Mequitazine

General

Type : Phenothiazine, Sulfur Compound, Not A\/B H target, Azabicyclo

Chemical_Nomenclature : 10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine

Canonical SMILES : C1CN2CCC1C(C2)CN3C4=CC=CC=C4SC5=CC=CC=C53

InChI : InChI=1S\/C20H22N2S\/c1-3-7-19-17(5-1)22(18-6-2-4-8-20(18)23-19)14-16-13-21-11-9-15(16)10-12-21\/h1-8,15-16H,9-14H2

InChIKey : HOKDBMAJZXIPGC-UHFFFAOYSA-N

Other name(s) : Metaplexan  ||  Primalan  ||  Virginan


MW : 322.5

Formula : C20H22N2S

CAS_number : 29216-28-2

PubChem : 4066

UniChem : HOKDBMAJZXIPGC-UHFFFAOYSA-N

Target

References (4)

Title : Inhibition of butyrylcholinesterase by phenothiazine derivatives - Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
Author(s) : Debord J , Merle L , Bollinger JC , Dantoine T
Ref : J Enzyme Inhib Med Chem , 17 :197 , 2002
Abstract :
PubMedSearch : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
PubMedID: 12443046

Title : An In Vitro Study on the Metabolism and Possible Drug Interactions of Rokitamycin, a Macrolide Antibiotic, Using Human Liver Microsomes - Zhao_1999_Drug.Metab.Dispos_27_776
Author(s) : Zhao XJ , Koyama E , Ishizaki T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 27 :776 , 1999
Abstract :
PubMedSearch : Zhao_1999_Drug.Metab.Dispos_27_776
PubMedID: 10383920

Title : An in-vitro study on the metabolism of rokitamycin and possible interactions of the drug with rat liver microsomes - Zhao_1999_J.Pharm.Pharmacol_51_1167
Author(s) : Zhao XJ , Ishizaki T
Ref : J Pharm Pharmacol , 51 :1167 , 1999
Abstract :
PubMedSearch : Zhao_1999_J.Pharm.Pharmacol_51_1167
PubMedID: 10579688

Title : Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics - Stanton_1993_Biochem.Pharmacol_45_2352
Author(s) : Stanton T , Bolden-Watson C , Cusack B , Richelson E
Ref : Biochemical Pharmacology , 45 :2352 , 1993
Abstract :
PubMedSearch : Stanton_1993_Biochem.Pharmacol_45_2352
PubMedID: 8100134