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aspfu-fmac

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus). Fumagillin biosynthesis acyltransferase

Comment

Relationship

Family : Thiohydrolase

Block : X

Position in NCBI Life Tree : Neosartorya fumigata

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Pezizomycotina N E > leotiomyceta N E > Eurotiomycetes N E > Eurotiomycetidae N E > Eurotiales N E > Aspergillaceae N E > Aspergillus N E > Aspergillus fumigatus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MNREDVEFPT CDGLILRGWL YPGTIRGPAI VMNQGFNTPK EILLPDVAVW FQQQGVTVLL YDNRCIGASD GEPRNDVKPA KLVEDFHDAL TFMARHPMVD EDKIILYGYS FSAMTALVAA GLDHRVGAAI SVTPIANYDF REKEKNNVMA LAMQDRVSTL AGNDPVYIPF VGDDGYNPAG WGNQYNMEQF RAFLGTSFFT NRTTVQSYYH VLAWQPYGAM RLIKGTPVMM VTPAEDTISS PADQRAVFDM IPEPNKEFDL VAGRGHMDVI NGEGAEEVLQ RQLAFMRKHL DF

References (9)

Title : Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway - Lin_2014_J.Am.Chem.Soc_136_4426
Author(s) : Lin HC , Tsunematsu Y , Dhingra S , Xu W , Fukutomi M , Chooi YH , Cane DE , Calvo AM , Watanabe K , Tang Y
Ref : Journal of the American Chemical Society , 136 :4426 , 2014
PubMedID: 24568283
Gene_locus related to this paper: aspfu-fmac

Title : Prototype of an intertwined secondary-metabolite supercluster - Wiemann_2013_Proc.Natl.Acad.Sci.U.S.A_110_17065
Author(s) : Wiemann P , Guo CJ , Palmer JM , Sekonyela R , Wang CC , Keller NP
Ref : Proc Natl Acad Sci U S A , 110 :17065 , 2013
PubMedID: 24082142
Gene_locus related to this paper: aspfu-psoB , aspfu-fmac

Title : The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of beta-trans-bergamotene - Lin_2013_J.Am.Chem.Soc_135_4616
Author(s) : Lin HC , Chooi YH , Dhingra S , Xu W , Calvo AM , Tang Y
Ref : Journal of the American Chemical Society , 135 :4616 , 2013
PubMedID: 23488861
Gene_locus related to this paper: aspfu-fmac

Title : The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus - Dhingra_2013_PLoS.One_8_e77147
Author(s) : Dhingra S , Lind AL , Lin HC , Tang Y , Rokas A , Calvo AM
Ref : PLoS ONE , 8 :e77147 , 2013
PubMedID: 24116213
Gene_locus related to this paper: aspfu-fmac

Title : An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis - Lazarus_2008_Inflamm.Res_57_18
Author(s) : Lazarus DD , Doyle EG , Bernier SG , Rogers AB , Labenski MT , Wakefield JD , Karp RM , Clark EJ , Lorusso J , Hoyt JG , Thompson CD , Hannig G , Westlin WF
Ref : Inflamm Res , 57 :18 , 2008
PubMedID: 18209961
Gene_locus related to this paper: aspfu-fmac

Title : Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus - Nierman_2005_Nature_438_1151
Author(s) : Nierman WC , Pain A , Anderson MJ , Wortman JR , Kim HS , Arroyo J , Berriman M , Abe K , Archer DB , Bermejo C , Bennett J , Bowyer P , Chen D , Collins M , Coulsen R , Davies R , Dyer PS , Farman M , Fedorova N , Feldblyum TV , Fischer R , Fosker N , Fraser A , Garcia JL , Garcia MJ , Goble A , Goldman GH , Gomi K , Griffith-Jones S , Gwilliam R , Haas B , Haas H , Harris D , Horiuchi H , Huang J , Humphray S , Jimenez J , Keller N , Khouri H , Kitamoto K , Kobayashi T , Konzack S , Kulkarni R , Kumagai T , Lafon A , Latge JP , Li W , Lord A , Lu C , Majoros WH , May GS , Miller BL , Mohamoud Y , Molina M , Monod M , Mouyna I , Mulligan S , Murphy L , O'Neil S , Paulsen I , Penalva MA , Pertea M , Price C , Pritchard BL , Quail MA , Rabbinowitsch E , Rawlins N , Rajandream MA , Reichard U , Renauld H , Robson GD , Rodriguez de Cordoba S , Rodriguez-Pena JM , Ronning CM , Rutter S , Salzberg SL , Sanchez M , Sanchez-Ferrero JC , Saunders D , Seeger K , Squares R , Squares S , Takeuchi M , Tekaia F , Turner G , Vazquez de Aldana CR , Weidman J , White O , Woodward J , Yu JH , Fraser C , Galagan JE , Asai K , Machida M , Hall N , Barrell B , Denning DW
Ref : Nature , 438 :1151 , 2005
PubMedID: 16372009
Gene_locus related to this paper: aspfc-b0xp50 , aspfc-b0xu40 , aspfc-b0xzj6 , aspfc-dpp5 , aspfu-apth1 , aspfu-axe1 , aspfu-CBPYA , aspfu-faec , aspfu-kex1 , aspfu-ppme1 , aspfu-q4wa39 , aspfu-q4wa78 , aspfu-q4wf56 , aspfu-q4wg73 , aspfu-q4wk44 , aspfu-q4wkh6 , aspfu-q4wnx3 , aspfu-q4wpb9 , aspfu-q4wqv2 , aspfu-q4wub2 , aspfu-q4wxr1 , aspfu-q4x0n6 , aspfu-q4x1n0 , aspfu-q5vjg7 , neofi-a1cwa6 , neofi-a1dfr9 , aspfm-a0a084bf80 , aspfu-fmac

Title : Fumagillin treatment of intestinal microsporidiosis - Molina_2002_N.Engl.J.Med_346_1963
Author(s) : Molina JM , Tourneur M , Sarfati C , Chevret S , de Gouvello A , Gobert JG , Balkan S , Derouin F
Ref : N Engl J Med , 346 :1963 , 2002
PubMedID: 12075057
Gene_locus related to this paper: aspfu-fmac

Title : The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2 - Sin_1997_Proc.Natl.Acad.Sci.U.S.A_94_6099
Author(s) : Sin N , Meng L , Wang MQ , Wen JJ , Bornmann WG , Crews CM
Ref : Proc Natl Acad Sci U S A , 94 :6099 , 1997
PubMedID: 9177176
Gene_locus related to this paper: aspfu-fmac

Title : The treatment of amebiasis with fumagillin -
Author(s) : Killough JH , Magill GB , Smith RC
Ref : Science , 115 :71 , 1952
PubMedID: 14913169
Gene_locus related to this paper: aspfu-fmac