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The server ESTHER (ESTerases and alpha/beta-Hydrolase Enzymes and Relatives) is dedicated to the analysis of proteins or protein domains belonging to the superfamily of alpha/beta-hydrolases, exemplified by the cholinesterases.



NEW Aljosa Bavec, Marko Golicnik, Stanko Gobec, and Jure Stojan announce that the 15th International Meeting on Cholinesterases and the 9th International Conference on Paraoxonases will take place in Kranj, Slovenia, from September 15th to 18th, 2024, at the Congress Centre Brdo. See the website now open (www.chepon2024.com)

The latest Newsletter is available here and previous issues can be retrieved from here. To receive the Newsletter by e-mail, please join the mailing list here

Jump to: Mutalign, human-ACHE, Esther overview, OverallTable, Meetings page, Table structures, Hall of Fame. Human a/b hydrolases
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  • March 13, 2024:
    The web site for the the 15th conference on cholinesterases and the 9th on paraoxonases is now open chepon2024 Due to security reasons the ESTHER database will change operating system in april. We hope it will be a smooth transition A-series agent A-234: initial in vitro and in vivo characterization is published by Hrabinova et al. Crystal structure and solution scattering of Geobacillus stearothermophilus S9 peptidase reveal structural adaptations for carboxypeptidase activity is published by Chandravanshi et al. and structure will be available soon (8WT1) Crystal structures of nanobodies bound to their antigen PA14 Cif (CFTR inhibitory factor, Epoxide Hydrolase Virulence Factor) are available (8EVD, 8F6U, 8F6V) and will be published soon by Simard et al. Polyketide trimming shapes dihydroxynaphthalene-melanin and anthraquinone pigments will be published soon by Schmalhofer et al. and Photorhabdus luminescens AntI polyketide shortening enzyme structures (8QBH, 8QBI, 8QD5, 8QD6) Aspergillus fumigatus yellowish-green heptaketide hydrolase Ayg1p structures (8QD1, 8QD2, 8QD3, 8QD4) and Wdyg1p from W. dermatitidis structures (8QD7, 8QD8, 8QD9, 8QDA, 8QDB) are available Discovery of the sEH inhibitor epoxykynin as a potent kynurenine pathway modulator is published by Dotsch et al. and structure of soluble epoxide hydrolase in complex with Epoxykinin is avalable (8QZD)

  • March 06, 2024:
    Structures of Epoxide hydrolase from Bosea sp. PAMC 26642 is available and from Caballeronia sordidicola PAMC 26510 are available (8HM5, 8HGU) and are published by Hwang et al. Crystal structure of engineered protein, Est30 variant KLS-MHETase M14 (I171K, M127S, and G130L) is available (8ILT) and published by Zhang et al. Engineered PETase enzyme from LCC - C09 mutant is available (8CMV) and will be published soon by Bhattacharya et al. Development of Oxadiazolone Activity-Based Probes Targeting FphE for Specific Detection of Staphylococcus aureus Infections is published by Jo et al. and structures of Staphylococcus aureus fluorophosphonate-binding serine hydrolases E, unbound dimer crystal form 1 and Oxadiazolone JJ004 bound are available (8T87, 8T88) Crystal structure and solution scattering of Geobacillus stearothermophilus S9 peptidase reveal structural adaptations for carboxypeptidase activity is published by Chandravanshi et al. and structure will be available soon (8WT1)

  • February 28, 2024:
    Structure-based characterization and improvement of an enzymatic activity of Acremonium alcalophilum (Sodiomyces alcalophilus) feruloyl esterase is published by Phienluphon et al. and structures of AaFaeD-CD will be available soon (8JH8, 8JH9) Structure of soluble epoxide hydrolase in complex with Epoxykinin is avalable (8QZD) and will be published soon by Kumar et al. Structure of hydroxynitrile lyase from Hevea brasiliensis with forty mutations is available (8SNI) and will be published soon by Walsh et al. Fruhauf et al. publish that bacterial lactonases ZenA with noncanonical structural features hydrolyze the mycotoxin zearalenone. More structures of Streptomyces coelicoflavus Lactonase ZenA are available (8CLQ) and of Rhodococcus erythropolis zearalenone lactonase (8CLV) in complex with hydrolyzed zearalenone A neuroligin-2-YAP axis regulates progression of pancreatic intraepithelial neoplasia is published by Middonti et al. A new and promiscuous alpha/beta hydrolase from Acinetobacter tandoii DSM 14970 T inactivates the mycotoxin ochratoxin A as published by Sanchez-Arroyo et al.

  • February 21, 2024:
    The secreted feruloyl esterase of Verticillium dahliae modulates host immunity via degradation of Gossypium hirsutum protein dihydroflavanol 4-reductase (GhDFR a positive regulator in plant innate immunity) as published by Wang et al. Fruhauf et al. publish that bacterial lactonases ZenA with noncanonical structural features hydrolyze the mycotoxin zearalenone. Structures of Streptomyces coelicoflavus Lactonase ZenA are available (8CLN, 8CLO, 8CLP) together with structures of zearalenone lactonase of Rhodococcus erythropolis (8CLT, 8CLU). As these enzymes differ from the previously isolated family of zearalenone lactonase, a new family was created Zearalenone-hydrolase-fam2 Structures of FphE, Staphylococcus aureus fluorophosphonate-binding serine hydrolases E, dimeric apo form and Oxadiazolone compound 3 bound are available (8G48, 8G49) and will be published soon by Fellner et al.

  • February 14, 2024:
    Photosensitization enabling Pauson-Khand-type reactions with nitrenes is published by Li et al. and structures of soluble epoxide hydrolase in complex with sEH-45 and sEH-48 are available (8QN0, 8QMZ) Structural insights into hydrolytic defluorination of difluoroacetate by microbial fluoroacetate dehalogenases are published by Khusnutdinova et al. and structure of fluoroacetate dehalogenase Daro3835 H274N mutant with D107-glycolyl intermediate is available (8SDD) Structure of FphI, Staphylococcus aureus fluorophosphonate-binding serine hydrolases I, apo form is available (8G0N) and will be published soon by Fellner et al. Crystal structure of GlacPETase is available (8X6V) and will be published soon by Qi et al. Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase is published by Kelly et al.

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Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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