ESTHER Database

An important review on cholinesterase-based inhibitors as multitarget small molecules for the therapy of Alzheimer's disease developped by their group is published by Marco-Contelles and Oset-Gasque ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity as published in a preprint by Jenkins et al. Plant tannase: evolutionary and functional divergence features is published by Ma et al. Differential senolytic inhibition of normal versus A-associated cholinesterases: implications in aging and Alzheimer's disease is published by Darvesh et al. Uncovering synaptic and cellular nanoarchitecture of brain tissue via seamless in situ trimming and milling for cryo-electron tomography is published as a preprint by Ning et al. Reduced GABAergic inhibition and impaired synapse elimination by neuroligin-2 deletion from Purkinje cells of the developing cerebellum is published by Lai et al. A critical role of Neuroligin 2 C-terminus in OCD and social behavior is published by Pandey et al. PLA2G7 promotes immune evasion of bladder cancer through the JAK-STAT-PDL1 axis Peng et al. Sustainable biosynthesis of diverse fatty acid esters of hydroxy fatty acids (FAHFAs) for industrial production is published by Ling et al. and structures of CalA-like lipase from Ustilago trichophora (native and S200A mutant) and CalA-like lipase from Kalmanozyma brasiliensis are available (9JC9, 9JCA, 9JCB) Lecithin:Cholesterol Acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL is published by Coleman et al. and structure of Lecithin:Cholesterol Acyltransferase bound to apolipoprotein A-I dimer in HDL is available (9MXZ)

ANGPTL3/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase as published by Kumari et al. Ne1, which encodes an alpha/beta hydrolase (ABH) protein generated by structural variation, triggers hybrid necrosis with Ne2 by activating autoimmune responses in wheat as published by Si et al. Kibdelosporangium banguiense polyethylene terephthalate (PET) hydrolase KbPETase is published as a preprint by Zheng et al.and will be available soon (9IW9) MAGL targeted PROTAC degrader simultaneously enhances P53 for synergistic treatment of glioblastoma stem cell is published by Yuan et al.

Mining thermophile genomes for new PETases with Eexceptional thermostabilities using sequence similarity networks is published by Hu et al. and crystal structure of Caldilinea aerophila Alpha/beta hydrolase fold-5 domain-containing protein AroC is available (9HE6) A family of alpha/beta hydrolases which removes phytol from chlorophyll metabolites for tocopherol biosynthesis in Arabidopsis is described by Bao et al. Replicating PET hydrolytic activity by positioning active sites with smaller synthetic protein scaffolds is published by Ding et al. Analysis of neurexin-neuroligin complexes supports an isoform-specific role for beta-neurexin-1 dysfunction in a mouse model of autism as published by Arias-Aragon et al. PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover as published by Ono et al. (PNLA6 is not an alpha/beta hydrolase but a paptatin lipase and is the Neurotoxic esterase (NTE) inhibited by OP) Couso-Ferrer et al. publish: Tracking malathion resistance in Spanish Ceratitis capitata populations: prevalence of resistance alleles/haplotypes before and after the withdrawal of malathion

Structures of soluble epoxide hydrolase in complex with PROTAC FL412, JSF67,JSF234 are available (8S75, 8S76, 8S77) and will be published soon by Kumar et al. An mRNA display approach for covalent targeting of a Staphylococcus aureus virulence factor is published by Wang et al. and structure of FphE, Staphylococcus aureus fluorophosphonate-binding serine hydrolases E, Oxadiazolone-peptide bound is available (9DRO) Crystal structure of a novel PU plastic degradation enzyme from Thermaerobacter marianensis is available (8YMA) and will be published soon by Li et al. Unprecedented alkylation of the catalytic Histidine in the aging of cholinesterases after inhibition by organophosphorus pesticides is described by Miller et al. In silico studies and in vitro evaluation of isatin-pyridine oxime hybrids as novel reactivators of acetylcholinesterase inhibited by an A-230 surrogate are published by Bernardo et al. Attenuating ABHD17 isoforms augments the S-acylation and function of NOD2 and a subset of Crohn's disease-associated NOD2 variants as published by Dixon et al. Highly specific miniaturized fluorescent monoacylglycerol lipase probes enable translational research are published by Hentsch et al.

Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging as published by Cadez et al. Novel potent and selective dual acetylcholinesterase inhibitors: N-substituted theobromine and theophylline derivatives are published by Biscussi et al. Multi-targeted benzylpiperidine-isatin hybrids: Design, synthesis, biological and in silico evaluation as monoamine oxidases and acetylcholinesterase inhibitors for neurodegenerative disease therapies are published by Negi et al. Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH) as published by Sundararaman et al. An mRNA display approach for covalent targeting of a Staphylococcus aureus virulence factor is published by Wang et al. Donepezil-based rational design of N-substituted quinazolinthioacetamide candidates as potential acetylcholine esterase inhibitors for the treatment of Alzheimer's disease is published by Al-Karmalawy et al.