5_AlphaBeta_hydrolase
Relationship
Comment
This family corresponds partially to PF12695 (Abhydrolase_5). This undefined family is progressively shrinking as some families are extracted (recently: Extracel-MCL-phaZ and yjfP_esterase-like) One thermostable esterase containing an immunoglobulin-like domain is in the seed of the family. The immunoglobulin-like domain is found in other esterases that belong to another esterase families A85-IroE-IroD-Fes-Yiel. Not all the members of the 5_AlphaBeta_hydrolase possess this domain
Database
Interpro : IPR029059 Alpha\/beta hydrolase fold-5 AB_hydrolase_5
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF12695 Abhydrolase_5
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Structure | Name | Proteins |
|---|---|---|
| 3DOH | Crystal Structure of a Thermostable Esterase | thema-TM0033 |
| 3DOI | Crystal Structure of a Thermostable Esterase complex with paraoxon | thema-TM0033 |
| 3WYD | C-terminal esterase domain of LC-Est1 | 9bact-3WYDseq |
| 4Q82 | Crystal Structure of Phospholipase\/Carboxylesterase from Haliangium ochraceum | halo1-d0lmj0 |
| Gene_locus | Name | Species |
|---|---|---|
| 9actn-a0a0c2axw1 | Streptomyces sp. AcH 505. Phospholipase | Streptomyces sp. AcH 505 |
| 9actn-a0a1c4kza8 | Streptomyces sp. TverLS-915. Dienelactone hydrolase family protein | Streptomyces sp. TverLS-915 |
| 9actn-a0a1h1sd54 | Microlunatus soli. Alpha\/beta hydrolase family protein | Microlunatus soli |
| 9actn-a0a372m1c2 | Streptomyces triticagri. Alpha\/beta fold hydrolase | Streptomyces triticagri |
| 9baci-a0a1i4juv5 | Gracilibacillus orientalis. Prolyl oligopeptidase family protein | Gracilibacillus orientalis |
| 9bacl-a0a1i3s9i3 | Paenibacillus sp. UNC496MF. Alpha\/beta hydrolase family protein | Paenibacillus sp. UNC496MF |
| 9bacl-a0a1u9k3n4 | Novibacillus thermophilus. Phospholipase | Novibacillus thermophilus |
| 9bacl-a0a1v4hdv3 | Paenibacillus ferrarius. Phospholipase | Paenibacillus ferrarius |
| 9bacl-a0a5c4tgu8 | Paenibacillus hemerocallicola. Phospholipase | Paenibacillus hemerocallicola |
| 9bacl-a0a6b8r9k2 | Paenibacillus psychroresistens. Phospholipase | Paenibacillus psychroresistens |
| 9bacl-a0a6c0g096 | Paenibacillus lycopersici. Prolyl oligopeptidase family serine peptidase | Paenibacillus lycopersici |
| 9bacl-h3smu8 | Paenibacillus dendritiformis C454. Phospholipase\/carboxylesterase | Paenibacillus dendritiformis C454 |
| 9bact-3WYDseq |  Uncultured bacteria C-terminal esterase domain of LC-Est1 |
uncultured bacteria |
| 9bact-a0a0c9q7s9 | Candidatus Brocadia sinica JPN1. Abhydrolase_2 domain-containing protein | Candidatus Brocadia sinica JPN1 |
| 9bact-a0a0e4a055 | Spirosoma radiotolerans. Phospholipase\/carboxylesterase | Spirosoma radiotolerans |
| 9bact-a0a0s6vpf3 | Candidatus Moduliflexus flocculans. Possible S9 family peptidase | Candidatus Moduliflexus flocculans |
| 9bact-a0a1i1ikm2 | Spirosoma endophyticum. Alpha\/beta hydrolase family protein | Spirosoma endophyticum |
| 9bact-a0a1m5egw2 | Dysgonomonas macrotermitis. Phospholipase\/Carboxylesterase | Dysgonomonas macrotermitis |
| 9bact-a0a1q2mb06 | Limihaloglobus sulfuriphilus. Esterase | Limihaloglobus sulfuriphilus |
| 9bact-a0a239ikg9 | Pontibacter ummariensis. Dienelactone hydrolase family protein | Pontibacter ummariensis |
| 9bact-a0a2a2wh71 | Rhodopirellula sp. SM50. Phospholipase | Rhodopirellula sp. SM50 |
| 9bact-a0a2t5c5t6 | Mangrovibacterium marinum. Phospholipase | Mangrovibacterium marinum |
| 9bact-a0a2u2b7e7 | Marinilabilia rubra. Phospholipase | Marinilabilia rubra |
| 9bact-a0a368krz5 | Blastopirellula cremea. Phospholipase | Blastopirellula cremea |
| 9bact-a0a368kvz0 | Blastopirellula cremea. Phospholipase | Blastopirellula cremea |
| 9bact-a0a419w719 | Mangrovibacterium diazotrophicum. Putative esterase | Mangrovibacterium diazotrophicum |
| 9bact-a0a512rjs4 | Chitinophaga cymbidii. Hydrolase | Chitinophaga cymbidii |
| 9bact-a0a512rlk2 | Chitinophaga cymbidii. Phospholipase | Chitinophaga cymbidii |
| 9bact-a0a514zxt0 | Spirosoma sp. KCTC 42546. Phospholipase | Spirosoma sp. KCTC 42546 |
| 9bact-a0a517r0i3 | Planctomycetes bacterium Pan189. Phospholipase\/Carboxylesterase | Planctomycetes bacterium Pan189 |
| 9bact-a0a517stm6 | Planctomycetes bacterium SV_7m_r. Poly(3-hydroxyoctanoate) depolymerase | Planctomycetes bacterium SV_7m_r |
| 9bact-a0a518amt1 | Aeoliella mucimassa. c-term of Glyco_hydro | Aeoliella mucimassa |
| 9bact-a0a518dm04 | Lignipirellula cremea. Esterase | Lignipirellula cremea |
| 9bact-a0a518em16 | Planctomycetes bacterium Poly30. Esterase | Planctomycetes bacterium Poly30 |
| 9bact-a0a518isg4 | Rosistilla oblonga. Endo-1,4-beta-xylanase Z | Rosistilla oblonga |
| 9bact-a0a521cxs1 | Aliifodinibius sediminis. Esterase | Aliifodinibius sediminis |
| 9bact-a0a5b1cj93 | Rubripirellula obstinata. Esterase | Rubripirellula obstinata |
| 9bact-a0a5c5ywa2 | Planctomycetes bacterium CA13. Poly(3-hydroxyoctanoate) depolymerase | Planctomycetes bacterium CA13 |
| 9bact-a0a5c5z1r9 | Planctomycetes bacterium CA13. Esterase | Planctomycetes bacterium CA13 |
| 9bact-a0a5c6d0t9 | Candidatus Brocadiaceae bacterium S225. Poly(3-hydroxyoctanoate) depolymerase | Candidatus Brocadiaceae bacterium S225 |
| 9bact-a0a5c6dvt4 | Novipirellula artificiosorum. Endo-1,4-beta-xylanase Z | Novipirellula artificiosorum |
| 9bact-a0a5c6e3a4 | Novipirellula aureliae. Poly(3-hydroxyoctanoate) depolymerase | Novipirellula aureliae |
| 9bact-a0a5c6rr58 | Phaeodactylibacter luteus. Prolyl oligopeptidase family serine peptidase | Phaeodactylibacter luteus |
| 9bact-a0a6b3phf2 | Flavihumibacter soli. Prolyl oligopeptidase family serine peptidase | Flavihumibacter soli |
| 9bact-a0a6c2txz3 | Pontiella desulfatans. Poly(3-hydroxyoctanoate) depolymerase | Pontiella desulfatans |
| 9bact-a0a6m0icj2 | Spirosoma agri. Phospholipase | Spirosoma agri |
| 9bact-a0a7w9snw2 | Armatimonas rosea. Putative peptidase | Armatimonas rosea |
| 9bact-a0a846ms39 | Thermonema lapsum. Putative peptidase | Thermonema lapsum |
| 9bact-a0a8j8hhc2 | Geothrix sp. Prolyl oligopeptidase family serine peptidase | Geothrix sp. |
| 9bact-b8y567 | uncultured bacterium FLS18 Esterase\/lipase lip18C FLS18C | uncultured bacterium FLS18 |
| 9bact-b8y568 | uncultured bacterium FLS18 Esterase\/lipase FSL18D lip18D FLS18D | uncultured bacterium FLS18 |
| 9bact-estC55.165 | uncultured bacterium. Lipolytic protein estC55-165 | uncultured bacterium |
| 9bact-estC55.241 | uncultured bacterium. Lipolytic protein estC55-241 | uncultured bacterium |
| 9bact-estC76.137 | uncultured bacterium. Lipolytic protein estC76-137 | uncultured bacterium |
| 9bact-h1xxs8 | Caldithrix abyssi DSM 13497. Phospholipase\/Carboxylesterase | Caldithrix abyssi DSM 13497 |
| 9bact-i3ijt8 | Candidatus Jettenia caeni. Putative phospholipase\/carboxylesterase | Candidatus Jettenia caeni |
| 9burk-a0a2g8t183 | Massilia psychrophila. Phospholipase | Massilia psychrophila |
| 9dein-a0a399eza3 | Calidithermus roseus. Poly(3-hydroxyoctanoate) depolymerase | Calidithermus roseus |
| 9dein-a0a399ezs4 | Meiothermus luteus. Poly(3-hydroxyoctanoate) depolymerase | Meiothermus luteus |
| 9dein-a0a399f775 | Meiothermus granaticius NBRC 107808. Poly(3-hydroxyoctanoate) depolymerase | Meiothermus granaticius NBRC 107808 |
| 9firm-a0a8j8mq45 | Vallitalea pronyensis. Dienelactone hydrolase family protein | Vallitalea pronyensis |
| 9flao-a0a086b4l5 | Chryseobacterium piperi. Phospholipase | Chryseobacterium piperi |
| 9flao-a0a2s7t5t0 | Aureicoccus marinus. Alpha\/beta hydrolase | Aureicoccus marinus |
| 9flao-a0a4r6qbr8 | Flavobacterium dankookense. Dienelactone hydrolase family protein | Flavobacterium dankookense |
| 9fung-a0a261xx90 | Bifiguratus adelaidae. Phospholipase | Bifiguratus adelaidae |
| 9gamm-a0a0h1aj55 | Luteimonas sp. FCS-9. Phospholipase | Luteimonas sp. FCS-9 |
| 9gamm-a0a0r0cdy8 | Pseudoxanthomonas dokdonensis. Phospholipase | Pseudoxanthomonas dokdonensis |
| 9gamm-a0a1i6lz40 | Dyella sp. OK004. Alpha\/beta hydrolase family protein | Dyella sp. OK004 |
| 9gamm-a0a1t5ll95 | Pseudoxanthomonas indica. Prolyl oligopeptidase family protein | Pseudoxanthomonas indica |
| 9gamm-a0a1v3pv93 | Rhodanobacter sp. B05. Esterase | Rhodanobacter sp. B05 |
| 9gamm-a0a286ddm5 | Pseudoxanthomonas wuyuanensis. Prolyl oligopeptidase family protein | Pseudoxanthomonas wuyuanensis |
| 9gamm-a0a2c6dl03 | Budvicia aquatica. Poly(3-hydroxybutyrate) depolymerase | Budvicia aquatica |
| 9gamm-a0a2n7qvq6 | Dyella sp. AD56. Poly(3-hydroxyoctanoate) depolymerase | Dyella sp. AD56 |
| 9gamm-a0a2u9t6h6 | Lysobacter maris. Phospholipase | Lysobacter maris |
| 9gamm-a0a4q6c6n9 | Xanthomonadaceae bacterium. Phospholipase | Xanthomonadaceae bacterium |
| 9gamm-a0a7w3flp4 | Stenotrophomonas tumulicola. Prolyl oligopeptidase family serine peptidase | Stenotrophomonas tumulicola |
| 9gamm-a0a7w8jrk7 | Rhodanobacter sp. ANJX3. Putative peptidase | Rhodanobacter sp. ANJX3 |
| 9gamm-a0a7w9z3w3 | Rhodanobacter sp. MP7CTX1. Putative peptidase | Rhodanobacter sp. MP7CTX1 |
| 9gamm-a0a7x5zk95 | Luteibacter anthropi. Prolyl oligopeptidase family serine peptidase | Luteibacter anthropi |
| 9gamm-a0a853jfc1 | Luteimonas salinisoli. Prolyl oligopeptidase family serine peptidase | Luteimonas salinisoli |
| 9gamm-a0a8j7vvh3 | Coralloluteibacterium stylophorae. Prolyl oligopeptidase family serine peptidase | Coralloluteibacterium stylophorae |
| 9hyph-a0a1b2ekp4 | Microvirga ossetica. Phospholipase | Microvirga ossetica |
| 9noso-a0a2k8srx4 | Nostoc flagelliforme CCNUN1. Putative peptidase | Nostoc flagelliforme CCNUN1 |
| 9noso-a0a367qpg5 | Nostoc minutum NIES-26. Phospholipase | Nostoc minutum NIES-26 |
| 9nost-k9wxf4 | Cylindrospermum stagnale PCC 7417. Putative peptidase | Cylindrospermum stagnale PCC 7417 |
| 9plan-a0a142wv60 | Planctomyces sp. SH-PL14. Esterase | Planctomyces sp. SH-PL14 |
| 9plan-a0a1p8wgy3 | Fuerstiella marisgermanici. Esterase, PHB depolymerase family | Fuerstiella marisgermanici |
| 9rhoo-a0a840bme8 | Niveibacterium umoris. Putative esterase | Niveibacterium umoris |
| 9sphi-a0a0b8t3y0 | Sphingobacterium deserti. Phospholipase\/carboxylesterase | Sphingobacterium deserti |
| 9sphn-a0a395lhj7 | Alteriqipengyuania lutimaris. Phospholipase | Alteriqipengyuania lutimaris |
| 9zzzz-EH82 | uncultured organism EH82 EH76 Uncharacterized protein | uncultured organism |
| 9zzzz-t1ci96 | mine drainage metagenome Phospholipase\/carboxylesterase EstA9 | mine drainage metagenome |
| actsz-a6vkk1 | Actinobacillus succinogenes (strain ATCC 55618 \/ 130Z) conserved hypothetical precursor | Actinobacillus succinogenes 130Z |
| anavt-q3m5j3 | Anabaena variabilis (strain ATCC 29413 \/ PCC 7937) phospholipase\/carboxylesterase | Anabaena variabilis |
| astec-e8rn60 | Asticcacaulis excentricus (strain ATCC 15261 \/ DSM 4724 \/ KCTC 12464 \/ NCIMB 9791 \/ VKM B-1370 \/ CB 48). Phospholipase\/Carboxylesterase | Asticcacaulis excentricus |
| bacfr-q64n33 | Bacteroides fragilis ( and strain ATCC 25285 \/ NCTC 9343) hypothetical protein | Bacteroides fragilis |
| bacsk-q5wbk1 | Bacillus clausii (strain KSM-K16) hypothetical protein | Bacillus clausii |
| bactn-BT3286 | Bacteroides thetaiotaomicron conserved hypothetical protein | Bacteroides thetaiotaomicron |
| braja-BLL1350 | Bradyrhizobium japonicum bll1350 protein | Bradyrhizobium japonicum |
| flaj1-a5fe33 | Flavobacterium johnsoniae (strain ATCC 17061 \/ DSM 2064 \/ UW101) (Cytophaga johnsonae) phospholipase\/carboxylesterase precursor | Flavobacterium johnsoniae UW101 |
| geos4-d3efm9 | Geobacillus sp.\; Paenibacillus uliginis\; Paenibacillus aquistagni . Phospholipase\/Carboxylesterase | Geobacillus sp. |
| halo1-d0lmj0 | Haliangium ochraceum (strain DSM 14365 \/ JCM 11303 \/ SMP-2) Phospholipase\/Carboxylesterase |
Haliangium ochraceum |
| meisd-d7bfp6 | Meiothermus silvanus (strain ATCC 700542 \/ DSM 9946 \/ VI-R2) (Thermus silvanus). Phospholipase\/Carboxylesterase | Meiothermus silvanus |
| mycua-a0pqs2 | Mycobacterium ulcerans (strain Agy99) Mycobacterium sp. (strain JLS) Mycobacterium marinum (strain ATCC BAA-535 \/ M) Putative uncharacterized protein | Mycobacterium ulcerans |
| myxxd-q1cxe9 | Myxococcus xanthus (strain DK 1622) Putative lipoprotein | Myxococcus xanthus |
| nosco-q3i1p4 | Nostoc commune UTEX 584 peptidase | Nostoc commune UTEX 584 |
| nosp7-b2j3d7 | Nostoc punctiforme (strain ATCC 29133 \/ PCC 73102). Dienelactone hydrolase | Nostoc punctiforme |
| pasmu-PM1358 | Pasteurella multocida hypothetical protein pm1358 | Pasteurella multocida |
| pirsd-d2r024 | Pirellula staleyi (strain ATCC 27377 \/ DSM 6068 \/ ICPB 4128) (Pirella staleyi). Phospholipase\/Carboxylesterase | Pirellula staleyi |
| pseuu-e6wrv7 | Pseudoxanthomonas suwonensis (strain 11-1). Putative phospholipase\/carboxylesterase protein | Pseudoxanthomonas suwonensis |
| rhime-RB0531 | Rhizobium meliloti (Sinorhizobium meliloti) hypothetical protein rb0531 | Sinorhizobium meliloti |
| rhoba-q7ule9 | Rhodopirellula baltica hypothetical protein | Rhodopirellula baltica |
| rhofd-q21zf7 | Rhodoferax ferrireducens (strain DSM 15236 \/ ATCC BAA-621 \/ T118) phospholipase\/carboxylesterase precursor | Rhodoferax ferrireducens |
| rhopa-q37hi0 | Rhodopseudomonas palustris BisB5 phospholipase\/carboxylesterase | Rhodopseudomonas palustris BisB5 |
| rhopa-q6ncc5 | Rhodopseudomonas palustris hypothetical protein | Rhodopseudomonas palustris |
| rubbr-f0sjb9 | Rubinisphaera brasiliensis (strain ATCC 49424 \/ DSM 5305 \/ JCM 21570 \/ IAM 15109 \/ NBRC 103401 \/ IFAM 1448) (Planctomyces brasiliensis). Phospholipase\/carboxylesterase | Rubinisphaera brasiliensis |
| solue-Q029Y4 | Solibacter usitatus Ellin6076 putative esterase precursor | Solibacter usitatus Ellin6076 |
| stiad-q09av6 | Stigmatella aurantiaca (strain DW4\/3-1) PKD domain protein | Stigmatella aurantiaca |
| stiad-q09db1 | Stigmatella aurantiaca (strain DW4\/3-1) Uncharacterized protein | Stigmatella aurantiaca |
| strmk-b2frv5 | Stenotrophomonas maltophilia (strain K279a). Peptidase_S9 domain-containing protein | Stenotrophomonas maltophilia |
| symth-q67nt3 | Symbiobacterium thermophilum hypothetical protein | Symbiobacterium thermophilum |
| theha-a0a326uec2 | Thermosporothrix hazakensis. Phospholipase\/carboxylesterase | Thermosporothrix hazakensis |
| thema-TM0033 | Thermotoga maritima (strain ATCC 43589 \/ MSB8 \/ DSM 3109 \/ JCM 10099)a EstA hypothetical 44.8 kda protein |
Thermotoga maritima |
| trurr-d7cxw6 | Truepera radiovictrix (strain DSM 17093 \/ CIP 108686 \/ LMG 22925 \/ RQ-24). Dienelactone hydrolase | Truepera radiovictrix |
| xanax-XAC2981 | Xanthomonas axonopodis (pv. citri) Xanthomonas campestris pv. vesicatoria (strain 85-10) hypothetical protein xac2981 | Xanthomonas axonopodis |
| xanca-XCC2811 | Xanthomonas campestris (pv. campestris) ( and strain 8004) hypothetical protein xcc2811 | Xanthomonas campestris |
| xanor-q5h3e2 | Xanthomonas oryzae pv. oryzae (and strain MAFF 311018) hypothetical protein | Xanthomonas oryzae |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| Malonyl-CoA | 3-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3-oxopropanoic acid | ecoli-ybff |
| P(3HO) | psefl-phaz pseac-q6ufw4 | |
| P(6HO) | psefl-phaz | |
| Paranitrophenylvalerate | (4-nitrophenyl) pentanoate | 9bact-TtEst2 |
| poly-3-hydroxynonanoate | pseac-q6ufw4 | |
| unsaturated-poly-3-hydroxynonanoate | pseac-q6ufw4 |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| AEBSF | 4-(2-aminoethyl)benzenesulfonyl fluoride | pig-dpp4 leima-OPB halo1-d0lmj0 human-FAP myctu-ym24 |
| HDFP | 1-(ethoxy-fluoro-oxidophosphaniumyl)hexadecane | human-PREPL |
| Palmostatin-B | (3S,4S)-3-decyl-4-[2-(3,4-dimethoxyphenyl)ethyl]oxetan-2-one | human-ABHD16A human-ABHD6 human-FASN human-ABHD17A human-ABHD17B human-ABHD17C human-LYPLA1 human-LYPLA2 human-PREPL |
| Paraoxon | diethyl (4-nitrophenyl) phosphate | human-PLA2G7 human-PNLIPRP2 humin-cut human-ACHE promi-c2lfd0 yeast-yjg8 bacpu-AXE sulto-ST0071 aspor-cutas pig-1plip fusso-cutas lacrh-B2CZF3 thema-TM0033 colgl-cutas psesp-Q9RBY1 actde-CXE1 myctu-a85c thema-TM0077 rhimi-lipas bacpu-w8fke7 9bact-KP212148 |
References (2)
| Title : Crystal structure and biochemical properties of a novel thermostable esterase containing an immunoglobulin-like domain - Levisson_2009_J.Mol.Biol_385_949 |
| Author(s) : Levisson M , Sun L , Hendriks S , Swinkels P , Akveld T , Bultema JB , Barendregt A , van den Heuvel RH , Dijkstra BW , Van der Oost J , Kengen SW |
| Ref : Journal of Molecular Biology , 385 :949 , 2009 |
| Abstract : |
| PubMedSearch : Levisson_2009_J.Mol.Biol_385_949 |
| PubMedID: 19013466 |
| Gene_locus related to this paper: thema-TM0033 |
| Title : Enzyme genomics: Application of general enzymatic screens to discover new enzymes - Kuznetsova_2005_FEMS.Microbiol.Rev_29_263 |
| Author(s) : Kuznetsova E , Proudfoot M , Sanders SA , Reinking J , Savchenko A , Arrowsmith CH , Edwards AM , Yakunin AF |
| Ref : FEMS Microbiology Reviews , 29 :263 , 2005 |
| Abstract : |
| PubMedSearch : Kuznetsova_2005_FEMS.Microbiol.Rev_29_263 |
| PubMedID: 15808744 |
| Gene_locus related to this paper: ecoli-yafa , ecoli-ybff , ecoli-ycjy , ecoli-yeiG , ecoli-YFBB , ecoli-yjfp , ecoli-ypfh , ecoli-yqia , ecoli-yuar |