Insect_Phospholipase
Relationship
Comment
Phospholipase A(1) (PLA(1)) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids and is conserved in a wide range of organisms. Included in this family are Vespid venom allergen phospholipase A1. Vespid phospholipase A1 (vPLA1) is one of the primary venom components with local inflammatory effects. 
In addition to causing allergic reactions, vPLA1 can hydrolyze the sn-1 fatty acids in phospholipids and convert them into their corresponding lyso compounds. vPLA1 may disrupt the phospholipid packing of biological membranes, causing severe hemolysis and leading to cardiac dysfunction and death in animals
Database
Interpro : IPR000734 Lipase , IPR002334 Dol\/Ves 1 allergen , IPR013818 Lipase
PIRSF : No PIRSF
Pdoc : PDOC00110
Pfam : PF00151 Lipase
Prints : PR00821 , PR00825
EC Number : 3.1.1.32
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| dinqu-pa1 | Dinoponera quadriceps (South American ant). Venom allergen 1 | Dinoponera quadriceps |
| dolma-ppla1 | Dolichovespula maculata mRNA for phospholipase A1 | Dolichovespula maculata |
| dolma-ppla12 | Dolichovespula maculata venom phospholipase A1 2 | Dolichovespula maculata |
| polan-pla1 | Polistes annularis phospholipase A1 mRNA | Polistes annularis |
| poldo-q6q252 | Polistes dominulus (European paper wasp) (Vespa dominula) venom phospholipase a1 1 precursor | Polistes dominulus |
| polpi-pa1 | Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp) Venom phospholipase A1 | Polybia paulista |
| solin-q68kk0 | Solenopsis invicta (Red imported fire ant) allergen sol I 1 precursor | Solenopsis invicta |
| vesaf-PA11 | Vespa affinis (Lesser banded hornet) Phospholipase A1 1, Allergen Vesp a 1, Ves a 1. Vespapase | Vespa affinis |
| vesba-pa1 |  Vespa basalis (hornet) phospholipase A 1 from venom |
Vespa basalis |
| vescr-PA1 | Vespa crabro (European hornet) Phospholipase A1 from venom | Vespa crabro |
| vesge-PA1 | Vespula germanica (German yellow jacket) (German wasp) ves g 1 allergen (fragment) | Vespula germanica |
| vesmc-ppla1 | Vespula maculifrons venom phospholipases A1 | Vespula maculifrons |
| vesmg-pa1 | Vespa magnifica (Hornet) Probable phospholipase A1 magnifin | Vespa magnifica |
| vessq-pa1 | Vespula squamosa (Southern yellow jacket) (Wasp). Phospholipase A1 | Vespula squamosa |
| vestr-vest1 | Vespa tropica (Greater banded hornet) (Sphex tropica). Phospholipase A1 VesT1.02 | Vespa tropica |
| vesve-pa1 | Vespa velutina (Asian yellow-legged hornet). Vesp v 1 | Vespa velutina |
| vesvu-pa1 | Vespula vulgaris (Yellow jacket) (Wasp) phospholipase a1 precursor (EC 3.1.1.32) (allergen ves v 1) | Vespula vulgaris |
References (1)
| Title : Crystal structure of vespid phospholipase A1 reveals insights into the mechanism for cause of membrane dysfunction - Hou_2016_Insect.Biochem.Mol.Biol_68_79 |
| Author(s) : Hou MH , Chuang CY , Ko TP , Hu NJ , Chou CC , Shih YP , Ho CL , Wang AH |
| Ref : Insect Biochemistry & Molecular Biology , 68 :79 , 2016 |
| Abstract : |
| PubMedSearch : Hou_2016_Insect.Biochem.Mol.Biol_68_79 |
| PubMedID: 26603193 |
| Gene_locus related to this paper: vesba-pa1 |