| Title : First-In-Human Effects of PPT1 Inhibition Using the Oral Treatment with GNS561\/Ezurpimtrostat in Patients with Primary and Secondary Liver Cancers - Harding_2022_Liver.Cancer_11_268 |
| Author(s) : Harding JJ , Awada A , Roth G , Decaens T , Merle P , Kotecki N , Dreyer C , Ansaldi C , Rachid M , Mezouar S , Menut A , Bestion EN , Paradis V , Halfon P , Abou-Alfa GK , Raymond E |
| Ref : Liver Cancer , 11 :268 , 2022 |
| Abstract : |
| PubMedSearch : Harding_2022_Liver.Cancer_11_268 |
| PubMedID: 35949290 |
| Title : GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions - Brun_2022_Autophagy_18_678 |
| Author(s) : Brun S , Bestion E , Raymond E , Bassissi F , Jilkova ZM , Mezouar S , Rachid M , Novello M , Tracz J , Hama A , Lalmanach G , Vanderlynden L , Legouffe R , Stauber J , Schubert T , Plach MG , Courcambeck J , Drouot C , Jacquemot G , Serdjebi C , Roth G , Baudoin JP , Ansaldi C , Decaens T , Halfon P |
| Ref : Autophagy , 18 :678 , 2022 |
| Abstract : |
| PubMedSearch : Brun_2022_Autophagy_18_678 |
| PubMedID: 34740311 |
| Gene_locus related to this paper: human-PPT1 |
| Title : GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma - Brun_2019_Invest.New.Drugs_37_1135 |
| Author(s) : Brun S , Bassissi F , Serdjebi C , Novello M , Tracz J , Autelitano F , Guillemot M , Fabre P , Courcambeck J , Ansaldi C , Raymond E , Halfon P |
| Ref : Invest New Drugs , 37 :1135 , 2019 |
| Abstract : |
| PubMedSearch : Brun_2019_Invest.New.Drugs_37_1135 |
| PubMedID: 30778887 |
| Title : Pharmacokinetics and safety of DTS-108, a human oligopeptide bound to SN-38 with an esterase-sensitive cross-linker in patients with advanced malignancies: a Phase I study - Coriat_2016_Int.J.Nanomedicine_11_6207 |
| Author(s) : Coriat R , Faivre SJ , Mir O , Dreyer C , Ropert S , Bouattour M , Desjardins R , Goldwasser F , Raymond E |
| Ref : Int J Nanomedicine , 11 :6207 , 2016 |
| Abstract : |
| PubMedSearch : Coriat_2016_Int.J.Nanomedicine_11_6207 |
| PubMedID: 27920527 |
| Title : Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans - Santos_2000_Clin.Cancer.Res_6_2012 |
| Author(s) : Santos A , Zanetta S , Cresteil T , Deroussent A , Pein F , Raymond E , Vernillet L , Risse ML , Boige V , Gouyette A , Vassal G |
| Ref : Clin Cancer Research , 6 :2012 , 2000 |
| Abstract : |
| PubMedSearch : Santos_2000_Clin.Cancer.Res_6_2012 |
| PubMedID: 10815927 |