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PGAP1

Relationship

Family: PGAP1

Block: X

Parent Family: No family

Comment

Post-GPI (Glycophosphatidylinositol; Glycosylphosphatidylinositol) attachment to proteins factor 1. The sequences found in this family are similar to PGAP1 (Q765A7_RAT). This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body. This family consists of several hypothetical bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold. The type VI lipase effectors Tle1-Tle5 secreted by the bacterial type VI secretion system (T6SS) have recently been identified as antibacterial effectors that hydrolyze membrane phospholipids. The Tle1-4 display phospholipase A1 and A2 (PLA1) (PLA2) activities. Tle1 belongs to Duf_2235 family (now T6SS-TLE1), TLE2 to Lipase_3, TLE3 to alpha/ beta hydrolase (now T6SS-TLE3) and here Tle4 belongs to PGAP1. There is one human gene in this family: PGAP1. Mutations in PGAP1 causes Mental retardation, autosomal recessive 42 MRT42 (another previouls included her was SERAC1 but now included in a separate family

Database

Interpro : IPR012908 GPI inositol-deacylase PGAP1-like , IPR039529 GPI inositol-deacylase

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF07819 PGAP1 GPI inositol-deacylase

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
4R1D Structure of complex structure of Pseudomonas aeruginosa PAO1 enzyme PA1510 and its inhibitor pseae-PA1510
8K9Q Cryo-EM structure of the GPI inositol-deacylase (PGAP1\/Bst1) from Chaetomium thermophilum chatd-g0s652
8K9R Cryo EM structure of the products-bound PGAP1(Bst1)-H443N from Chaetomium thermophilum chatd-g0s652
8K9T Cryo EM structure of the products-bound PGAP1(Bst1)-S327A from Chaetomium thermophilum chatd-g0s652

Gene_locus Name Species
9bact-b6vfq6 uncultured bacterium Lipase LipA uncultured bacterium
9bact-c7f9k2 uncultured bacterium Lipase\/esterase uncultured bacterium
9bact-d8v1j0 uncultured bacterium Esterase\/lipase clone EM3L7 uncultured bacterium
9burk-a6gq58 Limnobacter sp. MED105 Putative lipase transmembrane protein Limnobacter sp. MED105
9burk-c9yb37 Curvibacter putative symbiont of Hydra magnipapillata Putative uncharacterized protein Curvibacter putative symbiont of Hydra magnipapillata
9chlb-q4apz8 Chlorobium phaeobacteroides BS1 hypothetical protein Chlorobium phaeobacteroides BS1
9delt-a6fy80 Plesiocystis pacifica SIR-1 PGAP1-like protein Plesiocystis pacifica SIR-1
9firm-q2ahs1 Halothermothrix orenii H 168 hypothetical protein precursor Halothermothrix orenii H 168
9gamm-q1udv6 Psychrobacter sp. PRwf-1 hypothetical protein Psychrobacter sp. PRwf-1
9gamm-q1uec0 Psychrobacter sp. PRwf-1 hypothetical protein Psychrobacter sp. PRwf-1
9gamm-q1zes3 Psychromonas sp. CNPT3 hypothetical protein Psychromonas sp. CNPT3
9gamm-q1zes8 Psychromonas sp. CNPT3 hypothetical protein Psychromonas sp. CNPT3
9gamm-q1zet3 Psychromonas sp. CNPT3 hypothetical protein Psychromonas sp. CNPT3
9prot-q0ez31 Mariprofundus ferrooxydans PV-1 Esterase\/lipase\/thioesterase family active site Mariprofundus ferrooxydans PV-1
9zzzz-a0a0g3fj44 uncultured organism EH145 Uncharacterized protein uncultured organism
accpu-c7rq29 Accumulibacter phosphatis (strain UW-1) TIR protein Accumulibacter phosphatis
aciad-q6f6x6 Acinetobacter sp. (strain ADP1) hypothetical protein Acinetobacter sp.
aciad-q6fal1 Acinetobacter sp. (strain ADP1) hypothetical protein Acinetobacter sp.
acide-c5tag9 Acidovorax delafieldii 2AN PGAP1 family protein Acidovorax delafieldii 2AN
aciet-b9mcl3 Acidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))Acidovorax sp. (strain JS42) PGAP1 family protein Acidovorax ebreus
aerhh-a0kkj8 Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 \/ NCIB 9240) Putative lipase transmembrane protein Aeromonas hydrophila subsp. hydrophila
aers4-a4smh7 Aeromonas salmonicida (strain A449) Putative lipase transmembrane protein Aeromonas salmonicida
ailme-d2hdi6 Ailuropoda melanoleuca (Giant panda) Uncharacterized protein Ailuropoda melanoleuca
anade-q2ipl0 Anaeromyxobacter dehalogenans (strain 2CP-C) pgap1-like precursor Anaeromyxobacter dehalogenans
anoga-q7psq5 Anopheles gambiae str. PEST ensangp00000014894 (fragment) Anopheles gambiae
arath-At3g27325 Arabidopsis thaliana (Mouse-ear cress) At3g27325 similarity to negative regulator of vesicle formation Arabidopsis thaliana
arath-At5g17670 Arabidopsis thaliana (Mouse-ear cress) Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) MVA3.2, At5g17670 Hydrolase-like protein Arabidopsis thaliana
ashgo-BST1 Ashbya gossypii (Yeast) (Eremothecium gossypii) afr521wp Ashbya gossypii
aspfu-q4wgm4 Aspergillus fumigatus, Neosartorya fumigata, Neosartorya fischeri (Aspergillus fischerianus) gpi maturation protein (bst1), putative Aspergillus fumigatus Af293
aspor-q2usi0 Aspergillus oryzae negative regulator of copii vesicle formation Aspergillus oryzae
asptn-bst1 Aspergillus terreus (strain NIH 2624 \/ FGSC A1156) GPI inositol-deacylase Aspergillus terreus
bifdb-d2q844 Bifidobacterium dentium (strains ATCC 27534 \/ DSM 20436 \/ JCM 1195 \/ Bd1\; ATCC 27678) Alpha\/beta fold family hydrolase membrane associated protein Bifidobacterium dentium
bovin-e1bnq0 Bos taurus (Bovine) Uncharacterized protein Bos taurus
caebr-a8y4l4 Caenorhabditis briggsae hypothetical protein cbg23146 Caenorhabditis briggsae
caeel-T19B10.8 Caenorhabditis elegans t19b10.8 protein Caenorhabditis elegans
canal-q59vp0 Candida albicans (strains SC5314\; WO-1) hypothetical protein bst1 Candida albicans SC5314
canal-q5ai09 Candida albicans (strains SC5314\; WO-1) hypothetical protein tgl2 Candida albicans SC5314
canfa-e2r8v9 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein Canis lupus familiaris
canga-q6fly9 Candida glabrata (Yeast) (Torulopsis glabrata) candida glabrata strain cbs138 chromosome k complete sequence Candida glabrata
chagb-q2gtl6 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chagb-q2gw21 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chagb-q2h102 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chagb-q2hht3 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chatd-g0s652 Chaetomium thermophilum (strain DSM 1495 \/ CBS 144.50 \/ IMI 039719) (Thermochaetoides thermophila) GPI inositol-deacylase Thermochaetoides thermophila DSM 1495
cloac-CAC1028 Clostridium acetobutylicum lipase Clostridium acetobutylicum
cloth-a3dhx6 Clostridium thermocellum, hydrolase fold precursor Clostridium thermocellum ATCC 27405
cocim-bst1 Coccidioides immitis (Valley fever fungus) GPI inositol-deacylase Coccidioides immitis
comte-b7wsd9 Comamonas testosteroni KF-1 PGAP1 family protein Comamonas testosteroni KF-1
cryne-q5kf48 Cryptococcus neoformans (Filobasidiella neoformans) er-associated protein catabolism-related protein, putative Cryptococcus neoformans
cupnh-q0kcu9 Cupriavidus necator (strain ATCC 17699 \/ H16 \/ DSM 428 \/ Stanier 337) (Ralstonia eutropha) Predicted acetyltransferase and hydrolase with the alpha\/beta hydrolase fold Cupriavidus necator
cuppj-q46qh0 Cupriavidus pinatubonensis (strain JMP134 \/ LMG 1197) (Alcaligenes eutrophus) (Ralstonia eutropha) hypothetical protein Ralstonia eutropha
cuppj-q473w2 Cupriavidus pinatubonensis (strain JMP134 \/ LMG 1197) (Alcaligenes eutrophus) (Ralstonia eutropha) putative lipase transmembrane protein Ralstonia eutropha
cuptr-b3r3y6 Cupriavidus taiwanensis (strain R1 \/ LMG 19424) (Ralstonia taiwanensis (strain LMG 19424)) Putative LIPASE\/acetyltransferase TRANSMEMBRANE PROTEIN Cupriavidus taiwanensis
debha-q6bpc6 Debaryomyces hansenii (Yeast) (Torulaspora hansenii) lipase Debaryomyces hansenii
debha-q6brg1 Debaryomyces hansenii (Yeast) (Torulaspora hansenii) hansenii Debaryomyces hansenii
decar-q47fp1 Dechloromonas aromatica (strain RCB) putative lipase transmembrane protein Dechloromonas aromatica
delas-a9bxx5 Delftia acidovorans (strain DSM 14801 \/ SPH-1) PGAP1 family protein Delftia acidovorans
dicdi-q54vc2 Dictyostelium discoideum (Slime mold) hypothetical protein Dictyostelium discoideum
dicdi-q54xe3 Dictyostelium discoideum (Slime mold) hypothetical protein Dictyostelium discoideum
drome-CG3160 Drosophila melanogaster (Fruit fly) cg3160 sd04405p protein Drosophila melanogaster
drops-q29i09 Drosophila pseudoobscura (Fruit fly) ga16331-pa (fragment) Drosophila pseudoobscura
ecolx-e0quw2 Escherichia coli NC101 Putative uncharacterized protein Escherichia coli NC101
ecout-q1r7l6 Escherichia coli, Escherichia sp., hypothetical protein Escherichia coli
emeni-BST1 Aspergillus nidulans FGSC A4 hypothetical protein Aspergillus nidulans FGSC A4
emeni-q5awq3 Emericella nidulans (Aspergillus nidulans) FGSC A4 hypothetical protein Aspergillus nidulans FGSC A4
geomg-q39yy9 Geobacter metallireducens (strain GS-15 \/ ATCC 53774 \/ DSM 7210) hypothetical protein Geobacter metallireducens
geosl-q747u4 Geobacter sulfurreducens conserved domain protein Geobacter sulfurreducens
gibze-q4hyd8 Gibberella zeae (Fusarium graminearum) GPI inositol-deacylase Gibberella zeae
glovi-q7ndy7 Gloeobacter violaceus Gll4095 protein Gloeobacter violaceus
hahch-q2s796 Hahella chejuensis (strain KCTC 2396) hydrolase fold Hahella chejuensis
halo1-d0ljp4 Haliangium ochraceum (strain DSM 14365 \/ JCM 11303 \/ SMP-2) Putative uncharacterized protein Haliangium ochraceum
human-PGAP1 Homo sapiens (Human)GPI inositol-deacylase PGAP1 117.8 kd protein in ste2-frs2 intergenic region Homo sapiens
klula-q6cin9 Kluyveromyces lactis (Yeast) 1140 of kluyveromyces lactis Kluyveromyces lactis
leima-q4fw33 Leishmania major strain Friedlin hypothetical protein Leishmania major strain Friedlin
lepin-LA0587 Leptospira interrogans lactonizing lipase (EC 3.1.1.3) Leptospira interrogans
lepin-LA1345 Leptospira interrogans (and strain serogroup Icterohaemorrhagiae serovar copenhageni) hypothetical protein Leptospira interrogans
lepin-LA1861 Leptospira interrogans (and serogroup Icterohaemorrhagiae serovar copenhageni)conserved hypothetical protein Leptospira interrogans
lepin-LA2505 Leptospira interrogans (and serogroup Icterohaemorrhagiae serovar copenhageni) esterase, putative Leptospira interrogans
maggr-q0pnd5 Magnaporthe grisea (Crabgrass-specific blast fungus) (Pyricularia grisea) Magnaporthe oryzae (Rice blast fungus) (Pyricularia oryzae) Triacylglycerol lipase Magnaporthe grisea
mago7-a4qxi6 Magnaporthe oryzae (strain 70-15 \/ FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) GPI inositol-deacylase Magnaporthe oryzae
metpp-a2scm2 Methylibium petroleiphilum (strain PM1) Putative lipase transmembrane protein Methylibium petroleiphilum
mouse-q3uuq7 Mus musculus (Mouse) gpi deacylase full insert sequence. (fragment) Mus musculus
mycgi-a4t0x3 Mycobacterium gilvum (Mycobacterium flavescens), Mycobacterium sp., hypothetical protein Mycobacterium gilvum PYR-GCK
mycss-q1bcs4 Mycobacterium sp., pgap1-like Mycobacterium sp. KMS
nech7-c7ytb2 Nectria haematococca (strain 77-13-4 \/ FGSC 9596 \/ MPVI) (Fusarium solani subsp. pisi) Predicted protein Nectria haematococca
neucr-q6mfs7 Neurospora crassa related to sphingosine-1-phosphate lyase Neurospora crassa
neucr-q7rxv5 Neurospora crassa predicted protein (hypothetical protein b11e5.130) Neurospora crassa
neucr-q7sff7 Neurospora crassa predicted protein Neurospora crassa
niteu-TGL2 Nitrosomonas europaea esterase\/lipase\/thioesterase family active site (EC 3.1.1.3) Nitrosomonas europaea
nitmu-q2yap5 Nitrosospira multiformis (strain ATCC 25196 \/ NCIMB 11849) esterase\/lipase\/thioesterase family active site Nitrosospira multiformis
nocsj-A1SME4 Nocardioides sp. JS614 hypothetical protein (fragment) Nocardioides sp. JS614
orysa-q67tv0 Oryza sativa subsp. japonica subsp. indica (Rice) gpi inositol-deacylase pgap1-like protein Oryza sativa
orysa-q6z6y3 Oryza sativa (japonica cultivar-group) hypothetical protein p0576f08.31 Oryza sativa
parl1-a7hus8 Parvibaculum lavamentivorans (strain DS-1 \/ DSM 13023 \/ NCIMB 13966) Putative uncharacterized protein Parvibaculum lavamentivorans
phano-bst1 Phaeosphaeria nodorum (Glume blotch fungus) (Septoria nodorum) GPI inositol-deacylase Phaeosphaeria nodorum
pholl-q7n246 Photorhabdus luminescens subsp. laumondii similar to unknown protein Photorhabdus luminescens subsp. laumondii
pholl-q7n258 Photorhabdus luminescens subsp. laumondii similar to unknown protein Photorhabdus luminescens subsp. laumondii
pholu-ORF47 Photorhabdus luminescens (Xenorhabdus luminescens) orf47 Photorhabdus luminescens
phopr-q1z944 Photobacterium profundum 3TCK hypothetical protein Photobacterium profundum 3TCK
phopr-q6lq19 Photobacterium profundum (Photobacterium sp. (strain SS9)) (and 3TCK) hypothetical protein Photobacterium profundum
phopr-q6lql0 Photobacterium profundum (Photobacterium sp. (strain SS9)) hypothetical protein Photobacterium profundum
plaf7-q8ii19 Plasmodium falciparum (isolate 3D7) PF3D7_1134500 GPI inositol-deacylase Plasmodium falciparum
podan-b2ae59 Podospora anserina (strain S \/ DSM 980 \/ FGSC 10383) (Pleuraga anserina) Predicted CDS Pa_4_2940 Podospora anserina
podan-b2afn5 Podospora anserina (strain S \/ DSM 980 \/ FGSC 10383) (Pleuraga anserina) Predicted CDS Pa_5_12100 Podospora anserina
polna-a1vjc9 Polaromonas naphthalenivorans (strain CJ2) Putative lipase transmembrane protein Polaromonas naphthalenivorans
polsj-q124c9 Polaromonas sp. (strain JS666 \/ ATCC BAA-500) Putative lipase transmembrane protein Polaromonas sp.
pseae-PA1510 Pseudomonas aeruginosa hypothetical protein pa1510 Tle4 Pseudomonas aeruginosa
pseht-q3ijy1 Pseudoalteromonas haloplanktis (strain TAC 125) hypothetical protein Pseudoalteromonas haloplanktis
psyar-q4fuy7 Psychrobacter arcticum Psychrobacter cryohalolentis K5 hypothetical protein Psychrobacter arcticum
ralme-q1lpy4 Ralstonia metallidurans (strain CH34 \/ ATCC 43123 \/ DSM 2839) pgap1-like protein precursor Ralstonia metallidurans
ralp1-c6bjr8 Ralstonia pickettii (strain 12D) PGAP1 family protein Ralstonia pickettii
ralpj-b2u7t0 Ralstonia pickettii (strain 12J) PGAP1 family protein Ralstonia pickettii
ralso-RSC2082 Ralstonia solanacearum (Pseudomonas solanacearum) putative lipase transmembrane protein (EC 3.1.-.-) Ralstonia solanacearum
ralso-RSP0769 Ralstonia solanacearum (Pseudomonas solanacearum) putative transmembrane protein Ralstonia solanacearum
ralso-a3rqm7 Ralstonia solanacearum UW551 Lipase Ralstonia solanacearum UW551
ralso-b5s2a7 Ralstonia solanacearum MolK2 Lipase protein Ralstonia solanacearum MolK2
ralso-b5sii0 Ralstonia solanacearum IPO1609 Lipase protein Ralstonia solanacearum IPO1609
ralso-q8xsf9 Ralstonia solanacearum (Pseudomonas solanacearum) hypothetical protein rsp0517 Ralstonia solanacearum
ralso-q8xta6 Ralstonia solanacearum (Pseudomonas solanacearum) hypothetical protein rsp0208 Ralstonia solanacearum
ratno-q765a7 Rattus norvegicus (Rat) gpi deacylase Rattus norvegicus
rhofd-q21sk3 Rhodoferax ferrireducens (strain DSM 15236 \/ ATCC BAA-621 \/ T118) pgap1-like Rhodoferax ferrireducens
rhom4-d0mhw6 Rhodothermus marinus (Rhodothermus obamensis)\; uncultured bacterium. Esterase\/lipase\/thioesterase family protein estC55-213 Rhodothermus marinus
rhop5-q07nt1 Rhodopseudomonas palustris (strain BisA53) Putative uncharacterized protein Rhodopseudomonas palustris
rhopa-q379w1 Rhodopseudomonas palustris BisA53 hypothetical protein Rhodopseudomonas palustris BisA53
rhopa-q6n3c2 Rhodopseudomonas palustris hypothetical protein Rhodopseudomonas palustris
rhopb-q218h0 Rhodopseudomonas palustris (strain BisB18) hypothetical protein Rhodopseudomonas palustris
rhort-q2rtc8 Rhodospirillum rubrum (strain ATCC 11170 \/ NCIB 8255) TPR repeat Rhodospirillum rubrum
salrd-q2s1v7 Salinibacter ruber (strain DSM 13855) putative secreted lipase Salinibacter ruber
schpo-BST1 Schizosaccharomyces pombe (strain 972 \/ ATCC 24843) (Fission yeast) putative negative regulator of vesicle formation Schizosaccharomyces pombe
tetng-q4rk53 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tetts-q22sa5 Tetrahymena thermophila SB210 hypothetical protein Tetrahymena thermophila SB210
thaps-b8c0a3 Thalassiosira pseudonana (Marine diatom) Putative uncharacterized protein Thalassiosira pseudonana
triei-q10v22 Trichodesmium erythraeum (strain IMS101) Putative uncharacterized protein Trichodesmium erythraeum
triei-q114j5 Trichodesmium erythraeum (strain IMS101) NB-ARC Trichodesmium erythraeum
tryb2-q38dx1 Trypanosoma brucei hypothetical protein Trypanosoma brucei
trybb-q2pg85 Trypanosoma brucei brucei gpi inositol deacylase 2 Trypanosoma brucei
trycr-q4d3x3 Trypanosoma cruzi hypothetical protein Trypanosoma cruzi
trycr-q4d975 Trypanosoma cruzi hypothetical protein Trypanosoma cruzi
trycr-q4dt91 Trypanosoma cruzi hypothetical protein Trypanosoma cruzi
trycr-q4e5z2 Trypanosoma cruzi hypothetical protein Trypanosoma cruzi
ustma-q4p782 Ustilago maydis (strain 521 \/ FGSC 9021) (Corn smut fungus) hypothetical protein Ustilago maydis 521
vibch-VCA0092 Vibrio cholerae hypothetical protein vca0092 Vibrio cholerae
vibf1-q5dyj8 Vibrio fischeri (strain ATCC 700601 \/ ES114) acetyltransferase\/hydrolase family protein Vibrio fischeri
vibpa-VPA1249 Vibrio parahaemolyticus, Vibrio alginolyticus, hypothetical protein Vibrio parahaemolyticus
vibvu-VV20805 Vibrio vulnificus predicted acetyltransferase\/hydrolase Vibrio vulnificus
xanca-XCC0757 Xanthomonas campestris (pv. campestris) hypothetical protein xcc0757 Xanthomonas campestris
xenla-q66j01 Xenopus laevis (African clawed frog) mgc83827 protein Xenopus laevis
yarli-BST1B Yarrowia lipolytica (Yeast) (Candida lipolytica) GPI inositol-deacylase B Yarrowia lipolytica
yarli-q6c2z2 Yarrowia lipolytica (Candida lipolytica) lipolytica Yarrowia lipolytica
yarli-q6cf60 Yarrowia lipolytica (Candida lipolytica) lipolytica Yarrowia lipolytica
yeast-BST1 Saccharomyces cerevisiae (Baker's yeast), BST1, YFL025C, GPI inositol-deacylase Saccharomyces cerevisiae
yeast-tgl2 Saccharomyces cerevisiae (Baker's yeast) (and strains YJM789\; JAY291\; AWRI1631\; Lalvin EC1118 \/ Prise de mousse\; RM11-1a) lipase 2 (EC 3.1.1.3) (triacylglycerol lipase) Saccharomyces cerevisiae

Gene_locus_frgt Name Species
pig-f1sn10 Sus scrofa (Pig) Uncharacterized protein Sus scrofa
shefn-q07wz5 Shewanella frigidimarina (strain NCIMB 400) hypothetical protein precursor Shewanella frigidimarina NCIMB 400

Substrate Chemical Nomenclature Proteins
GPI-anchor

Inhibitor Chemical Nomenclature Proteins
HDFP 1-(ethoxy-fluoro-oxidophosphaniumyl)hexadecane human-PREPL
POPS (2S)-2-amino-3-[[(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropoxy]-hydroxyphosphoryl]oxypropanoic acid chatd-g0s652
Palmitate hexadecanoic acid bacan-BA4983    human-CES1    bovin-ppt    humla-1lipa    myctu-ym24    chatd-g0s652
Phosphatidylinositol(18-0_18-0) [(2~{R})-1-octadecoxy-3-[oxidanyl-[(2~{R},3~{R},5~{S},6~{R})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] octadecanoate || [(2R)-1-[hydroxy-[(2R,3S,5R,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxy-3-octadecoxypropan-2-yl] octadecanoate chatd-g0s652
Phosphatidylinositol(18-0_20-4) [(2R)-1-[hydroxy-[(5R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxy-3-octadecoxypropan-2-yl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate || [(2R)-1-[hydroxy-[(2R,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxy-3-octadecoxypropan-2-yl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate chatd-g0s652
Sal-A-alkyne plafa-PF10.0020    plafa-PF07.0040    plafa-a0a143zya4    plafa-PF10.0379    plafa-PF13.0153    plaf7-q8iik5    plaf7-q8ii19    plafa-MAL8P1.138
Salinipostin-A (3R,8aS)-5-butyl-3-oxo-3-pentadecoxy-8,8a-dihydro-1H-furo[3,4-e][1,3,2]dioxaphosphepin-6-one plafa-PF10.0020    plafa-PF07.0040    plafa-a0a143zya4    plafa-PF10.0379    plafa-PF13.0153    plaf7-q8iik5    plaf7-q8ii19    plafa-MAL8P1.138

References (4)

Title : Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis - Hong_2024_Nat.Commun_15_8
Author(s) : Hong J , Li T , Chao Y , Xu Y , Zhu Z , Zhou Z , Gu W , Qu Q , Li D
Ref : Nat Commun , 15 :8 , 2024
Abstract :
PubMedSearch : Hong_2024_Nat.Commun_15_8
PubMedID: 38167496
Gene_locus related to this paper: chatd-g0s652 , human-PGAP1

Title : Null mutation in PGAP1 impairing Gpi-anchor maturation in patients with intellectual disability and encephalopathy - Murakami_2014_PLoS.Genet_10_e1004320
Author(s) : Murakami Y , Tawamie H , Maeda Y , Buttner C , Buchert R , Radwan F , Schaffer S , Sticht H , Aigner M , Reis A , Kinoshita T , Jamra RA
Ref : PLoS Genet , 10 :e1004320 , 2014
Abstract :
PubMedSearch : Murakami_2014_PLoS.Genet_10_e1004320
PubMedID: 24784135
Gene_locus related to this paper: human-PGAP1

Title : The structural basis of the Tle4-Tli4 complex reveals the self-protection mechanism of H2-T6SS in Pseudomonas aeruginosa - Lu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_3233
Author(s) : Lu D , Zheng Y , Liao N , Wei L , Xu B , Liu X , Liu J
Ref : Acta Crystallographica D Biol Crystallogr , 70 :3233 , 2014
Abstract :
PubMedSearch : Lu_2014_Acta.Crystallogr.D.Biol.Crystallogr_70_3233
PubMedID: 25478841
Gene_locus related to this paper: pseae-PA1510

Title : Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p - Tanaka_2004_J.Biol.Chem_279_14256
Author(s) : Tanaka S , Maeda Y , Tashima Y , Kinoshita T
Ref : Journal of Biological Chemistry , 279 :14256 , 2004
Abstract :
PubMedSearch : Tanaka_2004_J.Biol.Chem_279_14256
PubMedID: 14734546
Gene_locus related to this paper: human-PGAP1 , ratno-q765a7 , yeast-BST1