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The server ESTHER (ESTerases and alpha/beta-Hydrolase Enzymes and Relatives) is dedicated to the analysis of proteins or protein domains belonging to the superfamily of alpha/beta-hydrolases, exemplified by the cholinesterases.



In these times of international uncertainty and uncomfortable situation due to Covid-19, the ESTHER team wishes each and all of you all the best. Please take care of you, yours, and all others around..

NEW Great news: Maria Laura Bolognesi, Doriano Lamba and Manuela Bartolini announce that the 14th International Meeting on Cholinesterases and 8th Conference of Paraoxonases will take place in-person from 18th to 21th September 2022 in the beautiful city of Bologna, Italy (14che8pon)

NEW The XVII International Symposium on Cholinergic Mechanisms (ISCM-2022) took place during May 8-12, 2022 in Dubrovnik, Croatia. (ISCM-2022)


The latest Newsletter is available here and previous issues can be retrieved from here. To receive the Newsletter by e-mail, please join the mailing list here

Jump to: Mutalign, human-ACHE, Esther overview, OverallTable, Meetings page, Table structures, Hall of Fame. Human a/b hydrolases
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  • August 10, 2022:
    Structure of a promiscuous thioesterase domain responsible for branching acylation in polyketide biosynthesis is published by Fraley et al. and is availble (7R0X) Molecular and biochemical differences of the tandem and cold-adapted PET hydrolases Ple628 and Ple629, isolated from a marine microbial consortium are published by Meyer-Cifuentes et al. and structures will be available soon (7VMD, 7VPA). An accompagnying paper Li et al. disclose also a structure available soon (7VPB) Identification and characterization of two novel compounds: heterozygous variants of Lipoprotein Lipase in two pedigrees with type I hyperlipoproteinemia are published by Wang et al. Novel copy number variation of COLQ gene in a Moroccan patient with congenital myasthenic syndrome is published by El Kadiri et al. A highly sensitive and selective enzyme activated fluorescent probe for in vivo profiling of carboxylesterase 2 is published by Liu et al. Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling is published by Li et al. Multiple substrate binding mode-guided engineering of a thermophilic PET hydrolase is published by Pfaff et al. and structures are or will be available soon (7CUV, 7W69, 7W6C, 7W6O, 7W6Q, 7W66, 7E30, 7E31)

  • August 03, 2022:
    A reverse catalytic triad Asp containing loop shaping a wide substrate binding pocket of a feruloyl esterase from Lactobacillus plantarum is published by Zhang et al. and structure is available (7EBO) The crystal structure of HotPETase, an evolved thermostable variant of IsPETase (7QVH) is available and a preprint is published by Bell et al. Shan et al. publish that alpha/beta-hydrolase D16B truncation results in premature sperm capacitation in cattle. Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair is published by Bolgi et al. and structures are available (6QZV; 6QZW) Identification of a Gain-of-Function LIPC variant as a novel cause of familial combined hypocholesterolemia is published by Dijk et al. We missed a preprint by Schenkmayerova et al. describes catalytic mechanism for Renilla-type bioluminescence and structures ara available since 01/06 (7OMD; 7OME; 7OMO; 7OMR)

  • July 20, 2022:
    Gregor Mendel was born 200 hundred years ago Cryo-EM structure of EDS1 and SAG101 with ATP-APDR is available (7XJP) an published by Huang et al.

  • July 13, 2022:
    Huang et al. publish that biochemical and structural data demonstrate that EDS1-PAD4 is a receptor complex for pRib-AMP/ADP, which allosterically promote EDS1-PAD4 interaction with ADR1-L1 but not NRG1A.pRib-AMP/ADP is a missing link in TIR signaling via EDS1-PAD4 and as likely second messengers for plant immunity. Structures are available (7XDD, 7XEY)

  • July 06, 2022:
    Structure-based design of dual partial peroxisome proliferator-activated receptor gamma agonists/Soluble epoxide hydrolase inhibitors is published by Lillich et al. and structure of soluble epoxide hydrolase in complex with FL217 (7P4K) is available A novel strigolactone receptor antagonist providing insights into the structural inhibition, conditioning, and germination of the crop parasite Striga is published by Arellano-Saab et al. and crystal structure of ShHTL7 from Striga hermonthica in complex with strigolactone antagonist RG6 (7SNU),is available. Crystal structure of BioH3 from Mycolicibacterium smegmatis (7WWF) is available and will be published soon by Yang et al. Structures of Omphalotus olearius (Jack o'lantern) macrocyclase OphP prolyl oligopeptidase (7ZAZ, 7ZB0, 7ZB1, 7ZB2) are available and will be published soon by Song, H. and Naismith, J.H. Sequence analysis and preliminary X-ray crystallographic analysis of an acetylesterase (LgEstI) from Lactococcus garvieae are published by Do et al. Shen et al. show that the Covid-19 oral drug Molnupiravir is a CES2 substrate: Potential drug-drug interactions and impact of CES2 polymorphism in vitro

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Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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