longtext: 9knk-pdb

content
HEADER    BIOSYNTHETIC PROTEIN                    19-NOV-24   9KNK
TITLE     CRYSTAL STRUCTURE OF FULL-LENGTH PHA SYNTHASE (PHAC) FROM AEROMONAS
TITLE    2 CAVIAE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PHA SYNTHASE;
COMPND   3 CHAIN: A, B, C;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: AEROMONAS CAVIAE;
SOURCE   3 ORGANISM_TAXID: 648;
SOURCE   4 GENE: PHAC;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    PHA SYNTHASE, FULL-LENGTH PHAC, DIMER, TUNNEL, CATALYTIC TRIAD,
KEYWDS   2 POLYHYDROXYALKANOATES, BIOSYNTHETIC PROTEIN
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.F.CHEK,S.Y.KIM,T.MORI,T.HAKOSHIMA
REVDAT   1   21-MAY-25 9KNK    0
JRNL        AUTH   M.F.CHEK,S.Y.KIM,T.MORI,K.MATSUMOTO,S.SATO,T.HAKOSHIMA
JRNL        TITL   STRUCTURES OF POLYHYDROXYALKANOATE SYNTHASE PHAC FROM
JRNL        TITL 2 AEROMONAS CAVIAE, PRODUCING BIODEGRADABLE PLASTICS.
JRNL        REF    ANGEW.CHEM.INT.ED.ENGL.              04626 2025
JRNL        REFN                   ESSN 1521-3773
JRNL        PMID   40276819
JRNL        DOI    10.1002/ANIE.202504626
REMARK   2
REMARK   2 RESOLUTION.    3.29 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.20.1_4487
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : GEOSTD + MONOMER LIBRARY + CDL V1.2
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.29
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.66
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.380
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.2
REMARK   3   NUMBER OF REFLECTIONS             : 31877
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.195
REMARK   3   R VALUE            (WORKING SET) : 0.193
REMARK   3   FREE R VALUE                     : 0.235
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.990
REMARK   3   FREE R VALUE TEST SET COUNT      : 1592
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 47.6600 -  7.3200    0.97     2814   149  0.1621 0.1828
REMARK   3     2  7.3100 -  5.8100    0.98     2765   145  0.2169 0.2204
REMARK   3     3  5.8100 -  5.0800    0.99     2760   146  0.1952 0.2780
REMARK   3     4  5.0800 -  4.6100    0.98     2736   144  0.1727 0.2134
REMARK   3     5  4.6100 -  4.2800    0.99     2792   147  0.1761 0.2238
REMARK   3     6  4.2800 -  4.0300    0.99     2734   142  0.1945 0.2758
REMARK   3     7  4.0300 -  3.8300    0.99     2767   146  0.2080 0.2697
REMARK   3     8  3.8300 -  3.6600    0.99     2758   144  0.2243 0.2615
REMARK   3     9  3.6600 -  3.5200    0.99     2763   146  0.2458 0.3165
REMARK   3    10  3.5200 -  3.4000    1.00     2761   144  0.2429 0.2982
REMARK   3    11  3.4000 -  3.2900    0.94     2635   139  0.2739 0.3143
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.393
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 26.036
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 111.0
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 116.0
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.003          12574
REMARK   3   ANGLE     :  0.585          17165
REMARK   3   CHIRALITY :  0.040           1948
REMARK   3   PLANARITY :  0.004           2218
REMARK   3   DIHEDRAL  :  4.013           1700
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : 1
REMARK   3   NCS GROUP : ens_1
REMARK   3    NCS OPERATOR : 1
REMARK   3     REFERENCE SELECTION: NULL
REMARK   3     SELECTION          : (chain "A" and (resid 6 through 18 or
REMARK   3                          (resid 19 and (name N or name CA or name
REMARK   3                          C or name O or name CB )) or resid 20
REMARK   3                          through 22 or (resid 23 through 27 and
REMARK   3                          (name N or name CA or name C or name O or
REMARK   3                          name CB )) or resid 28 through 29 or
REMARK   3                          (resid 30 and (name N or name CA or name
REMARK   3                          C or name O or name CB )) or resid 31
REMARK   3                          through 41 or resid 54 through 75 or
REMARK   3                          (resid 76 and (name N or name CA or name
REMARK   3                          C or name O or name CB )) or resid 77
REMARK   3                          through 78 or resid 105 through 111 or
REMARK   3                          (resid 112 and (name N or name CA or name
REMARK   3                          C or name O or name CB )) or resid 113
REMARK   3                          through 129 or (resid 130 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 131 through 133 or (resid 134
REMARK   3                          through 135 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          136 or (resid 137 through 140 and (name N
REMARK   3                          or name CA or name C or name O or name CB
REMARK   3                          )) or resid 141 through 144 or (resid 145
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 146 through 161
REMARK   3                          or (resid 162 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          163 through 167 or resid 172 through 176
REMARK   3                          or (resid 177 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          178 through 186 or (resid 187 through 188
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 189 through 190
REMARK   3                          or (resid 191 through 192 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 193 through 194 or resid 202
REMARK   3                          through 203 or (resid 204 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 205 through 206 or (resid 207
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 208 through 220
REMARK   3                          or (resid 221 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          222 through 236 or (resid 237 and (name N
REMARK   3                          or name CA or name C or name O or name CB
REMARK   3                          )) or resid 238 through 248 or (resid 249
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 250 through 283
REMARK   3                          or (resid 284 through 285 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 286 through 304 or (resid 305
REMARK   3                          through 307 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          308 through 310 or (resid 311 through 312
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 313 through 328
REMARK   3                          or (resid 329 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          330 through 334 or (resid 335 and (name N
REMARK   3                          or name CA or name C or name O or name CB
REMARK   3                          )) or resid 336 through 341 or (resid 342
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 343 through 358
REMARK   3                          or resid 361 through 370 or (resid 371
REMARK   3                          through 374 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          375 through 395 or resid 397 through 406
REMARK   3                          or (resid 407 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          408 or (resid 409 and (name N or name CA
REMARK   3                          or name C or name O or name CB )) or
REMARK   3                          resid 410 through 451 or (resid 452 and
REMARK   3                          (name N or name CA or name C or name O or
REMARK   3                          name CB )) or resid 453 or (resid 454 and
REMARK   3                          (name N or name CA or name C or name O or
REMARK   3                          name CB )) or resid 455 through 456 or
REMARK   3                          resid 458 or (resid 459 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 460 through 461 or (resid 462
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 463 or (resid
REMARK   3                          464 and (name N or name CA or name C or
REMARK   3                          name O or name CB )) or resid 465 through
REMARK   3                          487 or (resid 488 and (name N or name CA
REMARK   3                          or name C or name O or name CB )) or
REMARK   3                          resid 489 through 494 or (resid 495 and
REMARK   3                          (name N or name CA or name C or name O or
REMARK   3                          name CB )) or resid 496 through 499 or
REMARK   3                          (resid 500 and (name N or name CA or name
REMARK   3                          C or name O or name CB )) or resid 501
REMARK   3                          through 514 or (resid 515 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 516 through 521 or resid 525
REMARK   3                          through 544 or (resid 545 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 546 through 552 or (resid 553
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 558 through 583))
REMARK   3     ATOM PAIRS NUMBER  : NULL
REMARK   3     RMSD               : NULL
REMARK   3    NCS OPERATOR : 2
REMARK   3     REFERENCE SELECTION: NULL
REMARK   3     SELECTION          : (chain "B" and (resid 6 through 69 or
REMARK   3                          (resid 70 and (name N or name CA or name
REMARK   3                          C or name O or name CB )) or resid 71
REMARK   3                          through 119 or (resid 120 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 121 through 126 or (resid 127
REMARK   3                          through 128 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          129 or (resid 130 and (name N or name CA
REMARK   3                          or name C or name O or name CB )) or
REMARK   3                          resid 131 through 144 or (resid 145 and
REMARK   3                          (name N or name CA or name C or name O or
REMARK   3                          name CB )) or resid 146 through 161 or
REMARK   3                          (resid 162 and (name N or name CA or name
REMARK   3                          C or name O or name CB )) or resid 163
REMARK   3                          through 167 or resid 172 through 183 or
REMARK   3                          (resid 184 and (name N or name CA or name
REMARK   3                          C or name O or name CB )) or resid 185
REMARK   3                          through 186 or (resid 187 through 188 and
REMARK   3                          (name N or name CA or name C or name O or
REMARK   3                          name CB )) or resid 189 through 190 or
REMARK   3                          (resid 191 through 192 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 193 through 194 or resid 202
REMARK   3                          through 203 or (resid 204 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 205 through 206 or (resid 207
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 208 through 220
REMARK   3                          or (resid 221 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          222 through 248 or (resid 249 and (name N
REMARK   3                          or name CA or name C or name O or name CB
REMARK   3                          )) or resid 250 through 257 or (resid 258
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 259 through 283
REMARK   3                          or (resid 284 through 285 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 286 through 304 or (resid 305
REMARK   3                          through 307 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          308 through 311 or (resid 312 and (name N
REMARK   3                          or name CA or name C or name O or name CB
REMARK   3                          )) or resid 313 through 328 or (resid 329
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 330 through 334
REMARK   3                          or (resid 335 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          336 through 337 or (resid 338 and (name N
REMARK   3                          or name CA or name C or name O or name CB
REMARK   3                          )) or resid 339 through 341 or (resid 342
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 343 through 358
REMARK   3                          or resid 361 through 370 or (resid 371
REMARK   3                          through 374 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          375 or (resid 376 through 378 and (name N
REMARK   3                          or name CA or name C or name O or name CB
REMARK   3                          )) or resid 379 through 395 or resid 397
REMARK   3                          through 430 or (resid 431 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 432 through 453 or (resid 454
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 455 through 456
REMARK   3                          or resid 458 through 499 or (resid 500
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 501 through 521
REMARK   3                          or resid 525 through 552 or (resid 553
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or (resid 558 and (name N
REMARK   3                          or name CA or name C or name O or name CB
REMARK   3                          )) or resid 559 through 565 or (resid 566
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 567 through 583))
REMARK   3     ATOM PAIRS NUMBER  : NULL
REMARK   3     RMSD               : NULL
REMARK   3    NCS OPERATOR : 3
REMARK   3     REFERENCE SELECTION: NULL
REMARK   3     SELECTION          : (chain "C" and (resid 6 through 22 or
REMARK   3                          (resid 23 through 27 and (name N or name
REMARK   3                          CA or name C or name O or name CB )) or
REMARK   3                          resid 28 through 29 or (resid 30 and
REMARK   3                          (name N or name CA or name C or name O or
REMARK   3                          name CB )) or resid 31 through 41 or
REMARK   3                          resid 54 through 75 or (resid 76 and
REMARK   3                          (name N or name CA or name C or name O or
REMARK   3                          name CB )) or resid 77 through 78 or
REMARK   3                          resid 105 through 119 or (resid 120 and
REMARK   3                          (name N or name CA or name C or name O or
REMARK   3                          name CB )) or resid 121 through 126 or
REMARK   3                          (resid 127 through 128 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 129 through 139 or (resid 140
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 141 through 194
REMARK   3                          or resid 202 through 257 or (resid 258
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 259 through 310
REMARK   3                          or (resid 311 through 312 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 313 through 337 or (resid 338
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 339 through 375
REMARK   3                          or (resid 376 through 378 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 379 through 406 or (resid 407
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 408 or (resid
REMARK   3                          409 and (name N or name CA or name C or
REMARK   3                          name O or name CB )) or resid 410 through
REMARK   3                          430 or (resid 431 and (name N or name CA
REMARK   3                          or name C or name O or name CB )) or
REMARK   3                          resid 432 through 458 or (resid 459 and
REMARK   3                          (name N or name CA or name C or name O or
REMARK   3                          name CB )) or resid 460 through 461 or
REMARK   3                          (resid 462 and (name N or name CA or name
REMARK   3                          C or name O or name CB )) or resid 463 or
REMARK   3                          (resid 464 and (name N or name CA or name
REMARK   3                          C or name O or name CB )) or resid 465
REMARK   3                          through 487 or (resid 488 and (name N or
REMARK   3                          name CA or name C or name O or name CB ))
REMARK   3                          or resid 489 through 514 or (resid 515
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 516 through 544
REMARK   3                          or (resid 545 and (name N or name CA or
REMARK   3                          name C or name O or name CB )) or resid
REMARK   3                          546 through 553 or (resid 558 and (name N
REMARK   3                          or name CA or name C or name O or name CB
REMARK   3                          )) or resid 559 through 565 or (resid 566
REMARK   3                          and (name N or name CA or name C or name
REMARK   3                          O or name CB )) or resid 567 through 583))
REMARK   3     ATOM PAIRS NUMBER  : NULL
REMARK   3     RMSD               : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 9KNK COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 19-NOV-24.
REMARK 100 THE DEPOSITION ID IS D_1300053603.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 12-JUL-19
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 8.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SPRING-8
REMARK 200  BEAMLINE                       : BL41XU
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.999994
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS EIGER X 16M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XDS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 31906
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.290
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.3
REMARK 200  DATA REDUNDANCY                : 3.400
REMARK 200  R MERGE                    (I) : 0.06900
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 11.1400
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.29
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.42
REMARK 200  COMPLETENESS FOR SHELL     (%) : 96.8
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.41
REMARK 200  R MERGE FOR SHELL          (I) : 0.50800
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 54.56
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.71
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: SODIUM CHLORIDE, GLYCEROL, PEG6000,
REMARK 280  OCTYL BETA-D-GLUCOPYRANOSIDE, PH 8.0, VAPOR DIFFUSION, HANGING
REMARK 280  DROP, TEMPERATURE 277.15K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       78.31600
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       48.15000
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       78.31600
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       48.15000
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLY A    -1
REMARK 465     PRO A     0
REMARK 465     MET A     1
REMARK 465     SER A     2
REMARK 465     GLN A     3
REMARK 465     PRO A     4
REMARK 465     LEU A    43
REMARK 465     GLY A    44
REMARK 465     GLN A    45
REMARK 465     VAL A    46
REMARK 465     LEU A    47
REMARK 465     GLU A    48
REMARK 465     GLN A    49
REMARK 465     GLY A    50
REMARK 465     ALA A    80
REMARK 465     GLY A    81
REMARK 465     GLN A    82
REMARK 465     PRO A    83
REMARK 465     SER A    84
REMARK 465     GLU A    85
REMARK 465     PRO A    86
REMARK 465     VAL A    87
REMARK 465     ILE A    88
REMARK 465     THR A    89
REMARK 465     PRO A    90
REMARK 465     GLU A    91
REMARK 465     ARG A    92
REMARK 465     SER A    93
REMARK 465     ASP A    94
REMARK 465     ARG A    95
REMARK 465     ARG A    96
REMARK 465     PHE A    97
REMARK 465     LYS A    98
REMARK 465     ALA A    99
REMARK 465     GLU A   100
REMARK 465     ALA A   101
REMARK 465     TRP A   102
REMARK 465     SER A   103
REMARK 465     SER A   170
REMARK 465     ASP A   171
REMARK 465     THR A   198
REMARK 465     ASP A   199
REMARK 465     GLU A   200
REMARK 465     SER A   201
REMARK 465     GLU A   555
REMARK 465     GLY A   556
REMARK 465     ALA A   586
REMARK 465     CYS A   587
REMARK 465     PRO A   588
REMARK 465     THR A   589
REMARK 465     GLU A   590
REMARK 465     GLU A   591
REMARK 465     ASP A   592
REMARK 465     ALA A   593
REMARK 465     ALA A   594
REMARK 465     GLY B    -1
REMARK 465     PRO B     0
REMARK 465     MET B     1
REMARK 465     SER B     2
REMARK 465     GLN B     3
REMARK 465     PRO B     4
REMARK 465     SER B     5
REMARK 465     ASP B    42
REMARK 465     LEU B    43
REMARK 465     GLY B    44
REMARK 465     GLN B    45
REMARK 465     VAL B    46
REMARK 465     LEU B    47
REMARK 465     GLU B    48
REMARK 465     GLN B    49
REMARK 465     GLY B    50
REMARK 465     SER B    51
REMARK 465     GLN B    52
REMARK 465     GLN B    53
REMARK 465     SER B    79
REMARK 465     ALA B    80
REMARK 465     GLY B    81
REMARK 465     GLN B    82
REMARK 465     PRO B    83
REMARK 465     SER B    84
REMARK 465     GLU B    85
REMARK 465     PRO B    86
REMARK 465     VAL B    87
REMARK 465     ILE B    88
REMARK 465     THR B    89
REMARK 465     PRO B    90
REMARK 465     GLU B    91
REMARK 465     ARG B    92
REMARK 465     SER B    93
REMARK 465     ASP B    94
REMARK 465     ARG B    95
REMARK 465     ARG B    96
REMARK 465     PHE B    97
REMARK 465     LYS B    98
REMARK 465     ALA B    99
REMARK 465     GLU B   100
REMARK 465     ALA B   101
REMARK 465     TRP B   102
REMARK 465     SER B   103
REMARK 465     GLU B   104
REMARK 465     GLU B   169
REMARK 465     SER B   170
REMARK 465     ILE B   195
REMARK 465     ARG B   196
REMARK 465     LEU B   197
REMARK 465     THR B   198
REMARK 465     ASP B   554
REMARK 465     GLU B   555
REMARK 465     GLY B   556
REMARK 465     ALA B   586
REMARK 465     CYS B   587
REMARK 465     PRO B   588
REMARK 465     THR B   589
REMARK 465     GLU B   590
REMARK 465     GLU B   591
REMARK 465     ASP B   592
REMARK 465     ALA B   593
REMARK 465     ALA B   594
REMARK 465     GLY C    -1
REMARK 465     PRO C     0
REMARK 465     MET C     1
REMARK 465     SER C     2
REMARK 465     GLN C     3
REMARK 465     PRO C     4
REMARK 465     GLY C    44
REMARK 465     GLN C    45
REMARK 465     VAL C    46
REMARK 465     LEU C    47
REMARK 465     GLU C    48
REMARK 465     GLN C    49
REMARK 465     GLY C    50
REMARK 465     SER C    51
REMARK 465     ALA C    80
REMARK 465     GLY C    81
REMARK 465     GLN C    82
REMARK 465     PRO C    83
REMARK 465     SER C    84
REMARK 465     GLU C    85
REMARK 465     PRO C    86
REMARK 465     VAL C    87
REMARK 465     ILE C    88
REMARK 465     THR C    89
REMARK 465     PRO C    90
REMARK 465     GLU C    91
REMARK 465     ARG C    92
REMARK 465     SER C    93
REMARK 465     ASP C    94
REMARK 465     ARG C    95
REMARK 465     ARG C    96
REMARK 465     PHE C    97
REMARK 465     LYS C    98
REMARK 465     ALA C    99
REMARK 465     GLU C   100
REMARK 465     ALA C   101
REMARK 465     TRP C   102
REMARK 465     SER C   103
REMARK 465     LEU C   168
REMARK 465     GLU C   169
REMARK 465     SER C   170
REMARK 465     ASP C   171
REMARK 465     LEU C   197
REMARK 465     THR C   198
REMARK 465     ASP C   199
REMARK 465     GLU C   200
REMARK 465     LEU C   359
REMARK 465     GLY C   360
REMARK 465     ASN C   396
REMARK 465     ARG C   457
REMARK 465     GLY C   522
REMARK 465     ALA C   523
REMARK 465     GLU C   524
REMARK 465     GLU C   555
REMARK 465     GLY C   556
REMARK 465     SER C   557
REMARK 465     VAL C   584
REMARK 465     PHE C   585
REMARK 465     ALA C   586
REMARK 465     CYS C   587
REMARK 465     PRO C   588
REMARK 465     THR C   589
REMARK 465     GLU C   590
REMARK 465     GLU C   591
REMARK 465     ASP C   592
REMARK 465     ALA C   593
REMARK 465     ALA C   594
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470   M RES CSSEQI  ATOMS
REMARK 470     LYS A  70    CG   CD   CE   NZ
REMARK 470     LYS A  78    CG   CD   CE   NZ
REMARK 470     ARG A 120    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP A 127    CG   OD1  OD2
REMARK 470     LYS A 135    CG   CD   CE   NZ
REMARK 470     ARG A 139    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS A 165    CG   CD   CE   NZ
REMARK 470     GLU A 169    CG   CD   OE1  OE2
REMARK 470     GLU A 184    CG   CD   OE1  OE2
REMARK 470     GLN A 258    CG   CD   OE1  NE2
REMARK 470     GLU A 312    CG   CD   OE1  OE2
REMARK 470     LYS A 338    CG   CD   CE   NZ
REMARK 470     GLU A 376    CG   CD   OE1  OE2
REMARK 470     LYS A 378    CG   CD   CE   NZ
REMARK 470     LYS A 431    CG   CD   CE   NZ
REMARK 470     GLU A 524    CG   CD   OE1  OE2
REMARK 470     GLU A 558    CG   CD   OE1  OE2
REMARK 470     GLU A 566    CG   CD   OE1  OE2
REMARK 470     LYS B  19    CG   CD   CE   NZ
REMARK 470     MET B  23    CG   SD   CE
REMARK 470     LYS B  25    CG   CD   CE   NZ
REMARK 470     GLN B  27    CG   CD   OE1  NE2
REMARK 470     ARG B  30    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LEU B  76    CG   CD1  CD2
REMARK 470     LYS B  78    CG   CD   CE   NZ
REMARK 470     LYS B 112    CG   CD   CE   NZ
REMARK 470     GLN B 134    CG   CD   OE1  NE2
REMARK 470     LYS B 135    CG   CD   CE   NZ
REMARK 470     ARG B 137    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU B 138    CG   CD   OE1  OE2
REMARK 470     ARG B 139    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LEU B 140    CG   CD1  CD2
REMARK 470     LYS B 165    CG   CD   CE   NZ
REMARK 470     ARG B 177    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG B 188    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS B 237    CG   CD   CE   NZ
REMARK 470     ARG B 311    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS B 378    CG   CD   CE   NZ
REMARK 470     TYR B 407    CG   CD1  CD2  CE1  CE2  CZ   OH
REMARK 470     LYS B 409    CG   CD   CE   NZ
REMARK 470     LYS B 452    CG   CD   CE   NZ
REMARK 470     ARG B 457    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP B 459    CG   OD1  OD2
REMARK 470     LYS B 462    CG   CD   CE   NZ
REMARK 470     LYS B 464    CG   CD   CE   NZ
REMARK 470     LYS B 488    CG   CD   CE   NZ
REMARK 470     ARG B 495    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LYS B 515    CG   CD   CE   NZ
REMARK 470     GLU B 524    CG   CD   OE1  OE2
REMARK 470     GLU B 545    CG   CD   OE1  OE2
REMARK 470     LYS C  19    CG   CD   CE   NZ
REMARK 470     LYS C  25    CG   CD   CE   NZ
REMARK 470     LYS C  70    CG   CD   CE   NZ
REMARK 470     LYS C  78    CG   CD   CE   NZ
REMARK 470     GLU C 104    CG   CD   OE1  OE2
REMARK 470     LYS C 112    CG   CD   CE   NZ
REMARK 470     GLU C 130    CG   CD   OE1  OE2
REMARK 470     GLN C 134    CG   CD   OE1  NE2
REMARK 470     LYS C 135    CG   CD   CE   NZ
REMARK 470     ARG C 137    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU C 138    CG   CD   OE1  OE2
REMARK 470     ARG C 139    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG C 145    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU C 162    CG   CD   OE1  OE2
REMARK 470     LYS C 165    CG   CD   CE   NZ
REMARK 470     ARG C 177    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU C 184    CG   CD   OE1  OE2
REMARK 470     GLU C 187    CG   CD   OE1  OE2
REMARK 470     ARG C 188    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ASP C 191    CG   OD1  OD2
REMARK 470     GLN C 192    CG   CD   OE1  NE2
REMARK 470     ARG C 196    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU C 204    CG   CD   OE1  OE2
REMARK 470     ARG C 207    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU C 221    CG   CD   OE1  OE2
REMARK 470     LYS C 237    CG   CD   CE   NZ
REMARK 470     LYS C 249    CG   CD   CE   NZ
REMARK 470     GLN C 284    CG   CD   OE1  NE2
REMARK 470     GLU C 305    CG   CD   OE1  OE2
REMARK 470     GLU C 312    CG   CD   OE1  OE2
REMARK 470     MET C 329    CG   SD   CE
REMARK 470     ARG C 335    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG C 342    CG   CD   NE   CZ   NH1  NH2
REMARK 470     LEU C 371    CG   CD1  CD2
REMARK 470     GLU C 372    CG   CD   OE1  OE2
REMARK 470     GLN C 374    CG   CD   OE1  NE2
REMARK 470     LYS C 378    CG   CD   CE   NZ
REMARK 470     LYS C 452    CG   CD   CE   NZ
REMARK 470     ARG C 454    CG   CD   NE   CZ   NH1  NH2
REMARK 470     ARG C 495    CG   CD   NE   CZ   NH1  NH2
REMARK 470     GLU C 500    CG   CD   OE1  OE2
REMARK 470     ARG C 553    CG   CD   NE   CZ   NH1  NH2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    GLN A  37       46.44    -93.52
REMARK 500    LEU A  40      -51.87     63.94
REMARK 500    LEU A 129       31.59    -87.91
REMARK 500    MET A 255      -68.00    -96.32
REMARK 500    GLN A 284       33.54    -90.95
REMARK 500    TYR A 318     -146.35   -107.93
REMARK 500    GLU A 500       49.07    -93.57
REMARK 500    SER A 501     -158.87   -166.78
REMARK 500    TYR A 516     -156.33   -128.87
REMARK 500    GLU B 200       48.11    -88.29
REMARK 500    TYR B 251        8.25    -69.73
REMARK 500    MET B 255      -67.47    -96.61
REMARK 500    TYR B 318     -145.14   -109.29
REMARK 500    GLU B 500       48.64    -93.32
REMARK 500    SER B 501     -160.09   -166.21
REMARK 500    TYR B 516     -158.61   -128.58
REMARK 500    GLN C  37       59.43    -98.82
REMARK 500    LEU C  40       48.77    -93.87
REMARK 500    ASP C  41       14.49   -156.67
REMARK 500    LEU C 129       31.09    -86.99
REMARK 500    ALA C 202     -139.57   -145.15
REMARK 500    MET C 255      -65.92    -96.72
REMARK 500    TYR C 318     -150.72   -106.33
REMARK 500    GLU C 500       48.96    -91.93
REMARK 500    SER C 501     -160.78   -165.77
REMARK 500    TYR C 516     -160.01   -128.61
REMARK 500
REMARK 500 REMARK: NULL
DBREF  9KNK A    1   594  UNP    O32471   O32471_AERCA     1    594
DBREF  9KNK B    1   594  UNP    O32471   O32471_AERCA     1    594
DBREF  9KNK C    1   594  UNP    O32471   O32471_AERCA     1    594
SEQADV 9KNK GLY A   -1  UNP  O32471              EXPRESSION TAG
SEQADV 9KNK PRO A    0  UNP  O32471              EXPRESSION TAG
SEQADV 9KNK GLY B   -1  UNP  O32471              EXPRESSION TAG
SEQADV 9KNK PRO B    0  UNP  O32471              EXPRESSION TAG
SEQADV 9KNK GLY C   -1  UNP  O32471              EXPRESSION TAG
SEQADV 9KNK PRO C    0  UNP  O32471              EXPRESSION TAG
SEQRES   1 A  596  GLY PRO MET SER GLN PRO SER TYR GLY PRO LEU PHE GLU
SEQRES   2 A  596  ALA LEU ALA HIS TYR ASN ASP LYS LEU LEU ALA MET ALA
SEQRES   3 A  596  LYS ALA GLN THR GLU ARG THR ALA GLN ALA LEU LEU GLN
SEQRES   4 A  596  THR ASN LEU ASP ASP LEU GLY GLN VAL LEU GLU GLN GLY
SEQRES   5 A  596  SER GLN GLN PRO TRP GLN LEU ILE GLN ALA GLN MET ASN
SEQRES   6 A  596  TRP TRP GLN ASP GLN LEU LYS LEU MET GLN HIS THR LEU
SEQRES   7 A  596  LEU LYS SER ALA GLY GLN PRO SER GLU PRO VAL ILE THR
SEQRES   8 A  596  PRO GLU ARG SER ASP ARG ARG PHE LYS ALA GLU ALA TRP
SEQRES   9 A  596  SER GLU GLN PRO ILE TYR ASP TYR LEU LYS GLN SER TYR
SEQRES  10 A  596  LEU LEU THR ALA ARG HIS LEU LEU ALA SER VAL ASP ALA
SEQRES  11 A  596  LEU GLU GLY VAL PRO GLN LYS SER ARG GLU ARG LEU ARG
SEQRES  12 A  596  PHE PHE THR ARG GLN TYR VAL ASN ALA MET ALA PRO SER
SEQRES  13 A  596  ASN PHE LEU ALA THR ASN PRO GLU LEU LEU LYS LEU THR
SEQRES  14 A  596  LEU GLU SER ASP GLY GLN ASN LEU VAL ARG GLY LEU ALA
SEQRES  15 A  596  LEU LEU ALA GLU ASP LEU GLU ARG SER ALA ASP GLN LEU
SEQRES  16 A  596  ASN ILE ARG LEU THR ASP GLU SER ALA PHE GLU LEU GLY
SEQRES  17 A  596  ARG ASP LEU ALA LEU THR PRO GLY ARG VAL VAL GLN ARG
SEQRES  18 A  596  THR GLU LEU TYR GLU LEU ILE GLN TYR SER PRO THR THR
SEQRES  19 A  596  GLU THR VAL GLY LYS THR PRO VAL LEU ILE VAL PRO PRO
SEQRES  20 A  596  PHE ILE ASN LYS TYR TYR ILE MET ASP MET ARG PRO GLN
SEQRES  21 A  596  ASN SER LEU VAL ALA TRP LEU VAL ALA GLN GLY GLN THR
SEQRES  22 A  596  VAL PHE MET ILE SER TRP ARG ASN PRO GLY VAL ALA GLN
SEQRES  23 A  596  ALA GLN ILE ASP LEU ASP ASP TYR VAL VAL ASP GLY VAL
SEQRES  24 A  596  ILE ALA ALA LEU ASP GLY VAL GLU ALA ALA THR GLY GLU
SEQRES  25 A  596  ARG GLU VAL HIS GLY ILE GLY TYR CYS ILE GLY GLY THR
SEQRES  26 A  596  ALA LEU SER LEU ALA MET GLY TRP LEU ALA ALA ARG ARG
SEQRES  27 A  596  GLN LYS GLN ARG VAL ARG THR ALA THR LEU PHE THR THR
SEQRES  28 A  596  LEU LEU ASP PHE SER GLN PRO GLY GLU LEU GLY ILE PHE
SEQRES  29 A  596  ILE HIS GLU PRO ILE ILE ALA ALA LEU GLU ALA GLN ASN
SEQRES  30 A  596  GLU ALA LYS GLY ILE MET ASP GLY ARG GLN LEU ALA VAL
SEQRES  31 A  596  SER PHE SER LEU LEU ARG GLU ASN SER LEU TYR TRP ASN
SEQRES  32 A  596  TYR TYR ILE ASP SER TYR LEU LYS GLY GLN SER PRO VAL
SEQRES  33 A  596  ALA PHE ASP LEU LEU HIS TRP ASN SER ASP SER THR ASN
SEQRES  34 A  596  VAL ALA GLY LYS THR HIS ASN SER LEU LEU ARG ARG LEU
SEQRES  35 A  596  TYR LEU GLU ASN GLN LEU VAL LYS GLY GLU LEU LYS ILE
SEQRES  36 A  596  ARG ASN THR ARG ILE ASP LEU GLY LYS VAL LYS THR PRO
SEQRES  37 A  596  VAL LEU LEU VAL SER ALA VAL ASP ASP HIS ILE ALA LEU
SEQRES  38 A  596  TRP GLN GLY THR TRP GLN GLY MET LYS LEU PHE GLY GLY
SEQRES  39 A  596  GLU GLN ARG PHE LEU LEU ALA GLU SER GLY HIS ILE ALA
SEQRES  40 A  596  GLY ILE ILE ASN PRO PRO ALA ALA ASN LYS TYR GLY PHE
SEQRES  41 A  596  TRP HIS ASN GLY ALA GLU ALA GLU SER PRO GLU SER TRP
SEQRES  42 A  596  LEU ALA GLY ALA THR HIS GLN GLY GLY SER TRP TRP PRO
SEQRES  43 A  596  GLU MET MET GLY PHE ILE GLN ASN ARG ASP GLU GLY SER
SEQRES  44 A  596  GLU PRO VAL PRO ALA ARG VAL PRO GLU GLU GLY LEU ALA
SEQRES  45 A  596  PRO ALA PRO GLY HIS TYR VAL LYS VAL ARG LEU ASN PRO
SEQRES  46 A  596  VAL PHE ALA CYS PRO THR GLU GLU ASP ALA ALA
SEQRES   1 B  596  GLY PRO MET SER GLN PRO SER TYR GLY PRO LEU PHE GLU
SEQRES   2 B  596  ALA LEU ALA HIS TYR ASN ASP LYS LEU LEU ALA MET ALA
SEQRES   3 B  596  LYS ALA GLN THR GLU ARG THR ALA GLN ALA LEU LEU GLN
SEQRES   4 B  596  THR ASN LEU ASP ASP LEU GLY GLN VAL LEU GLU GLN GLY
SEQRES   5 B  596  SER GLN GLN PRO TRP GLN LEU ILE GLN ALA GLN MET ASN
SEQRES   6 B  596  TRP TRP GLN ASP GLN LEU LYS LEU MET GLN HIS THR LEU
SEQRES   7 B  596  LEU LYS SER ALA GLY GLN PRO SER GLU PRO VAL ILE THR
SEQRES   8 B  596  PRO GLU ARG SER ASP ARG ARG PHE LYS ALA GLU ALA TRP
SEQRES   9 B  596  SER GLU GLN PRO ILE TYR ASP TYR LEU LYS GLN SER TYR
SEQRES  10 B  596  LEU LEU THR ALA ARG HIS LEU LEU ALA SER VAL ASP ALA
SEQRES  11 B  596  LEU GLU GLY VAL PRO GLN LYS SER ARG GLU ARG LEU ARG
SEQRES  12 B  596  PHE PHE THR ARG GLN TYR VAL ASN ALA MET ALA PRO SER
SEQRES  13 B  596  ASN PHE LEU ALA THR ASN PRO GLU LEU LEU LYS LEU THR
SEQRES  14 B  596  LEU GLU SER ASP GLY GLN ASN LEU VAL ARG GLY LEU ALA
SEQRES  15 B  596  LEU LEU ALA GLU ASP LEU GLU ARG SER ALA ASP GLN LEU
SEQRES  16 B  596  ASN ILE ARG LEU THR ASP GLU SER ALA PHE GLU LEU GLY
SEQRES  17 B  596  ARG ASP LEU ALA LEU THR PRO GLY ARG VAL VAL GLN ARG
SEQRES  18 B  596  THR GLU LEU TYR GLU LEU ILE GLN TYR SER PRO THR THR
SEQRES  19 B  596  GLU THR VAL GLY LYS THR PRO VAL LEU ILE VAL PRO PRO
SEQRES  20 B  596  PHE ILE ASN LYS TYR TYR ILE MET ASP MET ARG PRO GLN
SEQRES  21 B  596  ASN SER LEU VAL ALA TRP LEU VAL ALA GLN GLY GLN THR
SEQRES  22 B  596  VAL PHE MET ILE SER TRP ARG ASN PRO GLY VAL ALA GLN
SEQRES  23 B  596  ALA GLN ILE ASP LEU ASP ASP TYR VAL VAL ASP GLY VAL
SEQRES  24 B  596  ILE ALA ALA LEU ASP GLY VAL GLU ALA ALA THR GLY GLU
SEQRES  25 B  596  ARG GLU VAL HIS GLY ILE GLY TYR CYS ILE GLY GLY THR
SEQRES  26 B  596  ALA LEU SER LEU ALA MET GLY TRP LEU ALA ALA ARG ARG
SEQRES  27 B  596  GLN LYS GLN ARG VAL ARG THR ALA THR LEU PHE THR THR
SEQRES  28 B  596  LEU LEU ASP PHE SER GLN PRO GLY GLU LEU GLY ILE PHE
SEQRES  29 B  596  ILE HIS GLU PRO ILE ILE ALA ALA LEU GLU ALA GLN ASN
SEQRES  30 B  596  GLU ALA LYS GLY ILE MET ASP GLY ARG GLN LEU ALA VAL
SEQRES  31 B  596  SER PHE SER LEU LEU ARG GLU ASN SER LEU TYR TRP ASN
SEQRES  32 B  596  TYR TYR ILE ASP SER TYR LEU LYS GLY GLN SER PRO VAL
SEQRES  33 B  596  ALA PHE ASP LEU LEU HIS TRP ASN SER ASP SER THR ASN
SEQRES  34 B  596  VAL ALA GLY LYS THR HIS ASN SER LEU LEU ARG ARG LEU
SEQRES  35 B  596  TYR LEU GLU ASN GLN LEU VAL LYS GLY GLU LEU LYS ILE
SEQRES  36 B  596  ARG ASN THR ARG ILE ASP LEU GLY LYS VAL LYS THR PRO
SEQRES  37 B  596  VAL LEU LEU VAL SER ALA VAL ASP ASP HIS ILE ALA LEU
SEQRES  38 B  596  TRP GLN GLY THR TRP GLN GLY MET LYS LEU PHE GLY GLY
SEQRES  39 B  596  GLU GLN ARG PHE LEU LEU ALA GLU SER GLY HIS ILE ALA
SEQRES  40 B  596  GLY ILE ILE ASN PRO PRO ALA ALA ASN LYS TYR GLY PHE
SEQRES  41 B  596  TRP HIS ASN GLY ALA GLU ALA GLU SER PRO GLU SER TRP
SEQRES  42 B  596  LEU ALA GLY ALA THR HIS GLN GLY GLY SER TRP TRP PRO
SEQRES  43 B  596  GLU MET MET GLY PHE ILE GLN ASN ARG ASP GLU GLY SER
SEQRES  44 B  596  GLU PRO VAL PRO ALA ARG VAL PRO GLU GLU GLY LEU ALA
SEQRES  45 B  596  PRO ALA PRO GLY HIS TYR VAL LYS VAL ARG LEU ASN PRO
SEQRES  46 B  596  VAL PHE ALA CYS PRO THR GLU GLU ASP ALA ALA
SEQRES   1 C  596  GLY PRO MET SER GLN PRO SER TYR GLY PRO LEU PHE GLU
SEQRES   2 C  596  ALA LEU ALA HIS TYR ASN ASP LYS LEU LEU ALA MET ALA
SEQRES   3 C  596  LYS ALA GLN THR GLU ARG THR ALA GLN ALA LEU LEU GLN
SEQRES   4 C  596  THR ASN LEU ASP ASP LEU GLY GLN VAL LEU GLU GLN GLY
SEQRES   5 C  596  SER GLN GLN PRO TRP GLN LEU ILE GLN ALA GLN MET ASN
SEQRES   6 C  596  TRP TRP GLN ASP GLN LEU LYS LEU MET GLN HIS THR LEU
SEQRES   7 C  596  LEU LYS SER ALA GLY GLN PRO SER GLU PRO VAL ILE THR
SEQRES   8 C  596  PRO GLU ARG SER ASP ARG ARG PHE LYS ALA GLU ALA TRP
SEQRES   9 C  596  SER GLU GLN PRO ILE TYR ASP TYR LEU LYS GLN SER TYR
SEQRES  10 C  596  LEU LEU THR ALA ARG HIS LEU LEU ALA SER VAL ASP ALA
SEQRES  11 C  596  LEU GLU GLY VAL PRO GLN LYS SER ARG GLU ARG LEU ARG
SEQRES  12 C  596  PHE PHE THR ARG GLN TYR VAL ASN ALA MET ALA PRO SER
SEQRES  13 C  596  ASN PHE LEU ALA THR ASN PRO GLU LEU LEU LYS LEU THR
SEQRES  14 C  596  LEU GLU SER ASP GLY GLN ASN LEU VAL ARG GLY LEU ALA
SEQRES  15 C  596  LEU LEU ALA GLU ASP LEU GLU ARG SER ALA ASP GLN LEU
SEQRES  16 C  596  ASN ILE ARG LEU THR ASP GLU SER ALA PHE GLU LEU GLY
SEQRES  17 C  596  ARG ASP LEU ALA LEU THR PRO GLY ARG VAL VAL GLN ARG
SEQRES  18 C  596  THR GLU LEU TYR GLU LEU ILE GLN TYR SER PRO THR THR
SEQRES  19 C  596  GLU THR VAL GLY LYS THR PRO VAL LEU ILE VAL PRO PRO
SEQRES  20 C  596  PHE ILE ASN LYS TYR TYR ILE MET ASP MET ARG PRO GLN
SEQRES  21 C  596  ASN SER LEU VAL ALA TRP LEU VAL ALA GLN GLY GLN THR
SEQRES  22 C  596  VAL PHE MET ILE SER TRP ARG ASN PRO GLY VAL ALA GLN
SEQRES  23 C  596  ALA GLN ILE ASP LEU ASP ASP TYR VAL VAL ASP GLY VAL
SEQRES  24 C  596  ILE ALA ALA LEU ASP GLY VAL GLU ALA ALA THR GLY GLU
SEQRES  25 C  596  ARG GLU VAL HIS GLY ILE GLY TYR CYS ILE GLY GLY THR
SEQRES  26 C  596  ALA LEU SER LEU ALA MET GLY TRP LEU ALA ALA ARG ARG
SEQRES  27 C  596  GLN LYS GLN ARG VAL ARG THR ALA THR LEU PHE THR THR
SEQRES  28 C  596  LEU LEU ASP PHE SER GLN PRO GLY GLU LEU GLY ILE PHE
SEQRES  29 C  596  ILE HIS GLU PRO ILE ILE ALA ALA LEU GLU ALA GLN ASN
SEQRES  30 C  596  GLU ALA LYS GLY ILE MET ASP GLY ARG GLN LEU ALA VAL
SEQRES  31 C  596  SER PHE SER LEU LEU ARG GLU ASN SER LEU TYR TRP ASN
SEQRES  32 C  596  TYR TYR ILE ASP SER TYR LEU LYS GLY GLN SER PRO VAL
SEQRES  33 C  596  ALA PHE ASP LEU LEU HIS TRP ASN SER ASP SER THR ASN
SEQRES  34 C  596  VAL ALA GLY LYS THR HIS ASN SER LEU LEU ARG ARG LEU
SEQRES  35 C  596  TYR LEU GLU ASN GLN LEU VAL LYS GLY GLU LEU LYS ILE
SEQRES  36 C  596  ARG ASN THR ARG ILE ASP LEU GLY LYS VAL LYS THR PRO
SEQRES  37 C  596  VAL LEU LEU VAL SER ALA VAL ASP ASP HIS ILE ALA LEU
SEQRES  38 C  596  TRP GLN GLY THR TRP GLN GLY MET LYS LEU PHE GLY GLY
SEQRES  39 C  596  GLU GLN ARG PHE LEU LEU ALA GLU SER GLY HIS ILE ALA
SEQRES  40 C  596  GLY ILE ILE ASN PRO PRO ALA ALA ASN LYS TYR GLY PHE
SEQRES  41 C  596  TRP HIS ASN GLY ALA GLU ALA GLU SER PRO GLU SER TRP
SEQRES  42 C  596  LEU ALA GLY ALA THR HIS GLN GLY GLY SER TRP TRP PRO
SEQRES  43 C  596  GLU MET MET GLY PHE ILE GLN ASN ARG ASP GLU GLY SER
SEQRES  44 C  596  GLU PRO VAL PRO ALA ARG VAL PRO GLU GLU GLY LEU ALA
SEQRES  45 C  596  PRO ALA PRO GLY HIS TYR VAL LYS VAL ARG LEU ASN PRO
SEQRES  46 C  596  VAL PHE ALA CYS PRO THR GLU GLU ASP ALA ALA
FORMUL   4  HOH   *7(H2 O)
HELIX    1 AA1 TYR A    6  GLN A   37  1                                  32
HELIX    2 AA2 PRO A   54  SER A   79  1                                  26
HELIX    3 AA3 GLN A  105  LEU A  129  1                                  25
HELIX    4 AA4 PRO A  133  ALA A  152  1                                  20
HELIX    5 AA5 PRO A  153  PHE A  156  5                                   4
HELIX    6 AA6 ASN A  160  LEU A  168  1                                   9
HELIX    7 AA7 GLN A  173  LEU A  197  1                                  25
HELIX    8 AA8 LYS A  249  ASP A  254  5                                   6
HELIX    9 AA9 ARG A  256  ASN A  259  5                                   4
HELIX   10 AB1 SER A  260  GLN A  268  1                                   9
HELIX   11 AB2 ASP A  288  ASP A  295  1                                   8
HELIX   12 AB3 GLY A  296  GLY A  309  1                                  14
HELIX   13 AB4 ILE A  320  ARG A  335  1                                  16
HELIX   14 AB5 PRO A  356  ILE A  363  5                                   8
HELIX   15 AB6 HIS A  364  GLY A  379  1                                  16
HELIX   16 AB7 ASP A  382  VAL A  388  1                                   7
HELIX   17 AB8 SER A  397  TYR A  403  1                                   7
HELIX   18 AB9 TYR A  403  LYS A  409  1                                   7
HELIX   19 AC1 PRO A  413  SER A  423  1                                  11
HELIX   20 AC2 GLY A  430  ARG A  439  1                                  10
HELIX   21 AC3 ASP A  459  VAL A  463  5                                   5
HELIX   22 AC4 LEU A  479  LYS A  488  1                                  10
HELIX   23 AC5 SER A  527  GLY A  534  1                                   8
HELIX   24 AC6 TRP A  542  ASP A  554  1                                  13
HELIX   25 AC7 GLY B    7  GLN B   37  1                                  31
HELIX   26 AC8 TRP B   55  LYS B   78  1                                  24
HELIX   27 AC9 PRO B  106  LEU B  129  1                                  24
HELIX   28 AD1 PRO B  133  MET B  151  1                                  19
HELIX   29 AD2 ALA B  152  PHE B  156  5                                   5
HELIX   30 AD3 ASN B  160  LEU B  168  1                                   9
HELIX   31 AD4 GLY B  172  ASN B  194  1                                  23
HELIX   32 AD5 LYS B  249  ASP B  254  5                                   6
HELIX   33 AD6 SER B  260  GLN B  268  1                                   9
HELIX   34 AD7 GLY B  281  ALA B  285  5                                   5
HELIX   35 AD8 ASP B  288  ASP B  295  1                                   8
HELIX   36 AD9 GLY B  296  GLY B  309  1                                  14
HELIX   37 AE1 ILE B  320  ARG B  335  1                                  16
HELIX   38 AE2 PRO B  356  ILE B  363  5                                   8
HELIX   39 AE3 HIS B  364  GLY B  379  1                                  16
HELIX   40 AE4 ASP B  382  VAL B  388  1                                   7
HELIX   41 AE5 SER B  397  TYR B  403  1                                   7
HELIX   42 AE6 TYR B  403  LYS B  409  1                                   7
HELIX   43 AE7 PRO B  413  SER B  423  1                                  11
HELIX   44 AE8 GLY B  430  ARG B  439  1                                  10
HELIX   45 AE9 ASP B  459  VAL B  463  5                                   5
HELIX   46 AF1 LEU B  479  LYS B  488  1                                  10
HELIX   47 AF2 PRO B  510  ASN B  514  5                                   5
HELIX   48 AF3 SER B  527  GLY B  534  1                                   8
HELIX   49 AF4 TRP B  542  ARG B  553  1                                  12
HELIX   50 AF5 TYR C    6  LEU C   35  1                                  30
HELIX   51 AF6 PRO C   54  SER C   79  1                                  26
HELIX   52 AF7 GLN C  105  LEU C  129  1                                  25
HELIX   53 AF8 PRO C  133  ALA C  152  1                                  20
HELIX   54 AF9 PRO C  153  THR C  159  5                                   7
HELIX   55 AG1 ASN C  160  THR C  167  1                                   8
HELIX   56 AG2 GLN C  173  ARG C  196  1                                  24
HELIX   57 AG3 LYS C  249  ASP C  254  5                                   6
HELIX   58 AG4 ARG C  256  ASN C  259  5                                   4
HELIX   59 AG5 SER C  260  GLN C  268  1                                   9
HELIX   60 AG6 VAL C  282  ILE C  287  5                                   6
HELIX   61 AG7 ASP C  288  ASP C  295  1                                   8
HELIX   62 AG8 GLY C  296  GLY C  309  1                                  14
HELIX   63 AG9 ILE C  320  ARG C  335  1                                  16
HELIX   64 AH1 HIS C  364  GLY C  379  1                                  16
HELIX   65 AH2 ASP C  382  VAL C  388  1                                   7
HELIX   66 AH3 LEU C  398  TYR C  403  1                                   6
HELIX   67 AH4 TYR C  403  LYS C  409  1                                   7
HELIX   68 AH5 PRO C  413  SER C  423  1                                  11
HELIX   69 AH6 GLY C  430  ARG C  439  1                                  10
HELIX   70 AH7 ASP C  459  VAL C  463  5                                   5
HELIX   71 AH8 LEU C  479  LYS C  488  1                                  10
HELIX   72 AH9 SER C  527  ALA C  535  1                                   9
HELIX   73 AI1 TRP C  542  ARG C  553  1                                  12
SHEET    1 AA111 THR A 536  GLY A 539  0
SHEET    2 AA111 GLY A 517  HIS A 520 -1  N  HIS A 520   O  THR A 536
SHEET    3 AA111 GLN A 494  ALA A 499 -1  N  LEU A 498   O  TRP A 519
SHEET    4 AA111 VAL A 467  ALA A 472  1  N  SER A 471   O  ALA A 499
SHEET    5 AA111 VAL A 341  PHE A 347  1  N  LEU A 346   O  VAL A 470
SHEET    6 AA111 VAL A 313  GLY A 317  1  N  GLY A 317   O  PHE A 347
SHEET    7 AA111 VAL A 240  VAL A 243  1  N  VAL A 243   O  ILE A 316
SHEET    8 AA111 VAL A 272  TRP A 277  1  O  PHE A 273   N  VAL A 240
SHEET    9 AA111 TYR A 223  TYR A 228 -1  N  ILE A 226   O  MET A 274
SHEET   10 AA111 GLY A 214  ARG A 219 -1  N  ARG A 215   O  GLN A 227
SHEET   11 AA111 ALA A 570  PRO A 571 -1  O  ALA A 570   N  VAL A 216
SHEET    1 AA2 2 THR A 234  VAL A 235  0
SHEET    2 AA2 2 VAL A 560  PRO A 561 -1  O  VAL A 560   N  VAL A 235
SHEET    1 AA3 2 ILE A 380  MET A 381  0
SHEET    2 AA3 2 VAL A 428  ALA A 429 -1  O  VAL A 428   N  MET A 381
SHEET    1 AA410 GLY B 214  ARG B 219  0
SHEET    2 AA410 TYR B 223  TYR B 228 -1  O  GLN B 227   N  ARG B 215
SHEET    3 AA410 VAL B 272  TRP B 277 -1  O  MET B 274   N  ILE B 226
SHEET    4 AA410 VAL B 240  VAL B 243  1  N  VAL B 240   O  PHE B 273
SHEET    5 AA410 VAL B 313  GLY B 317  1  O  ILE B 316   N  VAL B 243
SHEET    6 AA410 VAL B 341  PHE B 347  1  O  PHE B 347   N  GLY B 317
SHEET    7 AA410 VAL B 467  ALA B 472  1  O  VAL B 470   N  LEU B 346
SHEET    8 AA410 GLN B 494  ALA B 499  1  O  ALA B 499   N  SER B 471
SHEET    9 AA410 GLY B 517  HIS B 520 -1  O  TRP B 519   N  LEU B 498
SHEET   10 AA410 THR B 536  GLY B 539 -1  O  THR B 536   N  HIS B 520
SHEET    1 AA5 2 THR B 234  VAL B 235  0
SHEET    2 AA5 2 VAL B 560  PRO B 561 -1  O  VAL B 560   N  VAL B 235
SHEET    1 AA6 2 ILE B 380  MET B 381  0
SHEET    2 AA6 2 VAL B 428  ALA B 429 -1  O  VAL B 428   N  MET B 381
SHEET    1 AA711 THR C 536  GLY C 539  0
SHEET    2 AA711 GLY C 517  HIS C 520 -1  N  PHE C 518   O  GLN C 538
SHEET    3 AA711 GLN C 494  ALA C 499 -1  N  LEU C 498   O  TRP C 519
SHEET    4 AA711 VAL C 467  ALA C 472  1  N  SER C 471   O  ALA C 499
SHEET    5 AA711 VAL C 341  PHE C 347  1  N  LEU C 346   O  VAL C 470
SHEET    6 AA711 VAL C 313  GLY C 317  1  N  GLY C 317   O  THR C 345
SHEET    7 AA711 VAL C 240  VAL C 243  1  N  VAL C 243   O  ILE C 316
SHEET    8 AA711 VAL C 272  TRP C 277  1  O  PHE C 273   N  VAL C 240
SHEET    9 AA711 TYR C 223  TYR C 228 -1  N  ILE C 226   O  MET C 274
SHEET   10 AA711 GLY C 214  ARG C 219 -1  N  ARG C 215   O  GLN C 227
SHEET   11 AA711 ALA C 570  PRO C 571 -1  O  ALA C 570   N  VAL C 216
SHEET    1 AA8 2 THR C 234  VAL C 235  0
SHEET    2 AA8 2 VAL C 560  PRO C 561 -1  O  VAL C 560   N  VAL C 235
SHEET    1 AA9 2 ILE C 380  MET C 381  0
SHEET    2 AA9 2 VAL C 428  ALA C 429 -1  O  VAL C 428   N  MET C 381
CRYST1  156.632   96.300  142.999  90.00  90.46  90.00 C 1 2 1      12
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.006384  0.000000  0.000051        0.00000
SCALE2      0.000000  0.010384  0.000000        0.00000
SCALE3      0.000000  0.000000  0.006993        0.00000
MTRIX1   1  0.455322 -0.890060 -0.021791       91.16835    1
MTRIX2   1 -0.888201 -0.452408 -0.080169       63.27870    1
MTRIX3   1  0.061496  0.055857 -0.996543       93.25586    1
MTRIX1   2 -0.445573 -0.893455  0.056594       84.18570    1
MTRIX2   2  0.894495 -0.441721  0.069002       52.92851    1
MTRIX3   2 -0.036652  0.081368  0.996010      -49.96777    1
TER    4210      PHE A 585
TER    8286      PHE B 585
TER   12292      PRO C 583
MASTER      770    0    0   73   44    0    0   1212296    3    0  138
END