TerreulactoneD
Produced by Aspergillus terreus Fb000501. IC50 0.42 microM for ACHE IC50 >200 microM for BCHE
General
Type : Natural, Meroterpenoid
Chemical_Nomenclature : (1S,2S,7R,10R)-1,7-dihydroxy-5-methoxy-2,6,6,10-tetramethyl-14-(3,4,5-trimethoxyphenyl)-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-4,12(17),13-triene-3,16-dione
Canonical SMILES : CC1(C(=CC(=O)C2(C1(CCC3(C2(CC4=C(O3)C=C(OC4=O)C5=CC(=C(C(=C5)OC)OC)OC)O)C)O)C)OC)C
InChI : InChI=1S\/C30H36O10\/c1-26(2)23(37-7)14-22(31)28(4)29(26,33)10-9-27(3)30(28,34)15-17-19(40-27)13-18(39-25(17)32)16-11-20(35-5)24(38-8)21(12-16)36-6\/h11-14,33-34H,9-10,15H2,1-8H3\/t27-,28+,29-,30-\/m1\/s1
InChIKey : AENKBRFCOPMCEQ-GOGZTAQTSA-N
Other name(s) : Terreulactone D
MW : 556.6
Formula : C30H36O10
CAS_number :
PubChem : 10053434
UniChem : AENKBRFCOPMCEQ-GOGZTAQTSA-N
Target
Families : TerreulactoneD ligand of proteins in family
ACHE
References (2)
| Title : Terreulactones A, B, C, and D: novel acetylcholinesterase inhibitors produced by Aspergillus terreus. I. Taxonomy, fermentation, isolation and biological activities - Cho_2003_J.Antibiot.(Tokyo)_56_344 |
| Author(s) : Cho KM , Kim WG , Lee CK , Yoo ID |
| Ref : J Antibiot (Tokyo) , 56 :344 , 2003 |
| Abstract : |
| PubMedSearch : Cho_2003_J.Antibiot.(Tokyo)_56_344 |
| PubMedID: 12817807 |
| Title : Terreulactones A, B, C, and D: novel acetylcholinesterase inhibitors produced by Aspergillus terreus. II. Physico-chemical properties and structure determination - Kim_2003_J.Antibiot.(Tokyo)_56_351 |
| Author(s) : Kim WG , Cho KM , Lee CK , Yoo ID |
| Ref : J Antibiot (Tokyo) , 56 :351 , 2003 |
| Abstract : |
| PubMedSearch : Kim_2003_J.Antibiot.(Tokyo)_56_351 |
| PubMedID: 12817808 |