Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b
Compound 3b AChE IC50 = 0.05 +/- 0.02 microM), better than donepezil and baicalein. 3b inhibit the aggregation of A1-42 and penetrate the blood-brain barrier
General
Type : Coumarin,Piperidine,Carboxamide,Derivative of Donepezil
Chemical_Nomenclature : N-(7-methoxy-2-oxochromen-3-yl)[(3,5-dimethoxyphenyl)methyl]piperidine-4-carboxamide
Canonical SMILES : COC1=CC2=C(C=C1)C=C(C(=O)O2)NC(C3CCN(CC3)CC4=CC(=CC(=C4)OC)OC)=O
InChI : InChI=1S\/C25H28N2O6\/c1-30-19-5-4-18-12-22(25(29)33-23(18)14-19)26-24(28)17-6-8-27(9-7-17)15-16-10-20(31-2)13-21(11-16)32-3\/h4-5,10-14,17H,6-9,15H2,1-3H3,(H,26,28)
InChIKey : INSMYWZGUGANRA-UHFFFAOYSA-N
Other name(s) : Compound 3b
MW : 452.50
Formula : C25H28N2O6
CAS_number :
PubChem :
UniChem : INSMYWZGUGANRA-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b ligand of proteins in family: ACHE
Stucture :
Protein : human-ACHE
References (1)
| Title : Design, synthesis, and evaluation of dual-target inhibitors for the treatment of Alzheimer's disease - Zhai_2024_Arch.Pharm.(Weinheim)__e2300693 |
| Author(s) : Zhai J , Hao C , Wang X , Cao Y , Pan Y , Zhou M , Sun J , Li C |
| Ref : Arch Pharm (Weinheim) , :e2300693 , 2024 |
| Abstract : Zhai_2024_Arch.Pharm.(Weinheim)__e2300693 |
| ESTHER : Zhai_2024_Arch.Pharm.(Weinheim)__e2300693 |
| PubMedSearch : Zhai_2024_Arch.Pharm.(Weinheim)__e2300693 |
| PubMedID: 38332316 |