Phosphatidylinositol(18-0_20-4)
product of hydrolysis of GPI anchor. Portion of the GPI anchor. GPI, lipid anchor that binds a variety of proteins via the C-terminus to a phosphoethanolamine unit at the end of a complex glycosyl moiety. The phospholipid part is embedded in the membrane of the cell.. GPIs have a common pentasaccharide core structure 6-O-NEtP-ManAlpha1-2-ManAlpha1-6-ManAlpha1-4-GlcNAlpha1-6-Ino-1-P. Additional phosphorylations, glycosylations, or acylations at the 2-O position of the myo-inositol occur in a cell-type dependent manner. GPIs are heterogeneous in the glycan as well as the lipid part. Inositol can bear sn-1-alkyl-2-acylglycerol, sn-1,2-diacylglycerol, or ceramide adorned with lipid chains of different lengths and degrees of saturation.
General
Type : Phospholipid, Diacylglycerol
Chemical_Nomenclature : [(2R)-1-[hydroxy-[(5R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxy-3-octadecoxypropan-2-yl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate || [(2R)-1-[hydroxy-[(2R,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxy-3-octadecoxypropan-2-yl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
Canonical SMILES : CCCCCCCCCCCCCCCCCCOCC(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC(=O)CCCC=CCC=CCC=CCC=CCCCCC
InChI : InChI=1S\/C47H85O12P\/c1-3-5-7-9-11-13-15-17-19-21-22-24-26-28-30-32-34-36-41(48)58-40(39-57-60(54,55)59-47-45(52)43(50)42(49)44(51)46(47)53)38-56-37-35-33-31-29-27-25-23-20-18-16-14-12-10-8-6-4-2\/h11,13,17,19,22,24,28,30,40,42-47,49-53H,3-10,12,14-16,18,20-21,23,25-27,29,31-39H2,1-2H3,(H,54,55)\/b13-11-,19-17-,24-22-,30-28-\/t40-,42?,43-,44?,45?,46?,47?\/m1\/s1 || InChI=1S\/C47H85O12P\/c1-3-5-7-9-11-13-15-17-19-21-22-24-26-28-30-32-34-36-41(48)58-40(39-57-60(54,55)59-47-45(52)43(50)42(49)44(51)46(47)53)38-56-37-35-33-31-29-27-25-23-20-18-16-14-12-10-8-6-4-2\/h11,13,17,19,22,24,28,30,40,42-47,49-53H,3-10,12,14-16,18,20-21,23,25-27,29,31-39H2,1-2H3,(H,54,55)\/b13-11-,19-17-,24-22-,30-28-\/t40-,42?,43-,44+,45-,46-,47?\/m1\/s1
InChIKey : WVZYOWMZDZYUMR-WMXPFXFZSA-N || WVZYOWMZDZYUMR-FUJJFPPSSA-N
Other name(s) : PI(O-18:0\/20:4(5Z,8Z,11Z,14Z) || [(2~{R})-1-octadecoxy-3-[oxidanyl-[(2~{R},3~{R},5~{S},6~{R})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl](5~{Z},8~{Z},11~{Z},14~{Z})-icosa-5,8,11,14-tetraenoate || LYI
MW : 873.1
Formula : C47H85O12P
CAS_number :
UniChem : WVZYOWMZDZYUMR-WMXPFXFZSA-N, WVZYOWMZDZYUMR-FUJJFPPSSA-N
.gif)
Target
Families : Phosphatidylinositol(18-0_20-4) ligand of proteins in family
PGAP1
Structure :
8K9T
Protein :
chatd-g0s652
References (1)
| Title : Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis - Hong_2024_Nat.Commun_15_8 |
| Author(s) : Hong J , Li T , Chao Y , Xu Y , Zhu Z , Zhou Z , Gu W , Qu Q , Li D |
| Ref : Nat Commun , 15 :8 , 2024 |
| Abstract : |
| PubMedSearch : Hong_2024_Nat.Commun_15_8 |
| PubMedID: 38167496 |
| Gene_locus related to this paper: chatd-g0s652 , human-PGAP1 |