Saliba SW

References (2)

Title : New multifunctional AChE inhibitor drug prototypes protect against Abeta-induced memory deficit - Bellozi_2020_Neurol.Sci_41_451
Author(s) : Bellozi PMQ , Campos AC , Viegas FPD , Silva MF , Machado RP , Vaz SM , Riquiel MM , Carneiro-Junior WO , Lima IVA , Saliba SW , Vaz GN , Viegas C, Jr. , de Oliveira ACP
Ref : Neurol Sci , 41 :451 , 2020
Abstract : Alzheimer's disease (AD) is the most incident neurodegenerative disorder, characterized by accumulation of extracellular amyloid-beta (Abeta), intracellular neurofibrillary tangles, and cognitive impairment. The current available treatments are mainly based on the use of reversible acetylcholinesterase (AChE) inhibitors, which only ameliorate the cognitive deficits. However, it is important to develop disease-modifying drugs with neuroprotective effects in order to hamper the progression of the disease. Here, we describe the effect of four promising new drugs with additional protective characteristics on AD-associated memory changes. C57Bl/6 mice treated with the compounds received an intra-hippocampal injection of Abeta1-40 and were submitted to the novel object recognition test, to evaluate memory recovery. All the compounds prevented memory loss. Compounds PQM-56 (4c) and PQM-67 (4g) showed the best profile of memory recovery, representing potential drug candidates for AD treatment.
ESTHER : Bellozi_2020_Neurol.Sci_41_451
PubMedSearch : Bellozi_2020_Neurol.Sci_41_451
PubMedID: 31506829

Title : Repeated bifenthrin exposure alters hippocampal Nurr-1\/AChE and induces depression-like behavior in adult rats - Gargouri_2019_Behav.Brain.Res_370_111898
Author(s) : Gargouri B , Bouchard M , Saliba SW , Fetoui H , Fiebich BL
Ref : Behavioural Brain Research , 370 :111898 , 2019
Abstract : Exposure to insecticides has been associated with depression-like symptoms, especially among occupationally exposed populations, such as farmers. Although the neurotoxicity of pyrethroids such as bifenthrin (BF) is well established, it is still unclear whether exposure to BF may have deleterious effects on the hippocampus and thus behavior. We verified the hypothesis that repeated exposure to BF in a rat model elicits neurochemical and behavioral alterations, the latter of which reflects depression-related symptoms. Adult male Wistar rats (n = 12 per group) were orally administered with different doses of BF (0.6 or 2.1 mg/kg body weight (b.w.)) on a daily basis for 60 days; control rats received the vehicle (corn oil). Different biochemical changes were assessed in the hippocampus, a region of the brain regulating spatial memory; behavioral tests were also conducted. Our results revealed depressive-like behaviors that were expressed by increased despair behavior in the Forced-swimming test. Repeated exposure to BF also decreased acetylcholinesterase (AChE) activity in the hippocampus and butyrylcholinesterase (BuChE) activity in plasma. A significant reduction in the activities of hippocampal membrane-bound ATPases (Na(+)/K(+)-ATPase and Mg(2+)-ATPase) was also observed in BF-treated rats compared to controls. Furthermore, a significant decrease in mRNA expression and protein synthesis of both AChE and orphan nuclear receptor (Nurr-1), as well as in the expression of muscarinic-cholinergic receptor (M1 mAchR) and nicotinic-cholinergic receptor (nAchR2alpha) was observed in the hippocampus of treated rats compared to controls. Also, BF exposure induced apoptosis as assessed by hippocampal Casp-3 protein levels. Our findings suggest that repeated exposure to BF affects hippocampal signaling and Nurr-1/AChE, and this was accompanied by depression-like state in adult rats.
ESTHER : Gargouri_2019_Behav.Brain.Res_370_111898
PubMedSearch : Gargouri_2019_Behav.Brain.Res_370_111898
PubMedID: 30978409