longtext: 9knl-pdb

content
HEADER    BIOSYNTHETIC PROTEIN                    19-NOV-24   9KNL
TITLE     CRYSTAL STRUCTURE OF TRIETHYLENE GLYCOL-BOUND FULL-LENGTH PHA SYNTHASE
TITLE    2 (PHAC) FROM AEROMONAS CAVIAE
COMPND    MOL_ID: 1;
COMPND   2 MOLECULE: PHA SYNTHASE;
COMPND   3 CHAIN: A, B, C;
COMPND   4 ENGINEERED: YES
SOURCE    MOL_ID: 1;
SOURCE   2 ORGANISM_SCIENTIFIC: AEROMONAS CAVIAE;
SOURCE   3 ORGANISM_TAXID: 648;
SOURCE   4 GENE: PHAC;
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS    PHA SYNTHASE, FULL-LENGTH PHAC, DIMER, TUNNEL, CATALYTIC TRIAD,
KEYWDS   2 POLYHYDROXYALKANOATES, BIOSYNTHETIC PROTEIN
EXPDTA    X-RAY DIFFRACTION
AUTHOR    M.F.CHEK,S.Y.KIM,T.MORI,T.HAKOSHIMA
REVDAT   1   21-MAY-25 9KNL    0
JRNL        AUTH   M.F.CHEK,S.Y.KIM,T.MORI,K.MATSUMOTO,S.SATO,T.HAKOSHIMA
JRNL        TITL   STRUCTURES OF POLYHYDROXYALKANOATE SYNTHASE PHAC FROM
JRNL        TITL 2 AEROMONAS CAVIAE, PRODUCING BIODEGRADABLE PLASTICS.
JRNL        REF    ANGEW.CHEM.INT.ED.ENGL.              04626 2025
JRNL        REFN                   ESSN 1521-3773
JRNL        PMID   40276819
JRNL        DOI    10.1002/ANIE.202504626
REMARK   2
REMARK   2 RESOLUTION.    3.20 ANGSTROMS.
REMARK   3
REMARK   3 REFINEMENT.
REMARK   3   PROGRAM     : PHENIX 1.19.1_4122
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK   3
REMARK   3    REFINEMENT TARGET : GEOSTD + MONOMER LIBRARY + CDL V1.2
REMARK   3
REMARK   3  DATA USED IN REFINEMENT.
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.20
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 47.77
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.350
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.0
REMARK   3   NUMBER OF REFLECTIONS             : 34509
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT.
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.222
REMARK   3   R VALUE            (WORKING SET) : 0.221
REMARK   3   FREE R VALUE                     : 0.248
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.940
REMARK   3   FREE R VALUE TEST SET COUNT      : 3293
REMARK   3
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE
REMARK   3     1 47.7700 -  9.2100    0.98     2616   157  0.1916 0.2912
REMARK   3     2  9.2100 -  7.3200    0.98     2648   127  0.1981 0.2317
REMARK   3     3  7.3200 -  6.3900    0.99     2656   131  0.2279 0.2721
REMARK   3     4  6.3900 -  5.8100    0.99     2659   117  0.2329 0.2505
REMARK   3     5  5.8100 -  5.3900    0.99     2655   122  0.2107 0.1937
REMARK   3     6  5.3900 -  5.0800    0.99     2666   141  0.2026 0.2260
REMARK   3     7  5.0800 -  4.8200    0.99     2629   134  0.1936 0.1937
REMARK   3     8  4.8200 -  4.6100    0.99     2682   144  0.1843 0.1917
REMARK   3     9  4.6100 -  4.4400    1.00     2654   156  0.1852 0.2184
REMARK   3    10  4.4400 -  4.2800    0.99     2688   129  0.1918 0.2247
REMARK   3    11  4.2800 -  4.1500    0.99     2609   132  0.1981 0.1977
REMARK   3    12  4.1500 -  4.0300    0.99     2698   138  0.2283 0.2370
REMARK   3    13  4.0300 -  3.9200    1.00     2687   138  0.2186 0.2467
REMARK   3    14  3.9200 -  3.8300    0.99     2576   134  0.2253 0.2296
REMARK   3    15  3.8300 -  3.7400    0.99     2767   134  0.2286 0.2681
REMARK   3    16  3.7400 -  3.6600    0.99     2568   150  0.2406 0.2766
REMARK   3    17  3.6600 -  3.5900    0.99     2695   125  0.2382 0.2487
REMARK   3    18  3.5900 -  3.5200    0.99     2586   153  0.2637 0.2724
REMARK   3    19  3.5200 -  3.4600    0.99     2736   123  0.2705 0.2815
REMARK   3    20  3.4600 -  3.4000    0.99     2566   148  0.2854 0.2811
REMARK   3    21  3.4000 -  3.3400    0.99     2659   140  0.2963 0.3405
REMARK   3    22  3.3400 -  3.2900    1.00     2678   146  0.3068 0.2993
REMARK   3    23  3.2900 -  3.2400    1.00     2712   147  0.3147 0.3244
REMARK   3    24  3.2400 -  3.2000    0.96     2498   139  0.3440 0.3447
REMARK   3
REMARK   3  BULK SOLVENT MODELLING.
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL
REMARK   3   SOLVENT RADIUS     : 1.11
REMARK   3   SHRINKAGE RADIUS   : 0.90
REMARK   3   K_SOL              : NULL
REMARK   3   B_SOL              : NULL
REMARK   3
REMARK   3  ERROR ESTIMATES.
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.394
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 26.210
REMARK   3
REMARK   3  B VALUES.
REMARK   3   FROM WILSON PLOT           (A**2) : 77.59
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 93.16
REMARK   3   OVERALL ANISOTROPIC B VALUE.
REMARK   3    B11 (A**2) : NULL
REMARK   3    B22 (A**2) : NULL
REMARK   3    B33 (A**2) : NULL
REMARK   3    B12 (A**2) : NULL
REMARK   3    B13 (A**2) : NULL
REMARK   3    B23 (A**2) : NULL
REMARK   3
REMARK   3  TWINNING INFORMATION.
REMARK   3   FRACTION: NULL
REMARK   3   OPERATOR: NULL
REMARK   3
REMARK   3  DEVIATIONS FROM IDEAL VALUES.
REMARK   3                 RMSD          COUNT
REMARK   3   BOND      :  0.003          12670
REMARK   3   ANGLE     :  0.557          17210
REMARK   3   CHIRALITY :  0.041           1899
REMARK   3   PLANARITY :  0.005           2221
REMARK   3   DIHEDRAL  : 12.615           4613
REMARK   3
REMARK   3  TLS DETAILS
REMARK   3   NUMBER OF TLS GROUPS  : NULL
REMARK   3
REMARK   3  NCS DETAILS
REMARK   3   NUMBER OF NCS GROUPS : 1
REMARK   3   NCS GROUP : ens_1
REMARK   3    NCS OPERATOR : 1
REMARK   3     REFERENCE SELECTION: NULL
REMARK   3     SELECTION          : (chain "A" and (resid 7 through 35 or
REMARK   3                          resid 53 through 75 or resid 105 through
REMARK   3                          160 or resid 179 through 194 or resid 203
REMARK   3                          through 337 or resid 340 through 393 or
REMARK   3                          resid 398 through 429 or resid 433
REMARK   3                          through 445 or resid 450 through 524 or
REMARK   3                          resid 527 through 552 or resid 558
REMARK   3                          through 583))
REMARK   3     ATOM PAIRS NUMBER  : NULL
REMARK   3     RMSD               : NULL
REMARK   3    NCS OPERATOR : 2
REMARK   3     REFERENCE SELECTION: NULL
REMARK   3     SELECTION          : (chain "B" and (resid 7 through 35 or
REMARK   3                          resid 53 through 75 or resid 105 through
REMARK   3                          160 or resid 179 through 194 or resid 203
REMARK   3                          through 337 or resid 340 through 393 or
REMARK   3                          resid 398 through 429 or resid 433
REMARK   3                          through 445 or resid 450 through 524 or
REMARK   3                          resid 527 through 552 or resid 558
REMARK   3                          through 583))
REMARK   3     ATOM PAIRS NUMBER  : NULL
REMARK   3     RMSD               : NULL
REMARK   3    NCS OPERATOR : 3
REMARK   3     REFERENCE SELECTION: NULL
REMARK   3     SELECTION          : (chain "C" and (resid 7 through 35 or
REMARK   3                          resid 53 through 194 or resid 203 through
REMARK   3                          583))
REMARK   3     ATOM PAIRS NUMBER  : NULL
REMARK   3     RMSD               : NULL
REMARK   3
REMARK   3  OTHER REFINEMENT REMARKS: NULL
REMARK   4
REMARK   4 9KNL COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 19-NOV-24.
REMARK 100 THE DEPOSITION ID IS D_1300053605.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION
REMARK 200  DATE OF DATA COLLECTION        : 02-JUN-21
REMARK 200  TEMPERATURE           (KELVIN) : 100
REMARK 200  PH                             : 8.0
REMARK 200  NUMBER OF CRYSTALS USED        : 1
REMARK 200
REMARK 200  SYNCHROTRON              (Y/N) : Y
REMARK 200  RADIATION SOURCE               : SPRING-8
REMARK 200  BEAMLINE                       : BL45XU
REMARK 200  X-RAY GENERATOR MODEL          : NULL
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.000000
REMARK 200  MONOCHROMATOR                  : NULL
REMARK 200  OPTICS                         : NULL
REMARK 200
REMARK 200  DETECTOR TYPE                  : PIXEL
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200  DATA SCALING SOFTWARE          : XDS
REMARK 200
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 34523
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.200
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.6
REMARK 200  DATA REDUNDANCY                : 5.100
REMARK 200  R MERGE                    (I) : 0.17200
REMARK 200  R SYM                      (I) : NULL
REMARK 200   FOR THE DATA SET  : 9.4800
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.20
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.39
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.3
REMARK 200  DATA REDUNDANCY IN SHELL       : 5.09
REMARK 200  R MERGE FOR SHELL          (I) : 0.67700
REMARK 200  R SYM FOR SHELL            (I) : NULL
REMARK 200   FOR SHELL         : 2.780
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS   (%): 53.52
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.65
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: SODIUM CHLORIDE, GLYCEROL, PEG6000,
REMARK 280  OCTYL BETA-D-GLUCOPYRANOSIDE, TRIETHYLENE GLYCOL, PH 8.0, VAPOR
REMARK 280  DIFFUSION, HANGING DROP, TEMPERATURE 277.15K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1
REMARK 290
REMARK 290      SYMOP   SYMMETRY
REMARK 290     NNNMMM   OPERATOR
REMARK 290       1555   X,Y,Z
REMARK 290       2555   -X,Y,-Z
REMARK 290       3555   X+1/2,Y+1/2,Z
REMARK 290       4555   -X+1/2,Y+1/2,-Z
REMARK 290
REMARK 290     WHERE NNN -> OPERATOR NUMBER
REMARK 290           MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       78.35650
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       47.76500
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       78.35650
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       47.76500
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465   M RES C SSSEQI
REMARK 465     GLY A    -1
REMARK 465     PRO A     0
REMARK 465     MET A     1
REMARK 465     SER A     2
REMARK 465     GLN A     3
REMARK 465     PRO A     4
REMARK 465     SER A     5
REMARK 465     TYR A     6
REMARK 465     ASP A    41
REMARK 465     ASP A    42
REMARK 465     LEU A    43
REMARK 465     GLY A    44
REMARK 465     GLN A    45
REMARK 465     VAL A    46
REMARK 465     LEU A    47
REMARK 465     GLU A    48
REMARK 465     GLN A    49
REMARK 465     GLY A    50
REMARK 465     GLY A    81
REMARK 465     GLN A    82
REMARK 465     PRO A    83
REMARK 465     SER A    84
REMARK 465     GLU A    85
REMARK 465     PRO A    86
REMARK 465     VAL A    87
REMARK 465     ILE A    88
REMARK 465     THR A    89
REMARK 465     PRO A    90
REMARK 465     GLU A    91
REMARK 465     ARG A    92
REMARK 465     SER A    93
REMARK 465     ASP A    94
REMARK 465     ARG A    95
REMARK 465     ARG A    96
REMARK 465     PHE A    97
REMARK 465     LYS A    98
REMARK 465     ALA A    99
REMARK 465     GLU A   100
REMARK 465     ALA A   101
REMARK 465     TRP A   102
REMARK 465     SER A   103
REMARK 465     GLU A   104
REMARK 465     GLU A   555
REMARK 465     GLY A   556
REMARK 465     PRO A   588
REMARK 465     THR A   589
REMARK 465     GLU A   590
REMARK 465     GLU A   591
REMARK 465     ASP A   592
REMARK 465     ALA A   593
REMARK 465     ALA A   594
REMARK 465     GLY B    -1
REMARK 465     PRO B     0
REMARK 465     MET B     1
REMARK 465     SER B     2
REMARK 465     GLN B     3
REMARK 465     PRO B     4
REMARK 465     SER B     5
REMARK 465     LEU B    36
REMARK 465     GLN B    37
REMARK 465     THR B    38
REMARK 465     ASN B    39
REMARK 465     LEU B    40
REMARK 465     ASP B    41
REMARK 465     ASP B    42
REMARK 465     LEU B    43
REMARK 465     GLY B    44
REMARK 465     GLN B    45
REMARK 465     VAL B    46
REMARK 465     LEU B    47
REMARK 465     GLU B    48
REMARK 465     GLN B    49
REMARK 465     GLY B    50
REMARK 465     SER B    51
REMARK 465     LEU B    77
REMARK 465     LYS B    78
REMARK 465     SER B    79
REMARK 465     ALA B    80
REMARK 465     GLY B    81
REMARK 465     GLN B    82
REMARK 465     PRO B    83
REMARK 465     SER B    84
REMARK 465     GLU B    85
REMARK 465     PRO B    86
REMARK 465     VAL B    87
REMARK 465     ILE B    88
REMARK 465     THR B    89
REMARK 465     PRO B    90
REMARK 465     GLU B    91
REMARK 465     ARG B    92
REMARK 465     SER B    93
REMARK 465     ASP B    94
REMARK 465     ARG B    95
REMARK 465     ARG B    96
REMARK 465     PHE B    97
REMARK 465     LYS B    98
REMARK 465     ALA B    99
REMARK 465     GLU B   100
REMARK 465     ALA B   101
REMARK 465     TRP B   102
REMARK 465     SER B   103
REMARK 465     GLU B   104
REMARK 465     THR B   167
REMARK 465     LEU B   168
REMARK 465     GLU B   169
REMARK 465     SER B   170
REMARK 465     ASP B   171
REMARK 465     ILE B   195
REMARK 465     ARG B   196
REMARK 465     LEU B   197
REMARK 465     THR B   198
REMARK 465     GLY B   556
REMARK 465     PHE B   585
REMARK 465     ALA B   586
REMARK 465     CYS B   587
REMARK 465     PRO B   588
REMARK 465     THR B   589
REMARK 465     GLU B   590
REMARK 465     GLU B   591
REMARK 465     ASP B   592
REMARK 465     ALA B   593
REMARK 465     ALA B   594
REMARK 465     GLY C    -1
REMARK 465     PRO C     0
REMARK 465     MET C     1
REMARK 465     SER C     2
REMARK 465     GLN C     3
REMARK 465     PRO C     4
REMARK 465     SER C     5
REMARK 465     TYR C     6
REMARK 465     GLY C    44
REMARK 465     GLN C    45
REMARK 465     VAL C    46
REMARK 465     LEU C    47
REMARK 465     GLU C    48
REMARK 465     GLN C    49
REMARK 465     GLY C    50
REMARK 465     SER C    51
REMARK 465     GLN C    52
REMARK 465     LEU C    76
REMARK 465     LEU C    77
REMARK 465     LYS C    78
REMARK 465     SER C    79
REMARK 465     ALA C    80
REMARK 465     GLY C    81
REMARK 465     GLN C    82
REMARK 465     PRO C    83
REMARK 465     SER C    84
REMARK 465     GLU C    85
REMARK 465     PRO C    86
REMARK 465     VAL C    87
REMARK 465     ILE C    88
REMARK 465     THR C    89
REMARK 465     PRO C    90
REMARK 465     GLU C    91
REMARK 465     ARG C    92
REMARK 465     SER C    93
REMARK 465     ASP C    94
REMARK 465     ARG C    95
REMARK 465     ARG C    96
REMARK 465     PHE C    97
REMARK 465     LYS C    98
REMARK 465     ALA C    99
REMARK 465     GLU C   100
REMARK 465     ALA C   101
REMARK 465     TRP C   102
REMARK 465     SER C   103
REMARK 465     GLU C   104
REMARK 465     PRO C   161
REMARK 465     GLU C   162
REMARK 465     LEU C   163
REMARK 465     LEU C   164
REMARK 465     LYS C   165
REMARK 465     LEU C   166
REMARK 465     THR C   167
REMARK 465     LEU C   168
REMARK 465     GLU C   169
REMARK 465     SER C   170
REMARK 465     ASP C   171
REMARK 465     GLY C   172
REMARK 465     GLN C   173
REMARK 465     ASN C   174
REMARK 465     LEU C   175
REMARK 465     VAL C   176
REMARK 465     ARG C   177
REMARK 465     GLY C   178
REMARK 465     ARG C   196
REMARK 465     LEU C   197
REMARK 465     THR C   198
REMARK 465     ASP C   199
REMARK 465     GLU C   200
REMARK 465     SER C   201
REMARK 465     ALA C   202
REMARK 465     LYS C   338
REMARK 465     GLN C   339
REMARK 465     ARG C   394
REMARK 465     GLU C   395
REMARK 465     ASN C   396
REMARK 465     SER C   397
REMARK 465     GLY C   430
REMARK 465     LYS C   431
REMARK 465     THR C   432
REMARK 465     LEU C   446
REMARK 465     VAL C   447
REMARK 465     LYS C   448
REMARK 465     GLY C   449
REMARK 465     ALA C   525
REMARK 465     GLU C   526
REMARK 465     ARG C   553
REMARK 465     ASP C   554
REMARK 465     GLU C   555
REMARK 465     GLY C   556
REMARK 465     SER C   557
REMARK 465     VAL C   584
REMARK 465     PHE C   585
REMARK 465     ALA C   586
REMARK 465     CYS C   587
REMARK 465     PRO C   588
REMARK 465     THR C   589
REMARK 465     GLU C   590
REMARK 465     GLU C   591
REMARK 465     ASP C   592
REMARK 465     ALA C   593
REMARK 465     ALA C   594
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500  M RES CSSEQI        PSI       PHI
REMARK 500    GLN A 173      -41.66     83.20
REMARK 500    TYR A 251       10.68    -69.76
REMARK 500    ASP A 254       57.07   -142.35
REMARK 500    MET A 255      -71.10    -77.43
REMARK 500    CYS A 319     -115.66     52.78
REMARK 500    PHE A 353       31.82    -97.35
REMARK 500    TYR A 403      -54.79   -120.81
REMARK 500    GLU A 500       41.06    -91.97
REMARK 500    SER A 501     -156.41   -160.02
REMARK 500    TYR A 516     -167.50     56.34
REMARK 500    PHE A 585     -160.88     71.53
REMARK 500    TYR B 251       10.80    -69.93
REMARK 500    ASP B 254       55.90   -141.86
REMARK 500    MET B 255      -71.24    -78.44
REMARK 500    CYS B 319     -115.52     52.84
REMARK 500    PHE B 353       30.60    -97.33
REMARK 500    SER B 501     -154.81    -97.88
REMARK 500    ASP C 254       59.31   -140.88
REMARK 500    MET C 255      -75.51    -76.58
REMARK 500    CYS C 319     -114.49     52.34
REMARK 500    PHE C 353       32.02    -97.52
REMARK 500    TYR C 403      -53.73   -120.88
REMARK 500    SER C 501     -154.39   -128.56
REMARK 500    TYR C 516     -164.86   -127.62
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500  M RES CSSEQI        RMS     TYPE
REMARK 500    ARG A 137         0.08    SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
DBREF  9KNL A    1   594  UNP    O32471   O32471_AERCA     1    594
DBREF  9KNL B    1   594  UNP    O32471   O32471_AERCA     1    594
DBREF  9KNL C    1   594  UNP    O32471   O32471_AERCA     1    594
SEQADV 9KNL GLY A   -1  UNP  O32471              EXPRESSION TAG
SEQADV 9KNL PRO A    0  UNP  O32471              EXPRESSION TAG
SEQADV 9KNL GLY B   -1  UNP  O32471              EXPRESSION TAG
SEQADV 9KNL PRO B    0  UNP  O32471              EXPRESSION TAG
SEQADV 9KNL GLY C   -1  UNP  O32471              EXPRESSION TAG
SEQADV 9KNL PRO C    0  UNP  O32471              EXPRESSION TAG
SEQRES   1 A  596  GLY PRO MET SER GLN PRO SER TYR GLY PRO LEU PHE GLU
SEQRES   2 A  596  ALA LEU ALA HIS TYR ASN ASP LYS LEU LEU ALA MET ALA
SEQRES   3 A  596  LYS ALA GLN THR GLU ARG THR ALA GLN ALA LEU LEU GLN
SEQRES   4 A  596  THR ASN LEU ASP ASP LEU GLY GLN VAL LEU GLU GLN GLY
SEQRES   5 A  596  SER GLN GLN PRO TRP GLN LEU ILE GLN ALA GLN MET ASN
SEQRES   6 A  596  TRP TRP GLN ASP GLN LEU LYS LEU MET GLN HIS THR LEU
SEQRES   7 A  596  LEU LYS SER ALA GLY GLN PRO SER GLU PRO VAL ILE THR
SEQRES   8 A  596  PRO GLU ARG SER ASP ARG ARG PHE LYS ALA GLU ALA TRP
SEQRES   9 A  596  SER GLU GLN PRO ILE TYR ASP TYR LEU LYS GLN SER TYR
SEQRES  10 A  596  LEU LEU THR ALA ARG HIS LEU LEU ALA SER VAL ASP ALA
SEQRES  11 A  596  LEU GLU GLY VAL PRO GLN LYS SER ARG GLU ARG LEU ARG
SEQRES  12 A  596  PHE PHE THR ARG GLN TYR VAL ASN ALA MET ALA PRO SER
SEQRES  13 A  596  ASN PHE LEU ALA THR ASN PRO GLU LEU LEU LYS LEU THR
SEQRES  14 A  596  LEU GLU SER ASP GLY GLN ASN LEU VAL ARG GLY LEU ALA
SEQRES  15 A  596  LEU LEU ALA GLU ASP LEU GLU ARG SER ALA ASP GLN LEU
SEQRES  16 A  596  ASN ILE ARG LEU THR ASP GLU SER ALA PHE GLU LEU GLY
SEQRES  17 A  596  ARG ASP LEU ALA LEU THR PRO GLY ARG VAL VAL GLN ARG
SEQRES  18 A  596  THR GLU LEU TYR GLU LEU ILE GLN TYR SER PRO THR THR
SEQRES  19 A  596  GLU THR VAL GLY LYS THR PRO VAL LEU ILE VAL PRO PRO
SEQRES  20 A  596  PHE ILE ASN LYS TYR TYR ILE MET ASP MET ARG PRO GLN
SEQRES  21 A  596  ASN SER LEU VAL ALA TRP LEU VAL ALA GLN GLY GLN THR
SEQRES  22 A  596  VAL PHE MET ILE SER TRP ARG ASN PRO GLY VAL ALA GLN
SEQRES  23 A  596  ALA GLN ILE ASP LEU ASP ASP TYR VAL VAL ASP GLY VAL
SEQRES  24 A  596  ILE ALA ALA LEU ASP GLY VAL GLU ALA ALA THR GLY GLU
SEQRES  25 A  596  ARG GLU VAL HIS GLY ILE GLY TYR CYS ILE GLY GLY THR
SEQRES  26 A  596  ALA LEU SER LEU ALA MET GLY TRP LEU ALA ALA ARG ARG
SEQRES  27 A  596  GLN LYS GLN ARG VAL ARG THR ALA THR LEU PHE THR THR
SEQRES  28 A  596  LEU LEU ASP PHE SER GLN PRO GLY GLU LEU GLY ILE PHE
SEQRES  29 A  596  ILE HIS GLU PRO ILE ILE ALA ALA LEU GLU ALA GLN ASN
SEQRES  30 A  596  GLU ALA LYS GLY ILE MET ASP GLY ARG GLN LEU ALA VAL
SEQRES  31 A  596  SER PHE SER LEU LEU ARG GLU ASN SER LEU TYR TRP ASN
SEQRES  32 A  596  TYR TYR ILE ASP SER TYR LEU LYS GLY GLN SER PRO VAL
SEQRES  33 A  596  ALA PHE ASP LEU LEU HIS TRP ASN SER ASP SER THR ASN
SEQRES  34 A  596  VAL ALA GLY LYS THR HIS ASN SER LEU LEU ARG ARG LEU
SEQRES  35 A  596  TYR LEU GLU ASN GLN LEU VAL LYS GLY GLU LEU LYS ILE
SEQRES  36 A  596  ARG ASN THR ARG ILE ASP LEU GLY LYS VAL LYS THR PRO
SEQRES  37 A  596  VAL LEU LEU VAL SER ALA VAL ASP ASP HIS ILE ALA LEU
SEQRES  38 A  596  TRP GLN GLY THR TRP GLN GLY MET LYS LEU PHE GLY GLY
SEQRES  39 A  596  GLU GLN ARG PHE LEU LEU ALA GLU SER GLY HIS ILE ALA
SEQRES  40 A  596  GLY ILE ILE ASN PRO PRO ALA ALA ASN LYS TYR GLY PHE
SEQRES  41 A  596  TRP HIS ASN GLY ALA GLU ALA GLU SER PRO GLU SER TRP
SEQRES  42 A  596  LEU ALA GLY ALA THR HIS GLN GLY GLY SER TRP TRP PRO
SEQRES  43 A  596  GLU MET MET GLY PHE ILE GLN ASN ARG ASP GLU GLY SER
SEQRES  44 A  596  GLU PRO VAL PRO ALA ARG VAL PRO GLU GLU GLY LEU ALA
SEQRES  45 A  596  PRO ALA PRO GLY HIS TYR VAL LYS VAL ARG LEU ASN PRO
SEQRES  46 A  596  VAL PHE ALA CYS PRO THR GLU GLU ASP ALA ALA
SEQRES   1 B  596  GLY PRO MET SER GLN PRO SER TYR GLY PRO LEU PHE GLU
SEQRES   2 B  596  ALA LEU ALA HIS TYR ASN ASP LYS LEU LEU ALA MET ALA
SEQRES   3 B  596  LYS ALA GLN THR GLU ARG THR ALA GLN ALA LEU LEU GLN
SEQRES   4 B  596  THR ASN LEU ASP ASP LEU GLY GLN VAL LEU GLU GLN GLY
SEQRES   5 B  596  SER GLN GLN PRO TRP GLN LEU ILE GLN ALA GLN MET ASN
SEQRES   6 B  596  TRP TRP GLN ASP GLN LEU LYS LEU MET GLN HIS THR LEU
SEQRES   7 B  596  LEU LYS SER ALA GLY GLN PRO SER GLU PRO VAL ILE THR
SEQRES   8 B  596  PRO GLU ARG SER ASP ARG ARG PHE LYS ALA GLU ALA TRP
SEQRES   9 B  596  SER GLU GLN PRO ILE TYR ASP TYR LEU LYS GLN SER TYR
SEQRES  10 B  596  LEU LEU THR ALA ARG HIS LEU LEU ALA SER VAL ASP ALA
SEQRES  11 B  596  LEU GLU GLY VAL PRO GLN LYS SER ARG GLU ARG LEU ARG
SEQRES  12 B  596  PHE PHE THR ARG GLN TYR VAL ASN ALA MET ALA PRO SER
SEQRES  13 B  596  ASN PHE LEU ALA THR ASN PRO GLU LEU LEU LYS LEU THR
SEQRES  14 B  596  LEU GLU SER ASP GLY GLN ASN LEU VAL ARG GLY LEU ALA
SEQRES  15 B  596  LEU LEU ALA GLU ASP LEU GLU ARG SER ALA ASP GLN LEU
SEQRES  16 B  596  ASN ILE ARG LEU THR ASP GLU SER ALA PHE GLU LEU GLY
SEQRES  17 B  596  ARG ASP LEU ALA LEU THR PRO GLY ARG VAL VAL GLN ARG
SEQRES  18 B  596  THR GLU LEU TYR GLU LEU ILE GLN TYR SER PRO THR THR
SEQRES  19 B  596  GLU THR VAL GLY LYS THR PRO VAL LEU ILE VAL PRO PRO
SEQRES  20 B  596  PHE ILE ASN LYS TYR TYR ILE MET ASP MET ARG PRO GLN
SEQRES  21 B  596  ASN SER LEU VAL ALA TRP LEU VAL ALA GLN GLY GLN THR
SEQRES  22 B  596  VAL PHE MET ILE SER TRP ARG ASN PRO GLY VAL ALA GLN
SEQRES  23 B  596  ALA GLN ILE ASP LEU ASP ASP TYR VAL VAL ASP GLY VAL
SEQRES  24 B  596  ILE ALA ALA LEU ASP GLY VAL GLU ALA ALA THR GLY GLU
SEQRES  25 B  596  ARG GLU VAL HIS GLY ILE GLY TYR CYS ILE GLY GLY THR
SEQRES  26 B  596  ALA LEU SER LEU ALA MET GLY TRP LEU ALA ALA ARG ARG
SEQRES  27 B  596  GLN LYS GLN ARG VAL ARG THR ALA THR LEU PHE THR THR
SEQRES  28 B  596  LEU LEU ASP PHE SER GLN PRO GLY GLU LEU GLY ILE PHE
SEQRES  29 B  596  ILE HIS GLU PRO ILE ILE ALA ALA LEU GLU ALA GLN ASN
SEQRES  30 B  596  GLU ALA LYS GLY ILE MET ASP GLY ARG GLN LEU ALA VAL
SEQRES  31 B  596  SER PHE SER LEU LEU ARG GLU ASN SER LEU TYR TRP ASN
SEQRES  32 B  596  TYR TYR ILE ASP SER TYR LEU LYS GLY GLN SER PRO VAL
SEQRES  33 B  596  ALA PHE ASP LEU LEU HIS TRP ASN SER ASP SER THR ASN
SEQRES  34 B  596  VAL ALA GLY LYS THR HIS ASN SER LEU LEU ARG ARG LEU
SEQRES  35 B  596  TYR LEU GLU ASN GLN LEU VAL LYS GLY GLU LEU LYS ILE
SEQRES  36 B  596  ARG ASN THR ARG ILE ASP LEU GLY LYS VAL LYS THR PRO
SEQRES  37 B  596  VAL LEU LEU VAL SER ALA VAL ASP ASP HIS ILE ALA LEU
SEQRES  38 B  596  TRP GLN GLY THR TRP GLN GLY MET LYS LEU PHE GLY GLY
SEQRES  39 B  596  GLU GLN ARG PHE LEU LEU ALA GLU SER GLY HIS ILE ALA
SEQRES  40 B  596  GLY ILE ILE ASN PRO PRO ALA ALA ASN LYS TYR GLY PHE
SEQRES  41 B  596  TRP HIS ASN GLY ALA GLU ALA GLU SER PRO GLU SER TRP
SEQRES  42 B  596  LEU ALA GLY ALA THR HIS GLN GLY GLY SER TRP TRP PRO
SEQRES  43 B  596  GLU MET MET GLY PHE ILE GLN ASN ARG ASP GLU GLY SER
SEQRES  44 B  596  GLU PRO VAL PRO ALA ARG VAL PRO GLU GLU GLY LEU ALA
SEQRES  45 B  596  PRO ALA PRO GLY HIS TYR VAL LYS VAL ARG LEU ASN PRO
SEQRES  46 B  596  VAL PHE ALA CYS PRO THR GLU GLU ASP ALA ALA
SEQRES   1 C  596  GLY PRO MET SER GLN PRO SER TYR GLY PRO LEU PHE GLU
SEQRES   2 C  596  ALA LEU ALA HIS TYR ASN ASP LYS LEU LEU ALA MET ALA
SEQRES   3 C  596  LYS ALA GLN THR GLU ARG THR ALA GLN ALA LEU LEU GLN
SEQRES   4 C  596  THR ASN LEU ASP ASP LEU GLY GLN VAL LEU GLU GLN GLY
SEQRES   5 C  596  SER GLN GLN PRO TRP GLN LEU ILE GLN ALA GLN MET ASN
SEQRES   6 C  596  TRP TRP GLN ASP GLN LEU LYS LEU MET GLN HIS THR LEU
SEQRES   7 C  596  LEU LYS SER ALA GLY GLN PRO SER GLU PRO VAL ILE THR
SEQRES   8 C  596  PRO GLU ARG SER ASP ARG ARG PHE LYS ALA GLU ALA TRP
SEQRES   9 C  596  SER GLU GLN PRO ILE TYR ASP TYR LEU LYS GLN SER TYR
SEQRES  10 C  596  LEU LEU THR ALA ARG HIS LEU LEU ALA SER VAL ASP ALA
SEQRES  11 C  596  LEU GLU GLY VAL PRO GLN LYS SER ARG GLU ARG LEU ARG
SEQRES  12 C  596  PHE PHE THR ARG GLN TYR VAL ASN ALA MET ALA PRO SER
SEQRES  13 C  596  ASN PHE LEU ALA THR ASN PRO GLU LEU LEU LYS LEU THR
SEQRES  14 C  596  LEU GLU SER ASP GLY GLN ASN LEU VAL ARG GLY LEU ALA
SEQRES  15 C  596  LEU LEU ALA GLU ASP LEU GLU ARG SER ALA ASP GLN LEU
SEQRES  16 C  596  ASN ILE ARG LEU THR ASP GLU SER ALA PHE GLU LEU GLY
SEQRES  17 C  596  ARG ASP LEU ALA LEU THR PRO GLY ARG VAL VAL GLN ARG
SEQRES  18 C  596  THR GLU LEU TYR GLU LEU ILE GLN TYR SER PRO THR THR
SEQRES  19 C  596  GLU THR VAL GLY LYS THR PRO VAL LEU ILE VAL PRO PRO
SEQRES  20 C  596  PHE ILE ASN LYS TYR TYR ILE MET ASP MET ARG PRO GLN
SEQRES  21 C  596  ASN SER LEU VAL ALA TRP LEU VAL ALA GLN GLY GLN THR
SEQRES  22 C  596  VAL PHE MET ILE SER TRP ARG ASN PRO GLY VAL ALA GLN
SEQRES  23 C  596  ALA GLN ILE ASP LEU ASP ASP TYR VAL VAL ASP GLY VAL
SEQRES  24 C  596  ILE ALA ALA LEU ASP GLY VAL GLU ALA ALA THR GLY GLU
SEQRES  25 C  596  ARG GLU VAL HIS GLY ILE GLY TYR CYS ILE GLY GLY THR
SEQRES  26 C  596  ALA LEU SER LEU ALA MET GLY TRP LEU ALA ALA ARG ARG
SEQRES  27 C  596  GLN LYS GLN ARG VAL ARG THR ALA THR LEU PHE THR THR
SEQRES  28 C  596  LEU LEU ASP PHE SER GLN PRO GLY GLU LEU GLY ILE PHE
SEQRES  29 C  596  ILE HIS GLU PRO ILE ILE ALA ALA LEU GLU ALA GLN ASN
SEQRES  30 C  596  GLU ALA LYS GLY ILE MET ASP GLY ARG GLN LEU ALA VAL
SEQRES  31 C  596  SER PHE SER LEU LEU ARG GLU ASN SER LEU TYR TRP ASN
SEQRES  32 C  596  TYR TYR ILE ASP SER TYR LEU LYS GLY GLN SER PRO VAL
SEQRES  33 C  596  ALA PHE ASP LEU LEU HIS TRP ASN SER ASP SER THR ASN
SEQRES  34 C  596  VAL ALA GLY LYS THR HIS ASN SER LEU LEU ARG ARG LEU
SEQRES  35 C  596  TYR LEU GLU ASN GLN LEU VAL LYS GLY GLU LEU LYS ILE
SEQRES  36 C  596  ARG ASN THR ARG ILE ASP LEU GLY LYS VAL LYS THR PRO
SEQRES  37 C  596  VAL LEU LEU VAL SER ALA VAL ASP ASP HIS ILE ALA LEU
SEQRES  38 C  596  TRP GLN GLY THR TRP GLN GLY MET LYS LEU PHE GLY GLY
SEQRES  39 C  596  GLU GLN ARG PHE LEU LEU ALA GLU SER GLY HIS ILE ALA
SEQRES  40 C  596  GLY ILE ILE ASN PRO PRO ALA ALA ASN LYS TYR GLY PHE
SEQRES  41 C  596  TRP HIS ASN GLY ALA GLU ALA GLU SER PRO GLU SER TRP
SEQRES  42 C  596  LEU ALA GLY ALA THR HIS GLN GLY GLY SER TRP TRP PRO
SEQRES  43 C  596  GLU MET MET GLY PHE ILE GLN ASN ARG ASP GLU GLY SER
SEQRES  44 C  596  GLU PRO VAL PRO ALA ARG VAL PRO GLU GLU GLY LEU ALA
SEQRES  45 C  596  PRO ALA PRO GLY HIS TYR VAL LYS VAL ARG LEU ASN PRO
SEQRES  46 C  596  VAL PHE ALA CYS PRO THR GLU GLU ASP ALA ALA
HET    PGE  A 601      10
HET    PGE  A 602      10
HETNAM     PGE TRIETHYLENE GLYCOL
FORMUL   4  PGE    2(C6 H14 O4)
FORMUL   6  HOH   *10(H2 O)
HELIX    1 AA1 GLY A    7  GLN A   37  1                                  31
HELIX    2 AA2 PRO A   54  ALA A   80  1                                  27
HELIX    3 AA3 PRO A  106  LEU A  129  1                                  24
HELIX    4 AA4 PRO A  133  MET A  151  1                                  19
HELIX    5 AA5 ALA A  152  PHE A  156  5                                   5
HELIX    6 AA6 ASN A  160  LEU A  168  1                                   9
HELIX    7 AA7 GLN A  173  LEU A  197  1                                  25
HELIX    8 AA8 LYS A  249  ASP A  254  5                                   6
HELIX    9 AA9 SER A  260  GLN A  268  1                                   9
HELIX   10 AB1 GLY A  281  ALA A  285  5                                   5
HELIX   11 AB2 ASP A  288  ASP A  295  1                                   8
HELIX   12 AB3 GLY A  296  GLY A  309  1                                  14
HELIX   13 AB4 CYS A  319  ARG A  335  1                                  17
HELIX   14 AB5 PRO A  356  ILE A  363  5                                   8
HELIX   15 AB6 HIS A  364  GLY A  379  1                                  16
HELIX   16 AB7 ASP A  382  PHE A  390  1                                   9
HELIX   17 AB8 SER A  397  TYR A  403  1                                   7
HELIX   18 AB9 TYR A  403  LYS A  409  1                                   7
HELIX   19 AC1 PRO A  413  ASP A  424  1                                  12
HELIX   20 AC2 GLY A  430  ARG A  439  1                                  10
HELIX   21 AC3 ASP A  459  VAL A  463  5                                   5
HELIX   22 AC4 LEU A  479  LYS A  488  1                                  10
HELIX   23 AC5 PRO A  510  ASN A  514  5                                   5
HELIX   24 AC6 SER A  527  GLY A  534  1                                   8
HELIX   25 AC7 TRP A  542  ASN A  552  1                                  11
HELIX   26 AC8 HIS A  575  VAL A  579  5                                   5
HELIX   27 AC9 GLY B    7  LEU B   35  1                                  29
HELIX   28 AD1 PRO B   54  LEU B   76  1                                  23
HELIX   29 AD2 PRO B  106  LEU B  129  1                                  24
HELIX   30 AD3 PRO B  133  MET B  151  1                                  19
HELIX   31 AD4 ALA B  152  PHE B  156  5                                   5
HELIX   32 AD5 ASN B  160  LEU B  166  1                                   7
HELIX   33 AD6 GLN B  173  ASN B  194  1                                  22
HELIX   34 AD7 LYS B  249  MET B  253  5                                   5
HELIX   35 AD8 SER B  260  GLN B  268  1                                   9
HELIX   36 AD9 GLY B  281  ALA B  285  5                                   5
HELIX   37 AE1 ASP B  288  ASP B  295  1                                   8
HELIX   38 AE2 GLY B  296  GLY B  309  1                                  14
HELIX   39 AE3 CYS B  319  ARG B  335  1                                  17
HELIX   40 AE4 PRO B  356  PHE B  362  5                                   7
HELIX   41 AE5 HIS B  364  GLY B  379  1                                  16
HELIX   42 AE6 ASP B  382  PHE B  390  1                                   9
HELIX   43 AE7 SER B  397  TYR B  403  1                                   7
HELIX   44 AE8 TYR B  403  LYS B  409  1                                   7
HELIX   45 AE9 PRO B  413  SER B  423  1                                  11
HELIX   46 AF1 GLY B  430  ARG B  439  1                                  10
HELIX   47 AF2 ASP B  459  VAL B  463  5                                   5
HELIX   48 AF3 LEU B  479  LYS B  488  1                                  10
HELIX   49 AF4 SER B  527  GLY B  534  1                                   8
HELIX   50 AF5 TRP B  542  GLU B  555  1                                  14
HELIX   51 AF6 PRO C    8  LEU C   35  1                                  28
HELIX   52 AF7 PRO C   54  THR C   75  1                                  22
HELIX   53 AF8 PRO C  106  LEU C  129  1                                  24
HELIX   54 AF9 PRO C  133  MET C  151  1                                  19
HELIX   55 AG1 ALA C  152  PHE C  156  5                                   5
HELIX   56 AG2 ALA C  180  ILE C  195  1                                  16
HELIX   57 AG3 LYS C  249  ASP C  254  5                                   6
HELIX   58 AG4 SER C  260  GLN C  268  1                                   9
HELIX   59 AG5 GLY C  281  ALA C  285  5                                   5
HELIX   60 AG6 ASP C  288  ASP C  295  1                                   8
HELIX   61 AG7 GLY C  296  GLY C  309  1                                  14
HELIX   62 AG8 CYS C  319  ARG C  335  1                                  17
HELIX   63 AG9 PRO C  356  PHE C  362  5                                   7
HELIX   64 AH1 HIS C  364  GLY C  379  1                                  16
HELIX   65 AH2 ASP C  382  PHE C  390  1                                   9
HELIX   66 AH3 TYR C  399  TYR C  403  1                                   5
HELIX   67 AH4 TYR C  403  LYS C  409  1                                   7
HELIX   68 AH5 PRO C  413  ASP C  424  1                                  12
HELIX   69 AH6 ASN C  434  ARG C  439  1                                   6
HELIX   70 AH7 ASP C  459  VAL C  463  5                                   5
HELIX   71 AH8 LEU C  479  LYS C  488  1                                  10
HELIX   72 AH9 PRO C  528  GLY C  534  1                                   7
HELIX   73 AI1 TRP C  542  ASN C  552  1                                  11
SHEET    1 AA111 THR A 536  GLY A 539  0
SHEET    2 AA111 GLY A 517  HIS A 520 -1  N  PHE A 518   O  GLN A 538
SHEET    3 AA111 GLN A 494  ALA A 499 -1  N  LEU A 498   O  TRP A 519
SHEET    4 AA111 VAL A 467  ALA A 472  1  N  SER A 471   O  ALA A 499
SHEET    5 AA111 VAL A 341  PHE A 347  1  N  LEU A 346   O  LEU A 468
SHEET    6 AA111 VAL A 313  TYR A 318  1  N  GLY A 317   O  PHE A 347
SHEET    7 AA111 VAL A 240  VAL A 243  1  N  VAL A 243   O  ILE A 316
SHEET    8 AA111 VAL A 272  TRP A 277  1  O  PHE A 273   N  VAL A 240
SHEET    9 AA111 TYR A 223  TYR A 228 -1  N  ILE A 226   O  MET A 274
SHEET   10 AA111 GLY A 214  ARG A 219 -1  N  ARG A 215   O  GLN A 227
SHEET   11 AA111 ALA A 570  PRO A 571 -1  O  ALA A 570   N  VAL A 216
SHEET    1 AA2 2 THR A 234  VAL A 235  0
SHEET    2 AA2 2 VAL A 560  PRO A 561 -1  O  VAL A 560   N  VAL A 235
SHEET    1 AA3 2 ILE A 380  MET A 381  0
SHEET    2 AA3 2 VAL A 428  ALA A 429 -1  O  VAL A 428   N  MET A 381
SHEET    1 AA410 GLY B 214  ARG B 219  0
SHEET    2 AA410 TYR B 223  TYR B 228 -1  O  GLN B 227   N  ARG B 215
SHEET    3 AA410 VAL B 272  TRP B 277 -1  O  MET B 274   N  ILE B 226
SHEET    4 AA410 VAL B 240  VAL B 243  1  N  VAL B 240   O  PHE B 273
SHEET    5 AA410 VAL B 313  TYR B 318  1  O  ILE B 316   N  VAL B 243
SHEET    6 AA410 VAL B 341  PHE B 347  1  O  PHE B 347   N  GLY B 317
SHEET    7 AA410 VAL B 467  ALA B 472  1  O  LEU B 468   N  LEU B 346
SHEET    8 AA410 GLN B 494  ALA B 499  1  O  ALA B 499   N  SER B 471
SHEET    9 AA410 GLY B 517  HIS B 520 -1  O  TRP B 519   N  LEU B 498
SHEET   10 AA410 THR B 536  GLY B 539 -1  O  GLN B 538   N  PHE B 518
SHEET    1 AA5 2 THR B 234  VAL B 235  0
SHEET    2 AA5 2 VAL B 560  PRO B 561 -1  O  VAL B 560   N  VAL B 235
SHEET    1 AA6 2 ILE B 380  MET B 381  0
SHEET    2 AA6 2 VAL B 428  ALA B 429 -1  O  VAL B 428   N  MET B 381
SHEET    1 AA711 THR C 536  HIS C 537  0
SHEET    2 AA711 PHE C 518  HIS C 520 -1  N  HIS C 520   O  THR C 536
SHEET    3 AA711 GLN C 494  ALA C 499 -1  N  LEU C 498   O  TRP C 519
SHEET    4 AA711 VAL C 467  ALA C 472  1  N  SER C 471   O  ALA C 499
SHEET    5 AA711 VAL C 341  PHE C 347  1  N  LEU C 346   O  LEU C 468
SHEET    6 AA711 VAL C 313  TYR C 318  1  N  GLY C 315   O  THR C 343
SHEET    7 AA711 VAL C 240  VAL C 243  1  N  VAL C 243   O  ILE C 316
SHEET    8 AA711 VAL C 272  TRP C 277  1  O  PHE C 273   N  VAL C 240
SHEET    9 AA711 TYR C 223  TYR C 228 -1  N  ILE C 226   O  MET C 274
SHEET   10 AA711 GLY C 214  ARG C 219 -1  N  ARG C 215   O  GLN C 227
SHEET   11 AA711 ALA C 570  PRO C 571 -1  O  ALA C 570   N  VAL C 216
SHEET    1 AA8 2 THR C 234  GLY C 236  0
SHEET    2 AA8 2 PRO C 559  PRO C 561 -1  O  VAL C 560   N  VAL C 235
CRYST1  156.713   95.530  141.174  90.00  90.70  90.00 C 1 2 1      12
ORIGX1      1.000000  0.000000  0.000000        0.00000
ORIGX2      0.000000  1.000000  0.000000        0.00000
ORIGX3      0.000000  0.000000  1.000000        0.00000
SCALE1      0.006381  0.000000  0.000078        0.00000
SCALE2      0.000000  0.010468  0.000000        0.00000
SCALE3      0.000000  0.000000  0.007084        0.00000
MTRIX1   1  0.452082 -0.891060 -0.040428        5.91472    1
MTRIX2   1 -0.889918 -0.447498 -0.088265      -76.74218    1
MTRIX3   1  0.060558  0.075880 -0.995276       99.73037    1
MTRIX1   2 -0.451845 -0.890934  0.045534      -72.45915    1
MTRIX2   2  0.891522 -0.449134  0.058880       53.21401    1
MTRIX3   2 -0.032008  0.067199  0.997226      -48.43906    1
TER    4302      CYS A 587
TER    8457      VAL B 584
TER   12372      PRO C 583
MASTER      533    0    2   73   42    0    0   1212399    3   20  138
END