NZ
REMARK 470     ASP B 398    CG   OD1  OD2
REMARK 470     GLU B 409    CG   CD   OE1  OE2
REMARK 470     LYS B 420    CG   CD   CE   NZ
REMARK 470     GLU B 430    CG   CD   OE1  OE2
REMARK 470     HIS B 433    CG   ND1  CD2  CE1  NE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   NZ   LYS B   130     O    GLY B   158              2.09
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    GLU A 149      148.30   -170.16
REMARK 500    PRO A 197       -4.56    -56.63
REMARK 500    ARG A 275     -169.15   -102.92
REMARK 500    SER A 336     -112.54     59.33
REMARK 500    PHE A 435     -134.66     63.11
REMARK 500    GLU A 437       17.05     58.59
REMARK 500    ARG B 275     -167.08   -118.47
REMARK 500    SER B 336     -106.88     52.96
REMARK 500    PHE B 435     -145.60     63.00
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    ARG B 148         0.10    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
DBREF  9XHM A   21   456  PDB    9XHM     9XHM            21    456
DBREF  9XHM B   21   456  PDB    9XHM     9XHM            21    456
SEQRES   1 A  436  GLY PRO HIS MET GLN ASP LYS PRO ALA TYR GLU THR GLY
SEQRES   2 A  436  MET ILE PRO ALA ASP HIS ILE MET VAL PRO ASP GLY ASP
SEQRES   3 A  436  ILE GLN ALA SER ILE PHE LEU ILE SER ASP ALA ASN GLY
SEQRES   4 A  436  TRP THR GLU ALA ASP GLU THR ARG ALA LYS ALA LEU VAL
SEQRES   5 A  436  GLU LYS GLY ALA ALA VAL VAL GLY ILE ASP PHE LYS GLU
SEQRES   6 A  436  TYR LEU LYS ALA LEU GLU ALA ASP ASP ASP GLU CYS ILE
SEQRES   7 A  436  TYR MET ILE SER ASP ILE GLU SER LEU SER GLN GLN ILE
SEQRES   8 A  436  GLN ARG THR ALA GLY THR GLY SER TYR ARG LEU PRO ILE
SEQRES   9 A  436  VAL THR GLY ILE GLY LYS GLY GLY THR LEU ALA LEU ALA
SEQRES  10 A  436  MET ILE ALA GLN SER PRO VAL SER THR VAL ARG GLU ALA
SEQRES  11 A  436  VAL ALA VAL ASP PRO LYS ALA GLY LEU PRO LEU GLU LYS
SEQRES  12 A  436  ILE LEU CYS THR PRO ALA THR LYS ASP LYS VAL ASP GLY
SEQRES  13 A  436  GLU THR LEU TYR GLY LEU THR ASP GLY ALA LEU PRO ALA
SEQRES  14 A  436  PRO VAL SER VAL ILE PHE THR PRO ASP ALA ASP GLN LYS
SEQRES  15 A  436  GLY ARG ASP HIS VAL ASN ALA LEU VAL LYS LEU HIS SER
SEQRES  16 A  436  ASP ILE GLU VAL THR ASP VAL THR ASP LYS ALA ASP GLU
SEQRES  17 A  436  VAL LEU THR GLN THR LEU SER ASP LYS VAL ASP ALA ALA
SEQRES  18 A  436  GLY ASP SER GLY ASN PRO LEU GLY LEU PRO ILE THR VAL
SEQRES  19 A  436  LEU GLU ALA LYS PRO VAL MET ASP THR MET ALA VAL ILE
SEQRES  20 A  436  TYR SER GLY ASP GLY GLY TRP ARG ASP LEU ASP GLU GLU
SEQRES  21 A  436  VAL GLY SER ALA LEU GLN LYS GLN GLY VAL PRO VAL ILE
SEQRES  22 A  436  GLY VAL ASP ALA LEU ARG TYR PHE TRP LYS GLU LYS ASP
SEQRES  23 A  436  PRO LYS GLU VAL ALA GLY ASP LEU ALA ARG ILE ILE ASP
SEQRES  24 A  436  THR TYR ARG LYS GLU TRP GLU VAL LYS ASN VAL VAL LEU
SEQRES  25 A  436  ILE GLY TYR SER PHE GLY ALA ASP ILE ILE PRO ALA THR
SEQRES  26 A  436  TYR ASN LEU LEU PRO ASP ARG VAL LYS SER SER VAL ALA
SEQRES  27 A  436  GLN LEU SER LEU LEU GLY LEU SER ASN GLU VAL ASP PHE
SEQRES  28 A  436  GLU ILE SER VAL GLN GLY TRP LEU GLY VAL ALA GLY GLU
SEQRES  29 A  436  GLY LYS GLY GLY LYS THR VAL ASP ASP ILE ALA LYS ILE
SEQRES  30 A  436  ASP PRO LYS LEU VAL GLN CYS VAL TYR GLY THR GLU GLU
SEQRES  31 A  436  GLU ASP GLU ASP PRO CYS PRO GLY LEU LYS ALA LYS GLY
SEQRES  32 A  436  VAL GLU THR ILE GLY ILE GLU GLY GLY HIS HIS PHE ASP
SEQRES  33 A  436  GLU ASP TYR GLU ALA LEU ALA LYS ARG ILE VAL THR SER
SEQRES  34 A  436  LEU LYS THR ARG LEU ALA LYS
SEQRES   1 B  436  GLY PRO HIS MET GLN ASP LYS PRO ALA TYR GLU THR GLY
SEQRES   2 B  436  MET ILE PRO ALA ASP HIS ILE MET VAL PRO ASP GLY ASP
SEQRES   3 B  436  ILE GLN ALA SER ILE PHE LEU ILE SER ASP ALA ASN GLY
SEQRES   4 B  436  TRP THR GLU ALA ASP GLU THR ARG ALA LYS ALA LEU VAL
SEQRES   5 B  436  GLU LYS GLY ALA ALA VAL VAL GLY ILE ASP PHE LYS GLU
SEQRES   6 B  436  TYR LEU LYS ALA LEU GLU ALA ASP ASP ASP GLU CYS ILE
SEQRES   7 B  436  TYR MET ILE SER ASP ILE GLU SER LEU SER GLN GLN ILE
SEQRES   8 B  436  GLN ARG THR ALA GLY THR GLY SER TYR ARG LEU PRO ILE
SEQRES   9 B  436  VAL THR GLY ILE GLY LYS GLY GLY THR LEU ALA LEU ALA
SEQRES  10 B  436  MET ILE ALA GLN SER PRO VAL SER THR VAL ARG GLU ALA
SEQRES  11 B  436  VAL ALA VAL ASP PRO LYS ALA GLY LEU PRO LEU GLU LYS
SEQRES  12 B  436  ILE LEU CYS THR PRO ALA THR LYS ASP LYS VAL ASP GLY
SEQRES  13 B  436  GLU THR LEU TYR GLY LEU THR ASP GLY ALA LEU PRO ALA
SEQRES  14 B  436  PRO VAL SER VAL ILE PHE THR PRO ASP ALA ASP GLN LYS
SEQRES  15 B  436  GLY ARG ASP HIS VAL ASN ALA LEU VAL LYS LEU HIS SER
SEQRES  16 B  436  ASP ILE GLU VAL THR ASP VAL THR ASP LYS ALA ASP GLU
SEQRES  17 B  436  VAL LEU THR GLN THR LEU SER ASP LYS VAL ASP ALA ALA
SEQRES  18 B  436  GLY ASP SER GLY ASN PRO LEU GLY LEU PRO ILE THR VAL
SEQRES  19 B  436  LEU GLU ALA LYS PRO VAL MET ASP THR MET ALA VAL ILE
SEQRES  20 B  436  TYR SER GLY ASP GLY GLY TRP ARG ASP LEU ASP GLU GLU
SEQRES  21 B  436  VAL GLY SER ALA LEU GLN LYS GLN GLY VAL PRO VAL ILE
SEQRES  22 B  436  GLY VAL ASP ALA LEU ARG TYR PHE TRP LYS GLU LYS ASP
SEQRES  23 B  436  PRO LYS GLU VAL ALA GLY ASP LEU ALA ARG ILE ILE ASP
SEQRES  24 B  436  THR TYR ARG LYS GLU TRP GLU VAL LYS ASN VAL VAL LEU
SEQRES  25 B  436  ILE GLY TYR SER PHE GLY ALA ASP ILE ILE PRO ALA THR
SEQRES  26 B  436  TYR ASN LEU LEU PRO ASP ARG VAL LYS SER SER VAL ALA
SEQRES  27 B  436  GLN LEU SER LEU LEU GLY LEU SER ASN GLU VAL ASP PHE
SEQRES  28 B  436  GLU ILE SER VAL GLN GLY TRP LEU GLY VAL ALA GLY GLU
SEQRES  29 B  436  GLY LYS GLY GLY LYS THR VAL ASP ASP ILE ALA LYS ILE
SEQRES  30 B  436  ASP PRO LYS LEU VAL GLN CYS VAL TYR GLY THR GLU GLU
SEQRES  31 B  436  GLU ASP GLU ASP PRO CYS PRO GLY LEU LYS ALA LYS GLY
SEQRES  32 B  436  VAL GLU THR ILE GLY ILE GLU GLY GLY HIS HIS PHE ASP
SEQRES  33 B  436  GLU ASP TYR GLU ALA LEU ALA LYS ARG ILE VAL THR SER
SEQRES  34 B  436  LEU LYS THR ARG LEU ALA LYS
HET    EDO  A 501       4
HET    EDO  B 501       4
HETNAM     EDO 1,2-ETHANEDIOL
HETSYN     EDO ETHYLENE GLYCOL
FORMUL   3  EDO    2(C2 H6 O2)
HELIX    1 AA1 THR A   61  GLU A   73  1                                  13
HELIX    2 AA2 ASP A   82  ALA A   92  1                                  11
HELIX    3 AA3 MET A  100  THR A  114  1                                  15
HELIX    4 AA4 GLY A  129  ALA A  140  1                                  12
HELIX    5 AA5 ASP A  200  HIS A  214  1                                  15
HELIX    6 AA6 LYS A  225  GLY A  242  1                                  18
HELIX    7 AA7 ARG A  275  GLN A  288  1                                  14
HELIX    8 AA8 ASP A  296  PHE A  301  1                                   6
HELIX    9 AA9 ASP A  306  TRP A  325  1                                  20
HELIX   10 AB1 SER A  336  LEU A  349  1                                  14
HELIX   11 AB2 PRO A  350  SER A  355  1                                   6
HELIX   12 AB3 LYS A  389  LYS A  396  1                                   8
HELIX   13 AB4 GLU A  409  GLU A  411  5                                   3
HELIX   14 AB5 LEU A  419  GLY A  423  5                                   5
HELIX   15 AB6 ASP A  438  ALA A  455  1                                  18
HELIX   16 AB7 THR B   61  GLU B   73  1                                  13
HELIX   17 AB8 ASP B   82  ALA B   92  1                                  11
HELIX   18 AB9 TYR B   99  ARG B  113  1                                  15
HELIX   19 AC1 GLY B  129  ALA B  140  1                                  12
HELIX   20 AC2 ASP B  200  HIS B  214  1                                  15
HELIX   21 AC3 LYS B  225  ASP B  243  1                                  19
HELIX   22 AC4 ARG B  275  GLN B  288  1                                  14
HELIX   23 AC5 ASP B  296  PHE B  301  1                                   6
HELIX   24 AC6 ASP B  306  GLU B  326  1                                  21
HELIX   25 AC7 SER B  336  LEU B  348  1                                  13
HELIX   26 AC8 PRO B  350  SER B  356  1                                   7
HELIX   27 AC9 GLN B  376  GLY B  380  5                                   5
HELIX   28 AD1 LYS B  389  ALA B  395  1                                   7
HELIX   29 AD2 CYS B  416  GLY B  423  5                                   8
HELIX   30 AD3 ASP B  438  LYS B  456  1                                  19
SHEET    1 AA1 7 HIS A  39  MET A  41  0
SHEET    2 AA1 7 ALA A  76  ILE A  81 -1  O  GLY A  80   N  HIS A  39
SHEET    3 AA1 7 ALA A  49  ILE A  54  1  N  LEU A  53   O  ILE A  81
SHEET    4 AA1 7 PRO A 123  ILE A 128  1  O  ILE A 124   N  PHE A  52
SHEET    5 AA1 7 GLU A 149  VAL A 153  1  O  GLU A 149   N  VAL A 125
SHEET    6 AA1 7 VAL A 191  PHE A 195  1  O  ILE A 194   N  ALA A 152
SHEET    7 AA1 7 GLU A 218  ASP A 221  1  O  THR A 220   N  PHE A 195
SHEET    1 AA2 2 LYS A 173  VAL A 174  0
SHEET    2 AA2 2 GLU A 177  THR A 178 -1  O  GLU A 177   N  VAL A 174
SHEET    1 AA3 7 ILE A 252  LEU A 255  0
SHEET    2 AA3 7 VAL A 292  VAL A 295 -1  O  VAL A 292   N  LEU A 255
SHEET    3 AA3 7 THR A 263  TYR A 268  1  N  ILE A 267   O  VAL A 295
SHEET    4 AA3 7 ASN A 329  TYR A 335  1  O  ILE A 333   N  VAL A 266
SHEET    5 AA3 7 VAL A 357  LEU A 363  1  O  SER A 361   N  LEU A 332
SHEET    6 AA3 7 VAL A 402  GLY A 407  1  O  GLN A 403   N  LEU A 360
SHEET    7 AA3 7 GLU A 425  ILE A 429  1  O  ILE A 427   N  TYR A 406
SHEET    1 AA4 7 ILE B  40  MET B  41  0
SHEET    2 AA4 7 ALA B  76  VAL B  79 -1  O  VAL B  78   N  MET B  41
SHEET    3 AA4 7 ALA B  49  ILE B  54  1  N  ILE B  51   O  VAL B  79
SHEET    4 AA4 7 PRO B 123  ILE B 128  1  O  ILE B 124   N  SER B  50
SHEET    5 AA4 7 GLU B 149  VAL B 153  1  O  GLU B 149   N  VAL B 125
SHEET    6 AA4 7 VAL B 191  PHE B 195  1  O  SER B 192   N  ALA B 150
SHEET    7 AA4 7 GLU B 218  ASP B 221  1  O  GLU B 218   N  VAL B 193
SHEET    1 AA5 7 ILE B 252  LEU B 255  0
SHEET    2 AA5 7 VAL B 292  VAL B 295 -1  O  VAL B 292   N  LEU B 255
SHEET    3 AA5 7 THR B 263  TYR B 268  1  N  ILE B 267   O  VAL B 295
SHEET    4 AA5 7 ASN B 329  TYR B 335  1  O  ILE B 333   N  VAL B 266
SHEET    5 AA5 7 VAL B 357  LEU B 363  1  O  SER B 361   N  LEU B 332
SHEET    6 AA5 7 VAL B 402  GLY B 407  1  O  GLN B 403   N  LEU B 360
SHEET    7 AA5 7 GLU B 425  ILE B 429  1  O  ILE B 427   N  TYR B 406
SSBOND   1 CYS A   97    CYS A  166                          1555   1555  2.03
SSBOND   2 CYS A  404    CYS A  416                          1555   1555  2.02
SSBOND   3 CYS B   97    CYS B  166                          1555   1555  2.03
SSBOND   4 CYS B  404    CYS B  416                          1555   1555  2.03
CRYST1   66.565   76.273   77.219 113.86  98.35 106.78 P 1           2
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.015023  0.004530  0.004921        0.00000
SCALE2      0.000000  0.013694  0.007317        0.00000
SCALE3      0.000000  0.000000  0.014840        0.00000
TER    3106      LYS A 456
TER    6189      LYS B 456
MASTER      333    0    2   30   30    0    0    6 6195    2   16   68
END