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  2. Type Inhibitor
  3. Not AlphaBeta Hydrolase target

Not AlphaBeta Hydrolase target

General

Substrates or inhibitors which are not primarily found or designed to be ligand of any alpha/beta hydrolases. Some Alpha/beta hydrolases can be considered as off targets of these compounds
Inhibitor Main targeted enzyme families Type Structure
Chlorpropham Carb_B_Bacteria Herbicide Carbamate Not AlphaBeta Hydrolase target
Theobromine Purine Alkaloid Natural Not AlphaBeta Hydrolase target
Topiramate-phenolicacid-cpdT4 Pancreatic_lipase Not AlphaBeta Hydrolase target Sulfur Compound
Emodin Natural Pyridine Acridine Not AlphaBeta Hydrolase target
Periciazine BCHE Not AlphaBeta Hydrolase target Phenothiazine Multitarget Drug Sulfur Compound Piperidine Cyanide
Ranitidine ACHE Multitarget Not AlphaBeta Hydrolase target Sulfur Compound
Homocysteine-thiolactone ACHE Natural Sulfur Compound Not AlphaBeta Hydrolase target Thiophen
Embelin Multitarget Not AlphaBeta Hydrolase target Natural
Itopride ACHE Not AlphaBeta Hydrolase target Drug Carboxamide Dopamine antagonist Benzamide
KBR-2822 Sulfur Compound Organophosphate Trifluoro Not AlphaBeta Hydrolase target
(R)-BEL Not AlphaBeta Hydrolase target Naphthalen
Caffeic-acid-phenethyl-ester BCHE ACHE Canar_LipB Hydroxycinnamic-ester Acrylate Not AlphaBeta Hydrolase target Natural
Triclosan Not AlphaBeta Hydrolase target Fungicide Trichloro
Sofosbuvir Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target
Loperamide Carb_B_Chordata Piperidine Drug Not AlphaBeta Hydrolase target Opioid analgesic
JM-20 ACHE Benzodiazepin Not AlphaBeta Hydrolase target Pyridine Multitarget 2-nitrophenyl Azepane
Valsartan Pectinacetylesterase-Notum Not AlphaBeta Hydrolase target Drug Tetrazol
Felbinac Pectinacetylesterase-Notum Fragment inhibitor of Notum Drug Not AlphaBeta Hydrolase target
Sulfapyridine Pectinacetylesterase-Notum Fragment inhibitor of Notum Sulfonamide Sulfur Compound Antibiotic Pyridine Not AlphaBeta Hydrolase target Benzenesulfonamide
Fragment-147 Pectinacetylesterase-Notum Fragment inhibitor of Notum Carboxamide Pyridine Not AlphaBeta Hydrolase target
Cotinine Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Natural Alkaloid Drug Nicotinic agonist Not AlphaBeta Hydrolase target
Riluzole Pectinacetylesterase-Notum Drug Benzothiazol Trifluoro Sulfur Compound Not AlphaBeta Hydrolase target Fragment inhibitor of Notum
TDZD8 Pectinacetylesterase-Notum Not AlphaBeta Hydrolase target GSK-3 kinase inhibitor Thiadiazol Sulfur Compound
PPOH Pectinacetylesterase-Notum Not AlphaBeta Hydrolase target Alkyne
Bepridil Pectinacetylesterase-Notum Pyrrolidine Not AlphaBeta Hydrolase target Drug Calcium Channel Antagonist
BisQ ACHE Analogue of substrate Trimethylammonium Bisquaternary Not AlphaBeta Hydrolase target Nicotinic agonist Photoswitch
Methylphenylcarbamyl-chloride Not AlphaBeta Hydrolase target
Methylphenylcarbamyl-fluoride Not AlphaBeta Hydrolase target
Diphenylcarbamyl-chloride Not AlphaBeta Hydrolase target
p-phenylazophenyltrimethylammonium Photoswitch Trimethylammonium Not AlphaBeta Hydrolase target Nicotinic agonist
N-p-phenylazophenylcarbamylcholine Photoswitch Trimethylammonium Not AlphaBeta Hydrolase target Nicotinic agonist
CHEMBL442384-S0E-3WK8 Epoxide_hydrolase Benzothiazol Not AlphaBeta Hydrolase target Trifluoro Sulfur Compound
CHEMBL48137-49O-4Y2R Epoxide_hydrolase Piperazine Pyridine Cyanide Not AlphaBeta Hydrolase target Adrenergic-Receptor-ligand
Fenoverine BCHE Not AlphaBeta Hydrolase target Drug Phenothiazine Sulfur Compound Piperazine Benzodioxo
Hypaphorine ACHE Not AlphaBeta Hydrolase target Natural Derivative of Tryptophan Indole Propionate
Remdesivir Carb_B_Chordata Pro-Drug Drug Not AlphaBeta Hydrolase target Propionate Triazine Cyanide
CHEMBL2152538 Not AlphaBeta Hydrolase target Isoquinoline Quinazoline Leaving group
Evodiamine BCHE Derivative of Evodiamine Natural beta-carboline Not AlphaBeta Hydrolase target Multitarget
Kitazin ACHE Organophosphate Organothiophosphate Fungicide Not AlphaBeta Hydrolase target Sulfur Compound
Valnoctamide Epoxide_hydrolase Not AlphaBeta Hydrolase target
Progabide Epoxide_hydrolase Not AlphaBeta Hydrolase target
Chelerythrine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Benzodioxo Phenanthridinium
Sanguinarine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Benzodioxo Phenanthridinium
Palmatine ACHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline
Berberine ACHE BCHE Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline Benzodioxo Antioxidant
Harmine Natural Alkaloid Indole beta-carboline Not AlphaBeta Hydrolase target
Caffeine Pectinacetylesterase-Notum Lipase_3 Purine Alkaloid Natural Drug Not AlphaBeta Hydrolase target
S9B Organophosphate Cyclic OP NTE inhibitor Not AlphaBeta Hydrolase target Sulfur Compound Biotin derivative
N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide Pectinacetylesterase-Notum Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target
N-acetylserotonin Pectinacetylesterase-Notum Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural
Melatonin Pectinacetylesterase-Notum Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural Antioxidant
Theophylline Pectinacetylesterase-Notum Alkaloid Natural Purine Not AlphaBeta Hydrolase target
Regorafenib Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Trifluoro Carboxamide multi-kinase inhibitor
Sorafenib Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Trifluoro Carboxamide multi-kinase inhibitor
Hexyl-dcp Organophosphate Not AlphaBeta Hydrolase target OPIDN-OP
O-hexyl-O-2,5-dichlorophenyl-phosphoramidate Organophosphate Not AlphaBeta Hydrolase target OPIDN-OP
Talinolol Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Adrenergic-Receptor-ligand tert-Butyl
Morpholino-Talinolol Epoxide_hydrolase Urea derivative Not AlphaBeta Hydrolase target Adrenergic-Receptor-ligand Morpholine tert-Butyl
Amodiaquine ACHE Quinoline Not AlphaBeta Hydrolase target Drug
Fulvestrant Epoxide_hydrolase Trifluoro Sulfur Compound Drug Not AlphaBeta Hydrolase target Phenanthrene
5ALU-HD2 Epoxide_hydrolase Adamantyl Urea derivative Carboxamide Pyrimidine Not AlphaBeta Hydrolase target
Diuron ACHE Epoxide_hydrolase Herbicide Not AlphaBeta Hydrolase target Urea derivative
Molinate Carbamate Herbicide Sulfur Compound Azepane Not AlphaBeta Hydrolase target
L-benzylsuccinate Carboxypeptidase_S10 Not AlphaBeta Hydrolase target
Cyanofenphos ACHE Organophosphate NTE inhibitor Cyanide Not AlphaBeta Hydrolase target Sulfur Compound
DSF LYsophospholipase_carboxylesterase Acidic_Lipase Sulfur Compound Sulfonyl NTE inhibitor Not AlphaBeta Hydrolase target Lipase inhibitor
Phenyl-BDPO Organophosphate NTE inhibitor Cyclic OP Not AlphaBeta Hydrolase target
OBDPO Organophosphate NTE inhibitor Cyclic OP Not AlphaBeta Hydrolase target
EOPF Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target FAAH inhibitor
CBDP ACHE BCHE Carb_B_Chordata Organophosphate Cyclic OP NTE inhibitor Not AlphaBeta Hydrolase target
Oleanolic-acid ACHE Not AlphaBeta Hydrolase target Natural Terpenoid
Ursolic-acid ACHE ABHD12-PHARC Not AlphaBeta Hydrolase target Natural Terpenoid
Zeatin ACHE Not AlphaBeta Hydrolase target Natural Purine Aminopurin
Peganine ACHE BCHE Not AlphaBeta Hydrolase target Alkaloid Natural_modified
Desoxypeganine ACHE BCHE Not AlphaBeta Hydrolase target Alkaloid Natural Quinazoline
Gramine ACHE BCHE Alkaloid Natural Not AlphaBeta Hydrolase target Indole
2-Chloroprocaine BCHE Local anesthetic Not AlphaBeta Hydrolase target
5-hydroxy-tryptamine ACHE BCHE Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural 5-HT-receptor-ligand
17-desoxypancuronium BCHE Nicotinic antagonist Neuromuscular Nondepolarizing Agents Not AlphaBeta Hydrolase target Acetate Phenanthrene
Amitriptyline BCHE Not AlphaBeta Hydrolase target Muscarinic antagonist
Pyridophen-10 ACHE Muscarinic antagonist Propionate Carbamate Pro-Drug Multitarget Not AlphaBeta Hydrolase target PET probe
Dimethylhydroxycarbaphen BCHE Muscarinic antagonist Propionate Carbamate Pro-Drug Multitarget Not AlphaBeta Hydrolase target
Atracurium BCHE Not AlphaBeta Hydrolase target Neuromuscular Nondepolarizing Agents Drug Isoquinoline Propionate
Atropine ACHE Not AlphaBeta Hydrolase target Muscarinic antagonist Drug Alkaloid Natural Azabicyclo Propionate
Terbutaline-monocarbamate BCHE Derivative of Bambuterol Carbamate Drug tert-Butyl Not AlphaBeta Hydrolase target Pro-Drug
Bambuterol BCHE Derivative of Bambuterol Carbamate Drug tert-Butyl Not AlphaBeta Hydrolase target Pro-Drug
Bensulide BCHE Sulfur Compound Sulfonamide Organophosphate Herbicide Not AlphaBeta Hydrolase target Benzenesulfonamide
Carbachol ACHE BCHE Not AlphaBeta Hydrolase target Carbamate Trimethylammonium Analogue of substrate Drug Muscarinic agonist Nicotinic agonist
Chlorpromazine ACHE BCHE Not AlphaBeta Hydrolase target Phenothiazine Multitarget Drug Sulfur Compound
Cisplatin ACHE Not AlphaBeta Hydrolase target
cis-Diamminediaquaplatinum ACHE Not AlphaBeta Hydrolase target
Cocaine BCHE Natural Not AlphaBeta Hydrolase target Drug Alkaloid Benzoate
D-tubocurarine ACHE Natural Alkaloid Neuromuscular Nondepolarizing Agents Not AlphaBeta Hydrolase target Drug
Decamethonium BCHE Bisquaternary Trimethylammonium Neuromuscular Nondepolarizing Agents Nicotinic antagonist Drug Not AlphaBeta Hydrolase target
Dibucaine BCHE Local anesthetic Quinoline Drug Not AlphaBeta Hydrolase target Carboxamide
Dibutyrate-pancuronium BCHE Butyrate Nicotinic antagonist Not AlphaBeta Hydrolase target Phenanthrene Neuromuscular Nondepolarizing Agents
DPDCVP Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target
Dibutyl-dichlorovinyl-phosphate~DBVP Carb_B_Chordata Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target
Diethylcarbamazine ACHE Piperazine Anthelmintic Not AlphaBeta Hydrolase target Carboxamide
Duador BCHE Pyrrolidine Neuromuscular Nondepolarizing Agents Quinoline Not AlphaBeta Hydrolase target
Gallamine~Flaxedil ACHE BCHE Neuromuscular Nondepolarizing Agents Nicotinic antagonist Not AlphaBeta Hydrolase target
Tyramine BCHE Adrenergic Uptake Inhibitors Not AlphaBeta Hydrolase target Drug
Imipramine BCHE Adrenergic Uptake Inhibitors Not AlphaBeta Hydrolase target Drug Azepane Benzazepin
SN-38 Carb_B_Bacteria Carb_B_Chordata Drug Derivative of Irinotecan Not AlphaBeta Hydrolase target Pro-Drug
Irinotecan Carboxylesterase Carb_B_Chordata Carb_B_Bacteria Carbamate Drug Derivative of Irinotecan Not AlphaBeta Hydrolase target
Levamisole ACHE Not AlphaBeta Hydrolase target Anthelmintic Azabicyclo Sulfur Compound
Meperidine BCHE Carboxylesterase Carb_B_Chordata Piperidine Drug Not AlphaBeta Hydrolase target Opioid analgesic
Benactyzine BCHE Not AlphaBeta Hydrolase target Muscarinic antagonist
Jatrorrhizine Natural Alkaloid Not AlphaBeta Hydrolase target Isoquinoline
Methylprednisolone BCHE Drug Steroid Phenanthrene Not AlphaBeta Hydrolase target
Metoclopramide BCHE Benzamide Dopamine antagonist Drug Not AlphaBeta Hydrolase target
Mivacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Drug Not AlphaBeta Hydrolase target
N-methylatropine Not AlphaBeta Hydrolase target Muscarinic antagonist Propionate
Nicotine ACHE BCHE Pectinacetylesterase-Notum Derivative of Nicotine Pyrrolidine Nicotinic agonist Natural Alkaloid Drug Not AlphaBeta Hydrolase target
Pancuronium BCHE Nicotinic antagonist Neuromuscular Nondepolarizing Agents Not AlphaBeta Hydrolase target Aminosteroid
Paraquat BCHE ACHE Herbicide Not AlphaBeta Hydrolase target
Permethrin Pyrethroid Insecticide Not AlphaBeta Hydrolase target Phenoxyphenyl Cyclopropyl
Phenmedipham ACHE BCHE Carbamate Herbicide Not AlphaBeta Hydrolase target FAAH inhibitor
Phenothiazine ACHE Phenothiazine Not AlphaBeta Hydrolase target Multitarget Drug Sulfur Compound
Phenyl-saligenin-phosphate~PSP BCHE Organophosphate Cyclic OP NTE inhibitor Not AlphaBeta Hydrolase target
Phenyl-di-n-pentylphosphinate Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target
Triallate Trichloro Carbamate Herbicide Sulfur Compound Not AlphaBeta Hydrolase target
Phenyl-benzyl-carbamate Carbamate NTE inhibitor Not AlphaBeta Hydrolase target
DPPF Organophosphate NTE inhibitor Not AlphaBeta Hydrolase target
OSF Monoglyceridelipase_lysophospholip Sulfur Compound NTE inhibitor Not AlphaBeta Hydrolase target Sulfonyl
Procainamide BCHE ACHE Local anesthetic Not AlphaBeta Hydrolase target Anti-Arrhythmia Agents Benzamide
Procaine BCHE Local anesthetic Drug Not AlphaBeta Hydrolase target
Promazine ACHE BCHE Phenothiazine Drug Sulfur Compound Not AlphaBeta Hydrolase target
Fluphenazine Phenothiazine Sulfur Compound Not AlphaBeta Hydrolase target Trifluoro
Mequitazine Phenothiazine Sulfur Compound Not AlphaBeta Hydrolase target Azabicyclo
Trifluoperazine Phenothiazine Sulfur Compound Trifluoro Not AlphaBeta Hydrolase target
Prochlorperazine Phenothiazine Sulfur Compound Not AlphaBeta Hydrolase target
Perphenazine Phenothiazine Sulfur Compound Not AlphaBeta Hydrolase target
Chlorproethazine BCHE Phenothiazine Sulfur Compound Not AlphaBeta Hydrolase target
Triflupromazine Phenothiazine Sulfur Compound Trifluoro Not AlphaBeta Hydrolase target
Promethazine ACHE BCHE Phenothiazine Drug Not AlphaBeta Hydrolase target Muscarinic antagonist Sulfur Compound
Suberogorgin ACHE Not AlphaBeta Hydrolase target
Succinylcholine~Suxamethonium BCHE Neuromuscular Nondepolarizing Agents Bisquaternary Trimethylammonium Not AlphaBeta Hydrolase target
Tetracaine BCHE Local anesthetic Drug Not AlphaBeta Hydrolase target
Tolserine ACHE BCHE Derivative of physostigmine-eserine Carbamate Indole NTE inhibitor Not AlphaBeta Hydrolase target
Diethyl-maleate Synergist of insecticide Not AlphaBeta Hydrolase target
Piperonyl-butoxide Benzodioxo Synergist of insecticide Not AlphaBeta Hydrolase target
Vecuronium BCHE Neuromuscular Nondepolarizing Agents Nicotinic antagonist Aminosteroid Piperidine Drug Acetate Not AlphaBeta Hydrolase target Phenanthrene
Tamoxifen Carboxylesterase Carb_B_Chordata Drug Natural Not AlphaBeta Hydrolase target
Mevastatin Carboxylesterase Carb_B_Chordata Drug Natural Not AlphaBeta Hydrolase target Naphthalen Antibiotic
Terbutaline Not AlphaBeta Hydrolase target Drug tert-Butyl Derivative of Bambuterol
Pipecuronium BCHE Neuromuscular Nondepolarizing Agents Nicotinic antagonist Aminosteroid Piperazine Phenanthrene Not AlphaBeta Hydrolase target
Rocuronium Neuromuscular Nondepolarizing Agents Aminosteroid Drug Not AlphaBeta Hydrolase target Morpholine Phenanthrene
Doxacurium BCHE Neuromuscular Nondepolarizing Agents Isoquinoline Bisquaternary Not AlphaBeta Hydrolase target
Cisatracurium BCHE Propionate Isoquinoline Neuromuscular Nondepolarizing Agents Nicotinic antagonist Bisquaternary Not AlphaBeta Hydrolase target
Amiloride ACHE BCHE Carboxamide Drug Pyridine Not AlphaBeta Hydrolase target