strlu-c0l0l7

Streptomyces laurentii. TsrB TsrI protein

Comment

An alpha\/beta-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening\/macrocyclization

Relationship

Family : 6_AlphaBeta_hydrolase

Block : X

Position in NCBI Life Tree : Streptomyces laurentii

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Streptomycetales N E > Streptomycetaceae N E > Streptomyces N E > Streptomyces laurentii N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No inhibitor

Database

Sequence

Peptide

MRPVILVHGL LGTEDAHYAG CRKWWTRPVT EIRLPGHGTG GEIPPHPAAA AIDRVREAIR EQPEPPVVVG LSYLGAAVAF RAAAGFPATV AGIVMSGYSF LVSPDTLNRW LAGFTRMASH QPAAQRHFAE LHGPTWENLL TATFAELSDG CLRLPGVADL EHLPVPVQLV NGSLLQNERN AIGPAAAAGA DVAVIAGAGH VVPMDAPRVF AATVEDFADR VTAGRTAFHE RRRAAERAAA EPAVPPEAGT GTEPVARKAA THG

References (4)

Title : An alpha\/beta-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening\/macrocyclization - Zheng_2016_Proc.Natl.Acad.Sci.U.S.A_113_14318
Author(s) : Zheng Q , Wang S , Duan P , Liao R , Chen D , Liu W
Ref : Proc Natl Acad Sci U S A , 113 :14318 , 2016
PubMedID: 27911800
Gene_locus related to this paper: strlu-c0l0l7

Title : Complete Genome Sequence of Thiostrepton-Producing Streptomyces laurentii ATCC 31255 - Doi_2016_Genome.Announc_4_e00360
Author(s) : Doi K , Fujino Y , Nagayoshi Y , Ohshima T , Ogata S
Ref : Genome Announc , 4 : , 2016
PubMedID: 27257211
Gene_locus related to this paper: strlu-c0l0l7 , strlu-a0a160nuk7 , strlu-a0a169nf55

Title : Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications - Liao_2009_Chem.Biol_16_141
Author(s) : Liao R , Duan L , Lei C , Pan H , Ding Y , Zhang Q , Chen D , Shen B , Yu Y , Liu W
Ref : Chemical Biology , 16 :141 , 2009
PubMedID: 19246004
Gene_locus related to this paper: 9acto-c0jrv0 , 9acto-c0jrv6 , strlu-c0jry1 , 9actn-c0jrw3 , strlu-c0l0l7

Title : Thiostrepton biosynthesis: prototype for a new family of bacteriocins - Kelly_2009_J.Am.Chem.Soc_131_4327
Author(s) : Kelly WL , Pan L , Li C
Ref : Journal of the American Chemical Society , 131 :4327 , 2009
PubMedID: 19265401
Gene_locus related to this paper: strlu-c0jry1 , strlu-c0l0l7