Homo sapiens (Human) Monoacylglycerol lipase ABHD2 LABH2 LBH2 protein phps1-2
Monoacylglycerol lipase ABHD2 Enhanced neointimal hyperplasia was observed in Abhd2-deficient mice, using an experimental vascular cuff placement injury model. Abhd2 is expressed in vascular smooth muscle cells (SMCs). An association between the human ABHD2 gene and colorectal cancer and with Risks for Chronic Obstructive Pulmonary Disease is reported. ABHD2 is a steroid-activated (progesterone P4) enzyme that hydrolyzes 2-arachidonoylglycerol. ABHD2 is expressed in sperm and in ovaries. Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane . ABHD2 acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (Miller et al. 2016). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester (Manda et al. 2016). May also play a role in smooth muscle cells migration
Family : abh_upf0017
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG LSRFLLKSCP LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF ITMSDGATST FDLFEPLAEH CVGDDITMVI CPGIANHSEK QYIRTFVDYA QKNGYRCAVL NHLGALPNIE LTSPRMFTYG CTWEFGAMVN YIKKTYPLTQ LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL RAQETFMQWD QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE SLLTIPKSLS EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY ANAICQWERN KLQCSDTEQV EADLE
| Title : ABHD2 activity is not required for the non-genomic action of progesterone on human sperm - Arnolds_2025_Biorxiv__ |
| Author(s) : Arnolds O , Carter EM , Edwards M , Wigren E , Homan E , Ribera P , Bentley K , Haraldsson M , Theo-Emegano N , Loppnau P , Szewczyk MM , Cao MA , Barsyte-Lovejoy D , Vester K , Thrun A , Amaral A , Lesche R , Munchow J , Zhu WF , Temme L , Brenker C , Strunker T , Sundstrom M , Todd MH , Edwards AM , Tredup C , Gileadi O |
| Ref : Biorxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Arnolds_2025_Biorxiv__ |
| PubMedID: |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Progesterone induces meiosis through two obligate co-receptors with PLA2 activity - Nader_2025_Elife_13_RP92635 |
| Author(s) : Nader N , Assaf L , Zarif L , Halama A , Yadav S , Dib M , Attarwala N , Chen Q , Suhre K , Gross S , Machaca K |
| Ref : Elife , 13 :RP92635 , 2025 |
| Abstract : |
| PubMedSearch : Nader_2025_Elife_13_RP92635 |
| PubMedID: 39873665 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-beta - Lv_2024_Int.J.Chron.Obstruct.Pulmon.Dis_19_33 |
| Author(s) : Lv MY , Jin LL , Sang XQ , Shi WC , Qiang LX , Lin QY , Jin SD |
| Ref : Int J Chron Obstruct Pulmon Dis , 19 :33 , 2024 |
| Abstract : |
| PubMedSearch : Lv_2024_Int.J.Chron.Obstruct.Pulmon.Dis_19_33 |
| PubMedID: 38197032 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Anoikis-related gene signatures in colorectal cancer: implications for cell differentiation, immune infiltration, and prognostic prediction - Ding_2024_Sci.Rep_14_11525 |
| Author(s) : Ding T , Shang Z , Zhao H , Song R , Xiong J , He C , Liu D , Yi B |
| Ref : Sci Rep , 14 :11525 , 2024 |
| Abstract : |
| PubMedSearch : Ding_2024_Sci.Rep_14_11525 |
| PubMedID: 38773226 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Unveiling therapeutic biomarkers and druggable targets in ALS: An integrative microarray analysis, molecular docking, and structural dynamic studies - Eshak_2024_Comput.Biol.Chem_113_108211 |
| Author(s) : Eshak D , Arumugam M |
| Ref : Comput Biol Chem , 113 :108211 , 2024 |
| Abstract : |
| PubMedSearch : Eshak_2024_Comput.Biol.Chem_113_108211 |
| PubMedID: 39299050 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Sperm long non-coding RNAs as markers for ram fertility - Hitit_2024_Front.Vet.Sci_11_1337939 |
| Author(s) : Hitit M , Kaya A , Memili E |
| Ref : Front Vet Sci , 11 :1337939 , 2024 |
| Abstract : |
| PubMedSearch : Hitit_2024_Front.Vet.Sci_11_1337939 |
| PubMedID: 38799722 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Deciphering Estrus Expression in Gilts: The Role of Alternative Polyadenylation and LincRNAs in Reproductive Transcriptomics - Liu_2024_Animals.(Basel)_14_ |
| Author(s) : Liu M , Chen J , Zhang C , Liu S , Chao X , Yang H , Muhammad A , Zhou B , Ao W , Schinckel AP |
| Ref : Animals (Basel) , 14 : , 2024 |
| Abstract : |
| PubMedSearch : Liu_2024_Animals.(Basel)_14_ |
| PubMedID: 38473176 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Novel circular RNA hsa_circ_0036683 suppresses proliferation and migration by mediating the miR-4664-3p\/CDK2AP2 axis in non-small cell lung cancer - Liu_2024_Thorac.Cancer__ |
| Author(s) : Liu R , Zhang H , Xin J , Xie SY , Jiao F , Li YJ , Chu MY , Qiu J , Yan YF |
| Ref : Thorac Cancer , : , 2024 |
| Abstract : |
| PubMedSearch : Liu_2024_Thorac.Cancer__ |
| PubMedID: 39113208 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Multiomics analyses of Jining Grey goat and Boer goat reveal genomic regions associated with fatty acid and amino acid metabolism and muscle development - Liu_2024_Anim.Biosci_37_982 |
| Author(s) : Liu Z , Tan X , Jin Q , Zhan W , Liu G , Cui X , Wang J , Meng X , Zhu R , Wang K |
| Ref : Anim Biosci , 37 :982 , 2024 |
| Abstract : |
| PubMedSearch : Liu_2024_Anim.Biosci_37_982 |
| PubMedID: 37946414 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Caspase-9 Is a Positive Regulator of Osteoblastic Cell Migration Identified by diaPASEF Proteomics - Rihova_2024_J.Proteome.Res_23_2999 |
| Author(s) : Rihova K , Lapcik P , Vesela B , Knopfova L , Potesil D , Pokludova J , Smarda J , Matalova E , Bouchal P , Benes P |
| Ref : J Proteome Res , 23 :2999 , 2024 |
| Abstract : |
| PubMedSearch : Rihova_2024_J.Proteome.Res_23_2999 |
| PubMedID: 38498986 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Progesterone induces meiosis through two obligate co-receptors with PLA2 activity - Nader_2023_bioRxiv__ |
| Author(s) : Nader N , Zarif L , Halama A , Yadav S , Dib M , Attarwala N , Chen Q , Suhre K , Gross SS , Machaca K |
| Ref : Biorxiv , : , 2023 |
| Abstract : |
| PubMedSearch : Nader_2023_bioRxiv__ |
| PubMedID: 37905030 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha\/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin - Price_2023_PLoS.Genet_19_e1010713 |
| Author(s) : Price TR , Stapleton DS , Schueler KL , Norris MK , Parks BW , Yandell BS , Churchill GA , Holland WL , Keller MP , Attie AD |
| Ref : PLoS Genet , 19 :e1010713 , 2023 |
| Abstract : |
| PubMedSearch : Price_2023_PLoS.Genet_19_e1010713 |
| PubMedID: 37523383 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha\/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin - Price_2023_bioRxiv__ |
| Author(s) : Price TR , Stapleton DS , Schueler KL , Norris MK , Parks BW , Yandell BS , Churchill GA , Holland WL , Keller MP , Attie AD |
| Ref : Biorxiv , : , 2023 |
| Abstract : |
| PubMedSearch : Price_2023_bioRxiv__ |
| PubMedID: 36993241 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Radiometric Assay of ABHD2 Activity - Fazio_2023_Methods.Mol.Biol_2576_299 |
| Author(s) : Fazio D , Criscuolo E , Maccarrone M |
| Ref : Methods Mol Biol , 2576 :299 , 2023 |
| Abstract : |
| PubMedSearch : Fazio_2023_Methods.Mol.Biol_2576_299 |
| PubMedID: 36152197 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Vaspin accelerates the proliferation, invasion and metastasis of Triple-Negative breast cancer through MiR-33a-5p\/ABHD2 - Cao_2023_Cancer.Med_12_4530 |
| Author(s) : Cao XH , Chen X , Yang K , Wang YL , Liang MX , Fei YJ , Tang JH |
| Ref : Cancer Med , 12 :4530 , 2023 |
| Abstract : |
| PubMedSearch : Cao_2023_Cancer.Med_12_4530 |
| PubMedID: 36125462 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Membrane Cholesterol Inhibits Progesterone-Mediated Sperm Function through the Possible Involvement of ABHD2 - De Toni_2023_Int.J.Mol.Sci_24_ |
| Author(s) : De Toni L , Cosci I , Sabovic I , Di Nisio A , Guidolin D , Pedrucci F , Finocchi F , Dall'Acqua S , Foresta C , Ferlin A , Garolla A |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : |
| PubMedSearch : De Toni_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37298205 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : ABHD2 deficiency aggravates ovalbumin-induced airway remodeling through the PI3K\/Akt pathway in an animal model of chronic asthma - Qiang_2023_Pol.J.Vet.Sci_26_635 |
| Author(s) : Qiang L , Li X , Li Q , Bo H , Liu Y , Lv M , Chen X , Ju H , Sang X , Li Z , Jin S |
| Ref : Pol J Vet Sci , 26 :635 , 2023 |
| Abstract : |
| PubMedSearch : Qiang_2023_Pol.J.Vet.Sci_26_635 |
| PubMedID: 38088307 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : TDP-43 upregulates lipid metabolism modulator ABHD2 to suppress apoptosis in hepatocellular carcinoma - Liu_2022_Commun.Biol_5_816 |
| Author(s) : Liu BW , Wang XY , Cao JL , Chen LL , Wang YL , Zhao BQ , Zhou J , Shen ZF |
| Ref : Commun Biol , 5 :816 , 2022 |
| Abstract : |
| PubMedSearch : Liu_2022_Commun.Biol_5_816 |
| PubMedID: 35963893 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : A comparative mRNA- and miRNA transcriptomics reveals novel molecular signatures associated with metastatic prostate cancers - Shinawi_2022_Front.Genet_13_1066118 |
| Author(s) : Shinawi T , Nasser KK , Moradi FA , Mujalli A , Albaqami WF , Almukadi HS , Elango R , Shaik NA , Banaganapalli B |
| Ref : Front Genet , 13 :1066118 , 2022 |
| Abstract : |
| PubMedSearch : Shinawi_2022_Front.Genet_13_1066118 |
| PubMedID: 36468011 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Progesterone activates the cyclic AMP-protein kinase A signalling pathway by upregulating ABHD2 in fertile men - Jiang_2021_J.Int.Med.Res_49_300060521999527 |
| Author(s) : Jiang F , Zhu Y , Chen Y , Tang X , Liu L , Chen G , Liu Y , Sun X |
| Ref : J Internal Medicine Res , 49 :300060521999527 , 2021 |
| Abstract : |
| PubMedSearch : Jiang_2021_J.Int.Med.Res_49_300060521999527 |
| PubMedID: 33752482 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Alpha\/Beta Hydrolase Domain-Containing Protein 2 regulates the rhythm of follicular maturation and estrous stages of the female reproductive cycle - Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
| Author(s) : Bjorkgren I , Chung DH , Mendoza S , Gabelev-Khasin L , Modzelewski A , He L , Lishko PV |
| Ref : Front Cell Developmental Biology , 9 :710864 , 2021 |
| Abstract : |
| PubMedSearch : Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
| PubMedID: 34568325 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Gain of GAS5 reveals worse prognosis in kidney renal clear cell carcinoma and liver hepatocellular carcinoma from the Cancer Genome Atlas dataset - Li_2021_Transl.Cancer.Res_10_223 |
| Author(s) : Li J , Li Y , He X , Zhao Q |
| Ref : Transl Cancer Research , 10 :223 , 2021 |
| Abstract : |
| PubMedSearch : Li_2021_Transl.Cancer.Res_10_223 |
| PubMedID: 35116254 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction - Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| Author(s) : Baggelaar MP , den Dulk H , Florea BI , Fazio D , Perruzza D , Bernabo N , Raspa M , Janssen APA , Scavizzi F , Barboni B , Overkleeft HS , Maccarrone M , van der Stelt M |
| Ref : ACS Chemical Biology , 14 :2295 , 2019 |
| Abstract : |
| PubMedSearch : Baggelaar_2019_ACS.Chem.Biol_14_2295 |
| PubMedID: 31525885 |
| Gene_locus related to this paper: human-ABHD2 , human-ABHD3 |
| Title : Characterisation and localisation of the endocannabinoid system components in the adult human testis - Nielsen_2019_Sci.Rep_9_12866 |
| Author(s) : Nielsen JE , Rolland AD , Rajpert-De Meyts E , Janfelt C , Jorgensen A , Winge SB , Kristensen DM , Juul A , Chalmel F , Jegou B , Skakkebaek NE |
| Ref : Sci Rep , 9 :12866 , 2019 |
| Abstract : |
| PubMedSearch : Nielsen_2019_Sci.Rep_9_12866 |
| PubMedID: 31537814 |
| Gene_locus related to this paper: human-ABHD2 , human-MGLL |
| Title : Retinoic Acid Induces Differentiation of Mouse F9 Embryonic Carcinoma Cell by Modulating the miR-485 Targeting of Abhd2 - Yu_2019_Int.J.Mol.Sci_20_ |
| Author(s) : Yu M , Zhang L , Liu Y , Liu D , Guo Z |
| Ref : Int J Mol Sci , 20 : , 2019 |
| Abstract : |
| PubMedSearch : Yu_2019_Int.J.Mol.Sci_20_ |
| PubMedID: 31035455 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Asymmetrically Positioned Flagellar Control Units Regulate Human Sperm Rotation - Miller_2018_Cell.Rep_24_2606 |
| Author(s) : Miller MR , Kenny SJ , Mannowetz N , Mansell SA , Wojcik M , Mendoza S , Zucker RS , Xu K , Lishko PV |
| Ref : Cell Rep , 24 :2606 , 2018 |
| Abstract : |
| PubMedSearch : Miller_2018_Cell.Rep_24_2606 |
| PubMedID: 30184496 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids - Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
| Author(s) : Mannowetz N , Miller MR , Lishko PV |
| Ref : Proc Natl Acad Sci U S A , 114 :5743 , 2017 |
| Abstract : |
| PubMedSearch : Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
| PubMedID: 28507119 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2 - Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| Author(s) : Yun B , Lee H , Powell R , Reisdorph N , Ewing H , Gelb MH , Hsu KL , Cravatt BF , Leslie CC |
| Ref : Biochemical & Biophysical Research Communications , 490 :1226 , 2017 |
| Abstract : |
| PubMedSearch : Yun_2017_Biochem.Biophys.Res.Commun_490_1226 |
| PubMedID: 28684316 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone - Miller_2016_Science_352_555 |
| Author(s) : Miller MR , Mannowetz N , Iavarone AT , Safavi R , Gracheva EO , Smith JF , Hill RZ , Bautista DM , Kirichok Y , Lishko PV |
| Ref : Science , 352 :555 , 2016 |
| Abstract : |
| PubMedSearch : Miller_2016_Science_352_555 |
| PubMedID: 26989199 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Abhydrolase domain containing 2, an androgen target gene, promotes prostate cancer cell proliferation and migration - Obinata_2016_Eur.J.Cancer_57_39 |
| Author(s) : Obinata D , Takada S , Takayama K , Urano T , Ito A , Ashikari D , Fujiwara K , Yamada Y , Murata T , Kumagai J , Fujimura T , Ikeda K , Horie-Inoue K , Homma Y , Takahashi S , Inoue S |
| Ref : Eur J Cancer , 57 :39 , 2016 |
| Abstract : |
| PubMedSearch : Obinata_2016_Eur.J.Cancer_57_39 |
| PubMedID: 26854828 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Molecular characterization of human ABHD2 as TAG lipase and ester hydrolase - Manda_2016_Biosci.Rep_36_ |
| Author(s) : Manda NK , Thunuguntla VBSC , Veeramachaneni GK , Bokka CS , Guntupalli S , Bondili JS |
| Ref : Bioscience Reports , 36 : , 2016 |
| Abstract : |
| PubMedSearch : Manda_2016_Biosci.Rep_36_ |
| PubMedID: 27247428 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Associations of ABHD2 Genetic Variations with Risks for Chronic Obstructive Pulmonary Disease in a Chinese Han Population - Liu_2015_PLoS.One_10_e0123929 |
| Author(s) : Liu L , Li X , Yuan R , Zhang H , Qiang L , Shen J , Jin S |
| Ref : PLoS ONE , 10 :e0123929 , 2015 |
| Abstract : |
| PubMedSearch : Liu_2015_PLoS.One_10_e0123929 |
| PubMedID: 25880496 |
| Gene_locus related to this paper: human-ABHD2 |
| Title : Age-related pulmonary emphysema in mice lacking alpha\/beta hydrolase domain containing 2 gene - Jin_2009_Biochem.Biophys.Res.Commun_380_419 |
| Author(s) : Jin S , Zhao G , Li Z , Nishimoto Y , Isohama Y , Shen J , Ito T , Takeya M , Araki K , He P , Yamamura K |
| Ref : Biochemical & Biophysical Research Communications , 380 :419 , 2009 |
| Abstract : |
| PubMedSearch : Jin_2009_Biochem.Biophys.Res.Commun_380_419 |
| PubMedID: 19250629 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque - Miyata_2008_Biochem.Biophys.Res.Commun_365_207 |
| Author(s) : Miyata K , Nakayama M , Mizuta S , Hokimoto S , Sugamura K , Oshima S , Oike Y , Sugiyama S , Ogawa H , Yamamura K |
| Ref : Biochemical & Biophysical Research Communications , 365 :207 , 2008 |
| Abstract : |
| PubMedSearch : Miyata_2008_Biochem.Biophys.Res.Commun_365_207 |
| PubMedID: 17980156 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha\/beta hydrolase domain containing 2 gene - Miyata_2005_Biochem.Biophys.Res.Commun_329_296 |
| Author(s) : Miyata K , Oike Y , Hoshii T , Maekawa H , Ogawa H , Suda T , Araki K , Yamamura K |
| Ref : Biochemical & Biophysical Research Communications , 329 :296 , 2005 |
| Abstract : |
| PubMedSearch : Miyata_2005_Biochem.Biophys.Res.Commun_329_296 |
| PubMedID: 15721306 |
| Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
| Title : Primary structure of a human protein which bears structural similarities to members of the rhodopsin\/beta-adrenergic receptor family - |
| Author(s) : Rapiejko PJ , George ST , Malbon CC |
| Ref : Nucleic Acids Research , 16 :8721 , 1988 |
| PubMedID: 2843827 |
| Gene_locus related to this paper: human-ABHD2 |