| Title : Sexually dimorphic effects of hippocampal cholinergic deafferentation in rats - Jonasson_2004_Eur.J.Neurosci_20_3041 |
| Author(s) : Jonasson Z , Cahill JF , Tobey RE , Baxter MG |
| Ref : European Journal of Neuroscience , 20 :3041 , 2004 |
| Abstract : To determine whether the basal forebrain-hippocampal cholinergic system supports sexually dimorphic functionality, male and female Long-Evans rats were given either selective medial septum/vertical limb of the diagonal band (MS/VDB) cholinergic lesions using the neurotoxin 192 IgG-saporin or a control surgery and then postoperatively tested in a set of standard spatial learning tasks in the Morris water maze. Lesions were highly specific and effective as confirmed by both choline acetyltransferase/parvalbumin immunostaining and acetylcholinesterase histochemistry. Female controls performed worse than male controls in place learning and MS/VDB lesions failed to impair spatial learning in male rats, both consistent with previous findings. In female rats, MS/VDB cholinergic lesions facilitated spatial reference learning. A subsequent test of learning strategy in the water maze revealed a female bias for a response, relative to a spatial, strategy; MS/VDB cholinergic lesions enhanced the use of a spatial strategy in both sexes, but only significantly so in males. Together, these results indicate a sexually dimorphic function associated with MS/VDB-hippocampal cholinergic inputs. In female rats, these neurons appear to support sex-specific spatial learning processes. |
| ESTHER : Jonasson_2004_Eur.J.Neurosci_20_3041 |
| PubMedSearch : Jonasson_2004_Eur.J.Neurosci_20_3041 |
| PubMedID: 15579159 |