longtext: 9cfj-pdb

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HEADER    HYDROLASE                               27-JUN-24   9CFJ
TITLE     FLUVIRUCIN THIOESTERASE DOMAIN (FLUC TE)
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: FLUC;
COMPND   3 CHAIN: A;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: ACTINOMADURA VULGARIS;
SOURCE   3 ORGANISM_TAXID: 1233071;
SOURCE   4 GENE: FLUC;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    THIOESTERASE DOMAIN, NATURAL PRODUCTS, PKS, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    V.CHOUDHARY,J.L.SMITH
REVDAT   1   18-SEP-24 9CFJ    0
JRNL        AUTH   T.M.MCCULLOUGH,V.CHOUDHARY,D.L.AKEY,M.A.SKIBA,S.M.BERNARD,
JRNL        AUTH 2 J.D.KITTENDORF,J.J.SCHMIDT,D.H.SHERMAN,J.L.SMITH
JRNL        TITL   SUBSTRATE TRAPPING IN POLYKETIDE SYNTHASE THIOESTERASE
JRNL        TITL 2 DOMAINS: STRUCTURAL BASIS FOR MACROLACTONE FORMATION
JRNL        REF    ACS CATALYSIS                 V.  14       2024
JRNL        REFN                   ESSN 2155-5435
JRNL        DOI    10.1021/ACSCATAL.4C03637
REMARK   2
REMARK   2 RESOLUTION.    1.44 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.21_5207
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : GEOSTD + MONOMER LIBRARY + CDL V1.2
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.44
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 38.32
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.8
REMARK   3   NUMBER OF REFLECTIONS             : 88675
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.157
REMARK   3   R VALUE            (WORKING SET) : 0.156
REMARK   3   FREE R VALUE                     : 0.184
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.890
REMARK   3   FREE R VALUE TEST SET COUNT      : 4339
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 38.3200 -  4.4700    1.00     2989   122  0.1615 0.1778
REMARK   3     2  4.4700 -  3.5500    1.00     2881   147  0.1435 0.1512
REMARK   3     3  3.5500 -  3.1000    1.00     2873   131  0.1559 0.1693
REMARK   3     4  3.1000 -  2.8200    1.00     2841   146  0.1559 0.1871
REMARK   3     5  2.8200 -  2.6100    1.00     2849   140  0.1536 0.1920
REMARK   3     6  2.6100 -  2.4600    1.00     2826   138  0.1489 0.1968
REMARK   3     7  2.4600 -  2.3400    1.00     2826   154  0.1433 0.1734
REMARK   3     8  2.3400 -  2.2400    1.00     2795   157  0.1314 0.1728
REMARK   3     9  2.2400 -  2.1500    1.00     2848   142  0.1319 0.1624
REMARK   3    10  2.1500 -  2.0800    1.00     2803   142  0.1342 0.1817
REMARK   3    11  2.0800 -  2.0100    1.00     2808   121  0.1305 0.1520
REMARK   3    12  2.0100 -  1.9500    1.00     2835   141  0.1254 0.1633
REMARK   3    13  1.9500 -  1.9000    1.00     2837   132  0.1319 0.1544
REMARK   3    14  1.9000 -  1.8500    1.00     2772   164  0.1346 0.1673
REMARK   3    15  1.8500 -  1.8100    1.00     2787   168  0.1297 0.1687
REMARK   3    16  1.8100 -  1.7700    1.00     2802   156  0.1321 0.1697
REMARK   3    17  1.7700 -  1.7400    1.00     2787   150  0.1353 0.1767
REMARK   3    18  1.7400 -  1.7100    1.00     2858   128  0.1360 0.2301
REMARK   3    19  1.7100 -  1.6800    1.00     2795   140  0.1499 0.1847
REMARK   3    20  1.6800 -  1.6500    1.00     2814   117  0.2463 0.2883
REMARK   3    21  1.6500 -  1.6200    1.00     2784   133  0.2255 0.2556
REMARK   3    22  1.6200 -  1.6000    1.00     2846   137  0.2054 0.2360
REMARK   3    23  1.6000 -  1.5700    1.00     2752   169  0.1988 0.2545
REMARK   3    24  1.5700 -  1.5500    1.00     2795   163  0.2111 0.2439
REMARK   3    25  1.5500 -  1.5300    1.00     2809   143  0.2370 0.2476
REMARK   3    26  1.5300 -  1.5100    1.00     2762   161  0.2850 0.3085
REMARK   3    27  1.5100 -  1.4900    1.00     2775   163  0.3255 0.3078
REMARK   3    28  1.4900 -  1.4700    1.00     2775   153  0.4275 0.4383
REMARK   3    29  1.4700 -  1.4600    1.00     2796   146  0.5055 0.5495
REMARK   3    30  1.4600 -  1.4400    0.93     2616   135  0.6091 0.5974
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.10
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.248
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 15.652
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 23.61
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 31.76
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.005           2495
REMARK   3   ANGLE     :  0.750           3414
REMARK   3   CHIRALITY :  0.075            348
REMARK   3   PLANARITY :  0.006            473
REMARK   3   DIHEDRAL  : 14.879            966
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 9CFJ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 28-JUN-24.
REMARK 100 THE DEPOSITION ID IS D_1000285333.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 16-JUL-15
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : APS
REMARK 200  BEAMLINE                       : 23-ID-D
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.033
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XDS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 88675
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.440
REMARK 200  RESOLUTION RANGE LOW       (A) : 38.320
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8
REMARK 200  DATA REDUNDANCY                : 19.70
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 26.5000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.44
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 1.53
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHENIX
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 69.86
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.08
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 100 MM SODIUM ACETATE, 30% (V/V) PEG
REMARK 280  400, 100 MM MES PH 6.5, VAPOR DIFFUSION, SITTING DROP,
REMARK 280  TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 3 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -Y,X-Y,Z
REMARK 290       3555   -X+Y,-X,Z
REMARK 290       4555   Y,X,-Z
REMARK 290       5555   X-Y,-Y,-Z
REMARK 290       6555   -X,-X+Y,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -0.500000  0.866025  0.000000        0.00000
REMARK 290   SMTRY2   4  0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   5  0.000000 -1.000000  0.000000        0.00000
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   6 -0.500000 -0.866025  0.000000        0.00000
REMARK 290   SMTRY2   6 -0.866025  0.500000  0.000000        0.00000
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 375
REMARK 375 SPECIAL POSITION
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL
REMARK 375 POSITIONS.
REMARK 375
REMARK 375 ATOM RES CSSEQI
REMARK 375      HOH A2720  LIES ON A SPECIAL POSITION.
REMARK 375      HOH A2740  LIES ON A SPECIAL POSITION.
REMARK 480
REMARK 480 ZERO OCCUPANCY ATOM
REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO
REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS
REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 480   M RES C SSEQI ATOMS
REMARK 480     GLN A 2380   N    CA   C    O    CB   CG   CD
REMARK 480     GLN A 2380   OE1  NE2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE
REMARK 500   O    HOH A  2502     O    HOH A  2725              2.03
REMARK 500   O    HOH A  2540     O    HOH A  2552              2.06
REMARK 500   O    HOH A  2669     O    HOH A  2836              2.07
REMARK 500   O    HOH A  2572     O    HOH A  2752              2.11
REMARK 500   O    HOH A  2711     O    HOH A  2755              2.13
REMARK 500   O    HOH A  2503     O    HOH A  2744              2.13
REMARK 500   O    HOH A  2540     O    HOH A  2756              2.14
REMARK 500   O    HOH A  2672     O    HOH A  2755              2.18
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    OCS A2243     -129.57     55.80
REMARK 500    ASP A2277       30.58    -93.54
REMARK 500    GLU A2372     -112.54   -112.35
REMARK 500    LYS A2387       87.35   -151.82
REMARK 500
REMARK 500 REMARK: NULL
REMARK 610
REMARK 610 MISSING HETEROATOM
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 610 I=INSERTION CODE):
REMARK 610   M RES C SSEQI
REMARK 610     1PE A 2401
DBREF  9CFJ A 2114  2389  UNP    K4I6L4   K4I6L4_9ACTN  2114   2389
SEQRES   1 A  276  GLY GLY SER LEU SER SER LEU VAL ARG ALA ALA ALA PRO
SEQRES   2 A  276  ALA GLY LYS LEU GLN GLU GLY LEU ASP MET LEU GLU ALA
SEQRES   3 A  276  ALA ALA ARG LEU ARG PRO GLY PHE ARG THR LEU ASP GLU
SEQRES   4 A  276  LEU ASP ARG ALA TYR PRO PRO LEU ALA LEU ALA SER GLY
SEQRES   5 A  276  PRO ALA ARG PRO LYS LEU PHE CYS PHE SER THR PRO MET
SEQRES   6 A  276  ALA LEU GLY GLY ALA ALA GLN PHE ALA ARG LEU ALA VAL
SEQRES   7 A  276  HIS PHE GLN GLY VAL ARG ASP LEU TYR ALA LEU GLN VAL
SEQRES   8 A  276  PRO GLY TYR ALA PRO ASP ASP SER LEU PRO ASP ASN VAL
SEQRES   9 A  276  ASP VAL VAL VAL ARG MET TRP ALA GLU SER ILE ARG GLU
SEQRES  10 A  276  ALA ALA GLY ASP ASP PRO PHE VAL VAL MET GLY TYR OCS
SEQRES  11 A  276  GLY GLY GLY ASN PHE ALA HIS ALA ALA VAL SER TYR LEU
SEQRES  12 A  276  GLU ARG ASN GLY VAL ARG PRO GLU GLY LEU ILE LEU LEU
SEQRES  13 A  276  ASP THR PHE LEU PRO ASP SER ASP VAL ILE ASP GLU LEU
SEQRES  14 A  276  GLY GLY GLN MET LEU GLU GLY MET PHE ASP ARG ALA GLU
SEQRES  15 A  276  VAL TYR GLY PRO PHE SER ASP THR ARG MET THR ALA MET
SEQRES  16 A  276  GLY ARG TYR TYR ARG LEU PHE ARG GLU THR VAL VAL GLU
SEQRES  17 A  276  ASP ILE GLU THR PRO VAL LEU PHE LEU ARG PRO ASP THR
SEQRES  18 A  276  PRO LEU PRO SER GLY PRO ASP GLY GLU ARG SER ARG GLU
SEQRES  19 A  276  GLY ASN TRP ARG ALA SER TRP HIS LEU LYS HIS ASP LEU
SEQRES  20 A  276  CYS GLU VAL ARG GLY ASP HIS LEU THR MET LEU GLU GLY
SEQRES  21 A  276  GLU ALA GLY SER ILE ALA GLN ALA VAL GLU GLU TRP LEU
SEQRES  22 A  276  LYS PRO SER
MODRES 9CFJ OCS A 2243  CYS  MODIFIED RESIDUE
HET    OCS  A2243       9
HET    1PE  A2401       8
HET    1PE  A2402      16
HET    GOL  A2403       6
HET    GOL  A2404       6
HET    GOL  A2405       6
HETNAM     OCS CYSTEINESULFONIC ACID
HETNAM     1PE PENTAETHYLENE GLYCOL
HETNAM     GOL GLYCEROL
HETSYN     1PE PEG400
HETSYN     GOL GLYCERIN; PROPANE-1,2,3-TRIOL
FORMUL   1  OCS    C3 H7 N O5 S
FORMUL   2  1PE    2(C10 H22 O6)
FORMUL   4  GOL    3(C3 H8 O3)
FORMUL   7  HOH   *375(H2 O)
HELIX    1 AA1 SER A 2116  ALA A 2125  1                                  10
HELIX    2 AA2 LYS A 2129  ARG A 2142  1                                  14
HELIX    3 AA3 THR A 2149  LEU A 2153  5                                   5
HELIX    4 AA4 GLY A 2182  HIS A 2192  1                                  11
HELIX    5 AA5 ASN A 2216  GLY A 2233  1                                  18
HELIX    6 AA6 OCS A 2243  ASN A 2259  1                                  17
HELIX    7 AA7 ASP A 2277  ASP A 2292  1                                  16
HELIX    8 AA8 ARG A 2293  GLY A 2298  1                                   6
HELIX    9 AA9 SER A 2301  THR A 2318  1                                  18
HELIX   10 AB1 LEU A 2368  GLU A 2372  5                                   5
HELIX   11 AB2 GLU A 2374  LYS A 2387  1                                  14
SHEET    1 AA1 2 GLY A2146  PHE A2147  0
SHEET    2 AA1 2 LEU A2213  PRO A2214  1  O  LEU A2213   N  PHE A2147
SHEET    1 AA2 7 LEU A2160  PRO A2166  0
SHEET    2 AA2 7 ARG A2197  ALA A2201 -1  O  ALA A2201   N  LEU A2160
SHEET    3 AA2 7 LYS A2170  PHE A2174  1  N  LEU A2171   O  TYR A2200
SHEET    4 AA2 7 PHE A2237  TYR A2242  1  O  MET A2240   N  PHE A2174
SHEET    5 AA2 7 GLY A2265  LEU A2269  1  O  ILE A2267   N  VAL A2239
SHEET    6 AA2 7 VAL A2327  PRO A2332  1  O  LEU A2330   N  LEU A2268
SHEET    7 AA2 7 ASP A2359  VAL A2363  1  O  ASP A2359   N  PHE A2329
LINK         C   TYR A2242                 N   OCS A2243     1555   1555  1.34
LINK         C   OCS A2243                 N   GLY A2244     1555   1555  1.34
CISPEP   1 ARG A 2168    PRO A 2169          0        -2.53
CISPEP   2 ARG A 2168    PRO A 2169          0         1.85
CISPEP   3 GLY A 2298    PRO A 2299          0        -0.23
CRYST1  132.752  132.752   48.493  90.00  90.00 120.00 P 3 2 1       6
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.007533  0.004349  0.000000        0.00000
SCALE2      0.000000  0.008698  0.000000        0.00000
SCALE3      0.000000  0.000000  0.020622        0.00000
TER    2378      SER A2389
MASTER      288    0    6   11    9    0    0    6 2540    1   53   22
END