Fenchlorphos
General
Type : Organophosphate, Sulfur Compound, Trichloro
Chemical_Nomenclature : dimethoxy-sulfanylidene-(2,4,5-trichlorophenoxy)-$l^{5}-phosphane
Canonical SMILES : COP(=S)(OC)OC1=CC(=C(C=C1Cl)Cl)Cl
InChI : InChI=1S\/C8H8Cl3O3PS\/c1-12-15(16,13-2)14-8-4-6(10)5(9)3-7(8)11\/h3-4H,1-2H3
InChIKey : JHJOOSLFWRRSGU-UHFFFAOYSA-N
Other name(s) : O,O-dimethyl O-(2,4,5 trichlorophenyl phosphorothioate) || Phenol, 2,4,5-trichloro-, O-ester with O,O-dimethyl phosphorothioate || Ronnel || Dermafos || Trichlormetaphos || Blitex || Fenchlorophos || Korlan || Ectoral || Etrolene || Gesektin K || Moorman's medicated RID-EZY || Nankor || Rovan || Trichlorometafos || Trolene || Viozene || Fenclofos
MW : 321.54
Formula : C8H8Cl3O3PS
CAS_number : 299-84-3
PubChem : 9298
UniChem : JHJOOSLFWRRSGU-UHFFFAOYSA-N
Target
Families : Fenchlorphos ligand of proteins in family
ACHE
References (66)
| Title : A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant - Rimkus_2018_PLoS.One_13_e0190821 |
| Author(s) : Rimkus SA , Wassarman DA |
| Ref : PLoS ONE , 13 :e0190821 , 2018 |
| Abstract : |
| PubMedSearch : Rimkus_2018_PLoS.One_13_e0190821 |
| PubMedID: 29338042 |
| Title : A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant - Rimkus_2018_PLoS.One_13_e0190821 |
| Author(s) : Rimkus SA , Wassarman DA |
| Ref : PLoS ONE , 13 :e0190821 , 2018 |
| Abstract : |
| PubMedSearch : Rimkus_2018_PLoS.One_13_e0190821 |
| PubMedID: 29338042 |
| Title : A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant - Rimkus_2018_PLoS.One_13_e0190821 |
| Author(s) : Rimkus SA , Wassarman DA |
| Ref : PLoS ONE , 13 :e0190821 , 2018 |
| Abstract : |
| PubMedSearch : Rimkus_2018_PLoS.One_13_e0190821 |
| PubMedID: 29338042 |
| Title : Determining organohalides in animal fats using gel permeation chromatographic cleanup: repeatability study - Goodspeed_1991_J.Assoc.Off.Anal.Chem_74_388 |
| Author(s) : Goodspeed DP , Chestnut LI |
| Ref : J Assoc Off Analytical Chemistry , 74 :388 , 1991 |
| Abstract : |
| PubMedSearch : Goodspeed_1991_J.Assoc.Off.Anal.Chem_74_388 |
| PubMedID: 2050618 |
| Title : Determining organohalides in animal fats using gel permeation chromatographic cleanup: repeatability study - Goodspeed_1991_J.Assoc.Off.Anal.Chem_74_388 |
| Author(s) : Goodspeed DP , Chestnut LI |
| Ref : J Assoc Off Analytical Chemistry , 74 :388 , 1991 |
| Abstract : |
| PubMedSearch : Goodspeed_1991_J.Assoc.Off.Anal.Chem_74_388 |
| PubMedID: 2050618 |
| Title : Determining organohalides in animal fats using gel permeation chromatographic cleanup: repeatability study - Goodspeed_1991_J.Assoc.Off.Anal.Chem_74_388 |
| Author(s) : Goodspeed DP , Chestnut LI |
| Ref : J Assoc Off Analytical Chemistry , 74 :388 , 1991 |
| Abstract : |
| PubMedSearch : Goodspeed_1991_J.Assoc.Off.Anal.Chem_74_388 |
| PubMedID: 2050618 |
| Title : Effects of in vitro ronnel on metabolic activity in subcutaneous adipose tissue and skeletal muscle from steers - Trankina_1985_J.Anim.Sci_60_652 |
| Author(s) : Trankina ML , Beitz DC , Trenkle AH |
| Ref : J Anim Sci , 60 :652 , 1985 |
| Abstract : |
| PubMedSearch : Trankina_1985_J.Anim.Sci_60_652 |
| PubMedID: 2580822 |
| Title : Effects of in vitro ronnel on metabolic activity in subcutaneous adipose tissue and skeletal muscle from steers - Trankina_1985_J.Anim.Sci_60_652 |
| Author(s) : Trankina ML , Beitz DC , Trenkle AH |
| Ref : J Anim Sci , 60 :652 , 1985 |
| Abstract : |
| PubMedSearch : Trankina_1985_J.Anim.Sci_60_652 |
| PubMedID: 2580822 |
| Title : Effects of in vitro ronnel on metabolic activity in subcutaneous adipose tissue and skeletal muscle from steers - Trankina_1985_J.Anim.Sci_60_652 |
| Author(s) : Trankina ML , Beitz DC , Trenkle AH |
| Ref : J Anim Sci , 60 :652 , 1985 |
| Abstract : |
| PubMedSearch : Trankina_1985_J.Anim.Sci_60_652 |
| PubMedID: 2580822 |
| Title : Changes in plasma concentrations of thyroxine, triiodothyronine, cholesterol and total lipid in beef steers fed ronnel - Rumsey_1983_J.Anim.Sci_56_125 |
| Author(s) : Rumsey TS , Bitman J , Tao H |
| Ref : J Anim Sci , 56 :125 , 1983 |
| Abstract : |
| PubMedSearch : Rumsey_1983_J.Anim.Sci_56_125 |
| PubMedID: 6186657 |
| Title : Ovarian and testicular function in the blue fox (Alopex lagopus) after oral administration of fenchlorphos during the breeding season - |
| Author(s) : Berge GN , Mondain-Monval M , Smith A , Moller OM |
| Ref : Acta Vet Scand , 24 :200 , 1983 |
| PubMedID: 6193696 |
| Title : Changes in plasma concentrations of thyroxine, triiodothyronine, cholesterol and total lipid in beef steers fed ronnel - Rumsey_1983_J.Anim.Sci_56_125 |
| Author(s) : Rumsey TS , Bitman J , Tao H |
| Ref : J Anim Sci , 56 :125 , 1983 |
| Abstract : |
| PubMedSearch : Rumsey_1983_J.Anim.Sci_56_125 |
| PubMedID: 6186657 |
| Title : Ovarian and testicular function in the blue fox (Alopex lagopus) after oral administration of fenchlorphos during the breeding season - |
| Author(s) : Berge GN , Mondain-Monval M , Smith A , Moller OM |
| Ref : Acta Vet Scand , 24 :200 , 1983 |
| PubMedID: 6193696 |
| Title : Changes in plasma concentrations of thyroxine, triiodothyronine, cholesterol and total lipid in beef steers fed ronnel - Rumsey_1983_J.Anim.Sci_56_125 |
| Author(s) : Rumsey TS , Bitman J , Tao H |
| Ref : J Anim Sci , 56 :125 , 1983 |
| Abstract : |
| PubMedSearch : Rumsey_1983_J.Anim.Sci_56_125 |
| PubMedID: 6186657 |
| Title : Ovarian and testicular function in the blue fox (Alopex lagopus) after oral administration of fenchlorphos during the breeding season - |
| Author(s) : Berge GN , Mondain-Monval M , Smith A , Moller OM |
| Ref : Acta Vet Scand , 24 :200 , 1983 |
| PubMedID: 6193696 |
| Title : Modification of brain mitochondrial enzymes by the oxygen analogue of ronnel at various stages of development and aging - Sitkiewicz_1982_J.Neurochem_39_1308 |
| Author(s) : Sitkiewicz D , Skonieczna M , Rychla T , Gazdzik D , Podymniak S , Bicz W |
| Ref : Journal of Neurochemistry , 39 :1308 , 1982 |
| Abstract : |
| PubMedSearch : Sitkiewicz_1982_J.Neurochem_39_1308 |
| PubMedID: 6181202 |
| Title : Teratogenicity study on pyrethrum and rotenone (natural origin) and ronnel in pregnant rats - Khera_1982_J.Toxicol.Environ.Health_10_111 |
| Author(s) : Khera KS , Whalen C , Angers G |
| Ref : J Toxicol Environ Health , 10 :111 , 1982 |
| Abstract : |
| PubMedSearch : Khera_1982_J.Toxicol.Environ.Health_10_111 |
| PubMedID: 6182301 |
| Title : Modification of brain mitochondrial enzymes by the oxygen analogue of ronnel at various stages of development and aging - Sitkiewicz_1982_J.Neurochem_39_1308 |
| Author(s) : Sitkiewicz D , Skonieczna M , Rychla T , Gazdzik D , Podymniak S , Bicz W |
| Ref : Journal of Neurochemistry , 39 :1308 , 1982 |
| Abstract : |
| PubMedSearch : Sitkiewicz_1982_J.Neurochem_39_1308 |
| PubMedID: 6181202 |
| Title : Teratogenicity study on pyrethrum and rotenone (natural origin) and ronnel in pregnant rats - Khera_1982_J.Toxicol.Environ.Health_10_111 |
| Author(s) : Khera KS , Whalen C , Angers G |
| Ref : J Toxicol Environ Health , 10 :111 , 1982 |
| Abstract : |
| PubMedSearch : Khera_1982_J.Toxicol.Environ.Health_10_111 |
| PubMedID: 6182301 |
| Title : Modification of brain mitochondrial enzymes by the oxygen analogue of ronnel at various stages of development and aging - Sitkiewicz_1982_J.Neurochem_39_1308 |
| Author(s) : Sitkiewicz D , Skonieczna M , Rychla T , Gazdzik D , Podymniak S , Bicz W |
| Ref : Journal of Neurochemistry , 39 :1308 , 1982 |
| Abstract : |
| PubMedSearch : Sitkiewicz_1982_J.Neurochem_39_1308 |
| PubMedID: 6181202 |
| Title : Teratogenicity study on pyrethrum and rotenone (natural origin) and ronnel in pregnant rats - Khera_1982_J.Toxicol.Environ.Health_10_111 |
| Author(s) : Khera KS , Whalen C , Angers G |
| Ref : J Toxicol Environ Health , 10 :111 , 1982 |
| Abstract : |
| PubMedSearch : Khera_1982_J.Toxicol.Environ.Health_10_111 |
| PubMedID: 6182301 |
| Title : Effect of fenchlorphos intoxication on the respiration of brain mitochondria of rats at different age - |
| Author(s) : Sitkiewicz D , Gietka G , Bicz W |
| Ref : Neuropatol Pol , 19 :209 , 1981 |
| PubMedID: 6170914 |
| Title : [Determination of dermafos (fenchlorphos) residues in the tissues of hens and rabbits after single oral dose of pure and technical preparations] - Zasadowski_1981_Pol.Arch.Weter_23_143 |
| Author(s) : Zasadowski A |
| Ref : Pol Arch Weter , 23 :143 , 1981 |
| Abstract : |
| PubMedSearch : Zasadowski_1981_Pol.Arch.Weter_23_143 |
| PubMedID: 6170958 |
| Title : [Histochemical studies on the effect of fenchlorphos (0,0-dimethyl-0- 2,4,5-trichlophenyl thiophosphate) on perfused liver of albino rat] - |
| Author(s) : Sawicki B , Kuczynski M , Mackowiak J , Derewonko S |
| Ref : Patol Pol , 32 :79 , 1981 |
| PubMedID: 6171765 |
| Title : Effects of ronnel on growth, endocrine function and blood measurements in steers and rats - Rumsey_1981_J.Anim.Sci_53_217 |
| Author(s) : Rumsey TS , Tao H , Bitman J |
| Ref : J Anim Sci , 53 :217 , 1981 |
| Abstract : |
| PubMedSearch : Rumsey_1981_J.Anim.Sci_53_217 |
| PubMedID: 6172413 |
| Title : Effect of fenchlorphos intoxication on the respiration of brain mitochondria of rats at different age - |
| Author(s) : Sitkiewicz D , Gietka G , Bicz W |
| Ref : Neuropatol Pol , 19 :209 , 1981 |
| PubMedID: 6170914 |
| Title : [Determination of dermafos (fenchlorphos) residues in the tissues of hens and rabbits after single oral dose of pure and technical preparations] - Zasadowski_1981_Pol.Arch.Weter_23_143 |
| Author(s) : Zasadowski A |
| Ref : Pol Arch Weter , 23 :143 , 1981 |
| Abstract : |
| PubMedSearch : Zasadowski_1981_Pol.Arch.Weter_23_143 |
| PubMedID: 6170958 |
| Title : [Histochemical studies on the effect of fenchlorphos (0,0-dimethyl-0- 2,4,5-trichlophenyl thiophosphate) on perfused liver of albino rat] - |
| Author(s) : Sawicki B , Kuczynski M , Mackowiak J , Derewonko S |
| Ref : Patol Pol , 32 :79 , 1981 |
| PubMedID: 6171765 |
| Title : Effects of ronnel on growth, endocrine function and blood measurements in steers and rats - Rumsey_1981_J.Anim.Sci_53_217 |
| Author(s) : Rumsey TS , Tao H , Bitman J |
| Ref : J Anim Sci , 53 :217 , 1981 |
| Abstract : |
| PubMedSearch : Rumsey_1981_J.Anim.Sci_53_217 |
| PubMedID: 6172413 |
| Title : Effect of fenchlorphos intoxication on the respiration of brain mitochondria of rats at different age - |
| Author(s) : Sitkiewicz D , Gietka G , Bicz W |
| Ref : Neuropatol Pol , 19 :209 , 1981 |
| PubMedID: 6170914 |
| Title : [Determination of dermafos (fenchlorphos) residues in the tissues of hens and rabbits after single oral dose of pure and technical preparations] - Zasadowski_1981_Pol.Arch.Weter_23_143 |
| Author(s) : Zasadowski A |
| Ref : Pol Arch Weter , 23 :143 , 1981 |
| Abstract : |
| PubMedSearch : Zasadowski_1981_Pol.Arch.Weter_23_143 |
| PubMedID: 6170958 |
| Title : [Histochemical studies on the effect of fenchlorphos (0,0-dimethyl-0- 2,4,5-trichlophenyl thiophosphate) on perfused liver of albino rat] - |
| Author(s) : Sawicki B , Kuczynski M , Mackowiak J , Derewonko S |
| Ref : Patol Pol , 32 :79 , 1981 |
| PubMedID: 6171765 |
| Title : Effects of ronnel on growth, endocrine function and blood measurements in steers and rats - Rumsey_1981_J.Anim.Sci_53_217 |
| Author(s) : Rumsey TS , Tao H , Bitman J |
| Ref : J Anim Sci , 53 :217 , 1981 |
| Abstract : |
| PubMedSearch : Rumsey_1981_J.Anim.Sci_53_217 |
| PubMedID: 6172413 |
| Title : Isolation and concentration of organophosphorus pesticides from drinking water at the ng\/L level, using macroreticular resin - LeBel_1979_J.Assoc.Off.Anal.Chem_62_241 |
| Author(s) : LeBel GL , Williams DT , Griffith G , Benoit FM |
| Ref : J Assoc Off Analytical Chemistry , 62 :241 , 1979 |
| Abstract : |
| PubMedSearch : LeBel_1979_J.Assoc.Off.Anal.Chem_62_241 |
| PubMedID: 447594 |
| Title : Isolation and concentration of organophosphorus pesticides from drinking water at the ng\/L level, using macroreticular resin - LeBel_1979_J.Assoc.Off.Anal.Chem_62_241 |
| Author(s) : LeBel GL , Williams DT , Griffith G , Benoit FM |
| Ref : J Assoc Off Analytical Chemistry , 62 :241 , 1979 |
| Abstract : |
| PubMedSearch : LeBel_1979_J.Assoc.Off.Anal.Chem_62_241 |
| PubMedID: 447594 |
| Title : Isolation and concentration of organophosphorus pesticides from drinking water at the ng\/L level, using macroreticular resin - LeBel_1979_J.Assoc.Off.Anal.Chem_62_241 |
| Author(s) : LeBel GL , Williams DT , Griffith G , Benoit FM |
| Ref : J Assoc Off Analytical Chemistry , 62 :241 , 1979 |
| Abstract : |
| PubMedSearch : LeBel_1979_J.Assoc.Off.Anal.Chem_62_241 |
| PubMedID: 447594 |
| Title : The effect of O,O-dimethyl-O-(2,4,5-trichlorophenyl) phosphorothioate (fenchlorphos) on cholinesterases in the blue fox (Alopex lagopus) - |
| Author(s) : Soli NE , Andersen RA , Skaare JU , Mikalsen A |
| Ref : Acta Vet Scand , 18 :408 , 1977 |
| PubMedID: 71852 |
| Title : The effect of O,O-dimethyl-O-(2,4,5-trichlorophenyl) phosphorothioate (fenchlorphos) on cholinesterases in the blue fox (Alopex lagopus) - |
| Author(s) : Soli NE , Andersen RA , Skaare JU , Mikalsen A |
| Ref : Acta Vet Scand , 18 :408 , 1977 |
| PubMedID: 71852 |
| Title : The effect of O,O-dimethyl-O-(2,4,5-trichlorophenyl) phosphorothioate (fenchlorphos) on cholinesterases in the blue fox (Alopex lagopus) - |
| Author(s) : Soli NE , Andersen RA , Skaare JU , Mikalsen A |
| Ref : Acta Vet Scand , 18 :408 , 1977 |
| PubMedID: 71852 |
| Title : The activities of acetylcholinesterase, alkaline phosphatase and acid phosphatase of the rat brain following fenchlorphos intoxication - |
| Author(s) : Sulinski A , Skalska E , Obrusiewicz K |
| Ref : Neuropatol Pol , 14 :451 , 1976 |
| PubMedID: 63924 |
| Title : The activities of some oxidoreductases and respiratory control in rat brain mitochondria following fenchlorphos intoxication - |
| Author(s) : Rakowska I , Dybowska A , Malatynska E , Kielducka A |
| Ref : Neuropatol Pol , 14 :461 , 1976 |
| PubMedID: 63925 |
| Title : The activities of acetylcholinesterase, alkaline phosphatase and acid phosphatase of the rat brain following fenchlorphos intoxication - |
| Author(s) : Sulinski A , Skalska E , Obrusiewicz K |
| Ref : Neuropatol Pol , 14 :451 , 1976 |
| PubMedID: 63924 |
| Title : The activities of some oxidoreductases and respiratory control in rat brain mitochondria following fenchlorphos intoxication - |
| Author(s) : Rakowska I , Dybowska A , Malatynska E , Kielducka A |
| Ref : Neuropatol Pol , 14 :461 , 1976 |
| PubMedID: 63925 |
| Title : The activities of acetylcholinesterase, alkaline phosphatase and acid phosphatase of the rat brain following fenchlorphos intoxication - |
| Author(s) : Sulinski A , Skalska E , Obrusiewicz K |
| Ref : Neuropatol Pol , 14 :451 , 1976 |
| PubMedID: 63924 |
| Title : The activities of some oxidoreductases and respiratory control in rat brain mitochondria following fenchlorphos intoxication - |
| Author(s) : Rakowska I , Dybowska A , Malatynska E , Kielducka A |
| Ref : Neuropatol Pol , 14 :461 , 1976 |
| PubMedID: 63925 |
| Title : Studies on the effect of Fenchlorphos on postirradiation changes of serum proteins and nucleic acids content in rat liver - Mackowiak_1975_Strahlentherapie_150_97 |
| Author(s) : Mackowiak J , Wisniewski K |
| Ref : Strahlentherapie , 150 :97 , 1975 |
| Abstract : |
| PubMedSearch : Mackowiak_1975_Strahlentherapie_150_97 |
| PubMedID: 52206 |
| Title : Studies on the effect of Fenchlorphos on postirradiation changes of serum proteins and nucleic acids content in rat liver - Mackowiak_1975_Strahlentherapie_150_97 |
| Author(s) : Mackowiak J , Wisniewski K |
| Ref : Strahlentherapie , 150 :97 , 1975 |
| Abstract : |
| PubMedSearch : Mackowiak_1975_Strahlentherapie_150_97 |
| PubMedID: 52206 |
| Title : [Histochemical study of the effect of phosphoroorganic esters Z-50 (fenchlorfos) and Z-51 (bromophos) on cholinesteras activity in the course of the muscle phase in experimental trichinellosis in mice] - Ramisz_1975_Pol.Arch.Weter_17_623 |
| Author(s) : Ramisz A , Komorowski A |
| Ref : Pol Arch Weter , 17 :623 , 1975 |
| Abstract : |
| PubMedSearch : Ramisz_1975_Pol.Arch.Weter_17_623 |
| PubMedID: 52151 |
| Title : Problems of housefly (Musca domestica) control due to multiresistance to insesticides - Keiding_1975_J.Hyg.Epidemiol.Microbiol.Immunol_19_340 |
| Author(s) : Keiding J |
| Ref : J Hyg Epidemiol Microbiol Immunol , 19 :340 , 1975 |
| Abstract : |
| PubMedSearch : Keiding_1975_J.Hyg.Epidemiol.Microbiol.Immunol_19_340 |
| PubMedID: 52667 |
| Title : Studies on the effect of Fenchlorphos on postirradiation changes of serum proteins and nucleic acids content in rat liver - Mackowiak_1975_Strahlentherapie_150_97 |
| Author(s) : Mackowiak J , Wisniewski K |
| Ref : Strahlentherapie , 150 :97 , 1975 |
| Abstract : |
| PubMedSearch : Mackowiak_1975_Strahlentherapie_150_97 |
| PubMedID: 52206 |
| Title : [Histochemical study of the effect of phosphoroorganic esters Z-50 (fenchlorfos) and Z-51 (bromophos) on cholinesteras activity in the course of the muscle phase in experimental trichinellosis in mice] - Ramisz_1975_Pol.Arch.Weter_17_623 |
| Author(s) : Ramisz A , Komorowski A |
| Ref : Pol Arch Weter , 17 :623 , 1975 |
| Abstract : |
| PubMedSearch : Ramisz_1975_Pol.Arch.Weter_17_623 |
| PubMedID: 52151 |
| Title : Problems of housefly (Musca domestica) control due to multiresistance to insesticides - Keiding_1975_J.Hyg.Epidemiol.Microbiol.Immunol_19_340 |
| Author(s) : Keiding J |
| Ref : J Hyg Epidemiol Microbiol Immunol , 19 :340 , 1975 |
| Abstract : |
| PubMedSearch : Keiding_1975_J.Hyg.Epidemiol.Microbiol.Immunol_19_340 |
| PubMedID: 52667 |
| Title : [Histochemical study of the effect of phosphoroorganic esters Z-50 (fenchlorfos) and Z-51 (bromophos) on cholinesteras activity in the course of the muscle phase in experimental trichinellosis in mice] - Ramisz_1975_Pol.Arch.Weter_17_623 |
| Author(s) : Ramisz A , Komorowski A |
| Ref : Pol Arch Weter , 17 :623 , 1975 |
| Abstract : |
| PubMedSearch : Ramisz_1975_Pol.Arch.Weter_17_623 |
| PubMedID: 52151 |
| Title : Problems of housefly (Musca domestica) control due to multiresistance to insesticides - Keiding_1975_J.Hyg.Epidemiol.Microbiol.Immunol_19_340 |
| Author(s) : Keiding J |
| Ref : J Hyg Epidemiol Microbiol Immunol , 19 :340 , 1975 |
| Abstract : |
| PubMedSearch : Keiding_1975_J.Hyg.Epidemiol.Microbiol.Immunol_19_340 |
| PubMedID: 52667 |
| Title : [Absorption, tissue distribution and excretion of O,O-dimethyl-O-2,4,5- trichlorphenyl-phosphorothioate (Fenchlorphos) in rats] - |
| Author(s) : Palut D , Grzymala W |
| Ref : Rocz Panstw Zakl Hig , 22 :591 , 1971 |
| PubMedID: 4109663 |
| Title : [Absorption, tissue distribution and excretion of O,O-dimethyl-O-2,4,5- trichlorphenyl-phosphorothioate (Fenchlorphos) in rats] - |
| Author(s) : Palut D , Grzymala W |
| Ref : Rocz Panstw Zakl Hig , 22 :591 , 1971 |
| PubMedID: 4109663 |
| Title : [Absorption, tissue distribution and excretion of O,O-dimethyl-O-2,4,5- trichlorphenyl-phosphorothioate (Fenchlorphos) in rats] - |
| Author(s) : Palut D , Grzymala W |
| Ref : Rocz Panstw Zakl Hig , 22 :591 , 1971 |
| PubMedID: 4109663 |