Fenthion-oxon
In Australia and the USA, fenthion is used for agricultural purposes and to control cockroaches, crickets, flies, mosquitoes and spiders. It is also present in veterinary drug formulations to control fleas on dogs in Australia, and used as a mosquito adulticide, to control lice, flies, and ticks on cattle and swine or dragonfly larvae in aquaculture Like other organophosphotohionate pesticides fenthion is not active on AChE per se, but it has to be bioactivated: sulfoxidation to fenthion-sulfoxide (FEN-sulfoxide), catalyzed by cytochrome P450 or flavin-containing monooxygenase, and a CYP-mediated oxidative desulfuration to form fenthion-oxon
General
Type : Insecticide, Organophosphate, Sulfur Compound, Organothiophosphate
Chemical_Nomenclature : dimethyl (3-methyl-4-methylsulfanylphenyl) phosphate
Canonical SMILES : CC1=C(C=CC(=C1)OP(=O)(OC)OC)SC
InChI : InChI=1S\/C10H15O4PS\/c1-8-7-9(5-6-10(8)16-4)14-15(11,12-2)13-3\/h5-7H,1-4H3
InChIKey : ZNRZGJAHNMGWQN-UHFFFAOYSA-N
Other name(s) : Fenthion oxon || Fenthion-oxon || Fention oxon || Fenoxon || Fenthoxon || Bayoxon || SCHEMBL5933982 || ZINC2033887 || Bayer 35570 || BAY 35570
MW : 262.26
Formula : C10H15O4PS
CAS_number : 6552-12-1
PubChem : 23046
UniChem : ZNRZGJAHNMGWQN-UHFFFAOYSA-N
References (3)
| Title : Simultaneous Analysis of Fenthion and Its Five Metabolites in Produce Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry - Lee_2020_Molecules_25_1938 |
| Author(s) : Lee J , Kim JH |
| Ref : Molecules , 25 :1938 , 2020 |
| Abstract : |
| PubMedSearch : Lee_2020_Molecules_25_1938 |
| PubMedID: 32331373 |
| Title : The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion - Leoni_2008_Toxicol.Appl.Pharmacol_233_343 |
| Author(s) : Leoni C , Buratti FM , Testai E |
| Ref : Toxicol Appl Pharmacol , 233 :343 , 2008 |
| Abstract : |
| PubMedSearch : Leoni_2008_Toxicol.Appl.Pharmacol_233_343 |
| PubMedID: 18845175 |
| Title : Whole-body metabolism of the organophosphorus pesticide, fenthion, in goldfish, Carassius auratus - Kitamura_2000_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_126_259 |
| Author(s) : Kitamura S , Kadota T , Yoshida M , Jinno N , Ohta S |
| Ref : Comparative Biochemistry & Physiology C Toxicol Pharmacol , 126 :259 , 2000 |
| Abstract : |
| PubMedSearch : Kitamura_2000_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_126_259 |
| PubMedID: 11048676 |