Yuan GY

References (3)

Title : Biosynthesis of Cosmosporasides Reveals the Assembly Line for Fungal Hybrid Terpenoid Saccharides - Yuan_2023_Angew.Chem.Int.Ed.Engl__e202308887
Author(s) : Yuan GY , Zhang JM , Xu QD , Zhang HR , Hu C , Zou Y
Ref : Angew Chem Int Ed Engl , :e202308887 , 2023
Abstract : Fungal hybrid terpenoid saccharides constitute a new and growing family of natural products with significant biomedical and agricultural activities. One of the most representative families is cosmosporasides, which feature hybrid degree of oxidized terpenoid units and saccharide moieties, however, the assembly line of these building blocks is elusive to date. Herein, a cos cluster from Fusarium orthoceras was discovered for the synthesis of cosmosporaside C (1) by genome mining. A UbiA family intramembrane prenyltransferase (UbiA-type PT), a multifunctional cytochrome P450, an alpha,beta-hydrolase, an acetyltransferase, a dimethylallyl transferase (DMAT-type PT) and a glycosyltransferase, function cooperatively in the assembly of the scaffold of 1 using primary central metabolites. In addition, the absolute configurations of C-4, C-6 and C-7 of 1 are also established. Our work importantly clarifies the unexpected functions of UbiA-type and DMAT-type PTs and provides an example for understanding the synthetic logic of hybrid terpenoid saccharides in fungi.
ESTHER : Yuan_2023_Angew.Chem.Int.Ed.Engl__e202308887
PubMedSearch : Yuan_2023_Angew.Chem.Int.Ed.Engl__e202308887
PubMedID: 37647109
Gene_locus related to this paper: 9hypo-a0a8k0rxd4

Title : Association of serum adipose triglyceride lipase levels with obesity and diabetes - Yang_2014_Genet.Mol.Res_13_6746
Author(s) : Yang L , Chen SJ , Yuan GY , Zhou LB , Wang D , Wang XZ , Chen JJ
Ref : Genet Mol Res , 13 :6746 , 2014
Abstract : The aim of this study was to detect the serum adipose triglyceride lipase (ATGL) levels in obesity and newly diagnosed type 2 diabetes patients, and to explore the association between ATGL with glucose and lipid metabolism. We enrolled 66 patients with type 2 diabetes and 48 patients with normal glucose regulation, who were divided into an overweight or obese subgroup and a normal weight subgroup according to body mass index (BMI) >/= 25 kg/m(2). The enzyme-linked immunosorbent assay was used to detect fasting blood glucose, blood lipids, fasting insulin, and ATGL levels. The serum ATGL level in the overweight or obese group was lower than that in the non-obese group including patients with type 2 diabetes and normal glucose regulation: 239 +/- 61 vs 355 +/- 54 mg/L and 242 +/- 60 vs 383 +/- 58 mg/L, respectively (t = 22.53, t = 8.23, P < 0.05). The Pearson correlation analysis showed that fasting serum ATGL was negatively correlated with body fat content, BMI, waist-to-hip ratio, triglycerides, and the homeostatic model assessment-insulin resistance level (r = -0.271, r = -0.238, r = -0.375, r = -0.313, and r = -0.164, respectively, P < 0.05). The stepwise regression analysis showed that the waist-to-hip ratio and body fat content were independently associated with the serum ATGL level. Our results indicated that the ATGL level may be closely related to obesity.
ESTHER : Yang_2014_Genet.Mol.Res_13_6746
PubMedSearch : Yang_2014_Genet.Mol.Res_13_6746
PubMedID: 25177954

Title : Prognostic factors for chronic severe hepatitis and construction of a prognostic model - Li_2008_Hepatobiliary.Pancreat.Dis.Int_7_40
Author(s) : Li Q , Yuan GY , Tang KC , Liu GW , Wang R , Cao WK
Ref : Hepatobiliary Pancreat Dis Int , 7 :40 , 2008
Abstract : BACKGROUND: Chronic severe hepatitis is a serious illness with a high mortality rate. Discussion of prognostic judgment criteria for chronic severe hepatitis is of great value in clinical guidance. This study was designed to investigate the clinical and laboratory indices affecting the prognosis of chronic severe hepatitis and construct a prognostic model.
METHODS: The clinical and laboratory indices of 213 patients with chronic severe hepatitis within 24 hours after diagnosis were analyzed retrospectively. Death or survival was limited to within 3 months after diagnosis.
RESULTS: The mortality of all patients was 47.42%. Compared with the survival group, the age, basis of hepatocirrhosis, infection, degree of hepatic encephalopathy (HE) and the levels of total bilirubin (TBil), total cholesterol (CHO), cholinesterase (CHE), blood urea nitrogen (BUN), blood creatinine (Cr), blood sodium ion (Na), peripheral blood leukocytes (WBC), alpha-fetoprotein (AFP), international normalized ratio (INR) of blood coagulation and prothrombin time (PT) were significantly different in the group who died, but the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB) and hemoglobin (HGB) were not different between the two groups. At the same time, a regression model, Logit (P) =1.573XAge+1.338XHE-1.608XCHO+0.011XCr-0.109XNa+1.298XINR+11.057, was constructed by logistic regression analysis and the prognostic value of the model was higher than that of the MELD score.
CONCLUSIONS: Multivariate analysis excels univariate analysis in the prognosis of chronic severe hepatitis, and the regression model is of significant value in the prognosis of this disease.
ESTHER : Li_2008_Hepatobiliary.Pancreat.Dis.Int_7_40
PubMedSearch : Li_2008_Hepatobiliary.Pancreat.Dis.Int_7_40
PubMedID: 18234637