Family: Thiohydrolase

Block: X

Parent Family: Peptidase_S15


Under construction: extracted from Xaa-Pro-like_dom. Penicillium sp. Chain-fusing Polyketide Gregatin A GrgF belongs to this family. Thioesterase DcsB: A polyketide cyclase that forms medium-ring Lactones. The nucleophile can be Ser as in beab2-j4wat9 (Beauveria bassiana (White muscardine disease fungus) thioesterase DcsB) or Cys as in pensq-GrgF (Penicillium sp. Chain-fusing Polyketide Gregatin A GrgF). The C115S mutant functions as a thioesterase, while losing the ability to perform chain fusion.


Interpro : No interpro


Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (3)

Genes Proteins in Thiohydrolase family (182)

Fragments of genes in Thiohydrolase family (3)

Structures in Thiohydrolase family (3)

Substrates in Thiohydrolase family (1)

No Inhibitor

References (2)

Title : A Polyketide Cyclase That Forms Medium-Ring Lactones - Gao_2021_J.Am.Chem.Soc_143_80
Author(s) : Gao DW , Jamieson CS , Wang G , Yan Y , Zhou J , Houk KN , Tang Y
Ref : Journal of the American Chemical Society , 143 :80 , 2021
PubMedID: 33351624
Gene_locus related to this paper: beab2-j4wat9

Title : Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide Gregatin A - Wang_2020_J.Am.Chem.Soc_142_8464
Author(s) : Wang WG , Wang H , Du LQ , Li M , Chen L , Yu J , Cheng GG , Zhan MT , Hu QF , Zhang L , Yao M , Matsuda Y
Ref : Journal of the American Chemical Society , 142 :8464 , 2020
PubMedID: 32275405
Gene_locus related to this paper: pensq-GrgF