| Title : Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study - Panggabean_2023_Toxicol.Rep_11_330 |
| Author(s) : Panggabean AS , Setyopranoto I , Wicaksono AR , Rismawan A , Dwianingsih EK , Tama WN , Gofir A , Setyaningrum CTS , Sutarni S , Asmedi A , Rhamadianti AF , Bawono RG , Malueka RG |
| Ref : Toxicol Rep , 11 :330 , 2023 |
| Abstract : Uncontrolled and unsafe use of pesticides can lead to acute and chronic toxicity in farmers, with neuropathy being one of the most common symptoms of chronic toxicity. However, the effects of this toxicity on farmers' electroneuromyography (ENMG) are still unclear. To address this, we conducted a cross-sectional study from July to October 2017 in Ngablak District, Magelang, Central Java, Indonesia. Eligible farmers who were exposed to pesticides underwent electrophysiology examinations, as well as additional tests such as physical examination and laboratory testing. We collected general information such as age and work history by interview. In total, 64 farmers were included in this study. Out of these, 44 farmers were found to have polyneuropathy, with 41 of them having motor polyneuropathy and 19 of them having sensory polyneuropathy. Our findings showed that low blood cholinesterase was associated with distal latency prolongation (p-value: 0.014). The group exposed to organophosphate/carbamate pesticides was also significantly associated with prolonged distal latency (p-value: 0.012). However, motor polyneuropathy was significantly associated with chronic exposure to organophosphate/carbamate pesticides (p-value: 0.009) and not with low blood cholinesterase levels (p-value: 0.454). The study concludes that chronic exposure to organophosphate or carbamate pesticides could result in polyneuropathy disease, particularly in the motor system. |
| ESTHER : Panggabean_2023_Toxicol.Rep_11_330 |
| PubMedSearch : Panggabean_2023_Toxicol.Rep_11_330 |
| PubMedID: 37840896 |
| Title : Association of pesticide exposure with cognitive function in farmers - Setyopranoto_2023_Eur.Neurol__ |
| Author(s) : Setyopranoto I , Gofir A , Rahardjo LP , Panggabean AS , Dwianingsih EK , Setyaningsih I , Setyaningrum CTS , Sutarni S , Malueka RG |
| Ref : Eur Neurol , : , 2023 |
| Abstract : Introduction Organophosphate and carbamate are two types of pesticides that can induce cholinesterase suppression in humans. These lead to poisoning symptoms including muscle paralysis and respiratory depression in acute settings. In chronic settings, the mechanism of organophosphate and carbamate poisoning is still openly discussed. Accordingly, this study aimed to identify any correlations between erythrocyte cholinesterase and associations between type of pesticides with cognitive performance of the subjects. Methods This cross-sectional study was conducted in two sampling periods (July 2017 and October 2018) in Ngablak Districts, Magelang Regency, Central Java, Indonesia. The study subjects were farmers with history of pesticide exposure. Cholinesterase levels (ChE) were analyzed from blood samples. Cognitive performance was assessed using the Mini Mental State Examination (MMSE) and Stroop Test. Results In total, 151 subjects aged between 23 - 91 years old were included. The long-term organophosphate exposure group had significantly lower MMSE scores compared with other types of pesticides, but not in carbamate (p=0.017). After comparing "organophosphate only" and "carbamate only" groups, there were significant differences in MMSE scores (p=0.018) but not in blood ChE levels (p=0.286). Detailed assessment in MMSE domains showed significantly lower scores for orientation, attention, and registration domains (p < 0.05) in the organophosphate group. There were no significant associations between types of pesticides and blood ChE levels with the Stroop Test results (p > 0.05). Conclusions Long-term organophosphate exposure could produce lower cognitive function and the insignificant association between blood ChE levels to MMSE could lead to non-cholinergic pathways as its underlying pathology. |
| ESTHER : Setyopranoto_2023_Eur.Neurol__ |
| PubMedSearch : Setyopranoto_2023_Eur.Neurol__ |
| PubMedID: 37364544 |