ACHE

Relationship

Family: ACHE

Block: C

Parent Family: Cholinesterase

Comment

Acetylcholinesterase (ACHE; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly. Acetylcholinesterase is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen.

Database

Interpro : IPR000997 Cholinesterase , IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : PDOC00112

Pfam : PF00135 COesterase , PF08674 AChE_tetra

Prints : PR00878

EC Number : 3.1.1.7

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (316)

Genes Proteins in ACHE family (546)

Fragments of genes in ACHE family (366)

Structures in ACHE family (316)

Substrates in ACHE family (50)

Inhibitors in ACHE family (655)

References (5)

Title : Old and new questions about cholinesterases - Massoulie_2008_Chem.Biol.Interact_175_30
Author(s) : Massoulie J , Perrier N , Noureddine H , Liang D , Bon S
Ref : Chemico-Biological Interactions , 175 :30 , 2008
PubMedID: 18541228

Title : Acetylcholinesterase genes within the Diptera: takeover and loss in true flies - Huchard_2006_Proc.Biol.Sci_273_2595
Author(s) : Huchard E , Martinez M , Alout H , Douzery EJ , Lutfalla G , Berthomieu A , Berticat C , Raymond M , Weill M
Ref : Proc Biol Sci , 273 :2595 , 2006
PubMedID: 17002944
Gene_locus related to this paper: culpi-ACHE1 , culpi-ACHE2 , drobs-ACHE2 , drosi-ACHE , drowi-ACHE , gloff-ACHE2

Title : The cholinesterases: from genes to proteins - Taylor_1994_Annu.Rev.Pharmacol.Toxicol_34_281
Author(s) : Taylor P , Radic Z
Ref : Annual Review of Pharmacology & Toxicology , 34 :281 , 1994
PubMedID: 8042853

Title : Molecular and cellular biology of cholinesterases -
Author(s) : Massoulie J , Pezzementi L , Bon S , Krejci E , Vallette FM
Ref : Prog Neurobiol , 41 :31 , 1993
PubMedID: 8321908

Title : Comparison of butyrylcholinesterase and acetylcholinesterase. -
Author(s) : Chatonnet A , Lockridge O
Ref : Biochemical Journal , 260 :625 , 1989
PubMedID: 2669736