9actn-l7pij2

Streptomyces flocculus Streptonigrin methylesterase A (StnA) hydrolase

Comment

Streptonigrin (STN) is a highly functionalized aminoquinone antitumor antibiotic produced by Streptomyces flocculus. Streptonigrin methylesterase A (StnA) is one of the tailoring enzymes that modify the aminoquinone skeleton in the biosynthesis pathway of Streptomyces species

Relationship

Family : 6_AlphaBeta_hydrolase

Block : X

Position in NCBI Life Tree : Streptomyces flocculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Streptomycetales N E > Streptomycetaceae N E > Streptomyces N E > Streptomyces albus group N E > Streptomyces flocculus N E

Molecular evidence

No mutation

No kinetic

No disease

No inhibitor

Database

Sequence

Peptide

MTALSRLGEP PSGHDGNSEV RRIAMKRATV PVLRRVAAVC AAALLVTVGT GGPASATGTR SAICRATTVE VTLGKGTGKM WGELCRPAGS SPDTVVTMVH GATYNHNYWD FPYQPDKYSF RKMLNGAGYA TFVVDRLGTG NSTVPPSSEL NLTVEARQMH EVVQGLRTGR IGGTGFGKVV LAGYSLGSAV TSIEASTFHD VDAVLITALG HYNNPAGTQA IIDNGLSPND DPVLKDRHHY DDGYATTKPG SRKHVFYADR PMDPGVLATD ELTKDANVFT EAADPLVIDP AVSRAIDVPV MFALGDRDPL MCGDGYEDCS SQAALRAQEA PFWTSAPSFD VILVEDAGHG LNLVPNTRVY QDASRDWLDR VVGHG

References (3)

Title : A novel streptonigrin type alkaloid from the Streptomyces flocculus CGMCC 4.1223 mutant stnA\/Q2 - Wang_2020_Nat.Prod.Res__3
Author(s) : Wang X , Xu F , Huang T , Deng Z , Lin S
Ref : Nat Prod Res , :1 , 2020
PubMedID: 33280413
Gene_locus related to this paper: 9actn-l7pij2

Title : Crystal Structure of StnA for the Biosynthesis of Antitumor Drug Streptonigrin Reveals a Unique Substrate Binding Mode - Qian_2017_Sci.Rep_7_40254
Author(s) : Qian T , Wo J , Zhang Y , Song Q , Feng G , Luo R , Lin S , Wu G , Chen HF
Ref : Sci Rep , 7 :40254 , 2017
PubMedID: 28074848
Gene_locus related to this paper: 9actn-l7pij2

Title : Characterization of streptonigrin biosynthesis reveals a cryptic carboxyl methylation and an unusual oxidative cleavage of a N-C bond - Xu_2013_J.Am.Chem.Soc_135_1739
Author(s) : Xu F , Kong D , He X , Zhang Z , Han M , Xie X , Wang P , Cheng H , Tao M , Zhang L , Deng Z , Lin S
Ref : Journal of the American Chemical Society , 135 :1739 , 2013
PubMedID: 23301954
Gene_locus related to this paper: 9actn-l7pij2