Capone F

References (4)

Title : Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice - Ricceri_2006_Toxicol.Sci_93_105
Author(s) : Ricceri L , Venerosi A , Capone F , Cometa MF , Lorenzini P , Fortuna S , Calamandrei G
Ref : Toxicol Sci , 93 :105 , 2006
Abstract : Developmental exposure to the organophosphorous insecticide chlorpyrifos (CPF) induces long-term effects on brain and behavior in laboratory rodents. We evaluated in adult mice the behavioral effects of either fetal and/or neonatal CPF exposure at doses not inhibiting fetal and neonatal brain cholinesterase. CPF (3 or 6 mg/kg) was given by oral treatment to pregnant females on gestational days 15-18 and offspring were treated sc (1 or 3 mg/kg) on postnatal days (PNDs) 11-14. Serum and brain acetylcholinesterase (AChE) activity was evaluated at birth and 24 h from termination of postnatal treatments. On PND 70, male mice were assessed for spontaneous motor activity in an open-field test and in a socioagonistic encounter with an unfamiliar conspecific. Virgin females underwent a maternal induction test following presentation of foster pups. Both sexes were subjected to a plus-maze test to evaluate exploration and anxiety levels. Gestational and postnatal CPF exposure (higher doses) affected motor activity in the open field and enhanced synergically agonistic behavior. Postnatal CPF exposure increased maternal responsiveness toward pups in females. Mice of both sexes exposed to postnatal CPF showed reduced anxiety response in the plus-maze, an effect greater in females. Altogether, developmental exposure to CPF at doses that do not cause brain AChE inhibition induces long-term alterations in sex-specific behavior patterns of the mouse species. Late neonatal exposure on PNDs 11-14 was the most effective in causing behavioral changes. These findings support the hypothesis that developmental CPF may represent a risk factor for increased vulnerability to neurodevelopmental disorders in humans.
ESTHER : Ricceri_2006_Toxicol.Sci_93_105
PubMedSearch : Ricceri_2006_Toxicol.Sci_93_105
PubMedID: 16760416

Title : Effects of the novel acetylcholinesterase inhibitor N-octyl-1,2,3, 4- tetrahydro-9-aminoacridine on locomotor activity and avoidance learning in mice - Capone_1999_Neurobiol.Learn.Mem_71_301
Author(s) : Capone F , Oliverio A , Pomponi M , Marta M , Gatta F , Pavone F
Ref : Neurobiol Learn Mem , 71 :301 , 1999
Abstract : The acetylcholinesterase reversible inhibitor N-octyl-1,2,3, 4-tetrahydro-9-aminoacridine (THA-C8) is a new synthesized derivative of tacrine (THA) characterized by an alkyl chain in the molecular structure which ameliorates the penetrability of the compound into the central nervous system. THA-C8 (0.1-5 mg/kg) significantly reduced spontaneous locomotor activity in CD1 mice at a dose of 3 mg/kg. Moreover, THA-C8 (0.2-2 mg/kg) significantly improved shuttle-box avoidance acquisition at doses (0.25, 0.3, 1 mg/kg) not affecting locomotion and that are much lower than the doses reported to be effective for THA in animal models. From the data reported it seems that the new compound could be interesting for therapeutic purposes.
ESTHER : Capone_1999_Neurobiol.Learn.Mem_71_301
PubMedSearch : Capone_1999_Neurobiol.Learn.Mem_71_301
PubMedID: 10196108

Title : Shuttle-box avoidance learning in mice: improvement by combined glucose and tacrine - Pavone_1998_Neurobiol.Learn.Mem_69_204
Author(s) : Pavone F , Capone F , Battaglia M , Sansone M
Ref : Neurobiol Learn Mem , 69 :204 , 1998
Abstract : Glucose and the acetylcholinesterase inhibitor tacrine were tested, alone and in combination, in mice of the CD-1 strain subjected to five daily shuttle-box training sessions. Pretraining intraperitoneal administration of glucose alone (50-400 mg/kg) had no significant effect, while tacrine alone (0.5-3 mg/kg) improved avoidance acquisition at the dose of 2 mg/kg only. Significant avoidance learning improvements were instead produced by 50 or 100 mg/kg glucose combined with 0.5 or 1 mg/kg tacrine. The effects on shuttle-box avoidance acquisition produced by glucose combined with a cholinomimetic agent support the hypothesis that cholinergic mechanisms may be involved in the action of glucose on learning and memory. However, the main finding of the present study is related to the enhancement by glucose of the learning improving action of a drug clinically used as cognitive enhancer.
ESTHER : Pavone_1998_Neurobiol.Learn.Mem_69_204
PubMedSearch : Pavone_1998_Neurobiol.Learn.Mem_69_204
PubMedID: 9619996

Title : Studies on a new series of THA analogues: effects of the aromatic residues that line the gorge of AChE - Pomponi_1997_FEBS.Lett_409_155
Author(s) : Pomponi M , Marta M , Colella A , Sacchi S , Patamia M , Gatta F , Capone F , Oliverio A , Pavone F
Ref : FEBS Letters , 409 :155 , 1997
Abstract : A series of N-monoalkylsubstituted 1,2,3,4-tetrahydro-9-aminoacridines have been prepared after modelling simulation of the AChE-inhibitor complex. Molecular modelling has predicted a number of hydrophobic residues to be involved in the catalytic mechanism of this interaction between the binding sites of AChE and this series of aminoacridines. In these compounds the acridine moiety becomes sandwiched between the rings of PHE330 and TRP84. In particular, the alkyl chain shows the important role of aromatic groups as binding sites. Their in vitro inhibitory properties (enzyme from Electrophorus electricus) confirm the aromatic groups as a general and significant characteristic of the mechanism of AChE inhibition.
ESTHER : Pomponi_1997_FEBS.Lett_409_155
PubMedSearch : Pomponi_1997_FEBS.Lett_409_155
PubMedID: 9202137