Perphenazine

dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ),

General

Type : Phenothiazine, Sulfur Compound, Not A\/B H target

Chemical_Nomenclature : 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol

Canonical SMILES : C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO

InChI : InChI=1S\/C21H26ClN3OS\/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26\/h1-2,4-7,16,26H,3,8-15H2

InChIKey : RGCVKNLCSQQDEP-UHFFFAOYSA-N

Other name(s) : Trilafon  ||  Perphenazin  ||  Etaperazine  ||  CHEMBL567  ||  CHEBI:8028  ||  SCHEMBL42125  ||  ZINC19228902


MW : 404.0

Formula : C21H26ClN3OS

CAS_number : 58-39-9

PubChem : 4748

UniChem : RGCVKNLCSQQDEP-UHFFFAOYSA-N

Target

References (7)

Title : Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review - Otreba_2020_Eur.J.Pharmacol_887_173553
Author(s) : Otreba M , Kosmider L , Rzepecka-Stojko A
Ref : European Journal of Pharmacology , 887 :173553 , 2020
Abstract :
PubMedSearch : Otreba_2020_Eur.J.Pharmacol_887_173553
PubMedID: 32949606

Title : Inactivation of cholinesterase induced by chlorpromazine cation radicals - Muraoka_2003_Pharmacol.Toxicol_92_100
Author(s) : Muraoka S , Miura T
Ref : Pharmacol Toxicol , 92 :100 , 2003
Abstract :
PubMedSearch : Muraoka_2003_Pharmacol.Toxicol_92_100
PubMedID: 12747580

Title : Inhibition of butyrylcholinesterase by phenothiazine derivatives - Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
Author(s) : Debord J , Merle L , Bollinger JC , Dantoine T
Ref : J Enzyme Inhib Med Chem , 17 :197 , 2002
Abstract :
PubMedSearch : Debord_2002_J.Enzyme.Inhib.Med.Chem_17_197
PubMedID: 12443046

Title : Pharmacologic profile of perphenazine's metabolites - Sweet_2000_J.Clin.Psychopharmacol_20_181
Author(s) : Sweet RA , Pollock BG , Mulsant BH , Rosen J , Sorisio D , Kirshner M , Henteleff R , DeMichele MA
Ref : J Clin Psychopharmacol , 20 :181 , 2000
Abstract :
PubMedSearch : Sweet_2000_J.Clin.Psychopharmacol_20_181
PubMedID: 10770456

Title : Quantitative determination of perphenazine and its metabolites in plasma by high-performance liquid chromatography and coulometric detection - Foglia_1995_J.Chromatogr.B.Biomed.Appl_668_291
Author(s) : Foglia JP , Sorisio D , Kirshner MA , Mulsant BH , Perel JM
Ref : Journal of Chromatography B Biomed Appl , 668 :291 , 1995
Abstract :
PubMedSearch : Foglia_1995_J.Chromatogr.B.Biomed.Appl_668_291
PubMedID: 7581864

Title : Phenothiazines inhibit acetylcholinesterase by concentration-dependent-type kinetics. A study with trifluoperazine and perphenazine - Spinedi_1992_Biochem.Pharmacol_44_1511
Author(s) : Spinedi A , Pacini L , Limatola C , Luly P , Farias RN
Ref : Biochemical Pharmacology , 44 :1511 , 1992
Abstract :
PubMedSearch : Spinedi_1992_Biochem.Pharmacol_44_1511
PubMedID: 1417975

Title : Differential effect of anionic and cationic drugs on the synaptosome-associated acetylcholinesterase activity of dog brain - Deliconstantinos_1985_Biochem.J_229_81
Author(s) : Deliconstantinos G , Tsakiris S
Ref : Biochemical Journal , 229 :81 , 1985
Abstract :
PubMedSearch : Deliconstantinos_1985_Biochem.J_229_81
PubMedID: 4038267