| Title : Discovery of Caralluma-derived pregnane glycosides as potent and selective cholinesterase inhibitors: integrated in silico and in vitro evaluation - Al-Karmalawy_2026_RSC.Adv_16_24903 |
| Author(s) : Al-Karmalawy AA , Attia MI , Alnajjar R , El-Shiekh RA , Al Khatib AO , Yousef TA , Abdel-Sattar E |
| Ref : RSC Adv , 16 :24903 , 2026 |
| Abstract : |
| PubMedSearch : Al-Karmalawy_2026_RSC.Adv_16_24903 |
| PubMedID: 42137472 |
| Title : New benzimidazole-alkanesulfonate conjugates as cholinesterase inhibitors with in vitro and in silico validation - Omar_2026_Sci.Rep_16_ |
| Author(s) : Omar MA , Al-Ashmawy AAK , Abd El Salam HA , El-Shiekh RA , Aboulthana WM , Srour AM |
| Ref : Sci Rep , 16 : , 2026 |
| Abstract : |
| PubMedSearch : Omar_2026_Sci.Rep_16_ |
| PubMedID: 41813747 |
| Title : Design, Synthesis, X-Ray Crystallographic Characterization, Anticholinesterase and Antioxidant Evaluation, and Molecular Modeling of Novel Dispiroindene-Pyrrolidine Derivatives as Multifunctional Anti-Alzheimer Agents - Alsfouk_2026_Drug.Dev.Res_87_e70361 |
| Author(s) : Alsfouk AA , El-Shiekh RA , Kariuki BM , Sabry E , Abouelenein MG , Saleh A , Saleh MGA , Srour AM |
| Ref : Drug Dev Res , 87 :e70361 , 2026 |
| Abstract : |
| PubMedSearch : Alsfouk_2026_Drug.Dev.Res_87_e70361 |
| PubMedID: 42573021 |
| Title : Rational design and synthesis of dispiroindene-pyrrolidinedione scaffolds as multi-target directed ligands: potent AChE inhibitors with antioxidant activity and favorable biocompatibility in SH-SY5Y cells - Morsy_2026_Bioorg.Chem_180_110245 |
| Author(s) : Morsy NA , El-Shiekh RA , Ebrahium MM , Srour AM |
| Ref : Bioorg Chem , 180 :110245 , 2026 |
| Abstract : |
| PubMedSearch : Morsy_2026_Bioorg.Chem_180_110245 |
| PubMedID: 42462519 |
| Title : Phytochemical profiling of Olea europaea subsp. cuspidata aerial parts using LC-DAD-QToF: cholinesterase inhibition and molecular docking insights into potential Alzheimer's disease targets - El-Shiekh_2026_Nat.Prod.Res__1 |
| Author(s) : El-Shiekh RA , Mandour AA , Abdel-Sattar E , Ali NB |
| Ref : Nat Prod Res , :1 , 2026 |
| Abstract : |
| PubMedSearch : El-Shiekh_2026_Nat.Prod.Res__1 |
| PubMedID: 42683825 |
| Title : Donepezil-based rational design of N-substituted quinazolinthioacetamide candidates as potential acetylcholine esterase inhibitors for the treatment of Alzheimer's disease: in vitro and in vivo studies - Al-Karmalawy_2025_RSC.Med.Chem__ |
| Author(s) : Al-Karmalawy AA , Mohamed AF , Shalaby HN , Elmaaty AA , El-Shiekh RA , Zeidan MA , Alnajjar R , Alzahrani AYA , Al Mughram MH , Shaldam MA , Tawfik HO |
| Ref : RSC Med Chem , : , 2025 |
| Abstract : |
| PubMedSearch : Al-Karmalawy_2025_RSC.Med.Chem__ |
| PubMedID: 40027342 |
| Title : Machine learning tools for the characterization of bioactive metabolites derived from different parts of Ochrosia elliptica Labill. for the management of Alzheimer's disease - Salem_2025_RSC.Adv_15_10671 |
| Author(s) : Salem MA , Abdel-Sattar E , Mandour AA , El-Shiekh RA |
| Ref : RSC Adv , 15 :10671 , 2025 |
| Abstract : |
| PubMedSearch : Salem_2025_RSC.Adv_15_10671 |
| PubMedID: 40196831 |
| Title : Metabolites profiling, in-vitro and molecular docking studies of five legume seeds for Alzheimer's disease - Ibrahim_2024_Sci.Rep_14_19637 |
| Author(s) : Ibrahim RM , Abdel-Baki PM , Mohamed OG , Al-Karmalawy AA , Tripathi A , El-Shiekh RA |
| Ref : Sci Rep , 14 :19637 , 2024 |
| Abstract : |
| PubMedSearch : Ibrahim_2024_Sci.Rep_14_19637 |
| PubMedID: 39179586 |
| Title : LC\/MS-Based Metabolomics Reveals Chemical Variations of Two Broccoli Varieties in Relation to Their Anticholinesterase Activity: In vitro and In silico Studies - Ibrahim_2024_Plant.Foods.Hum.Nutr__ |
| Author(s) : Ibrahim RM , El-Shiekh RA , Mohamed OG , Al-Karmalawy AA , Tripathi A , Abdel-Baki PM |
| Ref : Plant Foods Hum Nutr , : , 2024 |
| Abstract : |
| PubMedSearch : Ibrahim_2024_Plant.Foods.Hum.Nutr__ |
| PubMedID: 38607508 |
| Title : Barbiturate-sulfonate hybrids as potent cholinesterase inhibitors: design, synthesis and molecular modeling studies - Kassem_2024_Future.Med.Chem__1 |
| Author(s) : Kassem AF , Omar MA , Temirak A , El-Shiekh RA , Srour AM |
| Ref : Future Med Chem , :1 , 2024 |
| Abstract : |
| PubMedSearch : Kassem_2024_Future.Med.Chem__1 |
| PubMedID: 39011621 |
| Title : Anticholinesterases activity of Murraya koenigii (L.) Spreng. and Murraya paniculata (L.) Jacq. essential oils with GC\/MS analysis and molecular docking - El-Shiekh_2023_Nat.Prod.Res__1 |
| Author(s) : El-Shiekh RA , Kassem HAH , Khaleel AE , Abd El-Mageed MMA |
| Ref : Nat Prod Res , :1 , 2023 |
| Abstract : |
| PubMedSearch : El-Shiekh_2023_Nat.Prod.Res__1 |
| PubMedID: 37516925 |
| Title : Hydrazone-sulfonate hybrids as potential cholinesterase inhibitors: design, synthesis and molecular modeling simulation - Omar_2023_Future.Med.Chem__ |
| Author(s) : Omar MA , El-Shiekh RA , Dawood DH , Temirak A , Srour AM |
| Ref : Future Med Chem , : , 2023 |
| Abstract : |
| PubMedSearch : Omar_2023_Future.Med.Chem__ |
| PubMedID: 37994559 |
| Title : Cholinesterase Inhibitors from an Endophytic Fungus Aspergillus niveus Fv-er401: Metabolomics, Isolation and Molecular Docking - Hamed_2023_Molecules_28_ |
| Author(s) : Hamed AA , El-Shiekh RA , Mohamed OG , Aboutabl EA , Fathy FI , Fawzy GA , Al-Taweel AM , Elsayed TR , Tripathi A , Al-Karmalawy AA |
| Ref : Molecules , 28 : , 2023 |
| Abstract : |
| PubMedSearch : Hamed_2023_Molecules_28_ |
| PubMedID: 36985531 |
| Title : Synthesis and molecular docking simulation of new benzimidazole-thiazole hybrids as cholinesterase inhibitors - Dawood_2023_Arch.Pharm.(Weinheim)__e2300201 |
| Author(s) : Dawood DH , Srour AM , Omar MA , Farghaly TA , El-Shiekh RA |
| Ref : Arch Pharm (Weinheim) , :e2300201 , 2023 |
| Abstract : |
| PubMedSearch : Dawood_2023_Arch.Pharm.(Weinheim)__e2300201 |
| PubMedID: 37937360 |
| Title : Hibiscus sabdariffa L.: A potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer's disease in mice - El-Shiekh_2020_Biomed.Pharmacother_128_110303 |
| Author(s) : El-Shiekh RA , Ashour RM , Abd El-Haleim EA , Ahmed KA , Abdel-Sattar E |
| Ref : Biomed Pharmacother , 128 :110303 , 2020 |
| Abstract : |
| PubMedSearch : El-Shiekh_2020_Biomed.Pharmacother_128_110303 |
| PubMedID: 32480228 |