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The server ESTHER (ESTerases and alpha/beta-Hydrolase Enzymes and Relatives) is dedicated to the analysis of proteins or protein domains belonging to the superfamily of alpha/beta-hydrolases, exemplified by the cholinesterases.



In these times of international uncertainty and uncomfortable situation due to Covid-19, the ESTHER team wishes each and all of you all the best. Please take care of you, yours, and all others around..

NEW The 14th International Meeting on Cholinesterases and 8th Conference of Paraoxonases took place in-person from 18th to 21th September 2022 in the beautiful city of Bologna, Italy. Many thanks to the organizers: Maria Laura Bolognesi, Doriano Lamba and Manuela Bartolini (14che8pon)

The latest Newsletter is available here and previous issues can be retrieved from here. To receive the Newsletter by e-mail, please join the mailing list here

Jump to: Mutalign, human-ACHE, Esther overview, OverallTable, Meetings page, Table structures, Hall of Fame. Human a/b hydrolases
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  • November 23, 2022:
    Crystal structure of carboxylesterase from Thermobifida fusca (apo, mutant and with inhibitor MHETA) are available (7W1I, 7W1J, 7W1K, 7W1L) and will be published soon by Han et al. Investigation of the halophilic PET hydrolase PET6 from Vibrio gazogenes is published by Weigert et al. and structure is available (7Z6B) Structure of 2-hydroxyisoflavanone dehydratase (2-HID), a member of a large carboxylesterase family that paradoxically catalyzes dehydration of 2-hydroxyisoflavanones to isoflavone is published by Wang et al. and structures will be available soon (8EA1, 8EA2) Crystal structures of HsaD from Mycobacterium tuberculosis apo and in complex with Cyclophostin-like Cyclophostin-like inhibitors are available (7ZJT; 7ZM1; 7ZM2; 7ZM3; 7ZM4) and are published by Barelier et al.

  • November 06, 2022:
    The crystal structure of mouse Ces2c, a potential ortholog of human CES2, shows structural similarities in substrate regulation and product release to human CES1 as published by Eisner et al. and stucture (8AXC) is available. Brown et al. show that Trypanosoma brucei Acyl-Protein Thioesterase-like (TbAPT-L) is a lipase with esterase activity for short and medium-chain fatty acids but has no depalmitoylation Activity Structures of human butyrylcholinesterase inhibiteed by diphenylacetamide compounds are available (7Q1M, 7Q1N, 7Q1O, 7Q1P) and will be published soon by Brazzolotto et al. A structure of an engineered PET hydrolase (variant of IsPETase Ideonella sakaiensis) is available (7VWN) and will be published soon by Xie and Jia

  • November 09, 2022:
    Gui et al. publish that intramolecular CC bond formation links Anthraquinone and Enediyne scaffolds in Tiancimycin biosynthesis. Structures of TnmK1 are available. (8E18, 8E19). Accordingly a new family (Tiancimycin-TnmK-Tripeptidase-HIP) was extracted from the huge AlphaBeta_hydrolase family.

  • November 02, 2022:
    Xiang et al. publish that an alpha/beta hydrolase family member (orysa-q6l556) negatively regulates salt tolerance but promotes flowering through three distinct functions in rice. Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering is published by Gerlitz et al. and stuctures of AChE in complex with paraoxon and oximes are available (8DT2, 8DT4, 8DT5, 8DT7)

  • October 26, 2022:
    Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering is published by Gerlitz et al. and stuctures of AChE in complex with paraoxon and oximes will be available soon available (8DT2, 8DT4, 8DT5, 8DT7) Gui et al. publish that intramolecular CC bond formation links Anthraquinone and Enediyne scaffolds in Tiancimycin biosynthesis. Structures of TnmK1 will be available soon (8E18, 8E19). Accordingly a new family (Tiancimycin-TnmK-Tripeptidase-HIP) was extracted from the huge AlphaBeta_hydrolase family. Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism as published by Wang et al.

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Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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