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vibvy-q7mdk6

Vibrio vulnificus Pathogenic Bacterial Toxin alpha/beta hydrolase domain

Comment

Lee, Y., Kim, B.S., Choi, S., Lee, E.Y., Park, S., Hwang, J., Kwon, Y., Hyung, J., Lee, C., Eom, S.H., Kim, M.H. Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain). One of the liberated protein is an alpha\/beta hydrolase which has a phosphatidylinositol-3-phosphate-specific phospholipase A1 activity which inhibits autophagy and endosomal trafficking (strains YJ016\; MO6-24\/O\; V15_P4S5T153)

Relationship

Family : 6_AlphaBeta_hydrolase

Block : X

Position in NCBI Life Tree : Vibrio vulnificus

Molecular evidence

No mutation

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MSGNEKHKEN VAIENDGTPP RDKESLSPLT RFLNNELYGE KDARRKIGEI TQTLLDHAVE NGESQKVTLK GEVGRLTGYY HQGAASSEGE TSATSGKVVL FLHGSGSSAE EQASEIRNHY QKQGIDMLAV NLRGYGESDG GPSEKGLYQD ARTMFNYLVN DKGIDPSNII IHGYSMGGPI AADLARYAAQ NGQAVSGLLL DRPMPSMTKA ITAHEVANPA GIVGAIAKAV NGQFSVEKNL KGLPKETPIL LLTDNEGLGE EGEKLRAKLA IAGYNVTGEQ TFYGHEASNR LMGQYADQIV SGLFNAEQAA VEAGEVLKGL EKDFKRYGDA LKPDTSVPGK SKDIRTTKDF LNGYKNDHAK EIVD

References

Title : Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity - Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031
Author(s) : Lee Y , Kim BS , Choi S , Lee EY , Park S , Hwang J , Kwon Y , Hyun J , Lee C , Kim JF , Eom SH , Kim MH
Ref : Proc Natl Acad Sci U S A , 116 :18031 , 2019
Abstract : Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031
ESTHER : Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031
PubMedSearch : Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031
PubMedID: 31427506
Gene_locus related to this paper: vibvy-q7mdk6