Faria MV

References (2)

Title : [Pesticide pollution in water systems in a small rural community in Southeast Brazil] - Veiga_2006_Cad.Saude.Publica_22_2391
Author(s) : Veiga MM , Silva DM , Veiga LB , Faria MV
Ref : Cad Saude Publica , 22 :2391 , 2006
Abstract : Recent advances in analytical techniques allow identifying pesticide pollution in water systems. In small rural communities, the negative effects of pesticide pollution can be aggravated by the lack of infrastructure and adverse socioeconomic conditions. This study investigated pesticide pollution in potential water supply sources in a tomato growing area in Paty do Alferes, Rio de Janeiro State, Brazil. The study selected 27 points where five monthly samples were collected. Pesticide pollution was determined by analyzing acetyl-cholinesterase inhibition. In 19 of the 27 sample points, some pesticide pollution was detected, and in two points the pesticide pollution was above the permitted limits. The results thus proved the incidence of pesticide pollution in water sources in Paty do Alferes that could jeopardize the local population's health.
ESTHER : Veiga_2006_Cad.Saude.Publica_22_2391
PubMedSearch : Veiga_2006_Cad.Saude.Publica_22_2391
PubMedID: 17091176

Title : Methyl parathion activation by a partially purified rat brain fraction - De Lima_1996_Toxicol.Lett_87_53
Author(s) : De Lima JS , Bastos Neto JdD , Bastos VL , da Cunha JC , Moraes FF , Ferreira MdF , Moreira JdD , Faria MV
Ref : Toxicology Letters , 87 :53 , 1996
Abstract : Organophosphorus pesticides are one of the most commonly used insecticide classes. They act through a potent inhibition of acetylcholinesterase (AChE). Many of them must undergo transformation into the corresponding oxon analogs to inhibit AChE. This study showed that a brain tissue subfraction transformed methyl parathion (O,O-dimethyl O-p-nitrophenyl phosphorothioate) in vitro. Methyl parathion activation was assayed by solvent extraction of the products followed by HPLC and GC-MS analyses and, indirectly, by the inhibition of AChE present in the incubation mixture. The lack of impairment of AChE after 2 h of incubation of the brain subfraction with methyl parathion and, alternatively, with NADPH, CO, SKF 525-A, piperonyl butoxide or nitrogen indicated that this brain subfraction transformed methyl parathion without the involvement of a mixed-function oxidative pathway. The results from HPLC analysis did not show a peak corresponding to methyl paraoxon (O,O-dimethyl O-p-nitrophenylphosphate), but showed the production of an unidentified peak which eluted nearby standard methyl parathion (retention times of 10.65 and 8.86 min, respectively). GC-MS analysis suggested that the unidentified product could be a methyl parathion isomer.
ESTHER : De Lima_1996_Toxicol.Lett_87_53
PubMedSearch : De Lima_1996_Toxicol.Lett_87_53
PubMedID: 8701445