BotH

Relationship

Family: BotH

Block: X

Parent Family: No family

Comment

"The bottromycin epimerase BotH defines a group of atypical alpha/beta-hydrolase-fold enzymes. BotH is a peptide epimerase responsible for the post-translational epimerization of L-Asp to D-Asp during bottromycin biosynthesis. D-amino acids endow peptides with diverse, desirable properties, but the post-translational and site-specific epimerization of L-amino acids into their D-counterparts is rare and chemically challenging. The activity does not rely on a catalytic triad. No conservation of Ser (replaced by Phe) nor His or Asp. The residues Phe110 and Val41 seem important in hydrogen bonding to substrate"

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

References (1)

Title : The bottromycin epimerase BotH defines a group of atypical alpha\/beta-hydrolase-fold enzymes - Sikandar_2020_Nat.Chem.Biol_16_1013
Author(s) : Sikandar A , Franz L , Adam S , Santos-Aberturas J , Horbal L , Luzhetskyy A , Truman AW , Kalinina OV , Koehnke J
Ref : Nat Chemical Biology , 16 :1013 , 2020
Abstract : Sikandar_2020_Nat.Chem.Biol_16_1013
ESTHER : Sikandar_2020_Nat.Chem.Biol_16_1013
PubMedSearch : Sikandar_2020_Nat.Chem.Biol_16_1013
PubMedID: 32601484
Gene_locus related to this paper: 9actn-k4mhv9

Structures (5)

Genes Proteins in BotH family (10)

No fragment of genes

Structures in BotH family (5)

Substrates in BotH family (4)

No Inhibitor