ESTHER Database

Crystal structure of SM0281, an alpha/beta hydrolase polyester-degrading carboxylesterase SM0281 from the symbiotic legume-associated rhizobacterium Sinorhizobium (Ensifer) melilotifrom is available (8TRF) and is published by Lemak et al. it has no significant similarity to known PETases (LCC, IsPETase, TfCut1, TfCut2) and to other characterized polyesterases Crystal Structures of the deep-sea halophilic PET hydrolases dsPETase01, dsPETase05, dsPETase06 Apo and mutant forms with inhibitors are available (9XUE, 9XUF, 9XUG, 9XUH, 9XUI) and are published in a preprint by Zhang et al. Cryo-EM structures of an intact human acetylcholinesterase (T-form) tetramer in complex with ColQ or PRiMA are available (13CO, 13CP) and are published by Cheung and Karasawa Tunable and self-reporting esterase-activated cyanide prodrugs exert cytoprotective effects as published by Tong et al. Fungal lipase LipA disarms macrophages by remodeling their lipidome, enabling full virulence in immunocompetent hosts as published by Goldman et al.

Structure of an ancestral reconstruction of a plant alpha/beta-hydrolase is available (7UKB) and functional characterisation of the reconstructed ancestral strigolactone receptor is published by Tuckey et al. Ontogeny of endocannabinoid modulation of neuromuscular transmission: contribution of postsynaptic nicotinic receptors and butyrylcholinesterase-sensitive mechanisms is published by Nevsky et al. Calcium-coupled proline ring puckering defines a structural switch in a thermophilic lipase (Geobacillus kaustophilus)-calcium-deficient as will be published by Eyerci et al. and structure (45IY) is available Cryo-EM structures of an intact human acetylcholinesterase (T-form) tetramer in complex with ColQ or PRiMA are available (13CO, 13CP) and will be published soon by Cheung and Karasawa Overcoming air-water interface-induced artifacts in cryo-EM with protein nanocrates is published by Jenkins et al. and proof-of-principle example of thyroglobulin (solving a known preferred orientation problem). Cryo-EM structure is available EMD-72176 Structure of polyester polyurethane hydrolase, PurH, inhibited by PMSF (30ZT) is available and will be published soon by Bloch an Panneerselvam Structures of Zearalenone degrading enzyme with a-zearalenol and thermostable mutants are available (9M5F, 9M5G, 9M6F) and are published Ouyang et al.

Structural insights into sequential phthalic acid ester degradation: Co-crystal structures of a dialkyl/monoalkyl phthalate hydrolase with intermediate and product are published by Chen et al. and crystal structure of Phthalate Hydrolase EstJ6 native and in complex are available (9VMR, 9VMU, 9VMW) Crystal structures of PA14 Cif bound to nanobodies VHH219 and VHH108 is available (9Y3I, 9Y3J) and will be published soon by Simard and Madden New families have been extracted (Duf_7379, Conditioned-medium-factor-Cterm)

Non-enzymatic hepatic ABHD6 interacts with Akt-FoxO1 axis to regulate metabolic health as published by Li et al. Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum is published by Delgado-Rey et al. and structure (10XN) is available Structures of MERS-CoV RBD in complex with receptor DPP4 (22EA, 22EB, 22DX, 22DY) are available and will be published soon by Wang, Y.J. and Sun, L. Pectin acetylesterases PAE8 and PAE9 double mutant reduces auxin and alters resistance against selected bacteria and fungi in Arabidopsis thaliana as published by Ahmad et al. Dual inhibitors of p38alpha mitogen-activated protein kinase and butyrylcholinesterase for the modulation of neuroinflammation and cognitive dysfunction are published by Knez et al. and structures of human BChE with inhibitors 8 and 21 are available (9GCQ, 9GCR)

New structures of FphA, Staphylococcus aureus fluorophosphonate-binding serine hydrolases A, apo form, crystal form 2 and 3 are available (9Q21, 9Q27) and will be publishesd soon by You and Fellner Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum is published by Delgado-Rey et al. and structure (10XN) will be available soon. Potato purple top Phytoplasma infection induces autophagy-associated lipid dynamics that support pathogen proliferation and depends on a specific lipase as published by Inaba et al.. Genome-wide identification of CXE gene family in soybean and functional characterization of GmCXE31 in lipid biosynthesis and salt tolerance are published by Guo et al. FphI, Staphylococcus aureus fluorophosphonate-binding serine hydrolases I, in complex with inhibitors are available (9NIX, 9NIZ) and arepublished by Randall et al. Beyond model substrates: Reevaluating enzymes claimed to hydrolyze zearalenone is publishd by Emodi et al. Adaptive variation in butyrylcholinesterase-influenced lipid metabolism during horse domestication as published by Zhang et al. Organophosphate pesticide poisoning: benefits and limitations of oxime therapy as published by Crepinsek et al. Association of ABHD12 variants with the spectrum of PHARC syndrome phenotypes is published by Romero-Vazquez et al.