PGAP1

Relationship

Family: PGAP1

Block: X

Parent Family: No family

Comment

Post-GPI (Glycophosphatidylinositol; Glycosylphosphatidylinositol) attachment to proteins factor 1. The sequences found in this family are similar to PGAP1 (Q765A7_RAT). This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body. This family consists of several hypothetical bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold. The type VI lipase effectors Tle1-Tle5 secreted by the bacterial type VI secretion system (T6SS) have recently been identified as antibacterial effectors that hydrolyze membrane phospholipids. The Tle1-4 display phospholipase A1 and A2 (PLA1) (PLA2) activities. Tle1 belongs to Duf_2235 family (now T6SS-TLE1), TLE2 to Lipase_3, TLE3 to alpha/ beta hydrolase (now T6SS-TLE3) and here Tle4 belongs to PGAP1. There are two human genes in this family. One is SERAC1. Mutations of SERAC1 causes MEGDEL syndrome, a recessive disorder of dystonia and deafness with encephalopathy and Leigh-like syndrome, impaired oxidative phosphorylation and 3-methylglutaconic aciduria. Clinical features included psychomotor retardation, recurrent infections in infancy, hypoglycemia, spasticity, dystonia, sensorineural deafness, brain atrophy, and lesions on brain imaging. Laboratory studies showed increased serum lactate and alanine, urinary 3-MGA, mitochondrial oxidative phosphorylation defects, abnormal mitochondria, an abnormal phosphatidylglycerol and cardiolipin spectrum in fibroblasts, and abnormal accumulation of unesterified cholesterol within cells. The other is PGAP1. Mutations in PGAP1 causes Mental retardation, autosomal recessive 42 MRT42

Database

Interpro : IPR012908 GPI inositol-deacylase PGAP1-like , IPR039529 GPI inositol-deacylase

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF07819 PGAP1 GPI inositol-deacylase

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
8K9Q Cryo-EM structure of the GPI inositol-deacylase (PGAP1\/Bst1) from Chaetomium thermophilum chatd-g0s652
8K9R Cryo EM structure of the products-bound PGAP1(Bst1)-H443N from Chaetomium thermophilum chatd-g0s652
8K9T Cryo EM structure of the products-bound PGAP1(Bst1)-S327A from Chaetomium thermophilum chatd-g0s652
4R1D Structure of complex structure of Pseudomonas aeruginosa PAO1 enzyme PA1510 and its inhibitor pseae-PA1510

Gene_locus Name Species
chatd-g0s652 Chaetomium thermophilum (strain DSM 1495 \/ CBS 144.50 \/ IMI 039719) (Thermochaetoides thermophila) GPI inositol-deacylase Thermochaetoides thermophila DSM 1495
9bact-b6vfq6 uncultured bacterium Lipase LipA uncultured bacterium
9bact-d8v1j0 uncultured bacterium Esterase\/lipase clone EM3L7 uncultured bacterium
plaf7-q8ii19 Plasmodium falciparum (isolate 3D7) PF3D7_1134500 GPI inositol-deacylase Plasmodium falciparum
9zzzz-a0a0g3fj44 uncultured organism EH145 Uncharacterized protein uncultured organism
nocsj-A1SME4 Nocardioides sp. JS614 hypothetical protein (fragment) Nocardioides sp. JS614
9bact-c7f9k2 uncultured bacterium Lipase\/esterase uncultured bacterium
9burk-a6gq58 Limnobacter sp. MED105 Putative lipase transmembrane protein Limnobacter sp. MED105
9burk-c9yb37 Curvibacter putative symbiont of Hydra magnipapillata Putative uncharacterized protein Curvibacter putative symbiont of Hydra magnipapillata
9chlb-q4apz8 Chlorobium phaeobacteroides BS1 hypothetical protein Chlorobium phaeobacteroides BS1
9delt-a6fy80 Plesiocystis pacifica SIR-1 PGAP1-like protein Plesiocystis pacifica SIR-1
9firm-q2ahs1 Halothermothrix orenii H 168 hypothetical protein precursor Halothermothrix orenii H 168
9gamm-q1udv6 Psychrobacter sp. PRwf-1 hypothetical protein Psychrobacter sp. PRwf-1
9gamm-q1uec0 Psychrobacter sp. PRwf-1 hypothetical protein Psychrobacter sp. PRwf-1
9gamm-q1zes3 Psychromonas sp. CNPT3 hypothetical protein Psychromonas sp. CNPT3
9gamm-q1zes8 Psychromonas sp. CNPT3 hypothetical protein Psychromonas sp. CNPT3
9gamm-q1zet3 Psychromonas sp. CNPT3 hypothetical protein Psychromonas sp. CNPT3
9prot-q0ez31 Mariprofundus ferrooxydans PV-1 Esterase\/lipase\/thioesterase family active site Mariprofundus ferrooxydans PV-1
accpu-c7rq29 Accumulibacter phosphatis (strain UW-1) TIR protein Accumulibacter phosphatis
aciad-q6f6x6 Acinetobacter sp. (strain ADP1) hypothetical protein Acinetobacter sp.
aciad-q6fal1 Acinetobacter sp. (strain ADP1) hypothetical protein Acinetobacter sp.
acide-c5tag9 Acidovorax delafieldii 2AN PGAP1 family protein Acidovorax delafieldii 2AN
aciet-b9mcl3 Acidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))Acidovorax sp. (strain JS42) PGAP1 family protein Acidovorax ebreus
aerhh-a0kkj8 Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 \/ NCIB 9240) Putative lipase transmembrane protein Aeromonas hydrophila subsp. hydrophila
aers4-a4smh7 Aeromonas salmonicida (strain A449) Putative lipase transmembrane protein Aeromonas salmonicida
ailme-d2hdi6 Ailuropoda melanoleuca (Giant panda) Uncharacterized protein Ailuropoda melanoleuca
anade-q2ipl0 Anaeromyxobacter dehalogenans (strain 2CP-C) pgap1-like precursor Anaeromyxobacter dehalogenans
anoga-q7psq5 Anopheles gambiae str. PEST ensangp00000014894 (fragment) Anopheles gambiae
arath-At3g27325 Arabidopsis thaliana (Mouse-ear cress) At3g27325 similarity to negative regulator of vesicle formation Arabidopsis thaliana
arath-At5g17670 Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) MVA3.2, At5g17670 Hydrolase-like protein Arabidopsis thaliana
ashgo-BST1 Ashbya gossypii (Yeast) (Eremothecium gossypii) afr521wp Ashbya gossypii
aspfu-q4wgm4 Aspergillus fumigatus, Neosartorya fumigata, Neosartorya fischeri (Aspergillus fischerianus) gpi maturation protein (bst1), putative Aspergillus fumigatus Af293
aspor-q2usi0 Aspergillus oryzae negative regulator of copii vesicle formation Aspergillus oryzae
asptn-bst1 Aspergillus terreus (strain NIH 2624 \/ FGSC A1156) GPI inositol-deacylase Aspergillus terreus
bifdb-d2q844 Bifidobacterium dentium (strains ATCC 27534 \/ DSM 20436 \/ JCM 1195 \/ Bd1\; ATCC 27678) Alpha\/beta fold family hydrolase membrane associated protein Bifidobacterium dentium
bovin-e1bnq0 Bos taurus (Bovine) Uncharacterized protein Bos taurus
bovin-srac1 Bos taurus (Bovine) Protein SERAC1 Bos taurus
caebr-a8y4l4 Caenorhabditis briggsae hypothetical protein cbg23146 Caenorhabditis briggsae
caeel-T19B10.8 Caenorhabditis elegans t19b10.8 protein Caenorhabditis elegans
canal-q5ai09 Candida albicans (strains SC5314\; WO-1) hypothetical protein tgl2 Candida albicans SC5314
canal-q59vp0 Candida albicans (strains SC5314\; WO-1) hypothetical protein bst1 Candida albicans SC5314
canfa-e2r8v9 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein Canis lupus familiaris
canga-q6fly9 Candida glabrata (Yeast) (Torulopsis glabrata) candida glabrata strain cbs138 chromosome k complete sequence Candida glabrata
chagb-q2gtl6 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chagb-q2gw21 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chagb-q2h102 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chagb-q2hht3 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
cloac-CAC1028 Clostridium acetobutylicum lipase Clostridium acetobutylicum
cloth-a3dhx6 Clostridium thermocellum, hydrolase fold precursor Clostridium thermocellum ATCC 27405
cocim-bst1 Coccidioides immitis (Valley fever fungus) GPI inositol-deacylase Coccidioides immitis
comte-b7wsd9 Comamonas testosteroni KF-1 PGAP1 family protein Comamonas testosteroni KF-1
cryne-q5kf48 Cryptococcus neoformans (Filobasidiella neoformans) er-associated protein catabolism-related protein, putative Cryptococcus neoformans
cupnh-q0kcu9 Cupriavidus necator (strain ATCC 17699 \/ H16 \/ DSM 428 \/ Stanier 337) (Ralstonia eutropha) Predicted acetyltransferase and hydrolase with the alpha\/beta hydrolase fold Cupriavidus necator
cuppj-q46qh0 Cupriavidus pinatubonensis (strain JMP134 \/ LMG 1197) (Alcaligenes eutrophus) (Ralstonia eutropha) hypothetical protein Ralstonia eutropha
cuppj-q473w2 Cupriavidus pinatubonensis (strain JMP134 \/ LMG 1197) (Alcaligenes eutrophus) (Ralstonia eutropha) putative lipase transmembrane protein Ralstonia eutropha
cuptr-b3r3y6 Cupriavidus taiwanensis (strain R1 \/ LMG 19424) (Ralstonia taiwanensis (strain LMG 19424)) Putative LIPASE\/acetyltransferase TRANSMEMBRANE PROTEIN Cupriavidus taiwanensis
danre-srac1 Danio rerio (Zebrafish) (Brachydanio rerio) Protein SERAC1 Danio rerio
debha-q6bpc6 Debaryomyces hansenii (Yeast) (Torulaspora hansenii) lipase Debaryomyces hansenii
debha-q6brg1 Debaryomyces hansenii (Yeast) (Torulaspora hansenii) hansenii Debaryomyces hansenii
decar-q47fp1 Dechloromonas aromatica (strain RCB) putative lipase transmembrane protein Dechloromonas aromatica
delas-a9bxx5 Delftia acidovorans (strain DSM 14801 \/ SPH-1) PGAP1 family protein Delftia acidovorans
dicdi-q54vc2 Dictyostelium discoideum (Slime mold) hypothetical protein Dictyostelium discoideum
dicdi-q54xe3 Dictyostelium discoideum (Slime mold) hypothetical protein Dictyostelium discoideum
drome-CG3160 Drosophila melanogaster (Fruit fly) cg3160 sd04405p protein Drosophila melanogaster
drops-q29i09 Drosophila pseudoobscura (Fruit fly) ga16331-pa (fragment) Drosophila pseudoobscura
ecolx-e0quw2 Escherichia coli NC101 Putative uncharacterized protein Escherichia coli NC101
ecout-q1r7l6 Escherichia coli, Escherichia sp., hypothetical protein Escherichia coli
emeni-BST1 Aspergillus nidulans FGSC A4 hypothetical protein Aspergillus nidulans FGSC A4
emeni-q5awq3 Emericella nidulans (Aspergillus nidulans) FGSC A4 hypothetical protein Aspergillus nidulans FGSC A4
geomg-q39yy9 Geobacter metallireducens (strain GS-15 \/ ATCC 53774 \/ DSM 7210) hypothetical protein Geobacter metallireducens
geosl-q747u4 Geobacter sulfurreducens conserved domain protein Geobacter sulfurreducens
gibze-q4hyd8 Gibberella zeae (Fusarium graminearum) GPI inositol-deacylase Gibberella zeae
glovi-q7ndy7 Gloeobacter violaceus Gll4095 protein Gloeobacter violaceus
hahch-q2s796 Hahella chejuensis (strain KCTC 2396) hydrolase fold Hahella chejuensis
halo1-d0ljp4 Haliangium ochraceum (strain DSM 14365 \/ JCM 11303 \/ SMP-2) Putative uncharacterized protein Haliangium ochraceum
human-PGAP1 Homo sapiens (Human)GPI inositol-deacylase PGAP1 117.8 kd protein in ste2-frs2 intergenic region Homo sapiens
human-SERAC1 Homo sapiens (Human) Protein SERAC1 Homo sapiens
klula-q6cin9 Kluyveromyces lactis (Yeast) 1140 of kluyveromyces lactis Kluyveromyces lactis
leima-q4fw33 Leishmania major strain Friedlin hypothetical protein Leishmania major strain Friedlin
lepin-LA0587 Leptospira interrogans lactonizing lipase (EC 3.1.1.3) Leptospira interrogans
lepin-LA1345 Leptospira interrogans (and strain serogroup Icterohaemorrhagiae serovar copenhageni) hypothetical protein Leptospira interrogans
lepin-LA1861 Leptospira interrogans (and serogroup Icterohaemorrhagiae serovar copenhageni)conserved hypothetical protein Leptospira interrogans
lepin-LA2505 Leptospira interrogans (and serogroup Icterohaemorrhagiae serovar copenhageni) esterase, putative Leptospira interrogans
maggr-q0pnd5 Magnaporthe grisea (Crabgrass-specific blast fungus) (Pyricularia grisea) Magnaporthe oryzae (Rice blast fungus) (Pyricularia oryzae) Triacylglycerol lipase Magnaporthe grisea
mago7-a4qxi6 Magnaporthe oryzae (strain 70-15 \/ FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) GPI inositol-deacylase Magnaporthe oryzae
metpp-a2scm2 Methylibium petroleiphilum (strain PM1) Putative lipase transmembrane protein Methylibium petroleiphilum
mouse-q3uuq7 Mus musculus (Mouse) gpi deacylase full insert sequence. (fragment) Mus musculus
mouse-srac1 Mus musculus (Mouse) Protein SERAC1 Mus musculus
mycgi-a4t0x3 Mycobacterium gilvum (Mycobacterium flavescens), Mycobacterium sp., hypothetical protein Mycobacterium gilvum PYR-GCK
mycss-q1bcs4 Mycobacterium sp., pgap1-like Mycobacterium sp. KMS
nech7-c7ytb2 Nectria haematococca (strain 77-13-4 \/ FGSC 9596 \/ MPVI) (Fusarium solani subsp. pisi) Predicted protein Nectria haematococca
neucr-q6mfs7 Neurospora crassa related to sphingosine-1-phosphate lyase Neurospora crassa
neucr-q7rxv5 Neurospora crassa predicted protein (hypothetical protein b11e5.130) Neurospora crassa
neucr-q7sff7 Neurospora crassa predicted protein Neurospora crassa
niteu-TGL2 Nitrosomonas europaea esterase\/lipase\/thioesterase family active site (EC 3.1.1.3) Nitrosomonas europaea
nitmu-q2yap5 Nitrosospira multiformis (strain ATCC 25196 \/ NCIMB 11849) esterase\/lipase\/thioesterase family active site Nitrosospira multiformis
orysa-q6z6y3 Oryza sativa (japonica cultivar-group) hypothetical protein p0576f08.31 Oryza sativa
orysa-q67tv0 Oryza sativa subsp. japonica subsp. indica (Rice) gpi inositol-deacylase pgap1-like protein Oryza sativa
parl1-a7hus8 Parvibaculum lavamentivorans (strain DS-1 \/ DSM 13023 \/ NCIMB 13966) Putative uncharacterized protein Parvibaculum lavamentivorans
phano-bst1 Phaeosphaeria nodorum (Glume blotch fungus) (Septoria nodorum) GPI inositol-deacylase Phaeosphaeria nodorum
pholl-q7n246 Photorhabdus luminescens subsp. laumondii similar to unknown protein Photorhabdus luminescens subsp. laumondii
pholl-q7n258 Photorhabdus luminescens subsp. laumondii similar to unknown protein Photorhabdus luminescens subsp. laumondii
pholu-ORF47 Photorhabdus luminescens (Xenorhabdus luminescens) orf47 Photorhabdus luminescens
phopr-q1z944 Photobacterium profundum 3TCK hypothetical protein Photobacterium profundum 3TCK
phopr-q6lq19 Photobacterium profundum (Photobacterium sp. (strain SS9)) (and 3TCK) hypothetical protein Photobacterium profundum
phopr-q6lql0 Photobacterium profundum (Photobacterium sp. (strain SS9)) hypothetical protein Photobacterium profundum
podan-b2ae59 Podospora anserina (strain S \/ DSM 980 \/ FGSC 10383) (Pleuraga anserina) Predicted CDS Pa_4_2940 Podospora anserina
podan-b2afn5 Podospora anserina (strain S \/ DSM 980 \/ FGSC 10383) (Pleuraga anserina) Predicted CDS Pa_5_12100 Podospora anserina
polna-a1vjc9 Polaromonas naphthalenivorans (strain CJ2) Putative lipase transmembrane protein Polaromonas naphthalenivorans
polsj-q124c9 Polaromonas sp. (strain JS666 \/ ATCC BAA-500) Putative lipase transmembrane protein Polaromonas sp.
pseae-PA1510 Pseudomonas aeruginosa hypothetical protein pa1510 Tle4 Pseudomonas aeruginosa
pseht-q3ijy1 Pseudoalteromonas haloplanktis (strain TAC 125) hypothetical protein Pseudoalteromonas haloplanktis
psyar-q4fuy7 Psychrobacter arcticum Psychrobacter cryohalolentis K5 hypothetical protein Psychrobacter arcticum
ralme-q1lpy4 Ralstonia metallidurans (strain CH34 \/ ATCC 43123 \/ DSM 2839) pgap1-like protein precursor Ralstonia metallidurans
ralp1-c6bjr8 Ralstonia pickettii (strain 12D) PGAP1 family protein Ralstonia pickettii
ralpj-b2u7t0 Ralstonia pickettii (strain 12J) PGAP1 family protein Ralstonia pickettii
ralso-a3rqm7 Ralstonia solanacearum UW551 Lipase Ralstonia solanacearum UW551
ralso-b5s2a7 Ralstonia solanacearum MolK2 Lipase protein Ralstonia solanacearum MolK2
ralso-b5sii0 Ralstonia solanacearum IPO1609 Lipase protein Ralstonia solanacearum IPO1609
ralso-q8xsf9 Ralstonia solanacearum (Pseudomonas solanacearum) hypothetical protein rsp0517 Ralstonia solanacearum
ralso-q8xta6 Ralstonia solanacearum (Pseudomonas solanacearum) hypothetical protein rsp0208 Ralstonia solanacearum
ralso-RSC2082 Ralstonia solanacearum (Pseudomonas solanacearum) putative lipase transmembrane protein (EC 3.1.-.-) Ralstonia solanacearum
ralso-RSP0769 Ralstonia solanacearum (Pseudomonas solanacearum) putative transmembrane protein Ralstonia solanacearum
ratno-q765a7 Rattus norvegicus (Rat) gpi deacylase Rattus norvegicus
rhofd-q21sk3 Rhodoferax ferrireducens (strain DSM 15236 \/ ATCC BAA-621 \/ T118) pgap1-like Rhodoferax ferrireducens
rhom4-d0mhw6 Rhodothermus marinus (Rhodothermus obamensis)\; uncultured bacterium. Esterase\/lipase\/thioesterase family protein estC55-213 Rhodothermus marinus
rhop5-q07nt1 Rhodopseudomonas palustris (strain BisA53) Putative uncharacterized protein Rhodopseudomonas palustris
rhopa-q6n3c2 Rhodopseudomonas palustris hypothetical protein Rhodopseudomonas palustris
rhopa-q379w1 Rhodopseudomonas palustris BisA53 hypothetical protein Rhodopseudomonas palustris BisA53
rhopb-q218h0 Rhodopseudomonas palustris (strain BisB18) hypothetical protein Rhodopseudomonas palustris
rhort-q2rtc8 Rhodospirillum rubrum (strain ATCC 11170 \/ NCIB 8255) TPR repeat Rhodospirillum rubrum
salrd-q2s1v7 Salinibacter ruber (strain DSM 13855) putative secreted lipase Salinibacter ruber
schpo-BST1 Schizosaccharomyces pombe (strain 972 \/ ATCC 24843) (Fission yeast) putative negative regulator of vesicle formation Schizosaccharomyces pombe
tetng-q4rk53 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tetts-q22sa5 Tetrahymena thermophila SB210 hypothetical protein Tetrahymena thermophila SB210
thaps-b8c0a3 Thalassiosira pseudonana (Marine diatom) Putative uncharacterized protein Thalassiosira pseudonana
triei-q10v22 Trichodesmium erythraeum (strain IMS101) Putative uncharacterized protein Trichodesmium erythraeum
triei-q114j5 Trichodesmium erythraeum (strain IMS101) NB-ARC Trichodesmium erythraeum
tryb2-q38dx1 Trypanosoma brucei hypothetical protein Trypanosoma brucei
trybb-q2pg85 Trypanosoma brucei brucei gpi inositol deacylase 2 Trypanosoma brucei
trycr-q4d3x3 Trypanosoma cruzi hypothetical protein Trypanosoma cruzi
trycr-q4d975 Trypanosoma cruzi hypothetical protein Trypanosoma cruzi
trycr-q4dt91 Trypanosoma cruzi hypothetical protein Trypanosoma cruzi
trycr-q4e5z2 Trypanosoma cruzi hypothetical protein Trypanosoma cruzi
ustma-q4p782 Ustilago maydis (strain 521 \/ FGSC 9021) (Corn smut fungus) hypothetical protein Ustilago maydis 521
vibch-VCA0092 Vibrio cholerae hypothetical protein vca0092 Vibrio cholerae
vibf1-q5dyj8 Vibrio fischeri (strain ATCC 700601 \/ ES114) acetyltransferase\/hydrolase family protein Vibrio fischeri
vibpa-VPA1249 Vibrio parahaemolyticus, Vibrio alginolyticus, hypothetical protein Vibrio parahaemolyticus
vibvu-VV20805 Vibrio vulnificus predicted acetyltransferase\/hydrolase Vibrio vulnificus
xanca-XCC0757 Xanthomonas campestris (pv. campestris) hypothetical protein xcc0757 Xanthomonas campestris
xenla-q66j01 Xenopus laevis (African clawed frog) mgc83827 protein Xenopus laevis
yarli-BST1B Yarrowia lipolytica (Yeast) (Candida lipolytica) GPI inositol-deacylase B Yarrowia lipolytica
yarli-q6c2z2 Yarrowia lipolytica (Candida lipolytica) lipolytica Yarrowia lipolytica
yarli-q6cf60 Yarrowia lipolytica (Candida lipolytica) lipolytica Yarrowia lipolytica
yeast-BST1 Saccharomyces cerevisiae (Baker's yeast), BST1, YFL025C, GPI inositol-deacylase Saccharomyces cerevisiae
yeast-tgl2 Saccharomyces cerevisiae (Baker's yeast) (and strains YJM789\; JAY291\; AWRI1631\; Lalvin EC1118 \/ Prise de mousse\; RM11-1a) lipase 2 (EC 3.1.1.3) (triacylglycerol lipase) Saccharomyces cerevisiae

Gene_locus_frgt Name Species
pig-f1sn10 Sus scrofa (Pig) Uncharacterized protein Sus scrofa
shefn-q07wz5 Shewanella frigidimarina (strain NCIMB 400) hypothetical protein precursor Shewanella frigidimarina NCIMB 400

Substrate Chemical Nomenclature Proteins
GPI-anchor

Inhibitor Chemical Nomenclature Proteins
phosphatidyl-inositol [(2R)-1-[hydroxy-[(2R,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxy-3-octadecoxypropan-2-yl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate chatd-g0s652
Palmitate hexadecanoic acid bacan-BA4983    human-CES1    bovin-ppt    humla-1lipa    myctu-ym24    chatd-g0s652
HDFP 1-(ethoxy-fluoro-oxidophosphaniumyl)hexadecane human-PREPL
Sal-A-alkyne plafa-PF10.0020    plafa-PF07.0040    plafa-a0a143zya4    plafa-PF10.0379    plafa-PF13.0153    plaf7-q8iik5    plaf7-q8ii19    plafa-MAL8P1.138
Salinipostin-A (3R,8aS)-5-butyl-3-oxo-3-pentadecoxy-8,8a-dihydro-1H-furo[3,4-e][1,3,2]dioxaphosphepin-6-one plafa-PF10.0020    plafa-PF07.0040    plafa-a0a143zya4    plafa-PF10.0379    plafa-PF13.0153    plaf7-q8iik5    plaf7-q8ii19    plafa-MAL8P1.138

References (5)

Title : Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis - Hong_2024_Nat.Commun_15_8
Author(s) : Hong J , Li T , Chao Y , Xu Y , Zhu Z , Zhou Z , Gu W , Qu Q , Li D
Ref : Nat Commun , 15 :8 , 2024
Abstract :
PubMedSearch : Hong_2024_Nat.Commun_15_8
PubMedID: 38167496
Gene_locus related to this paper: chatd-g0s652 , human-PGAP1

Title : The structural basis of the Tle4-Tli4 complex reveals the self-protection mechanism of H2-T6SS in Pseudomonas aeruginosa - Lu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_3233
Author(s) : Lu D , Zheng Y , Liao N , Wei L , Xu B , Liu X , Liu J
Ref : Acta Crystallographica D Biol Crystallogr , 70 :3233 , 2014
Abstract :
PubMedSearch : Lu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_3233
PubMedID: 25478841
Gene_locus related to this paper: pseae-PA1510

Title : Null mutation in PGAP1 impairing Gpi-anchor maturation in patients with intellectual disability and encephalopathy - Murakami_2014_PLoS.Genet_10_e1004320
Author(s) : Murakami Y , Tawamie H , Maeda Y , Buttner C , Buchert R , Radwan F , Schaffer S , Sticht H , Aigner M , Reis A , Kinoshita T , Jamra RA
Ref : PLoS Genet , 10 :e1004320 , 2014
Abstract :
PubMedSearch : Murakami_2014_PLoS.Genet_10_e1004320
PubMedID: 24784135
Gene_locus related to this paper: human-PGAP1

Title : Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness - Wortmann_2012_Nat.Genet_44_797
Author(s) : Wortmann SB , Vaz FM , Gardeitchik T , Vissers LE , Renkema GH , Schuurs-Hoeijmakers JH , Kulik W , Lammens M , Christin C , Kluijtmans LA , Rodenburg RJ , Nijtmans LG , Grunewald A , Klein C , Gerhold JM , Kozicz T , van Hasselt PM , Harakalova M , Kloosterman W , Baric I , Pronicka E , Ucar SK , Naess K , Singhal KK , Krumina Z , Gilissen C , van Bokhoven H , Veltman JA , Smeitink JA , Lefeber DJ , Spelbrink JN , Wevers RA , Morava E , de Brouwer AP
Ref : Nat Genet , 44 :797 , 2012
Abstract :
PubMedSearch : Wortmann_2012_Nat.Genet_44_797
PubMedID: 22683713
Gene_locus related to this paper: human-SERAC1

Title : Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p - Tanaka_2004_J.Biol.Chem_279_14256
Author(s) : Tanaka S , Maeda Y , Tashima Y , Kinoshita T
Ref : Journal of Biological Chemistry , 279 :14256 , 2004
Abstract :
PubMedSearch : Tanaka_2004_J.Biol.Chem_279_14256
PubMedID: 14734546
Gene_locus related to this paper: human-PGAP1 , ratno-q765a7 , yeast-BST1