Ramstrom O

References (4)

Title : Racemase activity of B. cepacia lipase leads to dual-function asymmetric dynamic kinetic resolution of alpha-aminonitriles -
Author(s) : Vongvilai P , Linder M , Sakulsombat M , Svedendahl Humble M , Berglund P , Brinck T , Ramstrom O
Ref : Angew Chem Int Ed Engl , 50 :6592 , 2011
PubMedID: 21633990

Title : Tandem driven dynamic self-inhibition of acetylcholinesterase - Zhang_2010_Chem.Commun.(Camb)_46_8457
Author(s) : Zhang Y , Angelin M , Larsson R , Albers A , Simons A , Ramstrom O
Ref : Chem Commun (Camb) , 46 :8457 , 2010
Abstract : A concept of tandem driven dynamic self-inhibition is demonstrated through dynamic inhibitors of acetylcholinesterase (AChE) using reversible transthiolesterification.
ESTHER : Zhang_2010_Chem.Commun.(Camb)_46_8457
PubMedSearch : Zhang_2010_Chem.Commun.(Camb)_46_8457
PubMedID: 20922228

Title : Catalytic self-screening of cholinesterase substrates from a dynamic combinatorial thioester library -
Author(s) : Larsson R , Pei Z , Ramstrom O
Ref : Angew Chem Int Ed Engl , 43 :3716 , 2004
PubMedID: 15248281

Title : Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors - Bunyapaiboonsri_2001_Chembiochem_2_438
Author(s) : Bunyapaiboonsri T , Ramstrom O , Lohmann S , Lehn JM , Peng L , Goeldner M
Ref : Chembiochem , 2 :438 , 2001
Abstract : A dynamic combinatorial library composed of interconverting acylhydrazones has been generated and screened towards inhibition of acetylcholinesterase from the electric ray Torpedo marmorata. Starting from a small set (13) of initial hydrazide and aldehyde building blocks, a library containing possibly 66 different species was obtained in a single operation. Of all possible acylhydrazones formed, active compounds containing two terminal cationic recognition groups separated by an appropriate distance, permitting two-site binding, could be rapidly identified by using a dynamic deconvolution--screening procedure, based on the sequential removal of starting building blocks. A very potent bis-pyridinium inhibitor (K(i)=1.09 nM, alphaK(i)=2.80 nM) was selected from the process and the contribution of various structural features to inhibitory potency was evaluated.
ESTHER : Bunyapaiboonsri_2001_Chembiochem_2_438
PubMedSearch : Bunyapaiboonsri_2001_Chembiochem_2_438
PubMedID: 11828475