ESTHER Database

Depalmitoylase ABHD16A negatively regulates the anti-hepatitis B virus activity of Interferon-inducible transmembrane (IFITM1) protein as published by Wen et al. The Alpha/Beta-Hydrolase fold superfamily in Brassica napus: Expression profiles and functional implications of clade-3 BnABH proteins in response to abiotic stress is published by Ding et al. Lead optimization of a Butyrylcholinesterase inhibitor for the treatment of Alzheimer's disease is published by Kosak et al. and structures of BChE inhibited by lead compound will be available soon (9I02, 9I03) Structural and functional investigation of putative peptidase from Mycolicibacterium phlei: An exclusive endopeptidase among S9C subfamily is published by Chandravanshi et al. New structures of Arabidopsis Carboxylesterase CXE15 and mutants are available (8ZRO, 8ZRG, 8ZR6, 8ZRF) and will be published soon by Arold and Hameed Crystal structure of Epoxide hydrolase MdEH (Mycobacterium dioxanotrophicus) is available (8ZP6) and will be published soon by Zhou et al.

Standardization guidelines and future trends for PET hydrolase research are published by Wei et al. Prediction of lipase-specific foldase-dependence in bacterial lipase subfamilies I.1 and I.2 is published by Hioki et al. New structures of Arabidopsis Carboxylesterase CXE15 and mutants are available (8ZRO, 8ZRG) and will be published soon by Arold and Hameed Structure of lgipase calB candida antarctica with lysine ligand is available (9FDE) and will be published soon by Jelsch et al. TIR-mediated immune signaling through the EDS1:PAD4:ADR1 node is conserved in monocots and dicots as published by Maruta et al. Discovery of a novel serine-targeting covalent inhibitor against HCES2A for treating drug-induced diarrhea and ulcerative colitis is published by Hu et al. High-affinity detection of biotinylated endogenous neuroligin-1 at excitatory and inhibitory synapses using a tagged knock-in mouse is published by Ducrot et al.

Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape as published by Vongsouthi et al. and structures of Ancestral PETase are available (8ETX, 8ETY) Zhang et al. publish that root microbiota regulates tiller number in rice, and structure rice DWARF14 in complex with Cyclo(L-Leu-L-Pro) is available (9JQG) They revealed that cyclo(Leu-Pro), produced by the tiller-inhibiting bacterium Exiguobacterium R2567, activates the rice strigolactone (SL) signaling pathway by binding to the SL receptor OsD14 Cryogenic APO structure of soluble Epoxide Hydrolase is available (9EXM) and will be published by Dunge et al. Structures of polyhydroxyalkanoate synthase PhaC from Aeromonas caviae, producing biodegradable plastics are available (9KNJ, 9KNK, 9KNL) and published by Chek et al. They show that the alpha/beta catalytic domain forms a tunnel that connects the catalytic center embedded inside the protein to the protein surface, and that this tunnel is a putative egress tunnel for the product PHA chain. An aggregation-induced conformation locking strategy facilitates the activation of lipase biocatalyst is published by Huang et al.. rs1051931 nonsynonymous polymorphism of platelet-activating factor acetylhydrolase gene PLA2G7 is associated with dysesthesia and pain severity after surgery as published by Hayashi et al. ABHD18 degrades cardiolipin by stepwise hydrolysis of fatty acids as published by Ren et al.

Weaker neuroligin 2 - neurexin 1 interaction tethers membranes and signal synaptogenesis through clustering as published by Boyd et al. Electron microscopy structures of full-length NL2 alone, and in complex with NRX1beta in several conformations are available (8G7Y, 8G7Z, 8G80, 8G81, 8G7D) Unveiling the crystal structure of thermostable dienelactone hydrolase exhibiting activity on terephthalate esters is published by Almeida et al. and structures are available (9BLD, 9BLE) Structure of the Burkholderia gladioli thioesterase domain (GbnD6 TE domain) from the gladiolin PKS is available (9F7B) and will be published soon by Alkhalaf et al. Volume 211 of Handbook of Clinical Neurology: Cholinergic involvement in neurodegenerative diseases, edited by A. Claudio Cuello is published and chapters are available : Chapters Treatment of acute organophosphate poisoning by using a cocaine hydrolase engineered from human butyrylcholinesterase is published by LeSaint et al. Ionic and non-ionic counterparts based on Bis(Uracilyl)Alkane moiety with highest selectivity towards Acetylcholinesterase for protection against organophosphate poisoning and treating Alzheimer's disease is published by Zueva et al. Disruption of the Karrikin receptor DWARF 14 LIKE (D14L) gene leads to distinct effects on root and shoot growth, and reprogramming of central metabolism in rice is published by Salem et al.

Structure of YqiA, Klebsiella pneumoniae serine hydrolase, unbound is available (9BI7) and will be published soon by Randall, G.T. and Fellner, M. PME-1 S156A and M335D knock-in mice deficient in methylesterase and PP2A inhibitory activity, respectively showed phenotypes distinct from the perinatal lethality of PME-1 null mice. The loss of methylesterase activity due to the S156A mutation resulted in systemic apoptosis characterized by brain atrophy: the layers of the cerebellum collapsed with fewer Purkinje cells and more microglia. M335D mutant pups did not appear deformed and had intact brains but died about two days after birth with a demonstrated loss of olfaction and apoptosis in the olfactory epithelium (Ikeda et al. ) A novel butyrylcholinesterase inhibitor induces antidepressant, pro-cognitive, and anti-anhedonic effects in Flinders Sensitive Line rats: The role of the ghrelin-dopamine cascade as published by Olivier et al. A review on non-oxime reactivators of organophosphate-inhibited cholinesterases is published by Knittelova et al. A preprint by Furlong et al. is investigating biomarkers of exposure to jet aircraft oil fumes using mass spectrometry Tailored phenyl ureas eradicate drug-resistant Mycobacterium tuberculosis by targeting mycolic acid cell wall assembly is published by Mostert et al. Incorporation of polylactic acid microplastics into the carbon cycle as a carbon source to remodel the endogenous metabolism of the gut is published by Bao et al.