Capasso F

References (1)

Title : Effect of caffeic acid phenethyl ester on gastric acid secretion in vitro - Borrelli_2005_Eur.J.Pharmacol_521_139
Author(s) : Borrelli F , Posadas I , Capasso R , Aviello G , Ascione V , Capasso F
Ref : European Journal of Pharmacology , 521 :139 , 2005
Abstract : Caffeic acid phenethyl ester (CAPE), one of the major components of propolis (honeybee resin), has demonstrated a wide spectrum of activities including suppression of eicosanoids by inhibition of cyclooxygenase-1 and cyclooxygenase-2 enzyme activities. The aim of this study was to investigate the effect of CAPE on basal and secretagogues-stimulated gastric acid secretion in vitro. In the isolated, lumen-perfused, stomach preparation of mouse, CAPE (10-100 microM) did not affect the basal gastric acid secretion nor the secretion stimulated by histamine, pentagastrin, isobutyl methylxanthine and high levels of K+. By contrast, CAPE increased the gastric acid secretion induced by the muscarinic receptor agonist, 5-methylfurmethide (5-MEF). CAPE also inhibited the acetylcholinesterase activity in an in vitro colorimetric assay. Eserine (10 microM), a well known acetylcholinesterase inhibitor, also increased 5-MEF-stimulated acid secretion. Our results show that CAPE increases gastric acid secretion stimulated by an acetylcholine agonist receptor likely through inhibition of acetylcholinesterase activity.
ESTHER : Borrelli_2005_Eur.J.Pharmacol_521_139
PubMedSearch : Borrelli_2005_Eur.J.Pharmacol_521_139
PubMedID: 16183057