SCHEMBL3294100
analogue of substrate of Organophosphorous Hydrolase, zinc containing phosphotriesterase Parathion hydrolase which are not alpha/beta hydrolase
General
Type : Organophosphate, Derivative of Paraoxon
Chemical_Nomenclature : diethyl (4-methylphenyl) phosphate
Canonical SMILES : CCOP(=O)(OCC)OC1=CC=C(C=C1)C
InChI : InChI=1S\/C11H17O4P\/c1-4-13-16(12,14-5-2)15-11-8-6-10(3)7-9-11\/h6-9H,4-5H2,1-3H3
InChIKey : UBSNERLLCAIDQQ-UHFFFAOYSA-N
Other name(s) : diethyl 4-methoxyphenyl phosphate || AC1LAVBQ || Diethyl p-tolyl phosphate || SCHEMBL3294100 || Diethyl (4-methylphenyl) phosphate
Target
References (5)
| Title : Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities - Reeves_2008_Protein.Eng.Des.Sel_21_405 |
| Author(s) : Reeves TE , Wales ME , Grimsley JK , Li P , Cerasoli DM , Wild JR |
| Ref : Protein Engineering Des Sel , 21 :405 , 2008 |
| Abstract : |
| PubMedSearch : Reeves_2008_Protein.Eng.Des.Sel_21_405 |
| PubMedID: 18434422 |
| Title : Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site - Grimsley_2005_Arch.Biochem.Biophys_442_169 |
| Author(s) : Grimsley JK , Calamini B , Wild JR , Mesecar AD |
| Ref : Archives of Biochemistry & Biophysics , 442 :169 , 2005 |
| Abstract : |
| PubMedSearch : Grimsley_2005_Arch.Biochem.Biophys_442_169 |
| PubMedID: 16188223 |
| Title : Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site - Hill_2003_J.Am.Chem.Soc_125_8990 |
| Author(s) : Hill CM , Li WS , Thoden JB , Holden HM , Raushel FM |
| Ref : Journal of the American Chemical Society , 125 :8990 , 2003 |
| Abstract : |
| PubMedSearch : Hill_2003_J.Am.Chem.Soc_125_8990 |
| PubMedID: 15369336 |
| Title : Three-dimensional structure of the zinc-containing phosphotriesterase with the bound substrate analog diethyl 4-methylbenzylphosphonate - Vanhooke_1996_Biochemistry_35_6020 |
| Author(s) : Vanhooke JL , Benning MM , Raushel FM , Holden HM |
| Ref : Biochemistry , 35 :6020 , 1996 |
| Abstract : |
| PubMedSearch : Vanhooke_1996_Biochemistry_35_6020 |
| PubMedID: 8634243 |
| Title : Three-dimensional structure of the binuclear metal center of phosphotriesterase - Benning_1995_Biochemistry_34_7973 |
| Author(s) : Benning MM , Kuo JM , Raushel FM , Holden HM |
| Ref : Biochemistry , 34 :7973 , 1995 |
| Abstract : |
| PubMedSearch : Benning_1995_Biochemistry_34_7973 |
| PubMedID: 7794910 |