9euro-PyaF

Pyrenula sp. pyrenulic acid (pya) biosynthetic gene cluster PyaF

Comment

The pyrenulic acid (pya) biosynthetic gene PyaF constructs a 6- and 7-membered fused bicyclic diether skeleton by catalyzing successive epoxide ring-opening 6-endo and 7-endo cyclization reactions

Relationship

Family : 6_AlphaBeta_hydrolase

Block : X

Position in NCBI Life Tree : Pyrenula sp.

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

Molecular evidence

No mutation

No structure

No kinetic

No disease

No inhibitor

Database

No Interpro

No Pfam

No UniProt

No PIRSF

No SUPERFAM

Sequence

Peptide

MSLSARAGLT AIVAIVAFVI AHRLYHEPLF AWIPFSTTPY WPPPAAISVP PPCSQPFTWE EGNCMVRLGD LNFELQVRGK HLPTPLDTSS PSDIPIIFPS PGWGLDCGLK FAGLESLFPS HTFLCMVVRG NYPSDRPPKE SDMTSTAMAH DLELLRMYLD LPRLRLYAHS IGGTIALGYA ELYPSHVASL VLVDAKMLDH DDTPTLMQFV RDRAADPRFS TSIAALKISA NFSDPAFPKN DPEYRHLLLD LLPWYFSRPE LHLPHYARQV QARPLASNWA LIAHDKANIR DPTPNKALLG TVIAPTLIIV GEHDAFCTKK VAEIMHAGIR DSELVVYDEC GNLPWVERKE DFTRKLEEWW SKY

References (1)

Title : Enzymatic Anti-Baldwin Ring-Closure Cascade for Fused Bicyclic Ether Formation - Sato_2025_J.Am.Chem.Soc__
Author(s) : Sato M , Ito Y , Kagoura T , Sakano S , Tsunematsu Y , Cheng J , Bianchi P , Houk KN , Watanabe K
Ref : Journal of the American Chemical Society , : , 2025
Abstract :
PubMedSearch : Sato_2025_J.Am.Chem.Soc__
PubMedID: 41218998
Gene_locus related to this paper: 9euro-PyaF