Bisabolol
. Six terpenoids (farnesol, (-)--bisabolol, cis-nerolidol, trans-nerolidol, methyleugenol, (R)-(+)-limonene) ,are strong AChE inhibitors against An. funestus and An. arabiensis, while there was a moderate inhibitory activity against An. gambiae AChE, but very weak activity against An. coluzzii, and Electric eel AChE Rants'o et al.
General
Chemical_Nomenclature : (2R)-6-methyl-2-[(1R)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol
Canonical SMILES : CC1=CC[C@@H](CC1)[C@@](C)(CCC=C(C)C)O
InChI : InChI=1S\/C15H26O\/c1-12(2)6-5-11-15(4,16)14-9-7-13(3)8-10-14\/h6-7,14,16H,5,8-11H2,1-4H3\/t14-,15+\/m0\/s1
InChIKey : RGZSQWQPBWRIAQ-LSDHHAIUSA-N
Other name(s) : 36HQN158VC || DTXSID5045964 || DTXCID3025964 || RefChem:917307 || alpha-Bisabolol || (+)-alpha-Bisabolol || CHEMBL1171719 || SCHEMBL24988 || SCHEMBL31157846 || CHEBI:192031
MW : 222.37
Formula : C15H26O
CAS_number : 515-69-5
PubChem : 1549992
UniChem : RGZSQWQPBWRIAQ-LSDHHAIUSA-N
Target
References (7)
| Title : Insecticidal Potential of Essential Oil and Sesquiterpene Alcohols from Leaves of Clausena indica (Dalz.) Oliver Against Spodoptera litura, Helicoverpa armigera, and Tribolium castaneum Under Laboratory and Field Conditions - Devi_2025_Neotrop.Entomol_54_68 |
| Author(s) : Devi JA , Thangapandian R , Vijayaraghavan C , Patel RRD , Kiran SR |
| Ref : Neotrop Entomol , 54 :68 , 2025 |
| Abstract : |
| PubMedSearch : Devi_2025_Neotrop.Entomol_54_68 |
| PubMedID: 40394399 |
| Title : In vitro and in silico neuroprotective evaluation of new biotransformation metabolites of (-)-alpha-bisabolol - Mansour_2025_Sci.Rep_15_27206 |
| Author(s) : Mansour R , Eldomany RA , Mira A , Sabry MA , El-Sharkawy SH , Soliman AF |
| Ref : Sci Rep , 15 :27206 , 2025 |
| Abstract : |
| PubMedSearch : Mansour_2025_Sci.Rep_15_27206 |
| PubMedID: 40715238 |
| Title : Evaluation of Bauhinia ungulata Essential Oil as a New Acetylcholinesterase Inhibitor from an in silico and in vitro Perspective in the Northern Amazon of Brazil - Medeiros_2024_J.Oleo.Sci_73_1091 |
| Author(s) : Medeiros S , Bezerra IC , Pedroza LAL , Silva AJD , Martins RMG , Menezes TM , Goncalves Reis de Melo AC , Neves JL , Gubert P , Filho AAM |
| Ref : J Oleo Sci , 73 :1091 , 2024 |
| Abstract : |
| PubMedSearch : Medeiros_2024_J.Oleo.Sci_73_1091 |
| PubMedID: 39085083 |
| Title : In vitro and in silico analysis of the Anopheles anticholinesterase activity of terpenoids - Rants'o_2022_Parasitol.Int_93_102713 |
| Author(s) : Rants'o TA , Koekemoer LL , van Zyl RL |
| Ref : Parasitol Int , 93 :102713 , 2022 |
| Abstract : |
| PubMedSearch : Rants'o_2022_Parasitol.Int_93_102713 |
| PubMedID: 36455706 |
| Title : alpha-bisabolol beta-D-fucopyranoside as a potential modulator of beta-amyloid peptide induced neurotoxicity: An in vitro &in silico study - Jeyakumar_2019_Bioorg.Chem_88_102935 |
| Author(s) : Jeyakumar M , Sathya S , Gandhi S , Tharra P , Suryanarayanan V , Singh SK , Baire B , Pandima Devi K |
| Ref : Bioorg Chem , 88 :102935 , 2019 |
| Abstract : |
| PubMedSearch : Jeyakumar_2019_Bioorg.Chem_88_102935 |
| PubMedID: 31030060 |
| Title : Antiaggregation Potential of Padina gymnospora against the Toxic Alzheimer's Beta-Amyloid Peptide 25-35 and Cholinesterase Inhibitory Property of Its Bioactive Compounds - Shanmuganathan_2015_PLoS.One_10_e0141708 |
| Author(s) : Shanmuganathan B , Sheeja Malar D , Sathya S , Pandima Devi K |
| Ref : PLoS ONE , 10 :e0141708 , 2015 |
| Abstract : |
| PubMedSearch : Shanmuganathan_2015_PLoS.One_10_e0141708 |
| PubMedID: 26536106 |
| Title : Chemical composition and larvicidal activity of leaf essential oil from Clausena dentata (Willd) M. Roam. (Rutaceae) against the chikungunya vector, Aedes aegypti Linn. (Diptera: Culicidae) - Rajkumar_2010_J.Asia.Pac.Entomol_13_107 |
| Author(s) : Rajkumar S , Jebanesan A |
| Ref : Journal of Asia-Pacific Entomology , 13 :107 , 2010 |
| Abstract : |
| PubMedSearch : Rajkumar_2010_J.Asia.Pac.Entomol_13_107 |
| PubMedID: |