ESTHER Database

The prestigious symposium honoring Palmer Taylor took place at Skaggs School of Pharmacy & Pharmaceutical Sciences, UC San Diego november 14-15 2025 Program The 18th International Symposium on Cholinergic Mechanisms (ISCM2026) will take place in Montreal, Canada, June 19-26 2026 ISCM2026 The articles from the proceedings of the 15th International Meeting on Cholinesterases together with the 9th Conference on Paraoxonase in Ljubljana are available in Chemico-Biological Interactions Chem.Biol.Interact or list The product of Ellmans reaction inhibits cholinesterases as published by Stojan et al. and human butyrylcholinesterase in complex with 5-thio-2-nitrobenzoate-Thiocholine (Thiocholine-TNB, TCh-TNB) Ellman reaction product is available (9QPU) An alpha/beta-hydrolase GmABHD6 controls seed oil content and yield in soybean as published by Yu et al. Dual cholinergic modulation in dementia: Quinuclidine carbamates targeting butyrylcholinesterase and 7 nicotinic receptor are published Mastnak-Sokolov et al. by and structures will be available soon (9SL8; 9SL9) Functional and structural characterization of PETase SM14 from marine-sponge Streptomyces sp. active on polyethylene terephthalate has been published a few months ago by Carletti et al. and structure is available (9HYD) Another crystal Structure of dsPETase05 from Biortus is available (9KMF) and will be published soon by Wan et al. Comparative analysis of cholinergic machinery in carcinomas: Discovery of membrane-tethered ChAT as evidence for surface-based ACh synthesis in neuroblastoma cells is published by Thakur et al. The selectivity of butyrylcholinesterase inhibitors is revisited by Gambardella et al. Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer as published by Liu et al. The Caenorhabditis elegans DPF-3 and human DPP4 have tripeptidyl peptidase activity as published by Trivedi et al.

The articles from the proceedings of the 15th International Meeting on Cholinesterases together with the 9th Conference on Paraoxonase in Ljubljana are available in Chemico-Biological Interactions Chem.Biol.Interact or list Crystal structure of human acetylcholinesterase in complex with the uncharged hybrid reactivator quinoline-3-hydroxy-pyridinaldoxime is available (9F6R) and will be published soon by Dias et al. Enzymatic anti-Baldwin ring-closure cascade for fused bicyclic ether formation is published by Sato et al. function of PyaF revealed

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function is published by Jenkins et al. Bifunctional carboxylesterase COE52 mediates Xanthotoxin detoxification through hormonal regulation and structural adaptation in Spodoptera litura as published by Li et al. Premature aging and neuropathic behaviours induced by an acute low-dose exposure to a sarin surrogate are published by Champault et al.

Structure of phosphorylated Thalassospira sp. esterase is available (7ZJO) and will be published soon by Lund, B.A. Crystal structure of TTL[Nle], thermophilic lipase TTL from Thermoanaerobacter thermohydrosulfuricus containing non-canonical amino acid Nle at the position of Met is available (9H0Z) and will be published soon by Hromic-Jahjefendic et al. Independent horizontal transfer of genes encoding alpha/beta-hydrolases with strigolactone binding and hydrolytic activities from bacteria to fungi and plants is analysed by Wang et al. and stucture of Microlunatus sagamiharensis CpD14-like Strigolactone receptor is available (9WLV) Crystal structures of AnAChE Cellulose-binding GDSL lipase/acylhydrolase also called fungal acetylcholinesterase from Aspergillus niger are available (9L1R, 9L1R, 9L27, 9L2A, 9L2B, 9L2C, 9L2H, 9L2J, 9L2P, 9L349L379L3A9L3B) but this hydrolase is not an alpha/beta hydrolase. Palmitoylation code and endosomal sorting regulate ABHD17A plasma membrane targeting and activity as published by Kim et al. Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism as published by Dufau et al. (another example of a non catalytic role for an alpha/beta hydrolase) Selective and orally bioavailable Dipeptidyl Peptidase 9 inhibitors with potent pyroptosis induction properties are published by Filippi et al.

Arabidopsis response to the apocarotenoid zaxinone involves interference with strigolactone signaling via binding to DWARF14 as published by Moreno et al. and structure of Arabidopsis Dwarf14 (AtD14) co-crystallized in the presence of Zaxinone is available (8Z53) Ligand binding promiscuity of acylpeptide hydrolase, structural analysis of a detoxifying serine hydrolase is published by Kiss-Szeman et al. A unique strand-breaker Pro residue in the hydrolase domain relaxes the active site into a partially inactivated but more spacious conformation, transforming the classical serine protease apparatus into a versatile yet potent hydrolysis center with broad specificity, distinguishing the mammalian enzyme not only from other APEHs but also from serine alpha/beta hydrolases. Structures of porcine ACPH and Aeropyrum pernix acylaminoacyl peptidase with inhibitors are available (9GOU, 9GNE, 9HXQ) Structure of MERS-CoV S ectodomain trimer in complex with receptor DPP4-750E is available (8Z4T) and will be published soon by Wang et al. Another crystal Structure of dsPETase05 from Biortus is available (9K0H) and will be published soon by Wan et al. Methods for assessing MAGL enzymatic activity: An extensive review of past and emerging approaches is published by Bononi et al. Tobacco protein HSR203J is a benzyl salicylate-specific esterase necessary for the Salicylic acid biosynthesis as published by Ma et al. A novel bifunctional peptide VAMP (Val-Ala-Met-Pro) mined from hemp seed protein hydrolysates improves glucose homeostasis by inhibiting intestinal DPP-IV and increasing the abundance of Akkermansia muciniphila is published by Chen et al. and structure is available (9LBT)