| Title : Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha\/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin - Price_2023_bioRxiv__ |
| Author(s) : Price TR , Stapleton DS , Schueler KL , Norris MK , Parks BW , Yandell BS , Churchill GA , Holland WL , Keller MP , Attie AD |
| Ref : Biorxiv , : , 2023 |
| Abstract : We and others have previously shown that genetic association can be used to make causal connections between gene loci and small molecules measured by mass spectrometry in the bloodstream and in tissues. We identified a locus on mouse chromosome 7 where several phospholipids in liver showed strong genetic association to distinct gene loci. In this study, we integrated gene expression data with genetic association data to identify a single gene at the chromosome 7 locus as the driver of the phospholipid phenotypes. The gene encodes alpha/beta-hydrolase domain 2 ( Abhd2 ), one of 23 members of the ABHD gene family. We validated this observation by measuring lipids in a mouse with a whole-body deletion of Abhd2 . The Abhd2 (KO) mice had a significant increase in liver levels of phosphatidylcholine and phosphatidylethanolamine. Unexpectedly, we also found a decrease in two key mitochondrial lipids, cardiolipin and phosphatidylglycerol, in male Abhd2 (KO) mice. These data suggest that Abhd2 plays a role in the synthesis, turnover, or remodeling of liver phospholipids. |
| ESTHER : Price_2023_bioRxiv__ |
| PubMedSearch : Price_2023_bioRxiv__ |
| PubMedID: 36993241 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
Price TR, Stapleton DS, Schueler KL, Norris MK, Parks BW, Yandell BS, Churchill GA, Holland WL, Keller MP, Attie AD (2023)
Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha\/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin
Biorxiv
:
Price TR, Stapleton DS, Schueler KL, Norris MK, Parks BW, Yandell BS, Churchill GA, Holland WL, Keller MP, Attie AD (2023)
Biorxiv
: