longtext: 9b80-pdb

content
HEADER    BIOSYNTHETIC PROTEIN                    28-MAR-24   9B80
TITLE     HUMAN ENDOGENOUS FASN WITH 1,3-DBP - CLASS 1 FOCUSED MODIFYING WING
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: FATTY ACID SYNTHASE;
COMPND   3 CHAIN: A, B;
COMPND   4 SYNONYM: TYPE I FATTY ACID SYNTHASE;
COMPND   5 EC: 2.3.1.85,2.3.1.38,2.3.1.39,2.3.1.41,1.1.1.100,4.2.1.59,1.3.1.39,
COMPND   6 3.1.2.14
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE   3 ORGANISM_COMMON: HUMAN;
SOURCE   4 ORGANISM_TAXID: 9606
KEYWDS    DE NOVO FATTY ACID SYNTHESIS FATTY ACID SYNTHASE, BIOSYNTHETIC
KEYWDS   2 PROTEIN
EXPDTA    ELECTRON MICROSCOPY
AUTHOR    W.CHOI,C.LI,Y.CHEN,Y.WANG,Y.CHENG
REVDAT   1   26-FEB-25 9B80    0
JRNL        AUTH   W.CHOI,C.LI,Y.CHEN,Y.WANG,Y.CHENG
JRNL        TITL   STRUCTURAL DYNAMICS OF HUMAN FATTY ACID SYNTHASE IN THE
JRNL        TITL 2 CONDENSING CYCLE
JRNL        REF    NATURE                                     2025
JRNL        REFN                   ESSN 1476-4687
JRNL        DOI    10.1038/S41586-025-08782-W
REMARK   2
REMARK   2 RESOLUTION.    2.70 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   SOFTWARE PACKAGES      : NULL
REMARK   3   RECONSTRUCTION SCHEMA  : NULL
REMARK   3
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK   3   PDB ENTRY                    : NULL
REMARK   3   REFINEMENT SPACE             : NULL
REMARK   3   REFINEMENT PROTOCOL          : NULL
REMARK   3   REFINEMENT TARGET            : NULL
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL
REMARK   3
REMARK   3 FITTING PROCEDURE : NULL
REMARK   3
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 2.700
REMARK   3   NUMBER OF PARTICLES               : 448162
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE
REMARK   3                                       CORRECTION
REMARK   3
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK   3
REMARK   3 OTHER DETAILS: NULL
REMARK   4
REMARK   4 9B80 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 29-MAR-24.
REMARK 100 THE DEPOSITION ID IS D_1000282788.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE
REMARK 245   SPECIMEN TYPE                  : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245   SAMPLE TYPE                    : PARTICLE
REMARK 245   PARTICLE TYPE                  : POINT
REMARK 245   NAME OF SAMPLE                 : HUMAN ENDOGENOUS FASN WITH 1,3
REMARK 245                                    -DBP
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL
REMARK 245   SAMPLE BUFFER                  : NULL
REMARK 245   PH                             : 8.00
REMARK 245   SAMPLE DETAILS                 : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245   DATE OF EXPERIMENT                : NULL
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL
REMARK 245   TEMPERATURE (KELVIN)              : NULL
REMARK 245   MICROSCOPE MODEL                  : TFS KRIOS
REMARK 245   DETECTOR TYPE                     : GATAN K3 (6K X 4K)
REMARK 245   MINIMUM DEFOCUS (NM)              : 800.00
REMARK 245   MAXIMUM DEFOCUS (NM)              : 1500.00
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL
REMARK 245   NOMINAL CS                        : NULL
REMARK 245   IMAGING MODE                      : BRIGHT FIELD
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 4580.00
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM
REMARK 245   NOMINAL MAGNIFICATION             : NULL
REMARK 245   CALIBRATED MAGNIFICATION          : NULL
REMARK 245   SOURCE                            : FIELD EMISSION GUN
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300
REMARK 245   IMAGING DETAILS                   : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247  OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     PRO A   977
REMARK 465     ASN A   978
REMARK 465     PRO A   979
REMARK 465     THR A   980
REMARK 465     VAL A  1145
REMARK 465     GLN A  1146
REMARK 465     ALA A  1147
REMARK 465     LEU A  1148
REMARK 465     GLN A  1149
REMARK 465     THR A  1150
REMARK 465     LYS A  1151
REMARK 465     VAL A  1152
REMARK 465     THR A  1153
REMARK 465     GLN A  1154
REMARK 465     GLN A  1155
REMARK 465     GLY A  1156
REMARK 465     LEU A  1157
REMARK 465     LYS A  1158
REMARK 465     MET A  1159
REMARK 465     VAL A  1160
REMARK 465     VAL A  1161
REMARK 465     PRO A  1162
REMARK 465     GLY A  1163
REMARK 465     LEU A  1164
REMARK 465     ASP A  1165
REMARK 465     GLY A  1166
REMARK 465     ALA A  1167
REMARK 465     GLN A  1168
REMARK 465     ILE A  1169
REMARK 465     PRO A  1170
REMARK 465     ARG A  1171
REMARK 465     ASP A  1172
REMARK 465     PRO A  1173
REMARK 465     SER A  1174
REMARK 465     GLN A  1175
REMARK 465     GLN A  1176
REMARK 465     GLU A  1177
REMARK 465     LEU A  1178
REMARK 465     PRO A  1179
REMARK 465     ARG A  1180
REMARK 465     LEU A  1181
REMARK 465     LEU A  1182
REMARK 465     SER A  1183
REMARK 465     ALA A  1184
REMARK 465     ALA A  1185
REMARK 465     CYS A  1186
REMARK 465     ARG A  1187
REMARK 465     LEU A  1188
REMARK 465     GLN A  1189
REMARK 465     LEU A  1190
REMARK 465     ASN A  1191
REMARK 465     GLY A  1192
REMARK 465     ASN A  1193
REMARK 465     LEU A  1194
REMARK 465     GLN A  1195
REMARK 465     LEU A  1196
REMARK 465     GLU A  1197
REMARK 465     LEU A  1198
REMARK 465     ALA A  1199
REMARK 465     GLN A  1200
REMARK 465     VAL A  1201
REMARK 465     LEU A  1202
REMARK 465     ALA A  1203
REMARK 465     GLN A  1204
REMARK 465     GLU A  1205
REMARK 465     ARG A  1206
REMARK 465     PRO A  1207
REMARK 465     LYS A  1208
REMARK 465     LEU A  1209
REMARK 465     PRO A  1210
REMARK 465     GLN A  1296
REMARK 465     TRP A  1297
REMARK 465     ASP A  1298
REMARK 465     PRO A  1299
REMARK 465     ALA A  1300
REMARK 465     ASP A  1301
REMARK 465     PRO A  1302
REMARK 465     ALA A  1303
REMARK 465     PRO A  1304
REMARK 465     SER A  1305
REMARK 465     ALA A  1306
REMARK 465     LEU A  1307
REMARK 465     GLY A  1308
REMARK 465     SER A  1309
REMARK 465     ALA A  1310
REMARK 465     ASP A  1311
REMARK 465     LEU A  1312
REMARK 465     CYS A  1317
REMARK 465     ALA A  1318
REMARK 465     VAL A  1319
REMARK 465     ALA A  1320
REMARK 465     ALA A  1321
REMARK 465     LEU A  1322
REMARK 465     GLY A  1323
REMARK 465     ASP A  1324
REMARK 465     PRO A  1325
REMARK 465     ALA A  1326
REMARK 465     SER A  1327
REMARK 465     ALA A  1328
REMARK 465     LEU A  1329
REMARK 465     SER A  1330
REMARK 465     ASN A  1331
REMARK 465     MET A  1332
REMARK 465     VAL A  1333
REMARK 465     ALA A  1334
REMARK 465     ALA A  1335
REMARK 465     LEU A  1336
REMARK 465     ARG A  1337
REMARK 465     GLU A  1338
REMARK 465     GLY A  1339
REMARK 465     GLY A  1340
REMARK 465     PHE A  1341
REMARK 465     LEU A  1342
REMARK 465     LEU A  1343
REMARK 465     LEU A  1344
REMARK 465     HIS A  1345
REMARK 465     THR A  1346
REMARK 465     LEU A  1347
REMARK 465     LEU A  1348
REMARK 465     ARG A  1349
REMARK 465     GLY A  1350
REMARK 465     HIS A  1351
REMARK 465     PRO A  1352
REMARK 465     LEU A  1353
REMARK 465     GLY A  1354
REMARK 465     ASP A  1355
REMARK 465     ILE A  1356
REMARK 465     VAL A  1357
REMARK 465     ALA A  1358
REMARK 465     PHE A  1359
REMARK 465     LEU A  1360
REMARK 465     THR A  1361
REMARK 465     SER A  1362
REMARK 465     THR A  1363
REMARK 465     GLU A  1364
REMARK 465     PRO A  1365
REMARK 465     GLN A  1366
REMARK 465     TYR A  1367
REMARK 465     GLY A  1368
REMARK 465     GLN A  1369
REMARK 465     GLY A  1370
REMARK 465     ILE A  1371
REMARK 465     LEU A  1372
REMARK 465     SER A  1373
REMARK 465     GLN A  1374
REMARK 465     ASP A  1375
REMARK 465     ALA A  1376
REMARK 465     TRP A  1377
REMARK 465     GLU A  1378
REMARK 465     ILE A  2068
REMARK 465     LEU A  2069
REMARK 465     VAL A  2070
REMARK 465     GLU A  2071
REMARK 465     THR A  2072
REMARK 465     MET A  2073
REMARK 465     SER A  2074
REMARK 465     THR A  2075
REMARK 465     ASN A  2076
REMARK 465     ASP A  2077
REMARK 465     THR A  2078
REMARK 465     GLU A  2113
REMARK 465     LYS A  2114
REMARK 465     ALA A  2115
REMARK 465     ALA A  2116
REMARK 465     ALA A  2117
REMARK 465     TYR A  2118
REMARK 465     ARG A  2119
REMARK 465     ASP A  2120
REMARK 465     ARG A  2121
REMARK 465     ASP A  2122
REMARK 465     SER A  2123
REMARK 465     GLN A  2124
REMARK 465     ARG A  2125
REMARK 465     ASP A  2126
REMARK 465     LEU A  2127
REMARK 465     VAL A  2128
REMARK 465     GLU A  2129
REMARK 465     ALA A  2130
REMARK 465     VAL A  2131
REMARK 465     ALA A  2132
REMARK 465     HIS A  2133
REMARK 465     ILE A  2134
REMARK 465     LEU A  2135
REMARK 465     GLY A  2136
REMARK 465     ILE A  2137
REMARK 465     ARG A  2138
REMARK 465     ASP A  2139
REMARK 465     LEU A  2140
REMARK 465     ALA A  2141
REMARK 465     ALA A  2142
REMARK 465     VAL A  2143
REMARK 465     ASN A  2144
REMARK 465     LEU A  2145
REMARK 465     ASP A  2146
REMARK 465     SER A  2147
REMARK 465     SER A  2148
REMARK 465     LEU A  2149
REMARK 465     ALA A  2150
REMARK 465     ASP A  2151
REMARK 465     LEU A  2152
REMARK 465     GLY A  2153
REMARK 465     LEU A  2154
REMARK 465     ASP A  2155
REMARK 465     SER A  2156
REMARK 465     LEU A  2157
REMARK 465     MET A  2158
REMARK 465     SER A  2159
REMARK 465     VAL A  2160
REMARK 465     GLU A  2161
REMARK 465     VAL A  2162
REMARK 465     ARG A  2163
REMARK 465     GLN A  2164
REMARK 465     THR A  2165
REMARK 465     LEU A  2166
REMARK 465     GLU A  2167
REMARK 465     ARG A  2168
REMARK 465     GLU A  2169
REMARK 465     LEU A  2170
REMARK 465     ASN A  2171
REMARK 465     LEU A  2172
REMARK 465     VAL A  2173
REMARK 465     LEU A  2174
REMARK 465     SER A  2175
REMARK 465     VAL A  2176
REMARK 465     ARG A  2177
REMARK 465     GLU A  2178
REMARK 465     VAL A  2179
REMARK 465     ARG A  2180
REMARK 465     GLN A  2181
REMARK 465     LEU A  2182
REMARK 465     THR A  2183
REMARK 465     LEU A  2184
REMARK 465     ARG A  2185
REMARK 465     LYS A  2186
REMARK 465     LEU A  2187
REMARK 465     GLN A  2188
REMARK 465     GLU A  2189
REMARK 465     LEU A  2190
REMARK 465     SER A  2191
REMARK 465     SER A  2192
REMARK 465     LYS A  2193
REMARK 465     ALA A  2194
REMARK 465     ASP A  2195
REMARK 465     GLU A  2196
REMARK 465     ALA A  2197
REMARK 465     SER A  2198
REMARK 465     GLU A  2199
REMARK 465     LEU A  2200
REMARK 465     ALA A  2201
REMARK 465     CYS A  2202
REMARK 465     PRO A  2203
REMARK 465     THR A  2204
REMARK 465     PRO A  2205
REMARK 465     LYS A  2206
REMARK 465     GLU A  2207
REMARK 465     ASP A  2208
REMARK 465     GLY A  2209
REMARK 465     LEU A  2210
REMARK 465     ALA A  2211
REMARK 465     GLN A  2212
REMARK 465     GLN A  2213
REMARK 465     GLN A  2214
REMARK 465     THR A  2215
REMARK 465     GLN A  2216
REMARK 465     LEU A  2217
REMARK 465     ASN A  2218
REMARK 465     LEU A  2219
REMARK 465     ARG A  2220
REMARK 465     SER A  2221
REMARK 465     LEU A  2222
REMARK 465     LEU A  2223
REMARK 465     VAL A  2224
REMARK 465     ASN A  2225
REMARK 465     PRO A  2226
REMARK 465     GLU A  2227
REMARK 465     GLY A  2228
REMARK 465     PRO A  2229
REMARK 465     THR A  2230
REMARK 465     LEU A  2231
REMARK 465     MET A  2232
REMARK 465     ARG A  2233
REMARK 465     LEU A  2234
REMARK 465     ASN A  2235
REMARK 465     SER A  2236
REMARK 465     VAL A  2237
REMARK 465     GLN A  2238
REMARK 465     SER A  2239
REMARK 465     SER A  2240
REMARK 465     GLU A  2241
REMARK 465     ARG A  2242
REMARK 465     PRO A  2243
REMARK 465     LEU A  2244
REMARK 465     PHE A  2245
REMARK 465     LEU A  2246
REMARK 465     VAL A  2247
REMARK 465     HIS A  2248
REMARK 465     PRO A  2249
REMARK 465     ILE A  2250
REMARK 465     GLU A  2251
REMARK 465     GLY A  2252
REMARK 465     SER A  2253
REMARK 465     THR A  2254
REMARK 465     THR A  2255
REMARK 465     VAL A  2256
REMARK 465     PHE A  2257
REMARK 465     HIS A  2258
REMARK 465     SER A  2259
REMARK 465     LEU A  2260
REMARK 465     ALA A  2261
REMARK 465     SER A  2262
REMARK 465     ARG A  2263
REMARK 465     LEU A  2264
REMARK 465     SER A  2265
REMARK 465     ILE A  2266
REMARK 465     PRO A  2267
REMARK 465     THR A  2268
REMARK 465     TYR A  2269
REMARK 465     GLY A  2270
REMARK 465     LEU A  2271
REMARK 465     GLN A  2272
REMARK 465     CYS A  2273
REMARK 465     THR A  2274
REMARK 465     ARG A  2275
REMARK 465     ALA A  2276
REMARK 465     ALA A  2277
REMARK 465     PRO A  2278
REMARK 465     LEU A  2279
REMARK 465     ASP A  2280
REMARK 465     SER A  2281
REMARK 465     ILE A  2282
REMARK 465     HIS A  2283
REMARK 465     SER A  2284
REMARK 465     LEU A  2285
REMARK 465     ALA A  2286
REMARK 465     ALA A  2287
REMARK 465     TYR A  2288
REMARK 465     TYR A  2289
REMARK 465     ILE A  2290
REMARK 465     ASP A  2291
REMARK 465     CYS A  2292
REMARK 465     ILE A  2293
REMARK 465     ARG A  2294
REMARK 465     GLN A  2295
REMARK 465     VAL A  2296
REMARK 465     GLN A  2297
REMARK 465     PRO A  2298
REMARK 465     GLU A  2299
REMARK 465     GLY A  2300
REMARK 465     PRO A  2301
REMARK 465     TYR A  2302
REMARK 465     ARG A  2303
REMARK 465     VAL A  2304
REMARK 465     ALA A  2305
REMARK 465     GLY A  2306
REMARK 465     TYR A  2307
REMARK 465     SER A  2308
REMARK 465     TYR A  2309
REMARK 465     GLY A  2310
REMARK 465     ALA A  2311
REMARK 465     CYS A  2312
REMARK 465     VAL A  2313
REMARK 465     ALA A  2314
REMARK 465     PHE A  2315
REMARK 465     GLU A  2316
REMARK 465     MET A  2317
REMARK 465     CYS A  2318
REMARK 465     SER A  2319
REMARK 465     GLN A  2320
REMARK 465     LEU A  2321
REMARK 465     GLN A  2322
REMARK 465     ALA A  2323
REMARK 465     GLN A  2324
REMARK 465     GLN A  2325
REMARK 465     SER A  2326
REMARK 465     PRO A  2327
REMARK 465     ALA A  2328
REMARK 465     PRO A  2329
REMARK 465     THR A  2330
REMARK 465     HIS A  2331
REMARK 465     ASN A  2332
REMARK 465     SER A  2333
REMARK 465     LEU A  2334
REMARK 465     PHE A  2335
REMARK 465     LEU A  2336
REMARK 465     PHE A  2337
REMARK 465     ASP A  2338
REMARK 465     GLY A  2339
REMARK 465     SER A  2340
REMARK 465     PRO A  2341
REMARK 465     THR A  2342
REMARK 465     TYR A  2343
REMARK 465     VAL A  2344
REMARK 465     LEU A  2345
REMARK 465     ALA A  2346
REMARK 465     TYR A  2347
REMARK 465     THR A  2348
REMARK 465     GLN A  2349
REMARK 465     SER A  2350
REMARK 465     TYR A  2351
REMARK 465     ARG A  2352
REMARK 465     ALA A  2353
REMARK 465     LYS A  2354
REMARK 465     LEU A  2355
REMARK 465     THR A  2356
REMARK 465     PRO A  2357
REMARK 465     GLY A  2358
REMARK 465     CYS A  2359
REMARK 465     GLU A  2360
REMARK 465     ALA A  2361
REMARK 465     GLU A  2362
REMARK 465     ALA A  2363
REMARK 465     GLU A  2364
REMARK 465     THR A  2365
REMARK 465     GLU A  2366
REMARK 465     ALA A  2367
REMARK 465     ILE A  2368
REMARK 465     CYS A  2369
REMARK 465     PHE A  2370
REMARK 465     PHE A  2371
REMARK 465     VAL A  2372
REMARK 465     GLN A  2373
REMARK 465     GLN A  2374
REMARK 465     PHE A  2375
REMARK 465     THR A  2376
REMARK 465     ASP A  2377
REMARK 465     MET A  2378
REMARK 465     GLU A  2379
REMARK 465     HIS A  2380
REMARK 465     ASN A  2381
REMARK 465     ARG A  2382
REMARK 465     VAL A  2383
REMARK 465     LEU A  2384
REMARK 465     GLU A  2385
REMARK 465     ALA A  2386
REMARK 465     LEU A  2387
REMARK 465     LEU A  2388
REMARK 465     PRO A  2389
REMARK 465     LEU A  2390
REMARK 465     LYS A  2391
REMARK 465     GLY A  2392
REMARK 465     LEU A  2393
REMARK 465     GLU A  2394
REMARK 465     GLU A  2395
REMARK 465     ARG A  2396
REMARK 465     VAL A  2397
REMARK 465     ALA A  2398
REMARK 465     ALA A  2399
REMARK 465     ALA A  2400
REMARK 465     VAL A  2401
REMARK 465     ASP A  2402
REMARK 465     LEU A  2403
REMARK 465     ILE A  2404
REMARK 465     ILE A  2405
REMARK 465     LYS A  2406
REMARK 465     SER A  2407
REMARK 465     HIS A  2408
REMARK 465     GLN A  2409
REMARK 465     GLY A  2410
REMARK 465     LEU A  2411
REMARK 465     ASP A  2412
REMARK 465     ARG A  2413
REMARK 465     GLN A  2414
REMARK 465     GLU A  2415
REMARK 465     LEU A  2416
REMARK 465     SER A  2417
REMARK 465     PHE A  2418
REMARK 465     ALA A  2419
REMARK 465     ALA A  2420
REMARK 465     ARG A  2421
REMARK 465     SER A  2422
REMARK 465     PHE A  2423
REMARK 465     TYR A  2424
REMARK 465     TYR A  2425
REMARK 465     LYS A  2426
REMARK 465     LEU A  2427
REMARK 465     ARG A  2428
REMARK 465     ALA A  2429
REMARK 465     ALA A  2430
REMARK 465     GLU A  2431
REMARK 465     GLN A  2432
REMARK 465     TYR A  2433
REMARK 465     THR A  2434
REMARK 465     PRO A  2435
REMARK 465     LYS A  2436
REMARK 465     ALA A  2437
REMARK 465     LYS A  2438
REMARK 465     TYR A  2439
REMARK 465     HIS A  2440
REMARK 465     GLY A  2441
REMARK 465     ASN A  2442
REMARK 465     VAL A  2443
REMARK 465     MET A  2444
REMARK 465     LEU A  2445
REMARK 465     LEU A  2446
REMARK 465     ARG A  2447
REMARK 465     ALA A  2448
REMARK 465     LYS A  2449
REMARK 465     THR A  2450
REMARK 465     GLY A  2451
REMARK 465     GLY A  2452
REMARK 465     ALA A  2453
REMARK 465     TYR A  2454
REMARK 465     GLY A  2455
REMARK 465     GLU A  2456
REMARK 465     ASP A  2457
REMARK 465     LEU A  2458
REMARK 465     GLY A  2459
REMARK 465     ALA A  2460
REMARK 465     ASP A  2461
REMARK 465     TYR A  2462
REMARK 465     ASN A  2463
REMARK 465     LEU A  2464
REMARK 465     SER A  2465
REMARK 465     GLN A  2466
REMARK 465     VAL A  2467
REMARK 465     CYS A  2468
REMARK 465     ASP A  2469
REMARK 465     GLY A  2470
REMARK 465     LYS A  2471
REMARK 465     VAL A  2472
REMARK 465     SER A  2473
REMARK 465     VAL A  2474
REMARK 465     HIS A  2475
REMARK 465     VAL A  2476
REMARK 465     ILE A  2477
REMARK 465     GLU A  2478
REMARK 465     GLY A  2479
REMARK 465     ASP A  2480
REMARK 465     HIS A  2481
REMARK 465     ARG A  2482
REMARK 465     THR A  2483
REMARK 465     LEU A  2484
REMARK 465     LEU A  2485
REMARK 465     GLU A  2486
REMARK 465     GLY A  2487
REMARK 465     SER A  2488
REMARK 465     GLY A  2489
REMARK 465     LEU A  2490
REMARK 465     GLU A  2491
REMARK 465     SER A  2492
REMARK 465     ILE A  2493
REMARK 465     ILE A  2494
REMARK 465     SER A  2495
REMARK 465     ILE A  2496
REMARK 465     ILE A  2497
REMARK 465     HIS A  2498
REMARK 465     SER A  2499
REMARK 465     SER A  2500
REMARK 465     LEU A  2501
REMARK 465     ALA A  2502
REMARK 465     GLU A  2503
REMARK 465     PRO A  2504
REMARK 465     ARG A  2505
REMARK 465     VAL A  2506
REMARK 465     SER A  2507
REMARK 465     VAL A  2508
REMARK 465     ARG A  2509
REMARK 465     GLU A  2510
REMARK 465     GLY A  2511
REMARK 465     PRO B   977
REMARK 465     ASN B   978
REMARK 465     PRO B   979
REMARK 465     THR B   980
REMARK 465     VAL B  1145
REMARK 465     GLN B  1146
REMARK 465     ALA B  1147
REMARK 465     LEU B  1148
REMARK 465     GLN B  1149
REMARK 465     THR B  1150
REMARK 465     LYS B  1151
REMARK 465     VAL B  1152
REMARK 465     THR B  1153
REMARK 465     GLN B  1154
REMARK 465     GLN B  1155
REMARK 465     GLY B  1156
REMARK 465     LEU B  1157
REMARK 465     LYS B  1158
REMARK 465     MET B  1159
REMARK 465     VAL B  1160
REMARK 465     VAL B  1161
REMARK 465     PRO B  1162
REMARK 465     GLY B  1163
REMARK 465     LEU B  1164
REMARK 465     ASP B  1165
REMARK 465     GLY B  1166
REMARK 465     ALA B  1167
REMARK 465     GLN B  1168
REMARK 465     ILE B  1169
REMARK 465     PRO B  1170
REMARK 465     ARG B  1171
REMARK 465     ASP B  1172
REMARK 465     PRO B  1173
REMARK 465     SER B  1174
REMARK 465     GLN B  1175
REMARK 465     GLN B  1176
REMARK 465     GLU B  1177
REMARK 465     LEU B  1178
REMARK 465     PRO B  1179
REMARK 465     ARG B  1180
REMARK 465     LEU B  1181
REMARK 465     LEU B  1182
REMARK 465     SER B  1183
REMARK 465     ALA B  1184
REMARK 465     ALA B  1185
REMARK 465     CYS B  1186
REMARK 465     ARG B  1187
REMARK 465     LEU B  1188
REMARK 465     GLN B  1189
REMARK 465     LEU B  1190
REMARK 465     ASN B  1191
REMARK 465     GLY B  1192
REMARK 465     ASN B  1193
REMARK 465     LEU B  1194
REMARK 465     GLN B  1195
REMARK 465     LEU B  1196
REMARK 465     GLU B  1197
REMARK 465     LEU B  1198
REMARK 465     ALA B  1199
REMARK 465     GLN B  1200
REMARK 465     VAL B  1201
REMARK 465     LEU B  1202
REMARK 465     ALA B  1203
REMARK 465     GLN B  1204
REMARK 465     GLU B  1205
REMARK 465     ARG B  1206
REMARK 465     PRO B  1207
REMARK 465     LYS B  1208
REMARK 465     LEU B  1209
REMARK 465     PRO B  1210
REMARK 465     GLN B  1296
REMARK 465     TRP B  1297
REMARK 465     ASP B  1298
REMARK 465     PRO B  1299
REMARK 465     ALA B  1300
REMARK 465     ASP B  1301
REMARK 465     PRO B  1302
REMARK 465     ALA B  1303
REMARK 465     PRO B  1304
REMARK 465     SER B  1305
REMARK 465     ALA B  1306
REMARK 465     LEU B  1307
REMARK 465     GLY B  1308
REMARK 465     SER B  1309
REMARK 465     ALA B  1310
REMARK 465     ASP B  1311
REMARK 465     LEU B  1312
REMARK 465     CYS B  1317
REMARK 465     ALA B  1318
REMARK 465     VAL B  1319
REMARK 465     ALA B  1320
REMARK 465     ALA B  1321
REMARK 465     LEU B  1322
REMARK 465     GLY B  1323
REMARK 465     ASP B  1324
REMARK 465     PRO B  1325
REMARK 465     ALA B  1326
REMARK 465     SER B  1327
REMARK 465     ALA B  1328
REMARK 465     LEU B  1329
REMARK 465     SER B  1330
REMARK 465     ASN B  1331
REMARK 465     MET B  1332
REMARK 465     VAL B  1333
REMARK 465     ALA B  1334
REMARK 465     ALA B  1335
REMARK 465     LEU B  1336
REMARK 465     ARG B  1337
REMARK 465     GLU B  1338
REMARK 465     GLY B  1339
REMARK 465     GLY B  1340
REMARK 465     PHE B  1341
REMARK 465     LEU B  1342
REMARK 465     LEU B  1343
REMARK 465     LEU B  1344
REMARK 465     HIS B  1345
REMARK 465     THR B  1346
REMARK 465     LEU B  1347
REMARK 465     LEU B  1348
REMARK 465     ARG B  1349
REMARK 465     GLY B  1350
REMARK 465     HIS B  1351
REMARK 465     PRO B  1352
REMARK 465     LEU B  1353
REMARK 465     GLY B  1354
REMARK 465     ASP B  1355
REMARK 465     ILE B  1356
REMARK 465     VAL B  1357
REMARK 465     ALA B  1358
REMARK 465     PHE B  1359
REMARK 465     LEU B  1360
REMARK 465     THR B  1361
REMARK 465     SER B  1362
REMARK 465     THR B  1363
REMARK 465     GLU B  1364
REMARK 465     PRO B  1365
REMARK 465     GLN B  1366
REMARK 465     TYR B  1367
REMARK 465     GLY B  1368
REMARK 465     GLN B  1369
REMARK 465     GLY B  1370
REMARK 465     ILE B  1371
REMARK 465     LEU B  1372
REMARK 465     SER B  1373
REMARK 465     GLN B  1374
REMARK 465     ASP B  1375
REMARK 465     ALA B  1376
REMARK 465     TRP B  1377
REMARK 465     GLU B  1378
REMARK 465     ILE B  2068
REMARK 465     LEU B  2069
REMARK 465     VAL B  2070
REMARK 465     GLU B  2071
REMARK 465     THR B  2072
REMARK 465     MET B  2073
REMARK 465     SER B  2074
REMARK 465     THR B  2075
REMARK 465     ASN B  2076
REMARK 465     ASP B  2077
REMARK 465     THR B  2078
REMARK 465     GLU B  2113
REMARK 465     LYS B  2114
REMARK 465     ALA B  2115
REMARK 465     ALA B  2116
REMARK 465     ALA B  2117
REMARK 465     TYR B  2118
REMARK 465     ARG B  2119
REMARK 465     ASP B  2120
REMARK 465     ARG B  2121
REMARK 465     ASP B  2122
REMARK 465     SER B  2123
REMARK 465     GLN B  2124
REMARK 465     ARG B  2125
REMARK 465     ASP B  2126
REMARK 465     LEU B  2127
REMARK 465     VAL B  2128
REMARK 465     GLU B  2129
REMARK 465     ALA B  2130
REMARK 465     VAL B  2131
REMARK 465     ALA B  2132
REMARK 465     HIS B  2133
REMARK 465     ILE B  2134
REMARK 465     LEU B  2135
REMARK 465     GLY B  2136
REMARK 465     ILE B  2137
REMARK 465     ARG B  2138
REMARK 465     ASP B  2139
REMARK 465     LEU B  2140
REMARK 465     ALA B  2141
REMARK 465     ALA B  2142
REMARK 465     VAL B  2143
REMARK 465     ASN B  2144
REMARK 465     LEU B  2145
REMARK 465     ASP B  2146
REMARK 465     SER B  2147
REMARK 465     SER B  2148
REMARK 465     LEU B  2149
REMARK 465     ALA B  2150
REMARK 465     ASP B  2151
REMARK 465     LEU B  2152
REMARK 465     GLY B  2153
REMARK 465     LEU B  2154
REMARK 465     ASP B  2155
REMARK 465     SER B  2156
REMARK 465     LEU B  2157
REMARK 465     MET B  2158
REMARK 465     SER B  2159
REMARK 465     VAL B  2160
REMARK 465     GLU B  2161
REMARK 465     VAL B  2162
REMARK 465     ARG B  2163
REMARK 465     GLN B  2164
REMARK 465     THR B  2165
REMARK 465     LEU B  2166
REMARK 465     GLU B  2167
REMARK 465     ARG B  2168
REMARK 465     GLU B  2169
REMARK 465     LEU B  2170
REMARK 465     ASN B  2171
REMARK 465     LEU B  2172
REMARK 465     VAL B  2173
REMARK 465     LEU B  2174
REMARK 465     SER B  2175
REMARK 465     VAL B  2176
REMARK 465     ARG B  2177
REMARK 465     GLU B  2178
REMARK 465     VAL B  2179
REMARK 465     ARG B  2180
REMARK 465     GLN B  2181
REMARK 465     LEU B  2182
REMARK 465     THR B  2183
REMARK 465     LEU B  2184
REMARK 465     ARG B  2185
REMARK 465     LYS B  2186
REMARK 465     LEU B  2187
REMARK 465     GLN B  2188
REMARK 465     GLU B  2189
REMARK 465     LEU B  2190
REMARK 465     SER B  2191
REMARK 465     SER B  2192
REMARK 465     LYS B  2193
REMARK 465     ALA B  2194
REMARK 465     ASP B  2195
REMARK 465     GLU B  2196
REMARK 465     ALA B  2197
REMARK 465     SER B  2198
REMARK 465     GLU B  2199
REMARK 465     LEU B  2200
REMARK 465     ALA B  2201
REMARK 465     CYS B  2202
REMARK 465     PRO B  2203
REMARK 465     THR B  2204
REMARK 465     PRO B  2205
REMARK 465     LYS B  2206
REMARK 465     GLU B  2207
REMARK 465     ASP B  2208
REMARK 465     GLY B  2209
REMARK 465     LEU B  2210
REMARK 465     ALA B  2211
REMARK 465     GLN B  2212
REMARK 465     GLN B  2213
REMARK 465     GLN B  2214
REMARK 465     THR B  2215
REMARK 465     GLN B  2216
REMARK 465     LEU B  2217
REMARK 465     ASN B  2218
REMARK 465     LEU B  2219
REMARK 465     ARG B  2220
REMARK 465     SER B  2221
REMARK 465     LEU B  2222
REMARK 465     LEU B  2223
REMARK 465     VAL B  2224
REMARK 465     ASN B  2225
REMARK 465     PRO B  2226
REMARK 465     GLU B  2227
REMARK 465     GLY B  2228
REMARK 465     PRO B  2229
REMARK 465     THR B  2230
REMARK 465     LEU B  2231
REMARK 465     MET B  2232
REMARK 465     ARG B  2233
REMARK 465     LEU B  2234
REMARK 465     ASN B  2235
REMARK 465     SER B  2236
REMARK 465     VAL B  2237
REMARK 465     GLN B  2238
REMARK 465     SER B  2239
REMARK 465     SER B  2240
REMARK 465     GLU B  2241
REMARK 465     ARG B  2242
REMARK 465     PRO B  2243
REMARK 465     LEU B  2244
REMARK 465     PHE B  2245
REMARK 465     LEU B  2246
REMARK 465     VAL B  2247
REMARK 465     HIS B  2248
REMARK 465     PRO B  2249
REMARK 465     ILE B  2250
REMARK 465     GLU B  2251
REMARK 465     GLY B  2252
REMARK 465     SER B  2253
REMARK 465     THR B  2254
REMARK 465     THR B  2255
REMARK 465     VAL B  2256
REMARK 465     PHE B  2257
REMARK 465     HIS B  2258
REMARK 465     SER B  2259
REMARK 465     LEU B  2260
REMARK 465     ALA B  2261
REMARK 465     SER B  2262
REMARK 465     ARG B  2263
REMARK 465     LEU B  2264
REMARK 465     SER B  2265
REMARK 465     ILE B  2266
REMARK 465     PRO B  2267
REMARK 465     THR B  2268
REMARK 465     TYR B  2269
REMARK 465     GLY B  2270
REMARK 465     LEU B  2271
REMARK 465     GLN B  2272
REMARK 465     CYS B  2273
REMARK 465     THR B  2274
REMARK 465     ARG B  2275
REMARK 465     ALA B  2276
REMARK 465     ALA B  2277
REMARK 465     PRO B  2278
REMARK 465     LEU B  2279
REMARK 465     ASP B  2280
REMARK 465     SER B  2281
REMARK 465     ILE B  2282
REMARK 465     HIS B  2283
REMARK 465     SER B  2284
REMARK 465     LEU B  2285
REMARK 465     ALA B  2286
REMARK 465     ALA B  2287
REMARK 465     TYR B  2288
REMARK 465     TYR B  2289
REMARK 465     ILE B  2290
REMARK 465     ASP B  2291
REMARK 465     CYS B  2292
REMARK 465     ILE B  2293
REMARK 465     ARG B  2294
REMARK 465     GLN B  2295
REMARK 465     VAL B  2296
REMARK 465     GLN B  2297
REMARK 465     PRO B  2298
REMARK 465     GLU B  2299
REMARK 465     GLY B  2300
REMARK 465     PRO B  2301
REMARK 465     TYR B  2302
REMARK 465     ARG B  2303
REMARK 465     VAL B  2304
REMARK 465     ALA B  2305
REMARK 465     GLY B  2306
REMARK 465     TYR B  2307
REMARK 465     SER B  2308
REMARK 465     TYR B  2309
REMARK 465     GLY B  2310
REMARK 465     ALA B  2311
REMARK 465     CYS B  2312
REMARK 465     VAL B  2313
REMARK 465     ALA B  2314
REMARK 465     PHE B  2315
REMARK 465     GLU B  2316
REMARK 465     MET B  2317
REMARK 465     CYS B  2318
REMARK 465     SER B  2319
REMARK 465     GLN B  2320
REMARK 465     LEU B  2321
REMARK 465     GLN B  2322
REMARK 465     ALA B  2323
REMARK 465     GLN B  2324
REMARK 465     GLN B  2325
REMARK 465     SER B  2326
REMARK 465     PRO B  2327
REMARK 465     ALA B  2328
REMARK 465     PRO B  2329
REMARK 465     THR B  2330
REMARK 465     HIS B  2331
REMARK 465     ASN B  2332
REMARK 465     SER B  2333
REMARK 465     LEU B  2334
REMARK 465     PHE B  2335
REMARK 465     LEU B  2336
REMARK 465     PHE B  2337
REMARK 465     ASP B  2338
REMARK 465     GLY B  2339
REMARK 465     SER B  2340
REMARK 465     PRO B  2341
REMARK 465     THR B  2342
REMARK 465     TYR B  2343
REMARK 465     VAL B  2344
REMARK 465     LEU B  2345
REMARK 465     ALA B  2346
REMARK 465     TYR B  2347
REMARK 465     THR B  2348
REMARK 465     GLN B  2349
REMARK 465     SER B  2350
REMARK 465     TYR B  2351
REMARK 465     ARG B  2352
REMARK 465     ALA B  2353
REMARK 465     LYS B  2354
REMARK 465     LEU B  2355
REMARK 465     THR B  2356
REMARK 465     PRO B  2357
REMARK 465     GLY B  2358
REMARK 465     CYS B  2359
REMARK 465     GLU B  2360
REMARK 465     ALA B  2361
REMARK 465     GLU B  2362
REMARK 465     ALA B  2363
REMARK 465     GLU B  2364
REMARK 465     THR B  2365
REMARK 465     GLU B  2366
REMARK 465     ALA B  2367
REMARK 465     ILE B  2368
REMARK 465     CYS B  2369
REMARK 465     PHE B  2370
REMARK 465     PHE B  2371
REMARK 465     VAL B  2372
REMARK 465     GLN B  2373
REMARK 465     GLN B  2374
REMARK 465     PHE B  2375
REMARK 465     THR B  2376
REMARK 465     ASP B  2377
REMARK 465     MET B  2378
REMARK 465     GLU B  2379
REMARK 465     HIS B  2380
REMARK 465     ASN B  2381
REMARK 465     ARG B  2382
REMARK 465     VAL B  2383
REMARK 465     LEU B  2384
REMARK 465     GLU B  2385
REMARK 465     ALA B  2386
REMARK 465     LEU B  2387
REMARK 465     LEU B  2388
REMARK 465     PRO B  2389
REMARK 465     LEU B  2390
REMARK 465     LYS B  2391
REMARK 465     GLY B  2392
REMARK 465     LEU B  2393
REMARK 465     GLU B  2394
REMARK 465     GLU B  2395
REMARK 465     ARG B  2396
REMARK 465     VAL B  2397
REMARK 465     ALA B  2398
REMARK 465     ALA B  2399
REMARK 465     ALA B  2400
REMARK 465     VAL B  2401
REMARK 465     ASP B  2402
REMARK 465     LEU B  2403
REMARK 465     ILE B  2404
REMARK 465     ILE B  2405
REMARK 465     LYS B  2406
REMARK 465     SER B  2407
REMARK 465     HIS B  2408
REMARK 465     GLN B  2409
REMARK 465     GLY B  2410
REMARK 465     LEU B  2411
REMARK 465     ASP B  2412
REMARK 465     ARG B  2413
REMARK 465     GLN B  2414
REMARK 465     GLU B  2415
REMARK 465     LEU B  2416
REMARK 465     SER B  2417
REMARK 465     PHE B  2418
REMARK 465     ALA B  2419
REMARK 465     ALA B  2420
REMARK 465     ARG B  2421
REMARK 465     SER B  2422
REMARK 465     PHE B  2423
REMARK 465     TYR B  2424
REMARK 465     TYR B  2425
REMARK 465     LYS B  2426
REMARK 465     LEU B  2427
REMARK 465     ARG B  2428
REMARK 465     ALA B  2429
REMARK 465     ALA B  2430
REMARK 465     GLU B  2431
REMARK 465     GLN B  2432
REMARK 465     TYR B  2433
REMARK 465     THR B  2434
REMARK 465     PRO B  2435
REMARK 465     LYS B  2436
REMARK 465     ALA B  2437
REMARK 465     LYS B  2438
REMARK 465     TYR B  2439
REMARK 465     HIS B  2440
REMARK 465     GLY B  2441
REMARK 465     ASN B  2442
REMARK 465     VAL B  2443
REMARK 465     MET B  2444
REMARK 465     LEU B  2445
REMARK 465     LEU B  2446
REMARK 465     ARG B  2447
REMARK 465     ALA B  2448
REMARK 465     LYS B  2449
REMARK 465     THR B  2450
REMARK 465     GLY B  2451
REMARK 465     GLY B  2452
REMARK 465     ALA B  2453
REMARK 465     TYR B  2454
REMARK 465     GLY B  2455
REMARK 465     GLU B  2456
REMARK 465     ASP B  2457
REMARK 465     LEU B  2458
REMARK 465     GLY B  2459
REMARK 465     ALA B  2460
REMARK 465     ASP B  2461
REMARK 465     TYR B  2462
REMARK 465     ASN B  2463
REMARK 465     LEU B  2464
REMARK 465     SER B  2465
REMARK 465     GLN B  2466
REMARK 465     VAL B  2467
REMARK 465     CYS B  2468
REMARK 465     ASP B  2469
REMARK 465     GLY B  2470
REMARK 465     LYS B  2471
REMARK 465     VAL B  2472
REMARK 465     SER B  2473
REMARK 465     VAL B  2474
REMARK 465     HIS B  2475
REMARK 465     VAL B  2476
REMARK 465     ILE B  2477
REMARK 465     GLU B  2478
REMARK 465     GLY B  2479
REMARK 465     ASP B  2480
REMARK 465     HIS B  2481
REMARK 465     ARG B  2482
REMARK 465     THR B  2483
REMARK 465     LEU B  2484
REMARK 465     LEU B  2485
REMARK 465     GLU B  2486
REMARK 465     GLY B  2487
REMARK 465     SER B  2488
REMARK 465     GLY B  2489
REMARK 465     LEU B  2490
REMARK 465     GLU B  2491
REMARK 465     SER B  2492
REMARK 465     ILE B  2493
REMARK 465     ILE B  2494
REMARK 465     SER B  2495
REMARK 465     ILE B  2496
REMARK 465     ILE B  2497
REMARK 465     HIS B  2498
REMARK 465     SER B  2499
REMARK 465     SER B  2500
REMARK 465     LEU B  2501
REMARK 465     ALA B  2502
REMARK 465     GLU B  2503
REMARK 465     PRO B  2504
REMARK 465     ARG B  2505
REMARK 465     VAL B  2506
REMARK 465     SER B  2507
REMARK 465     VAL B  2508
REMARK 465     ARG B  2509
REMARK 465     GLU B  2510
REMARK 465     GLY B  2511
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     PRO A 857    CG   CD
REMARK 470     GLU A 869    CG   CD   OE1  OE2
REMARK 470     HIS A1044    CG   ND1  CD2  CE1  NE2
REMARK 470     GLN A1106    CG   CD   OE1  NE2
REMARK 470     GLN A1107    CG   CD   OE1  NE2
REMARK 470     GLU A1108    CG   CD   OE1  OE2
REMARK 470     GLN A1109    CG   CD   OE1  NE2
REMARK 470     GLU A1124    CG   CD   OE1  OE2
REMARK 470     CYS A1127    SG
REMARK 470     LEU A1128    CG   CD1  CD2
REMARK 470     ARG A1131    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LEU A1134    CG   CD1  CD2
REMARK 470     GLN A1135    CG   CD   OE1  NE2
REMARK 470     GLU A1136    CG   CD   OE1  OE2
REMARK 470     GLU A1137    CG   CD   OE1  OE2
REMARK 470     LEU A1138    CG   CD1  CD2
REMARK 470     LEU A1140    CG   CD1  CD2
REMARK 470     CYS A1141    SG
REMARK 470     LYS A1142    CG   CD   CE   NZ
REMARK 470     LEU A1214    CG   CD1  CD2
REMARK 470     ASP A1220    CG   OD1  OD2
REMARK 470     LEU A1238    CG   CD1  CD2
REMARK 470     LYS A1239    CG   CD   CE   NZ
REMARK 470     MET A1240    CG   SD   CE
REMARK 470     GLU A1244    CG   CD   OE1  OE2
REMARK 470     HIS A1249    CG   ND1  CD2  CE1  NE2
REMARK 470     ILE A1256    CG1  CG2  CD1
REMARK 470     SER A1261    OG
REMARK 470     GLN A1267    CG   CD   OE1  NE2
REMARK 470     ASP A1274    CG   OD1  OD2
REMARK 470     ARG A1275    CG   CD   NE   CZ   NH1  NH2
REMARK 470     HIS A1276    CG   ND1  CD2  CE1  NE2
REMARK 470     GLN A1278    CG   CD   OE1  NE2
REMARK 470     LEU A1280    CG   CD1  CD2
REMARK 470     GLU A1281    CG   CD   OE1  OE2
REMARK 470     GLN A1284    CG   CD   OE1  NE2
REMARK 470     GLU A1286    CG   CD   OE1  OE2
REMARK 470     LEU A1287    CG   CD1  CD2
REMARK 470     GLN A1288    CG   CD   OE1  NE2
REMARK 470     GLN A1289    CG   CD   OE1  NE2
REMARK 470     HIS A1290    CG   ND1  CD2  CE1  NE2
REMARK 470     ASP A1291    CG   OD1  OD2
REMARK 470     VAL A1292    CG1  CG2
REMARK 470     GLN A1294    CG   CD   OE1  NE2
REMARK 470     LEU A1380    CG   CD1  CD2
REMARK 470     PHE A1381    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     ARG A1383    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS A1393    CG   CD   CE   NZ
REMARK 470     ARG A1404    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG A1405    CG   CD   NE   CZ   NH1  NH2
REMARK 470     PRO A1406    CG   CD
REMARK 470     THR A1407    OG1  CG2
REMARK 470     PRO A1408    CG   CD
REMARK 470     GLN A1409    CG   CD   OE1  NE2
REMARK 470     ASP A1419    CG   OD1  OD2
REMARK 470     THR A1420    OG1  CG2
REMARK 470     SER A1421    OG
REMARK 470     ARG A1423    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LEU A1432    CG   CD1  CD2
REMARK 470     GLU A1435    CG   CD   OE1  OE2
REMARK 470     ARG A1439    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASN A1467    CG   OD1  ND2
REMARK 470     ARG A1468    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG A1470    CG   CD   NE   CZ   NH1  NH2
REMARK 470     VAL A1472    CG1  CG2
REMARK 470     LEU A1477    CG   CD1  CD2
REMARK 470     THR A1480    OG1  CG2
REMARK 470     SER A1481    OG
REMARK 470     HIS A1482    CG   ND1  CD2  CE1  NE2
REMARK 470     PRO A1484    CG   CD
REMARK 470     GLU A1485    CG   CD   OE1  OE2
REMARK 470     VAL A1486    CG1  CG2
REMARK 470     ASP A1487    CG   OD1  OD2
REMARK 470     PRO A1488    CG   CD
REMARK 470     GLU A1492    CG   CD   OE1  OE2
REMARK 470     GLN A1494    CG   CD   OE1  NE2
REMARK 470     LYS A1495    CG   CD   CE   NZ
REMARK 470     TRP A1511    CG   CD1  CD2  NE1  CE2  CE3  CZ2
REMARK 470     TRP A1511    CZ3  CH2
REMARK 470     PHE A1517    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     GLN A1555    CG   CD   OE1  NE2
REMARK 470     PRO A1556    CG   CD
REMARK 470     THR A1557    OG1  CG2
REMARK 470     CYS A1558    SG
REMARK 470     PRO A1559    CG   CD
REMARK 470     LYS A1591    CG   CD   CE   NZ
REMARK 470     THR A1593    OG1  CG2
REMARK 470     ASP A1596    CG   OD1  OD2
REMARK 470     ARG A1666    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP A1797    CG   OD1  OD2
REMARK 470     ASP A1806    CG   OD1  OD2
REMARK 470     LYS A1847    CG   CD   CE   NZ
REMARK 470     GLU A1860    CG   CD   OE1  OE2
REMARK 470     LEU A1865    CG   CD1  CD2
REMARK 470     LYS A1866    CG   CD   CE   NZ
REMARK 470     LYS A1869    CG   CD   CE   NZ
REMARK 470     LYS A1871    CG   CD   CE   NZ
REMARK 470     ARG A1917    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASN A1982    CG   OD1  ND2
REMARK 470     THR A1984    OG1  CG2
REMARK 470     GLU A1986    CG   CD   OE1  OE2
REMARK 470     PHE A1987    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     CYS A2024    SG
REMARK 470     GLU A2051    CG   CD   OE1  OE2
REMARK 470     PRO B 857    CG   CD
REMARK 470     GLU B 869    CG   CD   OE1  OE2
REMARK 470     HIS B1044    CG   ND1  CD2  CE1  NE2
REMARK 470     GLN B1106    CG   CD   OE1  NE2
REMARK 470     GLN B1107    CG   CD   OE1  NE2
REMARK 470     GLU B1108    CG   CD   OE1  OE2
REMARK 470     GLN B1109    CG   CD   OE1  NE2
REMARK 470     GLU B1124    CG   CD   OE1  OE2
REMARK 470     CYS B1127    SG
REMARK 470     LEU B1128    CG   CD1  CD2
REMARK 470     ARG B1131    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LEU B1134    CG   CD1  CD2
REMARK 470     GLN B1135    CG   CD   OE1  NE2
REMARK 470     GLU B1136    CG   CD   OE1  OE2
REMARK 470     GLU B1137    CG   CD   OE1  OE2
REMARK 470     LEU B1138    CG   CD1  CD2
REMARK 470     LEU B1140    CG   CD1  CD2
REMARK 470     CYS B1141    SG
REMARK 470     LYS B1142    CG   CD   CE   NZ
REMARK 470     LEU B1214    CG   CD1  CD2
REMARK 470     ASP B1220    CG   OD1  OD2
REMARK 470     LEU B1238    CG   CD1  CD2
REMARK 470     LYS B1239    CG   CD   CE   NZ
REMARK 470     MET B1240    CG   SD   CE
REMARK 470     GLU B1244    CG   CD   OE1  OE2
REMARK 470     HIS B1249    CG   ND1  CD2  CE1  NE2
REMARK 470     ILE B1256    CG1  CG2  CD1
REMARK 470     SER B1261    OG
REMARK 470     GLN B1267    CG   CD   OE1  NE2
REMARK 470     ASP B1274    CG   OD1  OD2
REMARK 470     ARG B1275    CG   CD   NE   CZ   NH1  NH2
REMARK 470     HIS B1276    CG   ND1  CD2  CE1  NE2
REMARK 470     GLN B1278    CG   CD   OE1  NE2
REMARK 470     LEU B1280    CG   CD1  CD2
REMARK 470     GLU B1281    CG   CD   OE1  OE2
REMARK 470     GLN B1284    CG   CD   OE1  NE2
REMARK 470     GLU B1286    CG   CD   OE1  OE2
REMARK 470     LEU B1287    CG   CD1  CD2
REMARK 470     GLN B1288    CG   CD   OE1  NE2
REMARK 470     GLN B1289    CG   CD   OE1  NE2
REMARK 470     HIS B1290    CG   ND1  CD2  CE1  NE2
REMARK 470     ASP B1291    CG   OD1  OD2
REMARK 470     VAL B1292    CG1  CG2
REMARK 470     GLN B1294    CG   CD   OE1  NE2
REMARK 470     LEU B1380    CG   CD1  CD2
REMARK 470     PHE B1381    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     ARG B1383    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS B1393    CG   CD   CE   NZ
REMARK 470     ARG B1404    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG B1405    CG   CD   NE   CZ   NH1  NH2
REMARK 470     PRO B1406    CG   CD
REMARK 470     THR B1407    OG1  CG2
REMARK 470     PRO B1408    CG   CD
REMARK 470     GLN B1409    CG   CD   OE1  NE2
REMARK 470     ASP B1419    CG   OD1  OD2
REMARK 470     THR B1420    OG1  CG2
REMARK 470     SER B1421    OG
REMARK 470     ARG B1423    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LEU B1432    CG   CD1  CD2
REMARK 470     GLU B1435    CG   CD   OE1  OE2
REMARK 470     ARG B1439    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASN B1467    CG   OD1  ND2
REMARK 470     ARG B1468    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG B1470    CG   CD   NE   CZ   NH1  NH2
REMARK 470     VAL B1472    CG1  CG2
REMARK 470     LEU B1477    CG   CD1  CD2
REMARK 470     THR B1480    OG1  CG2
REMARK 470     SER B1481    OG
REMARK 470     HIS B1482    CG   ND1  CD2  CE1  NE2
REMARK 470     PRO B1484    CG   CD
REMARK 470     GLU B1485    CG   CD   OE1  OE2
REMARK 470     VAL B1486    CG1  CG2
REMARK 470     ASP B1487    CG   OD1  OD2
REMARK 470     PRO B1488    CG   CD
REMARK 470     GLU B1492    CG   CD   OE1  OE2
REMARK 470     GLN B1494    CG   CD   OE1  NE2
REMARK 470     LYS B1495    CG   CD   CE   NZ
REMARK 470     TRP B1511    CG   CD1  CD2  NE1  CE2  CE3  CZ2
REMARK 470     TRP B1511    CZ3  CH2
REMARK 470     PHE B1517    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     GLN B1555    CG   CD   OE1  NE2
REMARK 470     PRO B1556    CG   CD
REMARK 470     THR B1557    OG1  CG2
REMARK 470     CYS B1558    SG
REMARK 470     PRO B1559    CG   CD
REMARK 470     LYS B1591    CG   CD   CE   NZ
REMARK 470     THR B1593    OG1  CG2
REMARK 470     ASP B1596    CG   OD1  OD2
REMARK 470     ARG B1666    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP B1797    CG   OD1  OD2
REMARK 470     ASP B1806    CG   OD1  OD2
REMARK 470     LYS B1847    CG   CD   CE   NZ
REMARK 470     GLU B1860    CG   CD   OE1  OE2
REMARK 470     LEU B1865    CG   CD1  CD2
REMARK 470     LYS B1866    CG   CD   CE   NZ
REMARK 470     LYS B1869    CG   CD   CE   NZ
REMARK 470     LYS B1871    CG   CD   CE   NZ
REMARK 470     ARG B1917    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASN B1982    CG   OD1  ND2
REMARK 470     THR B1984    OG1  CG2
REMARK 470     GLU B1986    CG   CD   OE1  OE2
REMARK 470     PHE B1987    CG   CD1  CD2  CE1  CE2  CZ
REMARK 470     CYS B2024    SG
REMARK 470     GLU B2051    CG   CD   OE1  OE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A 872       32.21    -97.85
REMARK 500    THR A 879       77.58   -119.48
REMARK 500    ASP A 881       89.01   -156.01
REMARK 500    ASN A 949       55.19   -102.51
REMARK 500    ASP A 962        8.40     56.64
REMARK 500    ASP A 963       67.74   -163.54
REMARK 500    PRO A1222        1.46    -67.85
REMARK 500    SER A1394     -157.39   -128.98
REMARK 500    SER A1411       71.65     53.19
REMARK 500    SER A1421       -2.80     65.75
REMARK 500    ASP A1436       58.28    -92.95
REMARK 500    ILE A1446      -60.84   -121.83
REMARK 500    PHE A1632       52.93    -90.47
REMARK 500    GLU A1751        3.65     55.87
REMARK 500    LEU A1893       30.43    -96.17
REMARK 500    ARG A1976       52.14    -92.00
REMARK 500    ASP B 872       32.26    -97.91
REMARK 500    THR B 879       77.55   -119.49
REMARK 500    ASP B 881       88.97   -155.97
REMARK 500    ASN B 949       55.15   -102.46
REMARK 500    ASP B 962        8.43     56.59
REMARK 500    ASP B 963       67.74   -163.52
REMARK 500    PRO B1222        1.46    -67.82
REMARK 500    SER B1394     -157.40   -129.01
REMARK 500    SER B1411       71.64     53.18
REMARK 500    SER B1421       -2.74     65.73
REMARK 500    ASP B1436       58.29    -92.95
REMARK 500    ILE B1446      -60.88   -121.79
REMARK 500    PHE B1632       52.93    -90.40
REMARK 500    GLU B1751        3.58     55.93
REMARK 500    LEU B1893       30.47    -96.19
REMARK 500    ARG B1976       52.20    -92.00
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-44300   RELATED DB: EMDB
REMARK 900 COMPOSITE MAP
REMARK 900 RELATED ID: EMD-44301   RELATED DB: EMDB
REMARK 900 RELATED ID: EMD-44329   RELATED DB: EMDB
REMARK 900 FOCUSED CONDENSING MAP
REMARK 900 RELATED ID: EMD-44330   RELATED DB: EMDB
REMARK 900 HUMAN ENDOGENOUS FASN WITH 1,3-DBP - CLASS 1 FOCUSED MODIFYING
REMARK 900 DOMAIN
REMARK 900 RELATED ID: EMD-44371   RELATED DB: EMDB
REMARK 900 COMBINED MODIFYING WING WITH CLASSIFICATION RESULT
DBREF  9B80 A  857  2511  UNP    P49327   FAS_HUMAN      857   2511
DBREF  9B80 B  857  2511  UNP    P49327   FAS_HUMAN      857   2511
SEQRES   1 A 1655  PRO SER ALA ALA ILE TYR ASN ILE ASP THR SER SER GLU
SEQRES   2 A 1655  SER PRO ASP HIS TYR LEU VAL ASP HIS THR LEU ASP GLY
SEQRES   3 A 1655  ARG VAL LEU PHE PRO ALA THR GLY TYR LEU SER ILE VAL
SEQRES   4 A 1655  TRP LYS THR LEU ALA ARG ALA LEU GLY LEU GLY VAL GLU
SEQRES   5 A 1655  GLN LEU PRO VAL VAL PHE GLU ASP VAL VAL LEU HIS GLN
SEQRES   6 A 1655  ALA THR ILE LEU PRO LYS THR GLY THR VAL SER LEU GLU
SEQRES   7 A 1655  VAL ARG LEU LEU GLU ALA SER ARG ALA PHE GLU VAL SER
SEQRES   8 A 1655  GLU ASN GLY ASN LEU VAL VAL SER GLY LYS VAL TYR GLN
SEQRES   9 A 1655  TRP ASP ASP PRO ASP PRO ARG LEU PHE ASP HIS PRO GLU
SEQRES  10 A 1655  SER PRO THR PRO ASN PRO THR GLU PRO LEU PHE LEU ALA
SEQRES  11 A 1655  GLN ALA GLU VAL TYR LYS GLU LEU ARG LEU ARG GLY TYR
SEQRES  12 A 1655  ASP TYR GLY PRO HIS PHE GLN GLY ILE LEU GLU ALA SER
SEQRES  13 A 1655  LEU GLU GLY ASP SER GLY ARG LEU LEU TRP LYS ASP ASN
SEQRES  14 A 1655  TRP VAL SER PHE MET ASP THR MET LEU GLN MET SER ILE
SEQRES  15 A 1655  LEU GLY SER ALA LYS HIS GLY LEU TYR LEU PRO THR ARG
SEQRES  16 A 1655  VAL THR ALA ILE HIS ILE ASP PRO ALA THR HIS ARG GLN
SEQRES  17 A 1655  LYS LEU TYR THR LEU GLN ASP LYS ALA GLN VAL ALA ASP
SEQRES  18 A 1655  VAL VAL VAL SER ARG TRP LEU ARG VAL THR VAL ALA GLY
SEQRES  19 A 1655  GLY VAL HIS ILE SER GLY LEU HIS THR GLU SER ALA PRO
SEQRES  20 A 1655  ARG ARG GLN GLN GLU GLN GLN VAL PRO ILE LEU GLU LYS
SEQRES  21 A 1655  PHE CYS PHE THR PRO HIS THR GLU GLU GLY CYS LEU SER
SEQRES  22 A 1655  GLU ARG ALA ALA LEU GLN GLU GLU LEU GLN LEU CYS LYS
SEQRES  23 A 1655  GLY LEU VAL GLN ALA LEU GLN THR LYS VAL THR GLN GLN
SEQRES  24 A 1655  GLY LEU LYS MET VAL VAL PRO GLY LEU ASP GLY ALA GLN
SEQRES  25 A 1655  ILE PRO ARG ASP PRO SER GLN GLN GLU LEU PRO ARG LEU
SEQRES  26 A 1655  LEU SER ALA ALA CYS ARG LEU GLN LEU ASN GLY ASN LEU
SEQRES  27 A 1655  GLN LEU GLU LEU ALA GLN VAL LEU ALA GLN GLU ARG PRO
SEQRES  28 A 1655  LYS LEU PRO GLU ASP PRO LEU LEU SER GLY LEU LEU ASP
SEQRES  29 A 1655  SER PRO ALA LEU LYS ALA CYS LEU ASP THR ALA VAL GLU
SEQRES  30 A 1655  ASN MET PRO SER LEU LYS MET LYS VAL VAL GLU VAL LEU
SEQRES  31 A 1655  ALA GLY HIS GLY HIS LEU TYR SER ARG ILE PRO GLY LEU
SEQRES  32 A 1655  LEU SER PRO HIS PRO LEU LEU GLN LEU SER TYR THR ALA
SEQRES  33 A 1655  THR ASP ARG HIS PRO GLN ALA LEU GLU ALA ALA GLN ALA
SEQRES  34 A 1655  GLU LEU GLN GLN HIS ASP VAL ALA GLN GLY GLN TRP ASP
SEQRES  35 A 1655  PRO ALA ASP PRO ALA PRO SER ALA LEU GLY SER ALA ASP
SEQRES  36 A 1655  LEU LEU VAL CYS ASN CYS ALA VAL ALA ALA LEU GLY ASP
SEQRES  37 A 1655  PRO ALA SER ALA LEU SER ASN MET VAL ALA ALA LEU ARG
SEQRES  38 A 1655  GLU GLY GLY PHE LEU LEU LEU HIS THR LEU LEU ARG GLY
SEQRES  39 A 1655  HIS PRO LEU GLY ASP ILE VAL ALA PHE LEU THR SER THR
SEQRES  40 A 1655  GLU PRO GLN TYR GLY GLN GLY ILE LEU SER GLN ASP ALA
SEQRES  41 A 1655  TRP GLU SER LEU PHE SER ARG VAL SER LEU ARG LEU VAL
SEQRES  42 A 1655  GLY LEU LYS LYS SER PHE TYR GLY SER THR LEU PHE LEU
SEQRES  43 A 1655  CYS ARG ARG PRO THR PRO GLN ASP SER PRO ILE PHE LEU
SEQRES  44 A 1655  PRO VAL ASP ASP THR SER PHE ARG TRP VAL GLU SER LEU
SEQRES  45 A 1655  LYS GLY ILE LEU ALA ASP GLU ASP SER SER ARG PRO VAL
SEQRES  46 A 1655  TRP LEU LYS ALA ILE ASN CYS ALA THR SER GLY VAL VAL
SEQRES  47 A 1655  GLY LEU VAL ASN CYS LEU ARG ARG GLU PRO GLY GLY ASN
SEQRES  48 A 1655  ARG LEU ARG CYS VAL LEU LEU SER ASN LEU SER SER THR
SEQRES  49 A 1655  SER HIS VAL PRO GLU VAL ASP PRO GLY SER ALA GLU LEU
SEQRES  50 A 1655  GLN LYS VAL LEU GLN GLY ASP LEU VAL MET ASN VAL TYR
SEQRES  51 A 1655  ARG ASP GLY ALA TRP GLY ALA PHE ARG HIS PHE LEU LEU
SEQRES  52 A 1655  GLU GLU ASP LYS PRO GLU GLU PRO THR ALA HIS ALA PHE
SEQRES  53 A 1655  VAL SER THR LEU THR ARG GLY ASP LEU SER SER ILE ARG
SEQRES  54 A 1655  TRP VAL CYS SER SER LEU ARG HIS ALA GLN PRO THR CYS
SEQRES  55 A 1655  PRO GLY ALA GLN LEU CYS THR VAL TYR TYR ALA SER LEU
SEQRES  56 A 1655  ASN PHE ARG ASP ILE MET LEU ALA THR GLY LYS LEU SER
SEQRES  57 A 1655  PRO ASP ALA ILE PRO GLY LYS TRP THR SER GLN ASP SER
SEQRES  58 A 1655  LEU LEU GLY MET GLU PHE SER GLY ARG ASP ALA SER GLY
SEQRES  59 A 1655  LYS ARG VAL MET GLY LEU VAL PRO ALA LYS GLY LEU ALA
SEQRES  60 A 1655  THR SER VAL LEU LEU SER PRO ASP PHE LEU TRP ASP VAL
SEQRES  61 A 1655  PRO SER ASN TRP THR LEU GLU GLU ALA ALA SER VAL PRO
SEQRES  62 A 1655  VAL VAL TYR SER THR ALA TYR TYR ALA LEU VAL VAL ARG
SEQRES  63 A 1655  GLY ARG VAL ARG PRO GLY GLU THR LEU LEU ILE HIS SER
SEQRES  64 A 1655  GLY SER GLY GLY VAL GLY GLN ALA ALA ILE ALA ILE ALA
SEQRES  65 A 1655  LEU SER LEU GLY CYS ARG VAL PHE THR THR VAL GLY SER
SEQRES  66 A 1655  ALA GLU LYS ARG ALA TYR LEU GLN ALA ARG PHE PRO GLN
SEQRES  67 A 1655  LEU ASP SER THR SER PHE ALA ASN SER ARG ASP THR SER
SEQRES  68 A 1655  PHE GLU GLN HIS VAL LEU TRP HIS THR GLY GLY LYS GLY
SEQRES  69 A 1655  VAL ASP LEU VAL LEU ASN SER LEU ALA GLU GLU LYS LEU
SEQRES  70 A 1655  GLN ALA SER VAL ARG CYS LEU ALA THR HIS GLY ARG PHE
SEQRES  71 A 1655  LEU GLU ILE GLY LYS PHE ASP LEU SER GLN ASN HIS PRO
SEQRES  72 A 1655  LEU GLY MET ALA ILE PHE LEU LYS ASN VAL THR PHE HIS
SEQRES  73 A 1655  GLY VAL LEU LEU ASP ALA PHE PHE ASN GLU SER SER ALA
SEQRES  74 A 1655  ASP TRP ARG GLU VAL TRP ALA LEU VAL GLN ALA GLY ILE
SEQRES  75 A 1655  ARG ASP GLY VAL VAL ARG PRO LEU LYS CYS THR VAL PHE
SEQRES  76 A 1655  HIS GLY ALA GLN VAL GLU ASP ALA PHE ARG TYR MET ALA
SEQRES  77 A 1655  GLN GLY LYS HIS ILE GLY LYS VAL VAL VAL GLN VAL LEU
SEQRES  78 A 1655  ALA GLU GLU PRO GLU ALA VAL LEU LYS GLY ALA LYS PRO
SEQRES  79 A 1655  LYS LEU MET SER ALA ILE SER LYS THR PHE CYS PRO ALA
SEQRES  80 A 1655  HIS LYS SER TYR ILE ILE ALA GLY GLY LEU GLY GLY PHE
SEQRES  81 A 1655  GLY LEU GLU LEU ALA GLN TRP LEU ILE GLN ARG GLY VAL
SEQRES  82 A 1655  GLN LYS LEU VAL LEU THR SER ARG SER GLY ILE ARG THR
SEQRES  83 A 1655  GLY TYR GLN ALA LYS GLN VAL ARG ARG TRP ARG ARG GLN
SEQRES  84 A 1655  GLY VAL GLN VAL GLN VAL SER THR SER ASN ILE SER SER
SEQRES  85 A 1655  LEU GLU GLY ALA ARG GLY LEU ILE ALA GLU ALA ALA GLN
SEQRES  86 A 1655  LEU GLY PRO VAL GLY GLY VAL PHE ASN LEU ALA VAL VAL
SEQRES  87 A 1655  LEU ARG ASP GLY LEU LEU GLU ASN GLN THR PRO GLU PHE
SEQRES  88 A 1655  PHE GLN ASP VAL CYS LYS PRO LYS TYR SER GLY THR LEU
SEQRES  89 A 1655  ASN LEU ASP ARG VAL THR ARG GLU ALA CYS PRO GLU LEU
SEQRES  90 A 1655  ASP TYR PHE VAL VAL PHE SER SER VAL SER CYS GLY ARG
SEQRES  91 A 1655  GLY ASN ALA GLY GLN SER ASN TYR GLY PHE ALA ASN SER
SEQRES  92 A 1655  ALA MET GLU ARG ILE CYS GLU LYS ARG ARG HIS GLU GLY
SEQRES  93 A 1655  LEU PRO GLY LEU ALA VAL GLN TRP GLY ALA ILE GLY ASP
SEQRES  94 A 1655  VAL GLY ILE LEU VAL GLU THR MET SER THR ASN ASP THR
SEQRES  95 A 1655  ILE VAL SER GLY THR LEU PRO GLN ARG MET ALA SER CYS
SEQRES  96 A 1655  LEU GLU VAL LEU ASP LEU PHE LEU ASN GLN PRO HIS MET
SEQRES  97 A 1655  VAL LEU SER SER PHE VAL LEU ALA GLU LYS ALA ALA ALA
SEQRES  98 A 1655  TYR ARG ASP ARG ASP SER GLN ARG ASP LEU VAL GLU ALA
SEQRES  99 A 1655  VAL ALA HIS ILE LEU GLY ILE ARG ASP LEU ALA ALA VAL
SEQRES 100 A 1655  ASN LEU ASP SER SER LEU ALA ASP LEU GLY LEU ASP SER
SEQRES 101 A 1655  LEU MET SER VAL GLU VAL ARG GLN THR LEU GLU ARG GLU
SEQRES 102 A 1655  LEU ASN LEU VAL LEU SER VAL ARG GLU VAL ARG GLN LEU
SEQRES 103 A 1655  THR LEU ARG LYS LEU GLN GLU LEU SER SER LYS ALA ASP
SEQRES 104 A 1655  GLU ALA SER GLU LEU ALA CYS PRO THR PRO LYS GLU ASP
SEQRES 105 A 1655  GLY LEU ALA GLN GLN GLN THR GLN LEU ASN LEU ARG SER
SEQRES 106 A 1655  LEU LEU VAL ASN PRO GLU GLY PRO THR LEU MET ARG LEU
SEQRES 107 A 1655  ASN SER VAL GLN SER SER GLU ARG PRO LEU PHE LEU VAL
SEQRES 108 A 1655  HIS PRO ILE GLU GLY SER THR THR VAL PHE HIS SER LEU
SEQRES 109 A 1655  ALA SER ARG LEU SER ILE PRO THR TYR GLY LEU GLN CYS
SEQRES 110 A 1655  THR ARG ALA ALA PRO LEU ASP SER ILE HIS SER LEU ALA
SEQRES 111 A 1655  ALA TYR TYR ILE ASP CYS ILE ARG GLN VAL GLN PRO GLU
SEQRES 112 A 1655  GLY PRO TYR ARG VAL ALA GLY TYR SER TYR GLY ALA CYS
SEQRES 113 A 1655  VAL ALA PHE GLU MET CYS SER GLN LEU GLN ALA GLN GLN
SEQRES 114 A 1655  SER PRO ALA PRO THR HIS ASN SER LEU PHE LEU PHE ASP
SEQRES 115 A 1655  GLY SER PRO THR TYR VAL LEU ALA TYR THR GLN SER TYR
SEQRES 116 A 1655  ARG ALA LYS LEU THR PRO GLY CYS GLU ALA GLU ALA GLU
SEQRES 117 A 1655  THR GLU ALA ILE CYS PHE PHE VAL GLN GLN PHE THR ASP
SEQRES 118 A 1655  MET GLU HIS ASN ARG VAL LEU GLU ALA LEU LEU PRO LEU
SEQRES 119 A 1655  LYS GLY LEU GLU GLU ARG VAL ALA ALA ALA VAL ASP LEU
SEQRES 120 A 1655  ILE ILE LYS SER HIS GLN GLY LEU ASP ARG GLN GLU LEU
SEQRES 121 A 1655  SER PHE ALA ALA ARG SER PHE TYR TYR LYS LEU ARG ALA
SEQRES 122 A 1655  ALA GLU GLN TYR THR PRO LYS ALA LYS TYR HIS GLY ASN
SEQRES 123 A 1655  VAL MET LEU LEU ARG ALA LYS THR GLY GLY ALA TYR GLY
SEQRES 124 A 1655  GLU ASP LEU GLY ALA ASP TYR ASN LEU SER GLN VAL CYS
SEQRES 125 A 1655  ASP GLY LYS VAL SER VAL HIS VAL ILE GLU GLY ASP HIS
SEQRES 126 A 1655  ARG THR LEU LEU GLU GLY SER GLY LEU GLU SER ILE ILE
SEQRES 127 A 1655  SER ILE ILE HIS SER SER LEU ALA GLU PRO ARG VAL SER
SEQRES 128 A 1655  VAL ARG GLU GLY
SEQRES   1 B 1655  PRO SER ALA ALA ILE TYR ASN ILE ASP THR SER SER GLU
SEQRES   2 B 1655  SER PRO ASP HIS TYR LEU VAL ASP HIS THR LEU ASP GLY
SEQRES   3 B 1655  ARG VAL LEU PHE PRO ALA THR GLY TYR LEU SER ILE VAL
SEQRES   4 B 1655  TRP LYS THR LEU ALA ARG ALA LEU GLY LEU GLY VAL GLU
SEQRES   5 B 1655  GLN LEU PRO VAL VAL PHE GLU ASP VAL VAL LEU HIS GLN
SEQRES   6 B 1655  ALA THR ILE LEU PRO LYS THR GLY THR VAL SER LEU GLU
SEQRES   7 B 1655  VAL ARG LEU LEU GLU ALA SER ARG ALA PHE GLU VAL SER
SEQRES   8 B 1655  GLU ASN GLY ASN LEU VAL VAL SER GLY LYS VAL TYR GLN
SEQRES   9 B 1655  TRP ASP ASP PRO ASP PRO ARG LEU PHE ASP HIS PRO GLU
SEQRES  10 B 1655  SER PRO THR PRO ASN PRO THR GLU PRO LEU PHE LEU ALA
SEQRES  11 B 1655  GLN ALA GLU VAL TYR LYS GLU LEU ARG LEU ARG GLY TYR
SEQRES  12 B 1655  ASP TYR GLY PRO HIS PHE GLN GLY ILE LEU GLU ALA SER
SEQRES  13 B 1655  LEU GLU GLY ASP SER GLY ARG LEU LEU TRP LYS ASP ASN
SEQRES  14 B 1655  TRP VAL SER PHE MET ASP THR MET LEU GLN MET SER ILE
SEQRES  15 B 1655  LEU GLY SER ALA LYS HIS GLY LEU TYR LEU PRO THR ARG
SEQRES  16 B 1655  VAL THR ALA ILE HIS ILE ASP PRO ALA THR HIS ARG GLN
SEQRES  17 B 1655  LYS LEU TYR THR LEU GLN ASP LYS ALA GLN VAL ALA ASP
SEQRES  18 B 1655  VAL VAL VAL SER ARG TRP LEU ARG VAL THR VAL ALA GLY
SEQRES  19 B 1655  GLY VAL HIS ILE SER GLY LEU HIS THR GLU SER ALA PRO
SEQRES  20 B 1655  ARG ARG GLN GLN GLU GLN GLN VAL PRO ILE LEU GLU LYS
SEQRES  21 B 1655  PHE CYS PHE THR PRO HIS THR GLU GLU GLY CYS LEU SER
SEQRES  22 B 1655  GLU ARG ALA ALA LEU GLN GLU GLU LEU GLN LEU CYS LYS
SEQRES  23 B 1655  GLY LEU VAL GLN ALA LEU GLN THR LYS VAL THR GLN GLN
SEQRES  24 B 1655  GLY LEU LYS MET VAL VAL PRO GLY LEU ASP GLY ALA GLN
SEQRES  25 B 1655  ILE PRO ARG ASP PRO SER GLN GLN GLU LEU PRO ARG LEU
SEQRES  26 B 1655  LEU SER ALA ALA CYS ARG LEU GLN LEU ASN GLY ASN LEU
SEQRES  27 B 1655  GLN LEU GLU LEU ALA GLN VAL LEU ALA GLN GLU ARG PRO
SEQRES  28 B 1655  LYS LEU PRO GLU ASP PRO LEU LEU SER GLY LEU LEU ASP
SEQRES  29 B 1655  SER PRO ALA LEU LYS ALA CYS LEU ASP THR ALA VAL GLU
SEQRES  30 B 1655  ASN MET PRO SER LEU LYS MET LYS VAL VAL GLU VAL LEU
SEQRES  31 B 1655  ALA GLY HIS GLY HIS LEU TYR SER ARG ILE PRO GLY LEU
SEQRES  32 B 1655  LEU SER PRO HIS PRO LEU LEU GLN LEU SER TYR THR ALA
SEQRES  33 B 1655  THR ASP ARG HIS PRO GLN ALA LEU GLU ALA ALA GLN ALA
SEQRES  34 B 1655  GLU LEU GLN GLN HIS ASP VAL ALA GLN GLY GLN TRP ASP
SEQRES  35 B 1655  PRO ALA ASP PRO ALA PRO SER ALA LEU GLY SER ALA ASP
SEQRES  36 B 1655  LEU LEU VAL CYS ASN CYS ALA VAL ALA ALA LEU GLY ASP
SEQRES  37 B 1655  PRO ALA SER ALA LEU SER ASN MET VAL ALA ALA LEU ARG
SEQRES  38 B 1655  GLU GLY GLY PHE LEU LEU LEU HIS THR LEU LEU ARG GLY
SEQRES  39 B 1655  HIS PRO LEU GLY ASP ILE VAL ALA PHE LEU THR SER THR
SEQRES  40 B 1655  GLU PRO GLN TYR GLY GLN GLY ILE LEU SER GLN ASP ALA
SEQRES  41 B 1655  TRP GLU SER LEU PHE SER ARG VAL SER LEU ARG LEU VAL
SEQRES  42 B 1655  GLY LEU LYS LYS SER PHE TYR GLY SER THR LEU PHE LEU
SEQRES  43 B 1655  CYS ARG ARG PRO THR PRO GLN ASP SER PRO ILE PHE LEU
SEQRES  44 B 1655  PRO VAL ASP ASP THR SER PHE ARG TRP VAL GLU SER LEU
SEQRES  45 B 1655  LYS GLY ILE LEU ALA ASP GLU ASP SER SER ARG PRO VAL
SEQRES  46 B 1655  TRP LEU LYS ALA ILE ASN CYS ALA THR SER GLY VAL VAL
SEQRES  47 B 1655  GLY LEU VAL ASN CYS LEU ARG ARG GLU PRO GLY GLY ASN
SEQRES  48 B 1655  ARG LEU ARG CYS VAL LEU LEU SER ASN LEU SER SER THR
SEQRES  49 B 1655  SER HIS VAL PRO GLU VAL ASP PRO GLY SER ALA GLU LEU
SEQRES  50 B 1655  GLN LYS VAL LEU GLN GLY ASP LEU VAL MET ASN VAL TYR
SEQRES  51 B 1655  ARG ASP GLY ALA TRP GLY ALA PHE ARG HIS PHE LEU LEU
SEQRES  52 B 1655  GLU GLU ASP LYS PRO GLU GLU PRO THR ALA HIS ALA PHE
SEQRES  53 B 1655  VAL SER THR LEU THR ARG GLY ASP LEU SER SER ILE ARG
SEQRES  54 B 1655  TRP VAL CYS SER SER LEU ARG HIS ALA GLN PRO THR CYS
SEQRES  55 B 1655  PRO GLY ALA GLN LEU CYS THR VAL TYR TYR ALA SER LEU
SEQRES  56 B 1655  ASN PHE ARG ASP ILE MET LEU ALA THR GLY LYS LEU SER
SEQRES  57 B 1655  PRO ASP ALA ILE PRO GLY LYS TRP THR SER GLN ASP SER
SEQRES  58 B 1655  LEU LEU GLY MET GLU PHE SER GLY ARG ASP ALA SER GLY
SEQRES  59 B 1655  LYS ARG VAL MET GLY LEU VAL PRO ALA LYS GLY LEU ALA
SEQRES  60 B 1655  THR SER VAL LEU LEU SER PRO ASP PHE LEU TRP ASP VAL
SEQRES  61 B 1655  PRO SER ASN TRP THR LEU GLU GLU ALA ALA SER VAL PRO
SEQRES  62 B 1655  VAL VAL TYR SER THR ALA TYR TYR ALA LEU VAL VAL ARG
SEQRES  63 B 1655  GLY ARG VAL ARG PRO GLY GLU THR LEU LEU ILE HIS SER
SEQRES  64 B 1655  GLY SER GLY GLY VAL GLY GLN ALA ALA ILE ALA ILE ALA
SEQRES  65 B 1655  LEU SER LEU GLY CYS ARG VAL PHE THR THR VAL GLY SER
SEQRES  66 B 1655  ALA GLU LYS ARG ALA TYR LEU GLN ALA ARG PHE PRO GLN
SEQRES  67 B 1655  LEU ASP SER THR SER PHE ALA ASN SER ARG ASP THR SER
SEQRES  68 B 1655  PHE GLU GLN HIS VAL LEU TRP HIS THR GLY GLY LYS GLY
SEQRES  69 B 1655  VAL ASP LEU VAL LEU ASN SER LEU ALA GLU GLU LYS LEU
SEQRES  70 B 1655  GLN ALA SER VAL ARG CYS LEU ALA THR HIS GLY ARG PHE
SEQRES  71 B 1655  LEU GLU ILE GLY LYS PHE ASP LEU SER GLN ASN HIS PRO
SEQRES  72 B 1655  LEU GLY MET ALA ILE PHE LEU LYS ASN VAL THR PHE HIS
SEQRES  73 B 1655  GLY VAL LEU LEU ASP ALA PHE PHE ASN GLU SER SER ALA
SEQRES  74 B 1655  ASP TRP ARG GLU VAL TRP ALA LEU VAL GLN ALA GLY ILE
SEQRES  75 B 1655  ARG ASP GLY VAL VAL ARG PRO LEU LYS CYS THR VAL PHE
SEQRES  76 B 1655  HIS GLY ALA GLN VAL GLU ASP ALA PHE ARG TYR MET ALA
SEQRES  77 B 1655  GLN GLY LYS HIS ILE GLY LYS VAL VAL VAL GLN VAL LEU
SEQRES  78 B 1655  ALA GLU GLU PRO GLU ALA VAL LEU LYS GLY ALA LYS PRO
SEQRES  79 B 1655  LYS LEU MET SER ALA ILE SER LYS THR PHE CYS PRO ALA
SEQRES  80 B 1655  HIS LYS SER TYR ILE ILE ALA GLY GLY LEU GLY GLY PHE
SEQRES  81 B 1655  GLY LEU GLU LEU ALA GLN TRP LEU ILE GLN ARG GLY VAL
SEQRES  82 B 1655  GLN LYS LEU VAL LEU THR SER ARG SER GLY ILE ARG THR
SEQRES  83 B 1655  GLY TYR GLN ALA LYS GLN VAL ARG ARG TRP ARG ARG GLN
SEQRES  84 B 1655  GLY VAL GLN VAL GLN VAL SER THR SER ASN ILE SER SER
SEQRES  85 B 1655  LEU GLU GLY ALA ARG GLY LEU ILE ALA GLU ALA ALA GLN
SEQRES  86 B 1655  LEU GLY PRO VAL GLY GLY VAL PHE ASN LEU ALA VAL VAL
SEQRES  87 B 1655  LEU ARG ASP GLY LEU LEU GLU ASN GLN THR PRO GLU PHE
SEQRES  88 B 1655  PHE GLN ASP VAL CYS LYS PRO LYS TYR SER GLY THR LEU
SEQRES  89 B 1655  ASN LEU ASP ARG VAL THR ARG GLU ALA CYS PRO GLU LEU
SEQRES  90 B 1655  ASP TYR PHE VAL VAL PHE SER SER VAL SER CYS GLY ARG
SEQRES  91 B 1655  GLY ASN ALA GLY GLN SER ASN TYR GLY PHE ALA ASN SER
SEQRES  92 B 1655  ALA MET GLU ARG ILE CYS GLU LYS ARG ARG HIS GLU GLY
SEQRES  93 B 1655  LEU PRO GLY LEU ALA VAL GLN TRP GLY ALA ILE GLY ASP
SEQRES  94 B 1655  VAL GLY ILE LEU VAL GLU THR MET SER THR ASN ASP THR
SEQRES  95 B 1655  ILE VAL SER GLY THR LEU PRO GLN ARG MET ALA SER CYS
SEQRES  96 B 1655  LEU GLU VAL LEU ASP LEU PHE LEU ASN GLN PRO HIS MET
SEQRES  97 B 1655  VAL LEU SER SER PHE VAL LEU ALA GLU LYS ALA ALA ALA
SEQRES  98 B 1655  TYR ARG ASP ARG ASP SER GLN ARG ASP LEU VAL GLU ALA
SEQRES  99 B 1655  VAL ALA HIS ILE LEU GLY ILE ARG ASP LEU ALA ALA VAL
SEQRES 100 B 1655  ASN LEU ASP SER SER LEU ALA ASP LEU GLY LEU ASP SER
SEQRES 101 B 1655  LEU MET SER VAL GLU VAL ARG GLN THR LEU GLU ARG GLU
SEQRES 102 B 1655  LEU ASN LEU VAL LEU SER VAL ARG GLU VAL ARG GLN LEU
SEQRES 103 B 1655  THR LEU ARG LYS LEU GLN GLU LEU SER SER LYS ALA ASP
SEQRES 104 B 1655  GLU ALA SER GLU LEU ALA CYS PRO THR PRO LYS GLU ASP
SEQRES 105 B 1655  GLY LEU ALA GLN GLN GLN THR GLN LEU ASN LEU ARG SER
SEQRES 106 B 1655  LEU LEU VAL ASN PRO GLU GLY PRO THR LEU MET ARG LEU
SEQRES 107 B 1655  ASN SER VAL GLN SER SER GLU ARG PRO LEU PHE LEU VAL
SEQRES 108 B 1655  HIS PRO ILE GLU GLY SER THR THR VAL PHE HIS SER LEU
SEQRES 109 B 1655  ALA SER ARG LEU SER ILE PRO THR TYR GLY LEU GLN CYS
SEQRES 110 B 1655  THR ARG ALA ALA PRO LEU ASP SER ILE HIS SER LEU ALA
SEQRES 111 B 1655  ALA TYR TYR ILE ASP CYS ILE ARG GLN VAL GLN PRO GLU
SEQRES 112 B 1655  GLY PRO TYR ARG VAL ALA GLY TYR SER TYR GLY ALA CYS
SEQRES 113 B 1655  VAL ALA PHE GLU MET CYS SER GLN LEU GLN ALA GLN GLN
SEQRES 114 B 1655  SER PRO ALA PRO THR HIS ASN SER LEU PHE LEU PHE ASP
SEQRES 115 B 1655  GLY SER PRO THR TYR VAL LEU ALA TYR THR GLN SER TYR
SEQRES 116 B 1655  ARG ALA LYS LEU THR PRO GLY CYS GLU ALA GLU ALA GLU
SEQRES 117 B 1655  THR GLU ALA ILE CYS PHE PHE VAL GLN GLN PHE THR ASP
SEQRES 118 B 1655  MET GLU HIS ASN ARG VAL LEU GLU ALA LEU LEU PRO LEU
SEQRES 119 B 1655  LYS GLY LEU GLU GLU ARG VAL ALA ALA ALA VAL ASP LEU
SEQRES 120 B 1655  ILE ILE LYS SER HIS GLN GLY LEU ASP ARG GLN GLU LEU
SEQRES 121 B 1655  SER PHE ALA ALA ARG SER PHE TYR TYR LYS LEU ARG ALA
SEQRES 122 B 1655  ALA GLU GLN TYR THR PRO LYS ALA LYS TYR HIS GLY ASN
SEQRES 123 B 1655  VAL MET LEU LEU ARG ALA LYS THR GLY GLY ALA TYR GLY
SEQRES 124 B 1655  GLU ASP LEU GLY ALA ASP TYR ASN LEU SER GLN VAL CYS
SEQRES 125 B 1655  ASP GLY LYS VAL SER VAL HIS VAL ILE GLU GLY ASP HIS
SEQRES 126 B 1655  ARG THR LEU LEU GLU GLY SER GLY LEU GLU SER ILE ILE
SEQRES 127 B 1655  SER ILE ILE HIS SER SER LEU ALA GLU PRO ARG VAL SER
SEQRES 128 B 1655  VAL ARG GLU GLY
HELIX    1 AA1 ASP A  872  VAL A  876  5                                   5
HELIX    2 AA2 PRO A  887  GLY A  904  1                                  18
HELIX    3 AA3 GLY A  906  LEU A  910  5                                   5
HELIX    4 AA4 ASP A  965  ASP A  970  5                                   6
HELIX    5 AA5 GLN A  987  GLY A  998  1                                  12
HELIX    6 AA6 PRO A 1003  GLN A 1006  5                                   4
HELIX    7 AA7 ASN A 1025  SER A 1041  1                                  17
HELIX    8 AA8 ASP A 1058  LYS A 1065  1                                   8
HELIX    9 AA9 ALA A 1132  LEU A 1144  1                                  13
HELIX   10 AB1 SER A 1221  MET A 1235  1                                  15
HELIX   11 AB2 HIS A 1251  SER A 1254  5                                   4
HELIX   12 AB3 ARG A 1255  LEU A 1260  1                                   6
HELIX   13 AB4 ALA A 1282  LEU A 1287  1                                   6
HELIX   14 AB5 LEU A 1380  SER A 1385  1                                   6
HELIX   15 AB6 ASP A 1419  PHE A 1422  5                                   4
HELIX   16 AB7 ARG A 1423  LEU A 1432  1                                  10
HELIX   17 AB8 GLY A 1452  ARG A 1462  1                                  11
HELIX   18 AB9 GLY A 1489  GLY A 1499  1                                  11
HELIX   19 AC1 ASN A 1572  GLY A 1581  1                                  10
HELIX   20 AC2 SER A 1584  ILE A 1588  5                                   5
HELIX   21 AC3 SER A 1629  ASP A 1631  5                                   3
HELIX   22 AC4 THR A 1641  ALA A 1646  1                                   6
HELIX   23 AC5 VAL A 1648  VAL A 1660  1                                  13
HELIX   24 AC6 GLY A 1678  GLY A 1692  1                                  15
HELIX   25 AC7 SER A 1701  PHE A 1712  1                                  12
HELIX   26 AC8 ASP A 1716  THR A 1718  5                                   3
HELIX   27 AC9 THR A 1726  THR A 1736  1                                  11
HELIX   28 AD1 LYS A 1752  ARG A 1758  1                                   7
HELIX   29 AD2 LYS A 1771  GLN A 1776  1                                   6
HELIX   30 AD3 ALA A 1783  ASN A 1788  5                                   6
HELIX   31 AD4 LEU A 1795  ASN A 1801  5                                   7
HELIX   32 AD5 SER A 1803  ASP A 1820  1                                  18
HELIX   33 AD6 GLN A 1835  GLN A 1845  1                                  11
HELIX   34 AD7 GLY A 1895  ARG A 1907  1                                  13
HELIX   35 AD8 THR A 1922  GLN A 1935  1                                  14
HELIX   36 AD9 SER A 1948  GLY A 1963  1                                  16
HELIX   37 AE1 LEU A 1980  THR A 1984  5                                   5
HELIX   38 AE2 PRO A 1985  CYS A 1992  1                                   8
HELIX   39 AE3 LYS A 1993  CYS A 2010  1                                  18
HELIX   40 AE4 SER A 2023  GLY A 2025  5                                   3
HELIX   41 AE5 GLN A 2031  GLU A 2051  1                                  21
HELIX   42 AE6 ARG A 2087  ASN A 2100  1                                  14
HELIX   43 AE7 ASP B  872  VAL B  876  5                                   5
HELIX   44 AE8 PRO B  887  GLY B  904  1                                  18
HELIX   45 AE9 GLY B  906  LEU B  910  5                                   5
HELIX   46 AF1 ASP B  965  ASP B  970  5                                   6
HELIX   47 AF2 GLN B  987  GLY B  998  1                                  12
HELIX   48 AF3 PRO B 1003  GLN B 1006  5                                   4
HELIX   49 AF4 ASN B 1025  SER B 1041  1                                  17
HELIX   50 AF5 ASP B 1058  LYS B 1065  1                                   8
HELIX   51 AF6 ALA B 1132  LEU B 1144  1                                  13
HELIX   52 AF7 SER B 1221  MET B 1235  1                                  15
HELIX   53 AF8 HIS B 1251  SER B 1254  5                                   4
HELIX   54 AF9 ARG B 1255  LEU B 1260  1                                   6
HELIX   55 AG1 ALA B 1282  LEU B 1287  1                                   6
HELIX   56 AG2 LEU B 1380  SER B 1385  1                                   6
HELIX   57 AG3 ARG B 1423  LEU B 1432  1                                  10
HELIX   58 AG4 GLY B 1452  ARG B 1462  1                                  11
HELIX   59 AG5 GLY B 1489  GLY B 1499  1                                  11
HELIX   60 AG6 ASN B 1572  GLY B 1581  1                                  10
HELIX   61 AG7 SER B 1584  ILE B 1588  5                                   5
HELIX   62 AG8 SER B 1629  ASP B 1631  5                                   3
HELIX   63 AG9 THR B 1641  ALA B 1646  1                                   6
HELIX   64 AH1 VAL B 1648  VAL B 1660  1                                  13
HELIX   65 AH2 GLY B 1678  GLY B 1692  1                                  15
HELIX   66 AH3 SER B 1701  PHE B 1712  1                                  12
HELIX   67 AH4 ASP B 1716  THR B 1718  5                                   3
HELIX   68 AH5 THR B 1726  THR B 1736  1                                  11
HELIX   69 AH6 LYS B 1752  ARG B 1758  1                                   7
HELIX   70 AH7 LYS B 1771  GLN B 1776  1                                   6
HELIX   71 AH8 ALA B 1783  ASN B 1788  5                                   6
HELIX   72 AH9 LEU B 1795  ASN B 1801  5                                   7
HELIX   73 AI1 SER B 1803  ASP B 1820  1                                  18
HELIX   74 AI2 GLN B 1835  GLN B 1845  1                                  11
HELIX   75 AI3 GLY B 1895  ARG B 1907  1                                  13
HELIX   76 AI4 THR B 1922  GLN B 1935  1                                  14
HELIX   77 AI5 SER B 1948  GLY B 1963  1                                  16
HELIX   78 AI6 LEU B 1980  THR B 1984  5                                   5
HELIX   79 AI7 PRO B 1985  CYS B 1992  1                                   8
HELIX   80 AI8 LYS B 1993  CYS B 2010  1                                  18
HELIX   81 AI9 SER B 2023  GLY B 2025  5                                   3
HELIX   82 AJ1 GLN B 2031  GLU B 2051  1                                  21
HELIX   83 AJ2 ARG B 2087  ASN B 2100  1                                  14
SHEET    1 AA110 ALA A 860  ILE A 864  0
SHEET    2 AA110 VAL A 931  LEU A 938 -1  O  LEU A 933   N  TYR A 862
SHEET    3 AA110 ALA A 943  SER A 947 -1  O  SER A 947   N  GLU A 934
SHEET    4 AA110 LEU A 952  GLN A 960 -1  O  VAL A 953   N  VAL A 946
SHEET    5 AA110 VAL A 912  LEU A 919 -1  N  VAL A 918   O  SER A 955
SHEET    6 AA110 TYR A1047  ILE A1057 -1  O  ILE A1055   N  PHE A 914
SHEET    7 AA110 VAL A1092  SER A1095 -1  O  SER A1095   N  ALA A1054
SHEET    8 AA110 VAL A1086  ALA A1089 -1  N  THR A1087   O  ILE A1094
SHEET    9 AA110 GLN A1074  SER A1081 -1  N  SER A1081   O  VAL A1086
SHEET   10 AA110 TYR A1067  THR A1068 -1  N  TYR A1067   O  VAL A1075
SHEET    1 AA2 8 LEU A 985  ALA A 986  0
SHEET    2 AA2 8 ILE A1008  ALA A1011 -1  O  ALA A1011   N  LEU A 985
SHEET    3 AA2 8 SER A1017  LEU A1021 -1  O  ARG A1019   N  GLU A1010
SHEET    4 AA2 8 GLN A1074  SER A1081 -1  O  ALA A1076   N  LEU A1020
SHEET    5 AA2 8 VAL A1086  ALA A1089 -1  O  VAL A1086   N  SER A1081
SHEET    6 AA2 8 VAL A1092  SER A1095 -1  O  ILE A1094   N  THR A1087
SHEET    7 AA2 8 TYR A1047  ILE A1057 -1  N  ALA A1054   O  SER A1095
SHEET    8 AA2 8 HIS A1098  SER A1101 -1  O  HIS A1098   N  ARG A1051
SHEET    1 AA3 2 HIS A 878  THR A 879  0
SHEET    2 AA3 2 ASP A1000  TYR A1001 -1  O  ASP A1000   N  THR A 879
SHEET    1 AA4 8 ILE A1113  LYS A1116  0
SHEET    2 AA4 8 VAL A2105  LEU A2111 -1  O  PHE A2109   N  ILE A1113
SHEET    3 AA4 8 LEU A2056  TRP A2060  1  N  GLN A2059   O  LEU A2106
SHEET    4 AA4 8 TYR A2015  SER A2021  1  N  SER A2020   O  VAL A2058
SHEET    5 AA4 8 VAL A1965  ASN A1970  1  N  ASN A1970   O  VAL A2017
SHEET    6 AA4 8 SER A1886  ALA A1890  1  N  ALA A1890   O  PHE A1969
SHEET    7 AA4 8 LYS A1911  THR A1915  1  O  VAL A1913   N  ILE A1889
SHEET    8 AA4 8 GLN A1938  SER A1942  1  O  GLN A1940   N  LEU A1914
SHEET    1 AA5 3 ILE A1113  LYS A1116  0
SHEET    2 AA5 3 VAL A2105  LEU A2111 -1  O  PHE A2109   N  ILE A1113
SHEET    3 AA5 3 THR A2083  LEU A2084 -1  N  LEU A2084   O  VAL A2110
SHEET    1 AA6 6 CYS A1118  PRO A1121  0
SHEET    2 AA6 6 ALA A1510  ARG A1515 -1  O  ARG A1515   N  CYS A1118
SHEET    3 AA6 6 VAL A1505  ARG A1507 -1  N  VAL A1505   O  GLY A1512
SHEET    4 AA6 6 ARG A1470  ASN A1476  1  N  SER A1475   O  TYR A1506
SHEET    5 AA6 6 VAL A1441  ALA A1445  1  N  ALA A1445   O  LEU A1474
SHEET    6 AA6 6 ILE A1413  PRO A1416  1  N  ILE A1413   O  TRP A1442
SHEET    1 AA7 4 THR A1123  CYS A1127  0
SHEET    2 AA7 4 LEU A1388  SER A1394  1  O  LYS A1393   N  CYS A1127
SHEET    3 AA7 4 THR A1399  CYS A1403 -1  O  LEU A1402   N  VAL A1389
SHEET    4 AA7 4 VAL A1314  CYS A1315 -1  N  CYS A1315   O  PHE A1401
SHEET    1 AA8 3 LYS A1239  VAL A1245  0
SHEET    2 AA8 3 GLN A1267  THR A1273  1  O  THR A1271   N  GLU A1244
SHEET    3 AA8 3 ASP A1291  ALA A1293  1  O  ASP A1291   N  ALA A1272
SHEET    1 AA9 2 GLU A1525  THR A1528  0
SHEET    2 AA9 2 MET A1873  ILE A1876 -1  O  MET A1873   N  THR A1528
SHEET    1 AB1 2 ALA A1531  THR A1535  0
SHEET    2 AB1 2 ILE A1544  CYS A1548 -1  O  VAL A1547   N  PHE A1532
SHEET    1 AB2 5 SER A1625  LEU A1628  0
SHEET    2 AB2 5 GLN A1562  SER A1570 -1  N  CYS A1564   O  VAL A1626
SHEET    3 AB2 5 GLU A1602  ARG A1606 -1  O  SER A1604   N  TYR A1567
SHEET    4 AB2 5 ARG A1612  LEU A1616 -1  O  VAL A1613   N  GLY A1605
SHEET    5 AB2 5 LEU A1633  ASP A1635 -1  O  TRP A1634   N  MET A1614
SHEET    1 AB3 4 SER A1625  LEU A1628  0
SHEET    2 AB3 4 GLN A1562  SER A1570 -1  N  CYS A1564   O  VAL A1626
SHEET    3 AB3 4 LYS A1851  GLN A1855 -1  O  VAL A1854   N  ALA A1569
SHEET    4 AB3 4 CYS A1828  HIS A1832  1  N  PHE A1831   O  GLN A1855
SHEET    1 AB412 PHE A1720  ASN A1722  0
SHEET    2 AB412 ARG A1694  VAL A1699  1  N  THR A1697   O  ALA A1721
SHEET    3 AB412 THR A1670  ILE A1673  1  N  ILE A1673   O  PHE A1696
SHEET    4 AB412 VAL A1741  ASN A1746  1  O  LEU A1745   N  LEU A1672
SHEET    5 AB412 LEU A1760  GLU A1768  1  O  ARG A1765   N  ASP A1742
SHEET    6 AB412 THR A1790  GLY A1793  1  O  HIS A1792   N  PHE A1766
SHEET    7 AB412 THR B1790  GLY B1793 -1  O  PHE B1791   N  PHE A1791
SHEET    8 AB412 LEU B1760  GLU B1768  1  N  PHE B1766   O  HIS B1792
SHEET    9 AB412 VAL B1741  ASN B1746  1  N  ASP B1742   O  ARG B1765
SHEET   10 AB412 THR B1670  ILE B1673  1  N  LEU B1672   O  LEU B1745
SHEET   11 AB412 ARG B1694  VAL B1699  1  O  PHE B1696   N  ILE B1673
SHEET   12 AB412 PHE B1720  ASN B1722  1  O  ALA B1721   N  THR B1697
SHEET    1 AB5 2 PRO A1779  GLY A1781  0
SHEET    2 AB5 2 PRO B1779  GLY B1781 -1  O  LEU B1780   N  LEU A1780
SHEET    1 AB610 ALA B 860  ILE B 864  0
SHEET    2 AB610 VAL B 931  LEU B 938 -1  O  LEU B 933   N  TYR B 862
SHEET    3 AB610 ALA B 943  SER B 947 -1  O  SER B 947   N  GLU B 934
SHEET    4 AB610 LEU B 952  GLN B 960 -1  O  VAL B 953   N  VAL B 946
SHEET    5 AB610 VAL B 912  LEU B 919 -1  N  VAL B 918   O  SER B 955
SHEET    6 AB610 TYR B1047  ILE B1057 -1  O  ILE B1055   N  PHE B 914
SHEET    7 AB610 VAL B1092  SER B1095 -1  O  SER B1095   N  ALA B1054
SHEET    8 AB610 VAL B1086  ALA B1089 -1  N  THR B1087   O  ILE B1094
SHEET    9 AB610 GLN B1074  SER B1081 -1  N  SER B1081   O  VAL B1086
SHEET   10 AB610 TYR B1067  THR B1068 -1  N  TYR B1067   O  VAL B1075
SHEET    1 AB7 8 LEU B 985  ALA B 986  0
SHEET    2 AB7 8 ILE B1008  ALA B1011 -1  O  ALA B1011   N  LEU B 985
SHEET    3 AB7 8 SER B1017  LEU B1021 -1  O  ARG B1019   N  GLU B1010
SHEET    4 AB7 8 GLN B1074  SER B1081 -1  O  ALA B1076   N  LEU B1020
SHEET    5 AB7 8 VAL B1086  ALA B1089 -1  O  VAL B1086   N  SER B1081
SHEET    6 AB7 8 VAL B1092  SER B1095 -1  O  ILE B1094   N  THR B1087
SHEET    7 AB7 8 TYR B1047  ILE B1057 -1  N  ALA B1054   O  SER B1095
SHEET    8 AB7 8 HIS B1098  SER B1101 -1  O  HIS B1098   N  ARG B1051
SHEET    1 AB8 2 HIS B 878  THR B 879  0
SHEET    2 AB8 2 ASP B1000  TYR B1001 -1  O  ASP B1000   N  THR B 879
SHEET    1 AB9 8 ILE B1113  LYS B1116  0
SHEET    2 AB9 8 VAL B2105  LEU B2111 -1  O  PHE B2109   N  ILE B1113
SHEET    3 AB9 8 LEU B2056  TRP B2060  1  N  GLN B2059   O  LEU B2106
SHEET    4 AB9 8 TYR B2015  SER B2021  1  N  SER B2020   O  VAL B2058
SHEET    5 AB9 8 VAL B1965  ASN B1970  1  N  ASN B1970   O  VAL B2017
SHEET    6 AB9 8 SER B1886  ALA B1890  1  N  ALA B1890   O  PHE B1969
SHEET    7 AB9 8 LYS B1911  THR B1915  1  O  VAL B1913   N  ILE B1889
SHEET    8 AB9 8 GLN B1938  SER B1942  1  O  GLN B1940   N  LEU B1914
SHEET    1 AC1 3 ILE B1113  LYS B1116  0
SHEET    2 AC1 3 VAL B2105  LEU B2111 -1  O  PHE B2109   N  ILE B1113
SHEET    3 AC1 3 THR B2083  LEU B2084 -1  N  LEU B2084   O  VAL B2110
SHEET    1 AC2 6 CYS B1118  PRO B1121  0
SHEET    2 AC2 6 ALA B1510  ARG B1515 -1  O  ARG B1515   N  CYS B1118
SHEET    3 AC2 6 VAL B1505  ARG B1507 -1  N  VAL B1505   O  GLY B1512
SHEET    4 AC2 6 ARG B1470  ASN B1476  1  N  SER B1475   O  TYR B1506
SHEET    5 AC2 6 VAL B1441  ALA B1445  1  N  ALA B1445   O  LEU B1474
SHEET    6 AC2 6 ILE B1413  PRO B1416  1  N  ILE B1413   O  TRP B1442
SHEET    1 AC3 4 THR B1123  CYS B1127  0
SHEET    2 AC3 4 LEU B1388  SER B1394  1  O  LYS B1393   N  CYS B1127
SHEET    3 AC3 4 THR B1399  CYS B1403 -1  O  LEU B1402   N  VAL B1389
SHEET    4 AC3 4 VAL B1314  CYS B1315 -1  N  CYS B1315   O  PHE B1401
SHEET    1 AC4 3 LYS B1239  VAL B1245  0
SHEET    2 AC4 3 GLN B1267  THR B1273  1  O  THR B1271   N  GLU B1244
SHEET    3 AC4 3 ASP B1291  ALA B1293  1  O  ASP B1291   N  ALA B1272
SHEET    1 AC5 2 GLU B1525  THR B1528  0
SHEET    2 AC5 2 MET B1873  ILE B1876 -1  O  MET B1873   N  THR B1528
SHEET    1 AC6 2 ALA B1531  THR B1535  0
SHEET    2 AC6 2 ILE B1544  CYS B1548 -1  O  VAL B1547   N  PHE B1532
SHEET    1 AC7 5 SER B1625  LEU B1628  0
SHEET    2 AC7 5 GLN B1562  SER B1570 -1  N  CYS B1564   O  VAL B1626
SHEET    3 AC7 5 GLU B1602  ARG B1606 -1  O  SER B1604   N  TYR B1567
SHEET    4 AC7 5 ARG B1612  LEU B1616 -1  O  VAL B1613   N  GLY B1605
SHEET    5 AC7 5 LEU B1633  ASP B1635 -1  O  TRP B1634   N  MET B1614
SHEET    1 AC8 4 SER B1625  LEU B1628  0
SHEET    2 AC8 4 GLN B1562  SER B1570 -1  N  CYS B1564   O  VAL B1626
SHEET    3 AC8 4 LYS B1851  GLN B1855 -1  O  VAL B1854   N  ALA B1569
SHEET    4 AC8 4 CYS B1828  HIS B1832  1  N  PHE B1831   O  GLN B1855
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      1.000000  0.000000  0.000000        0.00000
SCALE2      0.000000  1.000000  0.000000        0.00000
SCALE3      0.000000  0.000000  1.000000        0.00000
TER    8078      ALA A2112
TER   16156      ALA B2112
MASTER     1496    0    0   83  128    0    0    616154    2    0  256
END