Carvacrol
Carvacrol is a phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1). It has a role as a TRPA1 channel agonist. Poor inhibitor of AChE or BCHE > 300 microM (De souza et al. 2020)
General
Type : Carvacrol-Thymol, Natural, Terpenoid
Chemical_Nomenclature : 2-methyl-5-propan-2-ylphenol
Canonical SMILES : CC1=C(C=C(C=C1)C(C)C)O
InChI : InChI=1S\/C10H14O\/c1-7(2)9-5-4-8(3)10(11)6-9\/h4-7,11H,1-3H3
InChIKey : RECUKUPTGUEGMW-UHFFFAOYSA-N
Other name(s) : 5-Isopropyl-2-methylphenol || Isopropyl-o-cresol || Antioxine || CHEBI:3440 || RefChem:5653 || o-Thymol || CHEMBL281202 || SCHEMBL24734 || SCHEMBL1804644 || SCHEMBL8025080 || SCHEMBL29544247
MW : 150.22
Formula : C10H14O
CAS_number : 499-75-2
PubChem : 10364
UniChem : RECUKUPTGUEGMW-UHFFFAOYSA-N
Target
References (23)
| Title : In Vitro and In Silico Investigations of the Acaricidal Activity of Carvacrol Against Rhipicephalus annulatus - Ibrahium_2026_Acta.Parasitol_71_168 |
| Author(s) : Ibrahium SM , Abdel-Baki AS , Abo El-Ela FI , Balegh AA , Wahba AA , Al-Quraishy S , Awad EM , Ahmed M , Mahmoud WG , Aboelhadid SM |
| Ref : Acta Parasitol , 71 :168 , 2026 |
| Abstract : |
| PubMedSearch : Ibrahium_2026_Acta.Parasitol_71_168 |
| PubMedID: 42484762 |
| Title : Multifunctional Carvacrol-based Organoselenium hybrids as anticholinesterase and antioxidant candidates for Alzheimer's therapy - Gomes_2025_Bioorg.Med.Chem_132_118447 |
| Author(s) : Gomes LS , Schuler M , Giannini GB , Zapp E , de Oliveira AS , Nascimento V |
| Ref : Bioorganic & Medicinal Chemistry , 132 :118447 , 2025 |
| Abstract : |
| PubMedSearch : Gomes_2025_Bioorg.Med.Chem_132_118447 |
| PubMedID: 41166828 |
| Title : Carvacrol\/thymol derivatives as highly selective BuChE inhibitors with anti-inflammatory activities: Discovery and bio-evaluation - Zhang_2025_Bioorg.Chem_160_108430 |
| Author(s) : Zhang YL , Yang HY , Gou J , Qi XM , Qiao YB , Li QS |
| Ref : Bioorg Chem , 160 :108430 , 2025 |
| Abstract : |
| PubMedSearch : Zhang_2025_Bioorg.Chem_160_108430 |
| PubMedID: 40209354 |
| Title : Haemaphysalis longicornis and Carvacrol as Acaricide: Efficacy and Mechanism of Action - Lee_2025_Molecules_30_ |
| Author(s) : Lee NH , Lee S , Chung N , Lee HS |
| Ref : Molecules , 30 : , 2025 |
| Abstract : |
| PubMedSearch : Lee_2025_Molecules_30_ |
| PubMedID: 40286112 |
| Title : Effects of Carvacrol on Oxidative Stress and Fibrosis in Streptozotocin-Induced Diabetic Nephropathy: Histological, Gene Expression, and Biochemical Insights - Canbaz_2025_Int.J.Mol.Sci_27_ |
| Author(s) : Canbaz HT , Sozen ME , Cinar Ayan I , Savas HB , Canbaz FA , Cuce G , Kalkan S |
| Ref : Int J Mol Sci , 27 : , 2025 |
| Abstract : |
| PubMedSearch : Canbaz_2025_Int.J.Mol.Sci_27_ |
| PubMedID: 41516168 |
| Title : Antinociceptive Analysis of Natural Monoterpenes Eugenol, Menthol, Carvacrol and Thymol in a Zebrafish Larval Model - Rocha_2024_Pharmaceuticals.(Basel)_17_ |
| Author(s) : Rocha CA , Felix LM , Monteiro SM , Venancio C |
| Ref : Pharmaceuticals (Basel) , 17 : , 2024 |
| Abstract : |
| PubMedSearch : Rocha_2024_Pharmaceuticals.(Basel)_17_ |
| PubMedID: 38675417 |
| Title : Carvacrol improves cognitive dysfunction by decreasing amyloid-beta accumulation and regulating neuroinflammation in ovariectomized renovascular hypertensive rats - Bayraktar_2024_Naunyn.Schmiedebergs.Arch.Pharmacol__ |
| Author(s) : Bayraktar D , Ertas B , Aydin Y , Sener G |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , : , 2024 |
| Abstract : |
| PubMedSearch : Bayraktar_2024_Naunyn.Schmiedebergs.Arch.Pharmacol__ |
| PubMedID: 39283526 |
| Title : Protective effects of carvacrol on lipid profiles, oxidative stress, hypertension, and cardiac dysfunction - A comprehensive review - Khazdair_2024_Food.Sci.Nutr_12_3137 |
| Author(s) : Khazdair MR , Moshtagh M , Anaeigoudari A , Jafari S , Kazemi T |
| Ref : Food Sci Nutr , 12 :3137 , 2024 |
| Abstract : |
| PubMedSearch : Khazdair_2024_Food.Sci.Nutr_12_3137 |
| PubMedID: 38726397 |
| Title : Synthesis of Carvacrol-Loaded Invasomes Nanoparticles Improved Acaricide Efficacy, Cuticle Invasion and Inhibition of Acetylcholinestrase against Hard Ticks - Gamal_2023_Microorganisms_11_ |
| Author(s) : Gamal A , Aboelhadid SM , Abo El-Ela FI , Abdel-Baki AS , Ibrahium SM , El-Mallah AM , Al-Quraishy S , Hassan AO , Gadelhaq SM |
| Ref : Microorganisms , 11 : , 2023 |
| Abstract : |
| PubMedSearch : Gamal_2023_Microorganisms_11_ |
| PubMedID: 36985306 |
| Title : Synthesis, characterization, biochemical, and molecular modeling studies of carvacrol-based new thiosemicarbazide and 1,3,4-thiadiazole derivatives - Alagoz_2023_Arch.Pharm.(Weinheim)__e2300370 |
| Author(s) : Alagoz T , Caliskan FG , Bilgicli HG , Zengin M , Sadeghi M , Taslimi P , Gulcin I |
| Ref : Arch Pharm (Weinheim) , :e2300370 , 2023 |
| Abstract : |
| PubMedSearch : Alagoz_2023_Arch.Pharm.(Weinheim)__e2300370 |
| PubMedID: 37743251 |
| Title : The effects of carvacrol on development and gene expression profiles in Spodoptera frugiperda - Liu_2023_Pestic.Biochem.Physiol_195_105539 |
| Author(s) : Liu J , Lin Y , Huang Y , Liu L , Cai X , Lin J , Shu B |
| Ref : Pestic Biochem Physiol , 195 :105539 , 2023 |
| Abstract : |
| PubMedSearch : Liu_2023_Pestic.Biochem.Physiol_195_105539 |
| PubMedID: 37666589 |
| Title : Anti-Cholinesterase and Anti-alpha-Amylase Activities and Neuroprotective Effects of Carvacrol and p-Cymene and Their Effects on Hydrogen Peroxide Induced Stress in SH-SY5Y Cells - Caputo_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Caputo L , Amato G , De Martino L , De Feo V , Nazzaro F |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : |
| PubMedSearch : Caputo_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37047044 |
| Title : Interaction of fungal lipase with potential phytotherapeutics - Naz_2022_PLoS.One_17_e0264460 |
| Author(s) : Naz F , Khan I , Islam A , Khan LA |
| Ref : PLoS ONE , 17 :e0264460 , 2022 |
| Abstract : |
| PubMedSearch : Naz_2022_PLoS.One_17_e0264460 |
| PubMedID: 35617167 |
| Title : Therapeutic effects of carvacrol on beta-amyloid-induced impairments in in-vitro and in-vivo models of Alzheimer's disease - Celik_2021_Eur.J.Neurosci__ |
| Author(s) : Celik Topkara K , Kilinc E , Cetinkaya A , Saylan A , Demir S |
| Ref : European Journal of Neuroscience , : , 2021 |
| Abstract : |
| PubMedSearch : Celik_2021_Eur.J.Neurosci__ |
| PubMedID: 34904309 |
| Title : Structure-activity relationships of sulfonamides derived from carvacrol and their potential for the treatment of Alzheimer's disease - de Souza_2020_RSC.Med.Chem_11_307 |
| Author(s) : de Souza MM , Andreolla MC , Ribeiro TC , Goncalves AE , Medeiros AR , de Souza AS , Ferreira LLG , Andricopulo AD , Yunes RA , de Oliveira AS |
| Ref : RSC Med Chem , 11 :307 , 2020 |
| Abstract : |
| PubMedSearch : de Souza_2020_RSC.Med.Chem_11_307 |
| PubMedID: 33479638 |
| Title : Comparison of sublethal effects of natural acaricides carvacrol and thymol on honeybees - Glavan_2020_Pestic.Biochem.Physiol_166_104567 |
| Author(s) : Glavan G , Novak S , Bozic J , Jemec Kokalj A |
| Ref : Pestic Biochem Physiol , 166 :104567 , 2020 |
| Abstract : |
| PubMedSearch : Glavan_2020_Pestic.Biochem.Physiol_166_104567 |
| PubMedID: 32448421 |
| Title : Synthesis, Anticholinesterase Activity and Molecular Modeling Studies of Novel Carvacrol Substituted Amide Derivatives - Zengin Kurt_2019_J.Biomol.Struct.Dyn__1 |
| Author(s) : Zengin Kurt B , Durdagi S , Celebi G , Ekhteiari Salmas R , Sonmez F |
| Ref : J Biomol Struct Dyn , :1 , 2019 |
| Abstract : |
| PubMedSearch : Zengin Kurt_2019_J.Biomol.Struct.Dyn__1 |
| PubMedID: 30836858 |
| Title : Evaluation of urinary 8-hydroxy-2-deoxyguanosine level in experimental Alzheimer's disease: Impact of carvacrol nanoparticles - Medhat_2019_Mol.Biol.Rep_46_4517 |
| Author(s) : Medhat D , El-Mezayen HA , el-Naggar ME , Farrag AR , Abdelgawad ME , Hussein J , Kamal MH |
| Ref : Mol Biol Rep , 46 :4517 , 2019 |
| Abstract : |
| PubMedSearch : Medhat_2019_Mol.Biol.Rep_46_4517 |
| PubMedID: 31209743 |
| Title : Ameliorative effect of carvacrol against propiconazole-induced neurobehavioral toxicity in rats - Noshy_2018_Neurotoxicol_67_141 |
| Author(s) : Noshy PA , Elhady MA , Khalaf AAA , Kamel MM , Hassanen EI |
| Ref : Neurotoxicology , 67 :141 , 2018 |
| Abstract : |
| PubMedSearch : Noshy_2018_Neurotoxicol_67_141 |
| PubMedID: 29852196 |
| Title : Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol\/carvacrol derivatives - Zengin Kurt_2017_Bioorg.Med.Chem_25_1352 |
| Author(s) : Zengin Kurt B , Gazioglu I , Dag A , Salmas RE , Kayik G , Durdagi S , Sonmez F |
| Ref : Bioorganic & Medicinal Chemistry , 25 :1352 , 2017 |
| Abstract : |
| PubMedSearch : Zengin Kurt_2017_Bioorg.Med.Chem_25_1352 |
| PubMedID: 28089589 |
| Title : Monoterpenoids (thymol, carvacrol and S-(+)-linalool) with anesthetic activity in silver catfish (Rhamdia quelen): evaluation of acetylcholinesterase and GABAergic activity - Bianchini_2017_Braz.J.Med.Biol.Res_50_e6346 |
| Author(s) : Bianchini AE , Garlet QI , da Cunha JA , Bandeira GJ , Brusque ICM , Salbego J , Heinzmann BM , Baldisserotto B |
| Ref : Brazilian Journal of Medical & Biological Research , 50 :e6346 , 2017 |
| Abstract : |
| PubMedSearch : Bianchini_2017_Braz.J.Med.Biol.Res_50_e6346 |
| PubMedID: 29069225 |
| Title : Acetylcholinesterase inhibition by nootkatone and carvacrol in arthropods - Anderson_2012_Pestic.Biochem.Physiol_102_124 |
| Author(s) : Anderson JA , Coats JR |
| Ref : Pesticide Biochemistry and Physiology , 102 :124 , 2012 |
| Abstract : |
| PubMedSearch : Anderson_2012_Pestic.Biochem.Physiol_102_124 |
| PubMedID: |
| Title : In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone - Jukic_2007_Phytother.Res_21_259 |
| Author(s) : Jukic M , Politeo O , Maksimovic M , Milos M |
| Ref : Phytother Res , 21 :259 , 2007 |
| Abstract : |
| PubMedSearch : Jukic_2007_Phytother.Res_21_259 |
| PubMedID: 17186491 |