Kelly JS

General

Full name : Kelly John S

First name : John S

Mail : MRC Neurochemical Pharmacology Unit, Medical School, Cambridge CB2 2QD

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Country : United Kingdom

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References (15)

Title : Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice - Young_2007_Eur.Neuropsychopharmacol_17_145
Author(s) : Young JW , Crawford N , Kelly JS , Kerr LE , Marston HM , Spratt C , Finlayson K , Sharkey J
Ref : European Neuropsychopharmacology , 17 :145 , 2007
Abstract : alpha7-Nicotinic acetylcholine receptors (alpha7-nAChR) have been implicated in a range of cognitive deficits in schizophrenia. Therefore we examined alpha7-nAChR knockout (KO), heterozygote (HT) and wildtype (WT) littermate mice in the 5-CSR (a rodent model of sustained attention) and odour span (a novel mouse working memory paradigm) tasks, and related performance to nAChR density. Whilst there was no difference between groups in baseline 5-CSR task performance, alpha7-nAChR KO's exhibited significantly higher omission levels compared to WT mice on increasing the attentional load, with HT mice performing at an intermediate level. Furthermore, alpha7-nAChR KO mice were significantly impaired in the odour span task when compared to WT mice, in a pattern consistent with impaired attention. These behavioural deficits were associated with the loss of alpha7-nAChRs, as alpha4beta2-nAChR density was unaltered in these mice. Thus these studies intimate that the attentional impairment in alpha7-nAChR transgenic mice maybe core to other deficits in cognition.
ESTHER : Young_2007_Eur.Neuropsychopharmacol_17_145
PubMedSearch : Young_2007_Eur.Neuropsychopharmacol_17_145
PubMedID: 16650968

Title : Identification of species differences in the pharmacology of the alpha-7 nicotinic receptor using the antagonist radioligand [3H]-methyllycaconitine. -
Author(s) : Crawford N , Finlayson K , Sharkey J , Kelly JS
Ref : Cholinergic Mechanisms, CRC Press :539 , 2004
PubMedID:

Title : Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor - Young_2004_Neuropsychopharmacology_29_891
Author(s) : Young JW , Finlayson K , Spratt C , Marston HM , Crawford N , Kelly JS , Sharkey J
Ref : Neuropsychopharmacology , 29 :891 , 2004
Abstract : In humans, nicotine has been shown to improve attention in both normal and impaired individuals. Observations in rats reflect some, but not all aspects of the nicotine-induced improvements in humans. To date these findings have not been replicated in mice. To examine the effect of nicotine on sustained attention in mice, we have established a version of the 5-choice serial reaction-time (5-CSR) task with graded levels of difficulty, based upon spatial displacement and a variable intertrial interval. Using this paradigm, microgram doses of nicotine produced a consistent reduction in the level of omissions and an improvement in proportion correct in normal mice. This improvement in sustained attention was made irrespectively of whether mice had previously received nicotine. In an attempt to elucidate which nicotinic acetylcholine receptor (nAChR) subtype(s) mediate this effect, we examined the performance of alpha7 nAChR knockout (KO) mice in the 5-CSR task. alpha7 nAChR KO mice not only acquired the task more slowly than their wild-type littermates, but on attaining asymptotic performance, they exhibited a higher level of omissions. In conclusion, by increasing the level of task difficulty, the performance of mice was maintained at sufficiently low levels to allow a demonstrable improvement in performance upon nicotine administration. Furthermore, as alpha7 KO mice are clearly impaired in the acquisition and asymptotic performance of this task, the alpha7 nAChR may be involved in mediating these effects of nicotine.
ESTHER : Young_2004_Neuropsychopharmacology_29_891
PubMedSearch : Young_2004_Neuropsychopharmacology_29_891
PubMedID: 14970827

Title : Alzheimer's disease: the tacrine legacy - Kelly_1999_Trends.Pharmacol.Sci_20_127
Author(s) : Kelly JS
Ref : Trends in Pharmacological Sciences , 20 :127 , 1999
Abstract :
ESTHER : Kelly_1999_Trends.Pharmacol.Sci_20_127
PubMedSearch : Kelly_1999_Trends.Pharmacol.Sci_20_127
PubMedID: 10348719

Title : Acetylcholine as an excitatory and inhibitory transmitter in the mammalian central nervous system -
Author(s) : Kelly JS , Dodd J , Dingledine R
Ref : Prog Brain Res , 49 :253 , 1979
PubMedID: 229514

Title : Cortical inhibition and gamma-aminobutyric acid -
Author(s) : Dreifuss JJ , Kelly JS , Krnjevic K
Ref : Experimental Brain Research , 9 :137 , 1969
PubMedID: 5346460

Title : Effects of copper on cortical neurones -
Author(s) : Dreifuss JJ , Kelly JS , Krnjevic K
Ref : Brain Research , 13 :607 , 1969
PubMedID: 5772439

Title : [Inhibitory post-synaptic potentials in the cerebral cortex] -
Author(s) : Dreifuss JJ , Kelly JS , Krnjevic K
Ref : Journal de Physiologie (Paris) , 61 Suppl 2 :274 , 1969
PubMedID: 5384828

Title : The action of glycine on cortical neurones -
Author(s) : Kelly JS , Krnjevic K
Ref : Experimental Brain Research , 9 :155 , 1969
PubMedID: 4310329

Title : Anionic permeability of cortical neurones -
Author(s) : Kelly JS , Krnjevic K , Morris ME , Yim GK
Ref : Experimental Brain Research , 7 :11 , 1969
PubMedID: 5791913

Title : Divalent cations and electrical properties of cortical cells -
Author(s) : Kelly JS , Krnjevic K , Somjen G
Ref : Journal of Neurobiology , 1 :197 , 1969
PubMedID: 5407043

Title : Anaesthetic action of magnesium ions -
Author(s) : Kato G , Kelly JS , Krnjevic K , Somjen G
Ref : Canadian Anaesthetist's Society Journal , 15 :539 , 1968
PubMedID: 4302382

Title : Effects of gamma-aminobutyric acid and glycine on cortical neurons -
Author(s) : Kelly JS , Krnjevic K
Ref : Nature , 219 :1380 , 1968
PubMedID: 5678021

Title : Anionic permeability of cortical neurones during inhibition -
Author(s) : Kelly JS , Krnjevic K , Morris ME , Yim GK
Ref : The Journal of Physiology , 196 :120P , 1968
PubMedID: 5652861

Title : Unresponsive cells in cerebral cortex -
Author(s) : Kelly JS , Krnjevic K , Yim GK
Ref : Brain Research , 6 :767 , 1967
PubMedID: 6080226