The server ESTHER (ESTerases and alpha/beta-Hydrolase Enzymes and Relatives) is dedicated to the analysis of proteins or protein domains belonging to the superfamily of alpha/beta-hydrolases, exemplified by the cholinesterases.
NEW The 15th International Meeting on Cholinesterases and 9th Conference of Paraoxonases will take place autumn 2024 in Slovenia.
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Human a/b hydrolases
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| - May 31, 2023:
Structure of modified oligopeptidase B from S. proteamaculans in intermediate conformation with 5 spermine molecule at 1.65 A resolution is available (8ONO) and will be published soon by Petrenko et al. Another crystal structure of carbohydrate esterase family 7 acetyl xylan esterase is available (7XMJ) and will be published soon by Jiang et al. Structural and functional investigation of a fungal member of carbohydrate esterase family 15 with potential specificity for rare xylans is published Mazurkewich et al. and structure will be available soon (8B48) A review on the role of NDRG1 in different cancers is published by Ghafouri-Fard et al. De novo computational design of a lipase with hydrolysis activity towards middle-chained fatty acid esters is published by Huang et al.
- May 24, 2023:
Salicylic acid attenuates brassinosteroid signaling via protein de-S-acylation by arath-AT5G20520 ABAPT11 (ABHD13-BEM46 family) as published by Liu et al. A crystal structure of HNLyase_Bact from Burkholderia pyrrocinia is available (8HFW) and will be published soon by Lu et al. The lipase cofactor CGI58 controls placental lipolysis: CGI58 interacts not only with PNPLA2 but also with PNPLA9, as published by Guerrero-Santoro et al.
- May 17, 2023:
Structure of porcine dipeptidyl peptidase 4 inhibitory peptide complex is available (7XNM) and will be published soon by li et al. Feruloyl esterase from Lactobacillus acidophilus native and mutant in complx with ethyl ferulate are available (7XRH, 7XRI) and will be published soon by Hwang et al.
- May 10, 2023:
Srtuctures of a thermostable lipase from Thermoanaerobacter thermohydrosulfuricus in complex with PMSF or a monoacylglycerol intermediate are available (7Q4H, 7Q4J) and will be published soon by Pinotsis et al. Crystal structure of Malassezia globosa LIP1, secretory lipase SMG1 mutant (G28C/P206C/Q34P/A37P/M176V/G177A/M294R/F278N) is available (7SPR) and will be published soon by Li et al. N-terminal PPE domain plays an integral role in extracellular transportation and stability of the immunomodulatory Rv3539 protein of the Mycobacterium tuberculosis as published by Anand et al. Structure of dimeric lipoprotein lipase reveals a pore for hydrolysis of acyl chains is published Gunn et al. and structure is available (8ERL)
- May 03, 2023:
Structure of dimeric lipoprotein lipase reveals a pore for hydrolysis of acyl chains is published in a preprint Gunn et al. and structure is available (8ERL) A new structure of human liver carboxylesterase 1 is available (8EOR) and will be published soon by Zhang et al. Dual-acting small molecules: Subtype-selective cannabinoid receptor 2 agonist/butyrylcholinesterase inhibitor hybrids show neuroprotection in an Alzheimer's disease mouse model as published by Spatz et al.
- Previous modifications
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