Chai PR

References (2)

Title : Novichok agents: a historical, current, and toxicological perspective - Chai_2018_Toxicol.Commun_2_45
Author(s) : Chai PR , Hayes BD , Erickson TB , Boyer EW
Ref : Toxicol Commun , 2 :45 , 2018
Abstract : The Novichok, or "newcomer" class of nerve agents are lesser characterized, weaponized organophosphate agents. The use of known Novichok agents in warfare is banned under the Chemical Weapons Convention of 1997. Novichok agents are considered more potent than VX gas and can be applied in unitary and binary forms. Like other nerve agents, Novichok agents irreversibly bind acetylcholinesterase and produce a cholinergic toxidrome. Uniquely, these agents are thought to also target neurons in the peripheral nervous system. Delayed treatment or massive exposure may therefore cause a debilitating neuropathy. The recent 2018 assassination attempt of Russian dissident Sergei Skripal and his daughter Yulia in the United Kingdom highlights the importance of recognizing the potential lethal effects of these nerve agents. Treatment of Novichok agent poisoning is similar to management of other nerve agents. Given increasing worldwide incidents attributed to chemical weapons such as Novichok agents, clinicians should know how to rapidly recognize symptoms of acute poisoning and administer life-saving antidotal therapy, when indicated.
ESTHER : Chai_2018_Toxicol.Commun_2_45
PubMedSearch : Chai_2018_Toxicol.Commun_2_45
PubMedID: 30003185

Title : Toxic chemical weapons of assassination and warfare: nerve agents VX and sarin - Chai_2017_Toxicol.Commun_1_21
Author(s) : Chai PR , Boyer EW , Al-Nahhas H , Erickson TB
Ref : Toxicol Commun , 1 :21 , 2017
Abstract : The use of VX and sarin as weapons of assassination and warfare raises important considerations for healthcare professionals who may encounter victims, bystanders, and responders who require prompt assessment and treatment. Chemical warfare agents such as VX and sarin constitute a considerable threat to the health of the civilian population, military personnel, and peacekeeping forces. Healthcare providers should recognize symptoms of nerve agent exposure, understand regional and international notification procedures for potential attacks, as well as the indications for and available supply of antidotal therapy.
ESTHER : Chai_2017_Toxicol.Commun_1_21
PubMedSearch : Chai_2017_Toxicol.Commun_1_21
PubMedID: 29974075