Lipase_bact_N_lipase
Relationship
Comment
This family has the N-terminal region of bacterial virulence factor lipase. The N-terminal region contains a potential signalling sequence. Most proteins with this N-terminal sequence have a typical alpha/beta hydrolase following in c-term. The N-terminal region is found also in proteins without lipase or alpha/beta hydrolases. The N-term domain is used to populate the family but is excluded here. Chuang et al. on aerhy-LIP found hydrolysis of p-nitrophenyl esters (optimum C10-C12) and triacylglycerols (optimum C8- C10)
Database
Interpro : IPR025920 Bacterial virulence factor lipase N-terminal domain , IPR020009 Extracellular lipase, Pla-1\/cef family Extracell_lipase_Pla-1\/cef_e
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF12262 Lipase_bact_N
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| 9bact-estC55.102 | uncultured bacterium. Lipolytic protein estC55-102 | uncultured bacterium |
| 9bact-estC55.102 | uncultured bacterium. Lipolytic protein estC55-102 | uncultured bacterium |
| 9zzzz-a0a0g3fe15 | uncultured organism EH75 Uncharacterized protein | uncultured organism |
| 9zzzz-a0a0g3fe15 | uncultured organism EH75 Uncharacterized protein | uncultured organism |
| aerhy-LIP | Aeromonas hydrophila extracellular lipase | Aeromonas hydrophila |
| aerhy-LIP | Aeromonas hydrophila extracellular lipase | Aeromonas hydrophila |
| aerhy-PLA | Aeromonas hydrophila phospholipase a1 | Aeromonas hydrophila |
| aerhy-PLA | Aeromonas hydrophila phospholipase a1 | Aeromonas hydrophila |
| aerhy-Q44055 | Aeromonas hydrophila phospholipase c | Aeromonas hydrophila |
| aerhy-Q44055 | Aeromonas hydrophila phospholipase c | Aeromonas hydrophila |
| aerhy-lipe | Aeromonas hydrophila extracellular lipase (lip) [H3 Genomic 2842 nt] | Aeromonas hydrophila |
| aerhy-lipe | Aeromonas hydrophila extracellular lipase (lip) [H3 Genomic 2842 nt] | Aeromonas hydrophila |
| sheon-SO2934 | Shewanella oneidensis conserved hypothetical protein | Shewanella oneidensis |
| sheon-SO2934 | Shewanella oneidensis conserved hypothetical protein | Shewanella oneidensis |
| vibch-VCA0863 | Vibrio cholerae lipase, putative | Vibrio cholerae |
| vibch-VCA0863 | Vibrio cholerae lipase, putative | Vibrio cholerae |
| vibpa-VPA0859 | Vibrio parahaemolyticus putative lipase | Vibrio parahaemolyticus |
| vibpa-VPA0859 | Vibrio parahaemolyticus putative lipase | Vibrio parahaemolyticus |
| vibvu-VV20248 | Vibrio vulnificus hydrolases of the alpha\/beta superfamily | Vibrio vulnificus |
| vibvu-VV20248 | Vibrio vulnificus hydrolases of the alpha\/beta superfamily | Vibrio vulnificus |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| Paranitrophenyl-decanoate | (4-nitrophenyl) decanoate | |
| Paranitrophenyl-decanoate | (4-nitrophenyl) decanoate | |
| Paranitrophenyl-laurate | (4-nitrophenyl) dodecanoate | copci-b9u443 thite-g2rae6 crysp-Q874E9 9gamm-urc15994 |
| Paranitrophenyl-laurate | (4-nitrophenyl) dodecanoate | copci-b9u443 thite-g2rae6 crysp-Q874E9 9gamm-urc15994 |
| Tributyrin | 2,3-di(butanoyloxy)propyl butanoate | bovin-balip rabit-1cxes pseae-llipa canar-LipB human-PNLIPRP2 talth-f6lqk7 nech7-c7yuz1 cavpo-2plrp human-CEL human-PNLIP canan-lipasA rhimi-lipas rhidl-lipas psesp-Q9RBY1 staha-Q9RGZ6 9bact-6EB3 pig-EST1 |
| Tributyrin | 2,3-di(butanoyloxy)propyl butanoate | bovin-balip rabit-1cxes pseae-llipa canar-LipB human-PNLIPRP2 talth-f6lqk7 nech7-c7yuz1 cavpo-2plrp human-CEL human-PNLIP canan-lipasA rhimi-lipas rhidl-lipas psesp-Q9RBY1 staha-Q9RGZ6 9bact-6EB3 pig-EST1 |
References (8)
| Title : Cloning, sequencing, and role in virulence of two phospholipases (A1 and C) from mesophilic Aeromonas sp. serogroup O:34 - Merino_1999_Infect.Immun_67_4008 |
| Author(s) : Merino S , Aguilar A , Nogueras MM , Regue M , Swift S , Tomas JM |
| Ref : Infect Immun , 67 :4008 , 1999 |
| Abstract : |
| PubMedSearch : Merino_1999_Infect.Immun_67_4008 |
| PubMedID: 10417167 |
| Gene_locus related to this paper: aerhy-PLA |
| Title : Cloning, sequencing, and role in virulence of two phospholipases (A1 and C) from mesophilic Aeromonas sp. serogroup O:34 - Merino_1999_Infect.Immun_67_4008 |
| Author(s) : Merino S , Aguilar A , Nogueras MM , Regue M , Swift S , Tomas JM |
| Ref : Infect Immun , 67 :4008 , 1999 |
| Abstract : |
| PubMedSearch : Merino_1999_Infect.Immun_67_4008 |
| PubMedID: 10417167 |
| Gene_locus related to this paper: aerhy-PLA |
| Title : Molecular analysis and expression of the extracellular lipase of Aeromonas hydrophila MCC-2 - Chuang_1997_Microbiology_143 ( Pt 3)_803 |
| Author(s) : Chuang YC , Chiou SF , Su JH , Wu ML , Chang MC |
| Ref : Microbiology , 143 ( Pt 3) :803 , 1997 |
| Abstract : |
| PubMedSearch : Chuang_1997_Microbiology_143 ( Pt 3)_803 |
| PubMedID: 9084164 |
| Gene_locus related to this paper: aerhy-LIP |
| Title : Molecular analysis and expression of the extracellular lipase of Aeromonas hydrophila MCC-2 - Chuang_1997_Microbiology_143 ( Pt 3)_803 |
| Author(s) : Chuang YC , Chiou SF , Su JH , Wu ML , Chang MC |
| Ref : Microbiology , 143 ( Pt 3) :803 , 1997 |
| Abstract : |
| PubMedSearch : Chuang_1997_Microbiology_143 ( Pt 3)_803 |
| PubMedID: 9084164 |
| Gene_locus related to this paper: aerhy-LIP |
| Title : Purification and characterization of a Chinese hamster ovary cell elongation factor of Vibrio hollisae - Kothary_1995_Infect.Immun_63_2418 |
| Author(s) : Kothary MH , Claverie EF , Miliotis MD , Madden JM , Richardson SH |
| Ref : Infect Immun , 63 :2418 , 1995 |
| Abstract : |
| PubMedSearch : Kothary_1995_Infect.Immun_63_2418 |
| PubMedID: 7790052 |
| Title : Purification and characterization of a Chinese hamster ovary cell elongation factor of Vibrio hollisae - Kothary_1995_Infect.Immun_63_2418 |
| Author(s) : Kothary MH , Claverie EF , Miliotis MD , Madden JM , Richardson SH |
| Ref : Infect Immun , 63 :2418 , 1995 |
| Abstract : |
| PubMedSearch : Kothary_1995_Infect.Immun_63_2418 |
| PubMedID: 7790052 |
| Title : Purification, gene cloning, amino acid sequence analysis, and expression of an extracellular lipase from an Aeromonas hydrophila human isolate - Anguita_1993_Appl.Environ.Microbiol_59_2411 |
| Author(s) : Anguita J , Rodriguez Aparicio LB , Naharro G |
| Ref : Applied Environmental Microbiology , 59 :2411 , 1993 |
| Abstract : |
| PubMedSearch : Anguita_1993_Appl.Environ.Microbiol_59_2411 |
| PubMedID: 8368830 |
| Gene_locus related to this paper: aerhy-lipe |
| Title : Purification, gene cloning, amino acid sequence analysis, and expression of an extracellular lipase from an Aeromonas hydrophila human isolate - Anguita_1993_Appl.Environ.Microbiol_59_2411 |
| Author(s) : Anguita J , Rodriguez Aparicio LB , Naharro G |
| Ref : Applied Environmental Microbiology , 59 :2411 , 1993 |
| Abstract : |
| PubMedSearch : Anguita_1993_Appl.Environ.Microbiol_59_2411 |
| PubMedID: 8368830 |
| Gene_locus related to this paper: aerhy-lipe |