This family has been recognized as alpha/beta hydrolase by Kamil et al. Previously associated with Lipoprotein_lipase family but is also close to phospholipase. vLIP may not serve as a traditional lipase enzyme, but the serine nucleophile position is essential in vivo for the viral functions of vLIP. Could be example of repurposing alpha/beta hydrolase fold toward a nonenzymatic role, possibly in lipid bonding
Interpro : IPR000734 Lipase
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF00151 Lipase , IPR013818 Lipase
Prints : No Print
EC Number : No EC Number
No structure scheme yet for this family
Genes Proteins in Avian-virus_vlip family (7)
No fragment of genes
No fragment of genesNo substrate
No Inhibitor
Title : vLIP, a viral lipase homologue, is a virulence factor of Marek's disease virus - Kamil_2005_J.Virol_79_6984 |
Author(s) : Kamil JP , Tischer BK , Trapp S , Nair VK , Osterrieder N , Kung HJ |
Ref : J Virol , 79 :6984 , 2005 |
PubMedID: 15890938 |
Gene_locus related to this paper: mardi-ORF1 |