vibvy-q7mdk6
Vibrio vulnificus Pathogenic Bacterial Toxin alpha/beta hydrolase domain
Comment
Lee, Y., Kim, B.S., Choi, S., Lee, E.Y., Park, S., Hwang, J., Kwon, Y., Hyung, J., Lee, C., Eom, S.H., Kim, M.H. Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain). One of the liberated protein is an alpha\/beta hydrolase which has a phosphatidylinositol-3-phosphate-specific phospholipase A1 activity which inhibits autophagy and endosomal trafficking (strains YJ016\; MO6-24\/O\; V15_P4S5T153)
Relationship
Family : 6_AlphaBeta_hydrolase
Block : X
Position in NCBI Life Tree : Vibrio vulnificus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Proteobacteria N E > Gammaproteobacteria N E > Vibrionales N E > Vibrionaceae N E > Vibrio N E > Vibrio vulnificus N E > cellular organisms N E > Bacteria N E > Proteobacteria N E > Gammaproteobacteria N E > Vibrionales N E > Vibrionaceae N E > Vibrio N E > Vibrio vulnificus N E > cellular organisms N E > Bacteria N E > Proteobacteria N E > Gammaproteobacteria N E > Vibrionales N E > Vibrionaceae N E > Vibrio N E > Vibrio vulnificus N EMolecular evidence
Sequence
Peptide
MSGNEKHKEN VAIENDGTPP RDKESLSPLT RFLNNELYGE KDARRKIGEI TQTLLDHAVE NGESQKVTLK GEVGRLTGYY HQGAASSEGE TSATSGKVVL FLHGSGSSAE EQASEIRNHY QKQGIDMLAV NLRGYGESDG GPSEKGLYQD ARTMFNYLVN DKGIDPSNII IHGYSMGGPI AADLARYAAQ NGQAVSGLLL DRPMPSMTKA ITAHEVANPA GIVGAIAKAV NGQFSVEKNL KGLPKETPIL LLTDNEGLGE EGEKLRAKLA IAGYNVTGEQ TFYGHEASNR LMGQYADQIV SGLFNAEQAA VEAGEVLKGL EKDFKRYGDA LKPDTSVPGK SKDIRTTKDF LNGYKNDHAK EIVD
References (3)
| Title : Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity - Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031 |
| Author(s) : Lee Y , Kim BS , Choi S , Lee EY , Park S , Hwang J , Kwon Y , Hyun J , Lee C , Kim JF , Eom SH , Kim MH |
| Ref : Proc Natl Acad Sci U S A , 116 :18031 , 2019 |
| Abstract : |
| PubMedSearch : Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031 |
| PubMedID: 31427506 |
| Gene_locus related to this paper: vibvy-q7mdk6 |
| Title : Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity - Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031 |
| Author(s) : Lee Y , Kim BS , Choi S , Lee EY , Park S , Hwang J , Kwon Y , Hyun J , Lee C , Kim JF , Eom SH , Kim MH |
| Ref : Proc Natl Acad Sci U S A , 116 :18031 , 2019 |
| Abstract : |
| PubMedSearch : Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031 |
| PubMedID: 31427506 |
| Gene_locus related to this paper: vibvy-q7mdk6 |
| Title : Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity - Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031 |
| Author(s) : Lee Y , Kim BS , Choi S , Lee EY , Park S , Hwang J , Kwon Y , Hyun J , Lee C , Kim JF , Eom SH , Kim MH |
| Ref : Proc Natl Acad Sci U S A , 116 :18031 , 2019 |
| Abstract : |
| PubMedSearch : Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031 |
| PubMedID: 31427506 |
| Gene_locus related to this paper: vibvy-q7mdk6 |