longtext: 9eh6-pdb

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HEADER    HYDROLASE                               22-NOV-24   9EH6
TITLE     CRYSTAL STRUCTURE OF AROC
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: ALPHA/BETA HYDROLASE FOLD-5 DOMAIN-CONTAINING PROTEIN;
COMPND   3 CHAIN: A, B;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: CALDILINEA AEROPHILA;
SOURCE   3 ORGANISM_TAXID: 133453;
SOURCE   4 STRAIN: CALDILINEA AEROPHILA;
SOURCE   5 GENE: CLDAP_20430;
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    ENZYME CATALYSIS, PET, SSNS, THERMOSTABILITY, HYDROLASE
EXPDTA    X-RAY DIFFRACTION
AUTHOR    Z.HU,K.KLUPT,D.ZECHEL,Z.JIA,G.HOWE
REVDAT   1   26-FEB-25 9EH6    0
JRNL        AUTH   Z.HU,K.KLUPT,D.ZECHEL,Z.JIA,G.HOWE
JRNL        TITL   MINING THERMOPHILE GENOMES FOR NEW PETASES WITH EXCEPTIONAL
JRNL        TITL 2 STABILITIES USING SEQUENCE SIMILARITY NETWORKS
JRNL        REF    TO BE PUBLISHED
JRNL        REFN
REMARK   2
REMARK   2 RESOLUTION.    2.25 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : REFMAC 5.8.0415
REMARK   3   AUTHORS     : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK   3               : NICHOLLS,WINN,LONG,VAGIN
REMARK   3
REMARK   3    REFINEMENT TARGET : NULL
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.25
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 40.50
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.7
REMARK   3   NUMBER OF REFLECTIONS             : 18673
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   CROSS-VALIDATION METHOD          : FREE R-VALUE
REMARK   3   FREE R VALUE TEST SET SELECTION  : NULL
REMARK   3   R VALUE     (WORKING + TEST SET) : NULL
REMARK   3   R VALUE            (WORKING SET) : 0.186
REMARK   3   FREE R VALUE                     : 0.240
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.831
REMARK   3   FREE R VALUE TEST SET COUNT      : 902
REMARK   3
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.
REMARK   3   TOTAL NUMBER OF BINS USED           : 20
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.25
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.31
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 1288
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 99.63
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2260
REMARK   3   BIN FREE R VALUE SET COUNT          : 64
REMARK   3   BIN FREE R VALUE                    : 0.2730
REMARK   3
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK   3   PROTEIN ATOMS            : 3286
REMARK   3   NUCLEIC ACID ATOMS       : 0
REMARK   3   HETEROGEN ATOMS          : 0
REMARK   3   SOLVENT ATOMS            : 119
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : NULL
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 20.62
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : 0.12100
REMARK   3    B22 (A**2) : 0.13200
REMARK   3    B33 (A**2) : 0.11300
REMARK   3    B12 (A**2) : 0.00000
REMARK   3    B13 (A**2) : -0.88600
REMARK   3    B23 (A**2) : 0.00000
REMARK   3
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.
REMARK   3   ESU BASED ON R VALUE                            (A): 0.386
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.241
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.166
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 6.732
REMARK   3
REMARK   3 CORRELATION COEFFICIENTS.
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.938
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.890
REMARK   3
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT
REMARK   3   BOND LENGTHS REFINED ATOMS        (A):  3371 ; 0.006 ; 0.012
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES):  4607 ; 1.456 ; 1.644
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):   433 ; 7.253 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):    22 ; 6.257 ; 5.000
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):   466 ;17.086 ;10.000
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):  NULL ;  NULL ;  NULL
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):   504 ; 0.104 ; 0.200
REMARK   3   GENERAL PLANES REFINED ATOMS      (A):  2700 ; 0.007 ; 0.020
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  1461 ; 0.219 ; 0.200
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  2266 ; 0.317 ; 0.200
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):   131 ; 0.144 ; 0.200
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2):  1741 ; 2.368 ; 1.922
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2):  2171 ; 4.051 ; 3.440
REMARK   3   MAIN-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  1630 ; 2.867 ; 2.160
REMARK   3   SIDE-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  2436 ; 4.497 ; 3.839
REMARK   3   SIDE-CHAIN ANGLE OTHER ATOMS   (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B REFINED ATOMS     (A**2):  NULL ;  NULL ;  NULL
REMARK   3   LONG RANGE B OTHER ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL
REMARK   3
REMARK   3  NCS RESTRAINTS STATISTICS
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED : MASK BULK SOLVENT
REMARK   3   PARAMETERS FOR MASK CALCULATION
REMARK   3   VDW PROBE RADIUS   : 1.20
REMARK   3   ION PROBE RADIUS   : 0.80
REMARK   3   SHRINKAGE RADIUS   : 0.80
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE NOT BEEN USED
REMARK   4
REMARK   4 9EH6 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 25-NOV-24.
REMARK 100 THE DEPOSITION ID IS D_1000290367.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 24-JAN-24
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : NULL
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : CLSI
REMARK 200  BEAMLINE                       : 08ID-1
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.95299
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 9M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 18709
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.250
REMARK 200  RESOLUTION RANGE LOW       (A) : 46.820
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.9
REMARK 200  DATA REDUNDANCY                : 6.400
REMARK 200  R MERGE                    (I) : NULL
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 16.2000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.25
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.32
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.9
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL
REMARK 200  R MERGE FOR SHELL          (I) : NULL
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: MOLREP
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 38.02
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.98
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 100 MM SODIUM ACETATE PH 4.5 8%
REMARK 280  PEG3350, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 298K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       23.40850
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 1340 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 17430 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -9.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     HIS A     1
REMARK 465     GLY A   220
REMARK 465     GLY A   221
REMARK 465     PHE A   222
REMARK 465     LEU A   223
REMARK 465     GLU A   224
REMARK 465     HIS A   225
REMARK 465     HIS A   226
REMARK 465     HIS A   227
REMARK 465     HIS A   228
REMARK 465     HIS A   229
REMARK 465     HIS A   230
REMARK 465     HIS B     1
REMARK 465     GLY B   220
REMARK 465     GLY B   221
REMARK 465     PHE B   222
REMARK 465     LEU B   223
REMARK 465     GLU B   224
REMARK 465     HIS B   225
REMARK 465     HIS B   226
REMARK 465     HIS B   227
REMARK 465     HIS B   228
REMARK 465     HIS B   229
REMARK 465     HIS B   230
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     MET A   2    SD   CE
REMARK 470     MET B   2    SD   CE
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    ASP A  16     -148.48   -125.07
REMARK 500    ALA A  33     -110.78    -59.16
REMARK 500    PHE A  79      -88.74    -97.50
REMARK 500    ASP A  80       74.29     59.37
REMARK 500    SER A 103     -124.33     62.28
REMARK 500    ASN A 180     -169.09   -122.00
REMARK 500    TRP A 186       74.22   -117.26
REMARK 500    TYR A 187     -155.72   -129.12
REMARK 500    ALA B  33      -94.23   -105.16
REMARK 500    VAL B  78       52.59    -91.92
REMARK 500    ARG B  83       -8.64    -55.80
REMARK 500    SER B 103     -130.27     62.79
REMARK 500    TYR B 187     -148.42   -134.67
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500                                 MODEL     OMEGA
REMARK 500 GLY A  188     GLU A  189                  149.37
REMARK 500 GLY B  188     GLU B  189                  139.69
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    ARG B  36         0.08    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
DBREF  9EH6 A    3   222  UNP    I0I495   I0I495_CALAS    26    245
DBREF  9EH6 B    3   222  UNP    I0I495   I0I495_CALAS    26    245
SEQADV 9EH6 HIS A    1  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 MET A    2  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 LEU A  223  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 GLU A  224  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS A  225  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS A  226  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS A  227  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS A  228  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS A  229  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS A  230  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS B    1  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 MET B    2  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 LEU B  223  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 GLU B  224  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS B  225  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS B  226  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS B  227  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS B  228  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS B  229  UNP  I0I495              EXPRESSION TAG
SEQADV 9EH6 HIS B  230  UNP  I0I495              EXPRESSION TAG
SEQRES   1 A  230  HIS MET LEU GLN PRO MET ALA GLN ALA LEU ALA SER LEU
SEQRES   2 A  230  GLN GLY ASP ASP ARG VAL GLY VAL ILE GLU GLY ARG TRP
SEQRES   3 A  230  ILE VAL PHE GLN PRO LEU ALA ALA PRO ARG SER THR GLY
SEQRES   4 A  230  PHE ILE PHE TYR PRO GLY GLY ARG VAL ASP PRO ARG ALA
SEQRES   5 A  230  TYR ALA PRO GLN ALA ARG ALA ILE ALA GLU GLN GLY PHE
SEQRES   6 A  230  LEU VAL VAL ILE THR PRO MET PRO LEU ASN LEU ALA VAL
SEQRES   7 A  230  PHE ASP ALA ASP ARG ALA SER GLU VAL MET ALA ALA PHE
SEQRES   8 A  230  PRO GLU ILE GLU HIS TRP VAL ILE GLY GLY HIS SER LEU
SEQRES   9 A  230  GLY GLY ALA MET ALA ALA ASN PHE ALA HIS ASN HIS ILE
SEQRES  10 A  230  GLY ALA VAL GLU GLY VAL VAL PHE TRP ALA ALA TYR PRO
SEQRES  11 A  230  ALA GLN SER ASP SER LEU ALA ASP ARG ASP ASP LEU THR
SEQRES  12 A  230  VAL TYR SER ILE TYR GLY THR LEU ASP GLY LEU ALA THR
SEQRES  13 A  230  PRO ASP LYS ILE GLU ALA SER ARG ALA LEU LEU PRO ALA
SEQRES  14 A  230  THR ALA ARG PHE ILE PRO ILE GLU GLY GLY ASN HIS ALA
SEQRES  15 A  230  GLN PHE GLY TRP TYR GLY GLU GLN PRO GLY ASP ASN PRO
SEQRES  16 A  230  ALA THR ILE SER ARG ALA GLN GLN GLN GLN MET THR VAL
SEQRES  17 A  230  ASP ALA THR VAL GLU ALA LEU ALA VAL VAL ASP GLY GLY
SEQRES  18 A  230  PHE LEU GLU HIS HIS HIS HIS HIS HIS
SEQRES   1 B  230  HIS MET LEU GLN PRO MET ALA GLN ALA LEU ALA SER LEU
SEQRES   2 B  230  GLN GLY ASP ASP ARG VAL GLY VAL ILE GLU GLY ARG TRP
SEQRES   3 B  230  ILE VAL PHE GLN PRO LEU ALA ALA PRO ARG SER THR GLY
SEQRES   4 B  230  PHE ILE PHE TYR PRO GLY GLY ARG VAL ASP PRO ARG ALA
SEQRES   5 B  230  TYR ALA PRO GLN ALA ARG ALA ILE ALA GLU GLN GLY PHE
SEQRES   6 B  230  LEU VAL VAL ILE THR PRO MET PRO LEU ASN LEU ALA VAL
SEQRES   7 B  230  PHE ASP ALA ASP ARG ALA SER GLU VAL MET ALA ALA PHE
SEQRES   8 B  230  PRO GLU ILE GLU HIS TRP VAL ILE GLY GLY HIS SER LEU
SEQRES   9 B  230  GLY GLY ALA MET ALA ALA ASN PHE ALA HIS ASN HIS ILE
SEQRES  10 B  230  GLY ALA VAL GLU GLY VAL VAL PHE TRP ALA ALA TYR PRO
SEQRES  11 B  230  ALA GLN SER ASP SER LEU ALA ASP ARG ASP ASP LEU THR
SEQRES  12 B  230  VAL TYR SER ILE TYR GLY THR LEU ASP GLY LEU ALA THR
SEQRES  13 B  230  PRO ASP LYS ILE GLU ALA SER ARG ALA LEU LEU PRO ALA
SEQRES  14 B  230  THR ALA ARG PHE ILE PRO ILE GLU GLY GLY ASN HIS ALA
SEQRES  15 B  230  GLN PHE GLY TRP TYR GLY GLU GLN PRO GLY ASP ASN PRO
SEQRES  16 B  230  ALA THR ILE SER ARG ALA GLN GLN GLN GLN MET THR VAL
SEQRES  17 B  230  ASP ALA THR VAL GLU ALA LEU ALA VAL VAL ASP GLY GLY
SEQRES  18 B  230  PHE LEU GLU HIS HIS HIS HIS HIS HIS
FORMUL   3  HOH   *119(H2 O)
HELIX    1 AA1 ALA A    7  SER A   12  1                                   6
HELIX    2 AA2 ASP A   49  ALA A   52  5                                   4
HELIX    3 AA3 TYR A   53  GLN A   63  1                                  11
HELIX    4 AA4 ARG A   83  PHE A   91  1                                   9
HELIX    5 AA5 SER A  103  HIS A  116  1                                  14
HELIX    6 AA6 ALA A  131  SER A  135  5                                   5
HELIX    7 AA7 THR A  156  SER A  163  1                                   8
HELIX    8 AA8 ARG A  164  LEU A  167  5                                   4
HELIX    9 AA9 HIS A  181  GLY A  185  5                                   5
HELIX   10 AB1 SER A  199  ASP A  219  1                                  21
HELIX   11 AB2 MET B    6  LEU B   13  1                                   8
HELIX   12 AB3 ASP B   49  ALA B   52  5                                   4
HELIX   13 AB4 TYR B   53  GLU B   62  1                                  10
HELIX   14 AB5 ARG B   83  PHE B   91  1                                   9
HELIX   15 AB6 SER B  103  HIS B  116  1                                  14
HELIX   16 AB7 ALA B  131  SER B  135  5                                   5
HELIX   17 AB8 THR B  156  SER B  163  1                                   8
HELIX   18 AB9 ARG B  164  LEU B  167  5                                   4
HELIX   19 AC1 HIS B  181  GLY B  185  5                                   5
HELIX   20 AC2 SER B  199  ASP B  219  1                                  21
SHEET    1 AA1 8 VAL A  19  GLU A  23  0
SHEET    2 AA1 8 ILE A  27  PRO A  31 -1  O  VAL A  28   N  ILE A  22
SHEET    3 AA1 8 LEU A  66  ILE A  69 -1  O  VAL A  67   N  PHE A  29
SHEET    4 AA1 8 THR A  38  TYR A  43  1  N  PHE A  42   O  VAL A  68
SHEET    5 AA1 8 HIS A  96  HIS A 102  1  O  VAL A  98   N  ILE A  41
SHEET    6 AA1 8 GLY A 122  TRP A 126  1  O  GLY A 122   N  ILE A  99
SHEET    7 AA1 8 THR A 143  GLY A 149  1  O  ILE A 147   N  PHE A 125
SHEET    8 AA1 8 ARG A 172  ILE A 176  1  O  ILE A 176   N  TYR A 148
SHEET    1 AA2 8 VAL B  19  GLU B  23  0
SHEET    2 AA2 8 ILE B  27  PRO B  31 -1  O  GLN B  30   N  GLY B  20
SHEET    3 AA2 8 LEU B  66  ILE B  69 -1  O  ILE B  69   N  ILE B  27
SHEET    4 AA2 8 THR B  38  TYR B  43  1  N  PHE B  40   O  VAL B  68
SHEET    5 AA2 8 HIS B  96  HIS B 102  1  O  HIS B  96   N  GLY B  39
SHEET    6 AA2 8 GLY B 122  TRP B 126  1  O  TRP B 126   N  GLY B 101
SHEET    7 AA2 8 THR B 143  GLY B 149  1  O  ILE B 147   N  PHE B 125
SHEET    8 AA2 8 ARG B 172  ILE B 176  1  O  ILE B 176   N  TYR B 148
CRYST1   56.189   46.817   76.468  90.00 101.97  90.00 P 1 21 1      4
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.017797  0.000000  0.003773        0.00000
SCALE2      0.000000  0.021360  0.000000        0.00000
SCALE3      0.000000  0.000000  0.013368        0.00000
TER    1644      ASP A 219
TER    3288      ASP B 219
MASTER      328    0    0   20   16    0    0    6 3405    2    0   36
END